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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BCL9L
Full Name:
B-cell CLL/lymphoma 9-like protein
Alias:
B-cell CLL/lymphoma 9-like; BCL9-2; DLNB11; Nuclear co-factor of beta-catenin signalling; Protein BCL9-2
Type:
Unknown function
Mass (Da):
157129
Number AA:
1499
UniProt ID:
Q86UU0
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003713
PhosphoSite+
KinaseNET
Biological Process:
GO:0030512
GO:0010718
GO:0010552
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
R
I
L
A
N
K
T
R
L
P
H
P
R
R
Site 2
S21
R
R
R
E
A
P
G
S
P
P
L
S
P
R
G
Site 3
S25
A
P
G
S
P
P
L
S
P
R
G
H
C
P
P
Site 4
T45
M
H
P
E
N
K
L
T
N
H
G
K
T
G
N
Site 5
S57
T
G
N
G
G
A
Q
S
Q
H
Q
N
V
N
Q
Site 6
S72
G
P
T
C
N
V
G
S
K
G
V
G
A
G
N
Site 7
S88
G
A
K
A
N
Q
I
S
P
S
N
S
S
L
K
Site 8
S90
K
A
N
Q
I
S
P
S
N
S
S
L
K
N
P
Site 9
S92
N
Q
I
S
P
S
N
S
S
L
K
N
P
Q
A
Site 10
S93
Q
I
S
P
S
N
S
S
L
K
N
P
Q
A
G
Site 11
S105
Q
A
G
V
P
P
F
S
S
L
K
G
K
V
K
Site 12
S106
A
G
V
P
P
F
S
S
L
K
G
K
V
K
R
Site 13
S116
G
K
V
K
R
D
R
S
V
S
V
D
S
G
E
Site 14
S118
V
K
R
D
R
S
V
S
V
D
S
G
E
Q
R
Site 15
S121
D
R
S
V
S
V
D
S
G
E
Q
R
E
A
G
Site 16
T129
G
E
Q
R
E
A
G
T
P
S
L
D
S
E
A
Site 17
S131
Q
R
E
A
G
T
P
S
L
D
S
E
A
K
E
Site 18
S134
A
G
T
P
S
L
D
S
E
A
K
E
V
A
P
Site 19
S143
A
K
E
V
A
P
R
S
K
R
R
C
V
L
E
Site 20
S156
L
E
R
K
Q
P
Y
S
G
D
E
W
C
S
G
Site 21
S162
Y
S
G
D
E
W
C
S
G
P
D
S
E
E
D
Site 22
S166
E
W
C
S
G
P
D
S
E
E
D
D
K
P
I
Site 23
T197
Q
L
G
P
G
Q
T
T
Q
L
P
L
S
E
S
Site 24
S202
Q
T
T
Q
L
P
L
S
E
S
S
V
P
G
A
Site 25
S204
T
Q
L
P
L
S
E
S
S
V
P
G
A
P
H
Site 26
S205
Q
L
P
L
S
E
S
S
V
P
G
A
P
H
G
Site 27
S262
V
L
Q
G
R
A
D
S
I
L
A
Y
H
Q
Q
Site 28
Y266
R
A
D
S
I
L
A
Y
H
Q
Q
N
V
P
R
Site 29
T285
Q
A
P
K
V
P
P
T
P
E
P
L
P
L
S
Site 30
S292
T
P
E
P
L
P
L
S
T
P
S
A
G
T
P
Site 31
T293
P
E
P
L
P
L
S
T
P
S
A
G
T
P
Q
Site 32
T298
L
S
T
P
S
A
G
T
P
Q
S
Q
P
P
P
Site 33
S301
P
S
A
G
T
P
Q
S
Q
P
P
P
L
P
P
Site 34
S316
P
P
P
P
A
P
G
S
A
P
P
A
L
P
P
Site 35
S330
P
E
G
P
P
E
D
S
S
Q
D
L
A
P
N
Site 36
S331
E
G
P
P
E
D
S
S
Q
D
L
A
P
N
S
Site 37
S338
S
Q
D
L
A
P
N
S
V
G
A
A
S
T
G
Site 38
S343
P
N
S
V
G
A
A
S
T
G
G
G
T
G
G
Site 39
T355
T
G
G
T
H
P
N
T
P
T
A
T
T
A
N
Site 40
S372
L
P
P
G
G
D
P
S
S
A
P
G
P
A
L
Site 41
S373
P
P
G
G
D
P
S
S
A
P
G
P
A
L
L
Site 42
S392
A
P
G
N
G
Q
R
S
L
V
G
S
E
G
L
Site 43
S396
G
Q
R
S
L
V
G
S
E
G
L
S
K
E
Q
Site 44
S400
L
V
G
S
E
G
L
S
K
E
Q
L
E
H
R
Site 45
S410
Q
L
E
H
R
E
R
S
L
Q
T
L
R
D
I
Site 46
T413
H
R
E
R
S
L
Q
T
L
R
D
I
E
R
L
Site 47
S424
I
E
R
L
L
L
R
S
G
E
T
E
P
F
L
Site 48
T456
P
P
P
Q
Q
P
P
T
A
P
P
S
G
L
K
Site 49
S460
Q
P
P
T
A
P
P
S
G
L
K
K
Y
E
E
Site 50
Y465
P
P
S
G
L
K
K
Y
E
E
P
L
Q
S
M
Site 51
S471
K
Y
E
E
P
L
Q
S
M
I
S
Q
T
Q
S
Site 52
S474
E
P
L
Q
S
M
I
S
Q
T
Q
S
L
G
G
Site 53
S478
S
M
I
S
Q
T
Q
S
L
G
G
P
P
L
E
Site 54
S512
I
Q
R
L
G
Q
D
S
L
T
P
E
Q
V
A
Site 55
T514
R
L
G
Q
D
S
L
T
P
E
Q
V
A
W
R
Site 56
Y527
W
R
K
L
Q
E
E
Y
Y
E
E
K
R
R
K
Site 57
Y528
R
K
L
Q
E
E
Y
Y
E
E
K
R
R
K
E
Site 58
S543
E
Q
I
G
L
H
G
S
R
P
L
Q
D
M
M
Site 59
Y564
V
R
G
P
P
P
P
Y
H
S
K
P
G
D
Q
Site 60
S566
G
P
P
P
P
Y
H
S
K
P
G
D
Q
W
P
Site 61
S650
L
P
P
M
G
G
P
S
N
F
A
Q
N
T
M
Site 62
T656
P
S
N
F
A
Q
N
T
M
P
Y
P
G
G
Q
Site 63
Y659
F
A
Q
N
T
M
P
Y
P
G
G
Q
G
E
A
Site 64
T671
G
E
A
E
R
F
M
T
P
R
V
R
E
E
L
Site 65
S688
H
Q
L
L
E
K
R
S
M
G
M
Q
R
P
L
Site 66
S700
R
P
L
G
M
A
G
S
G
M
G
Q
S
M
E
Site 67
T736
G
G
E
G
L
A
G
T
P
M
G
M
E
F
G
Site 68
S750
G
G
G
R
G
L
L
S
P
P
M
G
Q
S
G
Site 69
S756
L
S
P
P
M
G
Q
S
G
L
R
E
V
D
P
Site 70
S797
P
Q
Q
Q
M
L
M
S
Q
K
M
R
G
P
G
Site 71
S813
L
M
G
P
Q
G
L
S
P
E
E
M
A
R
V
Site 72
S825
A
R
V
R
A
Q
N
S
S
G
V
M
G
G
P
Site 73
S826
R
V
R
A
Q
N
S
S
G
V
M
G
G
P
Q
Site 74
S839
P
Q
K
M
L
M
P
S
Q
F
P
N
Q
G
Q
Site 75
S850
N
Q
G
Q
Q
G
F
S
G
G
Q
G
P
Y
Q
Site 76
Y856
F
S
G
G
Q
G
P
Y
Q
A
M
S
Q
D
M
Site 77
S871
G
N
T
Q
D
M
F
S
P
D
Q
S
S
M
P
Site 78
S875
D
M
F
S
P
D
Q
S
S
M
P
M
S
N
V
Site 79
S876
M
F
S
P
D
Q
S
S
M
P
M
S
N
V
G
Site 80
S880
D
Q
S
S
M
P
M
S
N
V
G
T
T
R
L
Site 81
T884
M
P
M
S
N
V
G
T
T
R
L
S
H
M
P
Site 82
S888
N
V
G
T
T
R
L
S
H
M
P
L
P
P
A
Site 83
S896
H
M
P
L
P
P
A
S
N
P
P
G
T
V
H
Site 84
T901
P
A
S
N
P
P
G
T
V
H
S
A
P
N
R
Site 85
S904
N
P
P
G
T
V
H
S
A
P
N
R
G
L
G
Site 86
S915
R
G
L
G
R
R
P
S
D
L
T
I
S
I
N
Site 87
T918
G
R
R
P
S
D
L
T
I
S
I
N
Q
M
G
Site 88
S920
R
P
S
D
L
T
I
S
I
N
Q
M
G
S
P
Site 89
S926
I
S
I
N
Q
M
G
S
P
G
M
G
H
L
K
Site 90
S934
P
G
M
G
H
L
K
S
P
T
L
S
Q
V
H
Site 91
T936
M
G
H
L
K
S
P
T
L
S
Q
V
H
S
P
Site 92
S938
H
L
K
S
P
T
L
S
Q
V
H
S
P
L
V
Site 93
S942
P
T
L
S
Q
V
H
S
P
L
V
T
S
P
S
Site 94
T946
Q
V
H
S
P
L
V
T
S
P
S
A
N
L
K
Site 95
S947
V
H
S
P
L
V
T
S
P
S
A
N
L
K
S
Site 96
S949
S
P
L
V
T
S
P
S
A
N
L
K
S
P
Q
Site 97
S954
S
P
S
A
N
L
K
S
P
Q
T
P
S
Q
M
Site 98
T957
A
N
L
K
S
P
Q
T
P
S
Q
M
V
P
L
Site 99
S959
L
K
S
P
Q
T
P
S
Q
M
V
P
L
P
S
Site 100
S966
S
Q
M
V
P
L
P
S
A
N
P
P
G
P
L
Site 101
S975
N
P
P
G
P
L
K
S
P
Q
V
L
G
S
S
Site 102
S981
K
S
P
Q
V
L
G
S
S
L
S
V
R
S
P
Site 103
S982
S
P
Q
V
L
G
S
S
L
S
V
R
S
P
T
Site 104
S984
Q
V
L
G
S
S
L
S
V
R
S
P
T
G
S
Site 105
S987
G
S
S
L
S
V
R
S
P
T
G
S
P
S
R
Site 106
T989
S
L
S
V
R
S
P
T
G
S
P
S
R
L
K
Site 107
S991
S
V
R
S
P
T
G
S
P
S
R
L
K
S
P
Site 108
S993
R
S
P
T
G
S
P
S
R
L
K
S
P
S
M
Site 109
S997
G
S
P
S
R
L
K
S
P
S
M
A
V
P
S
Site 110
S999
P
S
R
L
K
S
P
S
M
A
V
P
S
P
G
Site 111
S1004
S
P
S
M
A
V
P
S
P
G
W
V
A
S
P
Site 112
S1010
P
S
P
G
W
V
A
S
P
K
T
A
M
P
S
Site 113
T1013
G
W
V
A
S
P
K
T
A
M
P
S
P
G
V
Site 114
S1017
S
P
K
T
A
M
P
S
P
G
V
S
Q
N
K
Site 115
S1021
A
M
P
S
P
G
V
S
Q
N
K
Q
P
P
L
Site 116
S1032
Q
P
P
L
N
M
N
S
S
T
T
L
S
N
M
Site 117
S1033
P
P
L
N
M
N
S
S
T
T
L
S
N
M
E
Site 118
S1037
M
N
S
S
T
T
L
S
N
M
E
Q
G
T
L
Site 119
T1043
L
S
N
M
E
Q
G
T
L
P
P
S
G
P
R
Site 120
S1047
E
Q
G
T
L
P
P
S
G
P
R
S
S
S
S
Site 121
S1051
L
P
P
S
G
P
R
S
S
S
S
A
P
P
A
Site 122
S1052
P
P
S
G
P
R
S
S
S
S
A
P
P
A
N
Site 123
S1053
P
S
G
P
R
S
S
S
S
A
P
P
A
N
P
Site 124
S1054
S
G
P
R
S
S
S
S
A
P
P
A
N
P
P
Site 125
S1062
A
P
P
A
N
P
P
S
G
L
M
N
P
S
L
Site 126
S1068
P
S
G
L
M
N
P
S
L
P
F
T
S
S
P
Site 127
T1072
M
N
P
S
L
P
F
T
S
S
P
D
P
T
P
Site 128
S1074
P
S
L
P
F
T
S
S
P
D
P
T
P
S
Q
Site 129
T1078
F
T
S
S
P
D
P
T
P
S
Q
N
P
L
S
Site 130
S1080
S
S
P
D
P
T
P
S
Q
N
P
L
S
L
M
Site 131
S1085
T
P
S
Q
N
P
L
S
L
M
M
T
Q
M
S
Site 132
T1089
N
P
L
S
L
M
M
T
Q
M
S
K
Y
A
M
Site 133
S1092
S
L
M
M
T
Q
M
S
K
Y
A
M
P
S
S
Site 134
Y1094
M
M
T
Q
M
S
K
Y
A
M
P
S
S
T
P
Site 135
S1098
M
S
K
Y
A
M
P
S
S
T
P
L
Y
H
N
Site 136
S1099
S
K
Y
A
M
P
S
S
T
P
L
Y
H
N
A
Site 137
T1100
K
Y
A
M
P
S
S
T
P
L
Y
H
N
A
I
Site 138
Y1103
M
P
S
S
T
P
L
Y
H
N
A
I
K
T
I
Site 139
S1113
A
I
K
T
I
A
T
S
D
D
E
L
L
P
D
Site 140
S1133
P
P
P
P
P
Q
G
S
G
P
G
I
S
N
S
Site 141
S1138
Q
G
S
G
P
G
I
S
N
S
Q
P
S
Q
M
Site 142
S1140
S
G
P
G
I
S
N
S
Q
P
S
Q
M
H
L
Site 143
S1143
G
I
S
N
S
Q
P
S
Q
M
H
L
N
S
A
Site 144
S1149
P
S
Q
M
H
L
N
S
A
A
A
Q
S
P
M
Site 145
S1154
L
N
S
A
A
A
Q
S
P
M
G
M
N
L
P
Site 146
S1167
L
P
G
Q
Q
P
L
S
H
E
P
P
P
A
M
Site 147
S1177
P
P
P
A
M
L
P
S
P
T
P
L
G
S
N
Site 148
T1179
P
A
M
L
P
S
P
T
P
L
G
S
N
I
P
Site 149
S1183
P
S
P
T
P
L
G
S
N
I
P
L
H
P
N
Site 150
S1201
T
G
G
P
P
Q
N
S
M
M
M
A
P
G
G
Site 151
S1211
M
A
P
G
G
P
D
S
L
N
A
P
C
G
P
Site 152
S1221
A
P
C
G
P
V
P
S
S
S
Q
M
M
P
F
Site 153
S1222
P
C
G
P
V
P
S
S
S
Q
M
M
P
F
P
Site 154
S1223
C
G
P
V
P
S
S
S
Q
M
M
P
F
P
P
Site 155
Y1255
G
P
G
L
Q
Q
H
Y
P
S
G
M
A
L
P
Site 156
Y1293
A
G
R
M
G
D
A
Y
P
P
G
V
L
P
G
Site 157
S1311
V
L
N
D
P
E
L
S
E
V
I
R
P
T
P
Site 158
T1317
L
S
E
V
I
R
P
T
P
T
G
I
P
E
F
Site 159
S1327
G
I
P
E
F
D
L
S
R
I
I
P
S
E
K
Site 160
S1332
D
L
S
R
I
I
P
S
E
K
P
S
S
T
L
Site 161
S1336
I
I
P
S
E
K
P
S
S
T
L
Q
Y
F
P
Site 162
S1337
I
P
S
E
K
P
S
S
T
L
Q
Y
F
P
K
Site 163
T1338
P
S
E
K
P
S
S
T
L
Q
Y
F
P
K
S
Site 164
Y1341
K
P
S
S
T
L
Q
Y
F
P
K
S
E
N
Q
Site 165
S1345
T
L
Q
Y
F
P
K
S
E
N
Q
P
P
K
A
Site 166
T1370
Q
N
M
M
A
E
Q
T
P
S
R
P
P
N
L
Site 167
S1372
M
M
A
E
Q
T
P
S
R
P
P
N
L
P
G
Site 168
S1422
G
L
H
Q
G
V
M
S
P
P
Q
G
L
M
T
Site 169
T1429
S
P
P
Q
G
L
M
T
Q
Q
N
F
M
L
M
Site 170
Y1446
R
G
V
G
G
E
V
Y
S
Q
P
P
H
M
L
Site 171
S1447
G
V
G
G
E
V
Y
S
Q
P
P
H
M
L
S
Site 172
S1454
S
Q
P
P
H
M
L
S
P
Q
G
S
L
M
G
Site 173
S1458
H
M
L
S
P
Q
G
S
L
M
G
P
P
P
Q
Site 174
S1478
S
H
P
L
R
Q
R
S
V
S
L
D
S
Q
M
Site 175
S1480
P
L
R
Q
R
S
V
S
L
D
S
Q
M
G
Y
Site 176
S1483
Q
R
S
V
S
L
D
S
Q
M
G
Y
L
P
A
Site 177
Y1487
S
L
D
S
Q
M
G
Y
L
P
A
P
G
G
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation