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Updated November 2019
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Protein Info
Short Name:
PHLDB1
Full Name:
Pleckstrin homology-like domain family B member 1
Alias:
DLNB07; FLJ00141; KIAA0638; LL5A; LL5alpha; PHLB1; Pleckstrin homology-like domain, family B, member 1; Pleckstriny-like domain, family B, member 1; Protein LL5-alpha
Type:
Unknown function
Mass (Da):
151162
Number AA:
1377
UniProt ID:
Q86UU1
International Prot ID:
IPI00413100
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
G
P
G
C
Q
T
Q
T
M
V
Q
K
G
P
L
Site 2
S44
T
D
K
P
H
L
V
S
L
G
S
G
R
L
S
Site 3
S51
S
L
G
S
G
R
L
S
T
A
I
T
L
L
P
Site 4
T64
L
P
L
E
E
G
R
T
V
I
G
S
A
A
R
Site 5
S68
E
G
R
T
V
I
G
S
A
A
R
D
I
S
L
Site 6
S74
G
S
A
A
R
D
I
S
L
Q
G
P
G
L
A
Site 7
T93
Y
I
E
N
L
R
G
T
L
T
L
Y
P
C
G
Site 8
T95
E
N
L
R
G
T
L
T
L
Y
P
C
G
N
A
Site 9
T114
G
L
P
V
R
Q
P
T
R
L
T
Q
G
C
M
Site 10
S143
A
E
A
K
W
M
K
S
M
I
P
A
G
G
R
Site 11
S157
R
A
P
G
P
P
Y
S
P
V
P
A
E
S
E
Site 12
S163
Y
S
P
V
P
A
E
S
E
S
L
V
N
G
N
Site 13
S165
P
V
P
A
E
S
E
S
L
V
N
G
N
H
T
Site 14
T172
S
L
V
N
G
N
H
T
P
Q
T
A
T
R
G
Site 15
T175
N
G
N
H
T
P
Q
T
A
T
R
G
P
S
A
Site 16
S181
Q
T
A
T
R
G
P
S
A
C
A
S
H
S
S
Site 17
S185
R
G
P
S
A
C
A
S
H
S
S
L
V
S
S
Site 18
S188
S
A
C
A
S
H
S
S
L
V
S
S
I
E
K
Site 19
S191
A
S
H
S
S
L
V
S
S
I
E
K
D
L
Q
Site 20
S192
S
H
S
S
L
V
S
S
I
E
K
D
L
Q
E
Site 21
S203
D
L
Q
E
I
M
D
S
L
V
L
E
E
P
G
Site 22
T219
A
G
K
K
P
A
A
T
S
P
L
S
P
M
A
Site 23
S220
G
K
K
P
A
A
T
S
P
L
S
P
M
A
N
Site 24
S223
P
A
A
T
S
P
L
S
P
M
A
N
G
G
R
Site 25
Y231
P
M
A
N
G
G
R
Y
L
L
S
P
P
T
S
Site 26
S234
N
G
G
R
Y
L
L
S
P
P
T
S
P
G
A
Site 27
T237
R
Y
L
L
S
P
P
T
S
P
G
A
M
S
V
Site 28
S243
P
T
S
P
G
A
M
S
V
G
S
S
Y
E
N
Site 29
S246
P
G
A
M
S
V
G
S
S
Y
E
N
T
S
P
Site 30
S247
G
A
M
S
V
G
S
S
Y
E
N
T
S
P
A
Site 31
Y248
A
M
S
V
G
S
S
Y
E
N
T
S
P
A
F
Site 32
T251
V
G
S
S
Y
E
N
T
S
P
A
F
S
P
L
Site 33
S252
G
S
S
Y
E
N
T
S
P
A
F
S
P
L
S
Site 34
S256
E
N
T
S
P
A
F
S
P
L
S
S
P
A
S
Site 35
S259
S
P
A
F
S
P
L
S
S
P
A
S
S
G
S
Site 36
S260
P
A
F
S
P
L
S
S
P
A
S
S
G
S
C
Site 37
S263
S
P
L
S
S
P
A
S
S
G
S
C
A
S
H
Site 38
S264
P
L
S
S
P
A
S
S
G
S
C
A
S
H
S
Site 39
S266
S
S
P
A
S
S
G
S
C
A
S
H
S
P
S
Site 40
S269
A
S
S
G
S
C
A
S
H
S
P
S
G
Q
E
Site 41
S271
S
G
S
C
A
S
H
S
P
S
G
Q
E
P
G
Site 42
S273
S
C
A
S
H
S
P
S
G
Q
E
P
G
P
S
Site 43
S280
S
G
Q
E
P
G
P
S
V
P
P
L
V
P
A
Site 44
S290
P
L
V
P
A
R
S
S
S
Y
H
L
A
L
Q
Site 45
S291
L
V
P
A
R
S
S
S
Y
H
L
A
L
Q
P
Site 46
S301
L
A
L
Q
P
P
Q
S
R
P
S
G
A
R
S
Site 47
S304
Q
P
P
Q
S
R
P
S
G
A
R
S
E
S
P
Site 48
S308
S
R
P
S
G
A
R
S
E
S
P
R
L
S
R
Site 49
S310
P
S
G
A
R
S
E
S
P
R
L
S
R
K
G
Site 50
S314
R
S
E
S
P
R
L
S
R
K
G
G
H
E
R
Site 51
S324
G
G
H
E
R
P
P
S
P
G
L
R
G
L
L
Site 52
S334
L
R
G
L
L
T
D
S
P
A
A
T
V
L
A
Site 53
T338
L
T
D
S
P
A
A
T
V
L
A
E
A
R
R
Site 54
T347
L
A
E
A
R
R
A
T
E
S
P
R
L
G
G
Site 55
S349
E
A
R
R
A
T
E
S
P
R
L
G
G
Q
L
Site 56
S369
S
L
S
E
Y
P
A
S
G
A
L
S
Q
P
T
Site 57
S373
Y
P
A
S
G
A
L
S
Q
P
T
S
I
P
G
Site 58
T376
S
G
A
L
S
Q
P
T
S
I
P
G
S
P
K
Site 59
S377
G
A
L
S
Q
P
T
S
I
P
G
S
P
K
F
Site 60
S381
Q
P
T
S
I
P
G
S
P
K
F
Q
P
P
V
Site 61
T397
A
P
R
N
K
I
G
T
L
Q
D
R
P
P
S
Site 62
S404
T
L
Q
D
R
P
P
S
P
F
R
E
P
P
G
Site 63
S412
P
F
R
E
P
P
G
S
E
R
V
L
T
T
S
Site 64
T417
P
G
S
E
R
V
L
T
T
S
P
S
R
Q
L
Site 65
S419
S
E
R
V
L
T
T
S
P
S
R
Q
L
V
G
Site 66
S421
R
V
L
T
T
S
P
S
R
Q
L
V
G
R
T
Site 67
T428
S
R
Q
L
V
G
R
T
F
S
D
G
L
A
T
Site 68
S430
Q
L
V
G
R
T
F
S
D
G
L
A
T
R
T
Site 69
T437
S
D
G
L
A
T
R
T
L
Q
P
P
E
S
P
Site 70
S443
R
T
L
Q
P
P
E
S
P
R
L
G
R
R
G
Site 71
S453
L
G
R
R
G
L
D
S
M
R
E
L
P
P
L
Site 72
S461
M
R
E
L
P
P
L
S
P
S
L
S
R
R
A
Site 73
S463
E
L
P
P
L
S
P
S
L
S
R
R
A
L
S
Site 74
S465
P
P
L
S
P
S
L
S
R
R
A
L
S
P
L
Site 75
S470
S
L
S
R
R
A
L
S
P
L
P
T
R
T
T
Site 76
T474
R
A
L
S
P
L
P
T
R
T
T
P
D
P
K
Site 77
T477
S
P
L
P
T
R
T
T
P
D
P
K
L
N
R
Site 78
S489
L
N
R
E
V
A
E
S
P
R
P
R
R
W
A
Site 79
S501
R
W
A
A
H
G
A
S
P
E
D
F
S
L
T
Site 80
S506
G
A
S
P
E
D
F
S
L
T
L
G
A
R
G
Site 81
T508
S
P
E
D
F
S
L
T
L
G
A
R
G
R
R
Site 82
T516
L
G
A
R
G
R
R
T
R
S
P
S
P
T
L
Site 83
S518
A
R
G
R
R
T
R
S
P
S
P
T
L
G
E
Site 84
S520
G
R
R
T
R
S
P
S
P
T
L
G
E
S
L
Site 85
T522
R
T
R
S
P
S
P
T
L
G
E
S
L
A
P
Site 86
S526
P
S
P
T
L
G
E
S
L
A
P
H
K
G
S
Site 87
S533
S
L
A
P
H
K
G
S
F
S
G
R
L
S
P
Site 88
S535
A
P
H
K
G
S
F
S
G
R
L
S
P
A
Y
Site 89
S539
G
S
F
S
G
R
L
S
P
A
Y
S
L
G
S
Site 90
Y542
S
G
R
L
S
P
A
Y
S
L
G
S
L
T
G
Site 91
S543
G
R
L
S
P
A
Y
S
L
G
S
L
T
G
A
Site 92
S546
S
P
A
Y
S
L
G
S
L
T
G
A
S
P
C
Site 93
T548
A
Y
S
L
G
S
L
T
G
A
S
P
C
Q
S
Site 94
S551
L
G
S
L
T
G
A
S
P
C
Q
S
P
C
V
Site 95
S555
T
G
A
S
P
C
Q
S
P
C
V
Q
R
K
L
Site 96
S563
P
C
V
Q
R
K
L
S
S
G
D
L
R
V
P
Site 97
S564
C
V
Q
R
K
L
S
S
G
D
L
R
V
P
V
Site 98
T572
G
D
L
R
V
P
V
T
R
E
R
K
N
S
I
Site 99
S578
V
T
R
E
R
K
N
S
I
T
E
I
S
D
N
Site 100
T580
R
E
R
K
N
S
I
T
E
I
S
D
N
E
D
Site 101
S583
K
N
S
I
T
E
I
S
D
N
E
D
D
L
L
Site 102
Y592
N
E
D
D
L
L
E
Y
H
R
R
Q
R
Q
E
Site 103
T616
L
E
R
Q
R
L
E
T
I
L
N
L
C
A
E
Site 104
Y624
I
L
N
L
C
A
E
Y
S
R
A
D
G
G
P
Site 105
S625
L
N
L
C
A
E
Y
S
R
A
D
G
G
P
E
Site 106
S654
A
L
A
G
R
R
P
S
R
G
L
A
G
A
S
Site 107
S661
S
R
G
L
A
G
A
S
G
R
S
S
E
E
P
Site 108
S664
L
A
G
A
S
G
R
S
S
E
E
P
G
V
A
Site 109
S665
A
G
A
S
G
R
S
S
E
E
P
G
V
A
T
Site 110
T672
S
E
E
P
G
V
A
T
Q
R
L
W
E
S
M
Site 111
S678
A
T
Q
R
L
W
E
S
M
E
R
S
D
E
E
Site 112
S682
L
W
E
S
M
E
R
S
D
E
E
N
L
K
E
Site 113
S692
E
N
L
K
E
E
C
S
S
T
E
S
T
Q
Q
Site 114
S693
N
L
K
E
E
C
S
S
T
E
S
T
Q
Q
E
Site 115
T694
L
K
E
E
C
S
S
T
E
S
T
Q
Q
E
H
Site 116
S696
E
E
C
S
S
T
E
S
T
Q
Q
E
H
E
D
Site 117
T697
E
C
S
S
T
E
S
T
Q
Q
E
H
E
D
A
Site 118
S706
Q
E
H
E
D
A
P
S
T
K
L
Q
G
E
V
Site 119
S744
L
E
Q
Q
L
Q
E
S
A
R
E
A
E
M
E
Site 120
T800
K
E
A
E
A
L
E
T
E
T
K
L
F
E
D
Site 121
S817
F
Q
Q
L
E
R
E
S
R
V
E
E
E
R
E
Site 122
S833
A
G
Q
G
L
L
R
S
K
A
E
L
L
R
S
Site 123
S840
S
K
A
E
L
L
R
S
I
A
K
R
K
E
R
Site 124
S853
E
R
L
A
I
L
D
S
Q
A
G
Q
I
R
A
Site 125
S866
R
A
Q
A
V
Q
E
S
E
R
L
A
R
D
K
Site 126
S876
L
A
R
D
K
N
A
S
L
Q
L
L
Q
K
E
Site 127
T888
Q
K
E
K
E
K
L
T
V
L
E
R
R
Y
H
Site 128
Y894
L
T
V
L
E
R
R
Y
H
S
L
T
G
G
R
Site 129
S896
V
L
E
R
R
Y
H
S
L
T
G
G
R
P
F
Site 130
T898
E
R
R
Y
H
S
L
T
G
G
R
P
F
P
K
Site 131
T906
G
G
R
P
F
P
K
T
T
S
T
L
K
E
M
Site 132
S942
G
T
G
P
A
A
A
S
P
H
S
S
P
P
P
Site 133
S945
P
A
A
A
S
P
H
S
S
P
P
P
L
P
A
Site 134
S946
A
A
A
S
P
H
S
S
P
P
P
L
P
A
K
Site 135
Y961
A
S
R
Q
L
Q
V
Y
R
S
K
M
D
G
E
Site 136
S963
R
Q
L
Q
V
Y
R
S
K
M
D
G
E
A
T
Site 137
S971
K
M
D
G
E
A
T
S
P
L
P
R
T
R
S
Site 138
T976
A
T
S
P
L
P
R
T
R
S
G
P
L
P
S
Site 139
S978
S
P
L
P
R
T
R
S
G
P
L
P
S
S
S
Site 140
S983
T
R
S
G
P
L
P
S
S
S
G
S
S
S
S
Site 141
S984
R
S
G
P
L
P
S
S
S
G
S
S
S
S
S
Site 142
S985
S
G
P
L
P
S
S
S
G
S
S
S
S
S
S
Site 143
S987
P
L
P
S
S
S
G
S
S
S
S
S
S
Q
L
Site 144
S988
L
P
S
S
S
G
S
S
S
S
S
S
Q
L
S
Site 145
S989
P
S
S
S
G
S
S
S
S
S
S
Q
L
S
V
Site 146
S990
S
S
S
G
S
S
S
S
S
S
Q
L
S
V
A
Site 147
S991
S
S
G
S
S
S
S
S
S
Q
L
S
V
A
T
Site 148
S992
S
G
S
S
S
S
S
S
Q
L
S
V
A
T
L
Site 149
S995
S
S
S
S
S
Q
L
S
V
A
T
L
G
R
S
Site 150
T998
S
S
Q
L
S
V
A
T
L
G
R
S
P
S
P
Site 151
S1002
S
V
A
T
L
G
R
S
P
S
P
K
S
A
L
Site 152
S1004
A
T
L
G
R
S
P
S
P
K
S
A
L
L
T
Site 153
S1007
G
R
S
P
S
P
K
S
A
L
L
T
Q
N
G
Site 154
T1011
S
P
K
S
A
L
L
T
Q
N
G
T
G
S
L
Site 155
S1017
L
T
Q
N
G
T
G
S
L
P
R
N
L
A
A
Site 156
T1025
L
P
R
N
L
A
A
T
L
Q
D
I
E
T
K
Site 157
T1031
A
T
L
Q
D
I
E
T
K
R
Q
L
A
L
Q
Site 158
Y1109
G
E
E
G
E
H
A
Y
D
T
L
S
L
E
S
Site 159
T1111
E
G
E
H
A
Y
D
T
L
S
L
E
S
S
D
Site 160
S1113
E
H
A
Y
D
T
L
S
L
E
S
S
D
S
M
Site 161
S1117
D
T
L
S
L
E
S
S
D
S
M
E
T
S
I
Site 162
S1119
L
S
L
E
S
S
D
S
M
E
T
S
I
S
T
Site 163
S1123
S
S
D
S
M
E
T
S
I
S
T
G
G
N
S
Site 164
S1125
D
S
M
E
T
S
I
S
T
G
G
N
S
A
C
Site 165
S1130
S
I
S
T
G
G
N
S
A
C
S
P
D
N
M
Site 166
S1133
T
G
G
N
S
A
C
S
P
D
N
M
S
S
A
Site 167
S1138
A
C
S
P
D
N
M
S
S
A
S
G
L
D
M
Site 168
S1139
C
S
P
D
N
M
S
S
A
S
G
L
D
M
G
Site 169
S1168
E
K
N
R
L
M
E
S
R
E
R
E
M
E
L
Site 170
S1196
Q
V
E
R
R
L
Q
S
E
S
A
R
R
Q
Q
Site 171
S1198
E
R
R
L
Q
S
E
S
A
R
R
Q
Q
L
V
Site 172
S1217
K
M
R
E
K
Q
F
S
Q
A
R
P
L
T
R
Site 173
T1223
F
S
Q
A
R
P
L
T
R
Y
L
P
I
R
K
Site 174
Y1225
Q
A
R
P
L
T
R
Y
L
P
I
R
K
E
D
Site 175
T1237
K
E
D
F
D
L
K
T
H
I
E
S
S
G
H
Site 176
Y1262
S
S
K
V
C
R
G
Y
L
V
K
M
G
G
K
Site 177
S1288
D
R
L
K
R
T
L
S
Y
Y
V
D
K
H
E
Site 178
Y1290
L
K
R
T
L
S
Y
Y
V
D
K
H
E
T
K
Site 179
Y1312
Q
A
I
E
E
V
Y
Y
D
H
L
R
S
A
A
Site 180
T1327
K
K
R
F
F
R
F
T
M
V
T
E
S
P
N
Site 181
S1332
R
F
T
M
V
T
E
S
P
N
P
A
L
T
F
Site 182
T1338
E
S
P
N
P
A
L
T
F
C
V
K
T
H
D
Site 183
Y1348
V
K
T
H
D
R
L
Y
Y
M
V
A
P
S
A
Site 184
Y1349
K
T
H
D
R
L
Y
Y
M
V
A
P
S
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation