KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
USP48
Full Name:
Ubiquitin carboxyl-terminal hydrolase 48
Alias:
Deubiquitinating enzyme 48; FLJ11328; FLJ20103; FLJ23054; FLJ23277; MGC14879; RAP1GA1; Ubiquitin specific peptidase 48; Ubiquitin specific protease 31; Ubiquitin specific protease 48; Ubiquitin thioesterase 48; Ubiquitin-specific-processing protease 48; UBP48; USP31
Type:
EC 3.1.2.15; Ubiquitin conjugating system; Protease
Mass (Da):
119032
Number AA:
1035
UniProt ID:
Q86UV5
International Prot ID:
IPI00328815
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0008234
GO:0004221
GO:0004843
PhosphoSite+
KinaseNET
Biological Process:
GO:0006511
GO:0006508
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
A
A
W
R
W
A
E
T
V
R
P
E
E
V
S
Site 2
S24
T
V
R
P
E
E
V
S
Q
E
H
I
E
T
A
Site 3
T30
V
S
Q
E
H
I
E
T
A
Y
R
I
W
L
E
Site 4
S71
L
G
E
I
D
E
N
S
F
H
N
I
D
D
P
Site 5
S87
C
E
R
R
K
K
N
S
F
V
G
L
T
N
L
Site 6
Y127
C
P
S
T
C
S
D
Y
M
L
G
D
G
I
Q
Site 7
Y139
G
I
Q
E
E
K
D
Y
E
P
Q
T
I
C
E
Site 8
S158
L
F
A
L
L
Q
N
S
N
R
R
Y
I
D
P
Site 9
Y162
L
Q
N
S
N
R
R
Y
I
D
P
S
G
F
V
Site 10
S166
N
R
R
Y
I
D
P
S
G
F
V
K
A
L
G
Site 11
T196
F
M
S
L
L
E
D
T
L
S
K
Q
K
N
P
Site 12
S198
S
L
L
E
D
T
L
S
K
Q
K
N
P
D
V
Site 13
S234
G
R
E
S
K
L
L
S
K
F
Y
E
L
E
L
Site 14
T250
I
Q
G
H
K
Q
L
T
D
C
I
S
E
F
L
Site 15
S254
K
Q
L
T
D
C
I
S
E
F
L
K
E
E
K
Site 16
Y268
K
L
E
G
D
N
R
Y
F
C
E
N
C
Q
S
Site 17
T305
R
F
V
F
D
R
Q
T
G
H
K
K
K
L
N
Site 18
T313
G
H
K
K
K
L
N
T
Y
I
G
F
S
E
I
Site 19
Y314
H
K
K
K
L
N
T
Y
I
G
F
S
E
I
L
Site 20
Y326
E
I
L
D
M
E
P
Y
V
E
H
K
G
G
S
Site 21
Y334
V
E
H
K
G
G
S
Y
V
Y
E
L
S
A
V
Site 22
Y350
I
H
R
G
V
S
A
Y
S
G
H
Y
I
A
H
Site 23
Y367
D
P
Q
S
G
E
W
Y
K
F
N
D
E
D
I
Site 24
S396
D
L
A
E
P
S
K
S
Q
T
R
K
P
K
C
Site 25
T398
A
E
P
S
K
S
Q
T
R
K
P
K
C
G
K
Site 26
T407
K
P
K
C
G
K
G
T
H
C
S
R
N
A
Y
Site 27
Y414
T
H
C
S
R
N
A
Y
M
L
V
Y
R
L
Q
Site 28
T422
M
L
V
Y
R
L
Q
T
Q
E
K
P
N
T
T
Site 29
T428
Q
T
Q
E
K
P
N
T
T
V
Q
V
P
A
F
Site 30
S461
M
A
E
M
R
K
Q
S
V
D
K
G
K
A
K
Site 31
Y476
H
E
E
V
K
E
L
Y
Q
R
L
P
A
G
A
Site 32
Y486
L
P
A
G
A
E
P
Y
E
F
V
S
L
E
W
Site 33
T502
Q
K
W
L
D
E
S
T
P
T
K
P
I
D
N
Site 34
T504
W
L
D
E
S
T
P
T
K
P
I
D
N
H
A
Site 35
S525
K
L
H
P
D
K
I
S
I
M
K
R
I
S
E
Site 36
Y539
E
Y
A
A
D
I
F
Y
S
R
Y
G
G
G
P
Site 37
S540
Y
A
A
D
I
F
Y
S
R
Y
G
G
G
P
R
Site 38
T549
Y
G
G
G
P
R
L
T
V
K
A
L
C
K
E
Site 39
Y575
K
N
Q
L
N
E
D
Y
K
T
V
N
N
L
L
Site 40
T577
Q
L
N
E
D
Y
K
T
V
N
N
L
L
K
A
Site 41
S597
D
G
F
W
V
G
K
S
S
L
R
S
W
R
Q
Site 42
S598
G
F
W
V
G
K
S
S
L
R
S
W
R
Q
L
Site 43
S601
V
G
K
S
S
L
R
S
W
R
Q
L
A
L
E
Site 44
S620
Q
D
G
D
A
E
Q
S
N
G
K
M
N
G
S
Site 45
S627
S
N
G
K
M
N
G
S
T
L
N
K
D
E
S
Site 46
T628
N
G
K
M
N
G
S
T
L
N
K
D
E
S
K
Site 47
S634
S
T
L
N
K
D
E
S
K
E
E
R
K
E
E
Site 48
S660
P
H
G
E
L
C
I
S
E
N
E
R
R
L
V
Site 49
S668
E
N
E
R
R
L
V
S
K
E
A
W
S
K
L
Site 50
Y678
A
W
S
K
L
Q
Q
Y
F
P
K
A
P
E
F
Site 51
Y688
K
A
P
E
F
P
S
Y
K
E
C
C
S
Q
C
Site 52
T718
M
I
A
N
E
Q
K
T
S
L
P
N
L
F
Q
Site 53
S719
I
A
N
E
Q
K
T
S
L
P
N
L
F
Q
D
Site 54
S733
D
K
N
R
P
C
L
S
N
W
P
E
D
T
D
Site 55
T739
L
S
N
W
P
E
D
T
D
V
L
Y
I
V
S
Site 56
T761
R
K
F
V
R
K
P
T
R
C
S
P
V
S
S
Site 57
S764
V
R
K
P
T
R
C
S
P
V
S
S
V
G
N
Site 58
S767
P
T
R
C
S
P
V
S
S
V
G
N
S
A
L
Site 59
T784
P
H
G
G
L
M
F
T
F
A
S
M
T
K
E
Site 60
S787
G
L
M
F
T
F
A
S
M
T
K
E
D
S
K
Site 61
T820
V
D
H
V
I
K
I
T
R
I
E
V
G
D
V
Site 62
T832
G
D
V
N
P
S
E
T
Q
Y
I
S
E
P
K
Site 63
Y834
V
N
P
S
E
T
Q
Y
I
S
E
P
K
L
C
Site 64
S836
P
S
E
T
Q
Y
I
S
E
P
K
L
C
P
E
Site 65
Y859
Q
Q
R
D
L
R
E
Y
T
Q
A
T
I
Y
V
Site 66
T860
Q
R
D
L
R
E
Y
T
Q
A
T
I
Y
V
H
Site 67
Y865
E
Y
T
Q
A
T
I
Y
V
H
K
V
V
D
N
Site 68
S879
N
K
K
V
M
K
D
S
A
P
E
L
N
V
S
Site 69
S886
S
A
P
E
L
N
V
S
S
S
E
T
E
E
D
Site 70
S887
A
P
E
L
N
V
S
S
S
E
T
E
E
D
K
Site 71
S888
P
E
L
N
V
S
S
S
E
T
E
E
D
K
E
Site 72
T890
L
N
V
S
S
S
E
T
E
E
D
K
E
E
A
Site 73
T914
F
N
Q
S
N
G
G
T
K
R
Q
K
I
S
H
Site 74
Y924
Q
K
I
S
H
Q
N
Y
I
A
Y
Q
K
Q
V
Site 75
Y927
S
H
Q
N
Y
I
A
Y
Q
K
Q
V
I
R
R
Site 76
S935
Q
K
Q
V
I
R
R
S
M
R
H
R
K
V
R
Site 77
S976
A
P
F
D
Q
N
L
S
I
D
G
K
I
L
S
Site 78
Y1011
A
D
E
P
I
A
D
Y
A
A
M
D
D
V
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation