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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Nedd4-BP2
Full Name:
NEDD4-binding protein 2
Alias:
B3BP; BCL-3 binding protein; KIAA1413; N4B2; N4BP2; NEDD4 binding protein 2; Nedd4-binding protein 2
Type:
Hydrolase; EC 3.-.-.-; Kinase (non-protein)
Mass (Da):
198801
Number AA:
1770
UniProt ID:
Q86UW6
International Prot ID:
IPI00328825
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0046404
GO:0004519
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
G
G
N
P
F
R
K
T
A
N
P
K
E
V
V
Site 2
S25
N
P
K
E
V
V
V
S
S
V
A
S
R
E
E
Site 3
S26
P
K
E
V
V
V
S
S
V
A
S
R
E
E
P
Site 4
S29
V
V
V
S
S
V
A
S
R
E
E
P
T
T
T
Site 5
T35
A
S
R
E
E
P
T
T
T
L
P
S
M
G
E
Site 6
T36
S
R
E
E
P
T
T
T
L
P
S
M
G
E
T
Site 7
T52
V
D
Q
E
E
L
F
T
S
I
S
E
I
F
S
Site 8
S53
D
Q
E
E
L
F
T
S
I
S
E
I
F
S
D
Site 9
S55
E
E
L
F
T
S
I
S
E
I
F
S
D
L
D
Site 10
T90
C
L
L
E
L
S
A
T
D
T
K
I
E
E
S
Site 11
T92
L
E
L
S
A
T
D
T
K
I
E
E
S
S
S
Site 12
S97
T
D
T
K
I
E
E
S
S
S
Q
S
F
V
A
Site 13
S98
D
T
K
I
E
E
S
S
S
Q
S
F
V
A
S
Site 14
S99
T
K
I
E
E
S
S
S
Q
S
F
V
A
S
E
Site 15
S101
I
E
E
S
S
S
Q
S
F
V
A
S
E
N
Q
Site 16
S105
S
S
Q
S
F
V
A
S
E
N
Q
V
G
A
A
Site 17
S125
E
K
R
P
E
E
E
S
E
D
S
K
M
D
S
Site 18
S128
P
E
E
E
S
E
D
S
K
M
D
S
F
L
D
Site 19
S132
S
E
D
S
K
M
D
S
F
L
D
M
Q
L
T
Site 20
S144
Q
L
T
E
D
L
D
S
L
I
Q
N
A
F
E
Site 21
S155
N
A
F
E
K
L
N
S
S
P
D
D
Q
V
Y
Site 22
S156
A
F
E
K
L
N
S
S
P
D
D
Q
V
Y
S
Site 23
Y162
S
S
P
D
D
Q
V
Y
S
F
L
P
S
Q
D
Site 24
S163
S
P
D
D
Q
V
Y
S
F
L
P
S
Q
D
V
Site 25
S167
Q
V
Y
S
F
L
P
S
Q
D
V
N
S
F
N
Site 26
S172
L
P
S
Q
D
V
N
S
F
N
D
S
S
E
F
Site 27
S176
D
V
N
S
F
N
D
S
S
E
F
I
N
P
D
Site 28
S177
V
N
S
F
N
D
S
S
E
F
I
N
P
D
S
Site 29
S184
S
E
F
I
N
P
D
S
S
N
M
T
P
I
F
Site 30
S185
E
F
I
N
P
D
S
S
N
M
T
P
I
F
S
Site 31
T188
N
P
D
S
S
N
M
T
P
I
F
S
T
Q
N
Site 32
S206
N
G
E
N
L
E
N
S
G
S
T
L
S
L
N
Site 33
S208
E
N
L
E
N
S
G
S
T
L
S
L
N
P
L
Site 34
S211
E
N
S
G
S
T
L
S
L
N
P
L
P
S
H
Site 35
S217
L
S
L
N
P
L
P
S
H
S
V
L
N
E
S
Site 36
S219
L
N
P
L
P
S
H
S
V
L
N
E
S
K
C
Site 37
T232
K
C
F
I
K
D
N
T
L
A
L
E
S
N
Y
Site 38
S237
D
N
T
L
A
L
E
S
N
Y
P
E
D
S
L
Site 39
Y239
T
L
A
L
E
S
N
Y
P
E
D
S
L
L
S
Site 40
S243
E
S
N
Y
P
E
D
S
L
L
S
S
S
L
N
Site 41
S247
P
E
D
S
L
L
S
S
S
L
N
V
A
S
D
Site 42
S248
E
D
S
L
L
S
S
S
L
N
V
A
S
D
S
Site 43
S261
D
S
I
A
G
C
S
S
L
N
Q
K
Q
K
E
Site 44
S272
K
Q
K
E
L
L
E
S
E
C
V
E
A
Q
F
Site 45
S280
E
C
V
E
A
Q
F
S
E
A
P
V
D
L
D
Site 46
S289
A
P
V
D
L
D
A
S
E
P
Q
A
C
L
N
Site 47
T305
P
G
L
D
L
P
G
T
G
G
D
Q
K
S
T
Site 48
S311
G
T
G
G
D
Q
K
S
T
R
V
S
D
V
F
Site 49
S315
D
Q
K
S
T
R
V
S
D
V
F
L
P
S
E
Site 50
S342
P
T
K
G
K
D
V
S
Y
C
P
V
L
A
P
Site 51
Y395
A
H
W
R
S
V
N
Y
T
F
P
P
S
V
I
Site 52
T396
H
W
R
S
V
N
Y
T
F
P
P
S
V
I
S
Site 53
S400
V
N
Y
T
F
P
P
S
V
I
S
H
T
S
P
Site 54
S403
T
F
P
P
S
V
I
S
H
T
S
P
T
K
V
Site 55
S406
P
S
V
I
S
H
T
S
P
T
K
V
W
R
N
Site 56
T417
V
W
R
N
K
D
G
T
S
A
Y
Q
V
Q
E
Site 57
Y420
N
K
D
G
T
S
A
Y
Q
V
Q
E
T
P
V
Site 58
T425
S
A
Y
Q
V
Q
E
T
P
V
S
Q
V
V
R
Site 59
S428
Q
V
Q
E
T
P
V
S
Q
V
V
R
K
K
T
Site 60
S454
G
L
P
G
S
G
K
S
F
L
A
R
T
L
Q
Site 61
S466
T
L
Q
E
D
N
P
S
G
V
I
L
S
T
D
Site 62
Y475
V
I
L
S
T
D
D
Y
F
Y
I
N
G
Q
Y
Site 63
Y477
L
S
T
D
D
Y
F
Y
I
N
G
Q
Y
Q
F
Site 64
Y488
Q
Y
Q
F
D
V
K
Y
L
G
E
A
H
E
W
Site 65
S509
E
A
F
E
K
K
I
S
P
I
I
I
D
N
T
Site 66
Y526
Q
A
W
E
M
K
P
Y
V
A
L
S
Q
K
H
Site 67
S530
M
K
P
Y
V
A
L
S
Q
K
H
K
Y
K
V
Site 68
Y535
A
L
S
Q
K
H
K
Y
K
V
L
F
R
E
P
Site 69
T544
V
L
F
R
E
P
D
T
W
W
K
F
K
P
K
Site 70
Y573
I
T
R
M
L
E
H
Y
Q
R
F
V
S
V
P
Site 71
S578
E
H
Y
Q
R
F
V
S
V
P
I
I
M
S
S
Site 72
S586
V
P
I
I
M
S
S
S
V
P
E
K
I
E
R
Site 73
Y599
E
R
I
E
L
C
A
Y
S
C
E
D
R
S
T
Site 74
S600
R
I
E
L
C
A
Y
S
C
E
D
R
S
T
S
Site 75
S605
A
Y
S
C
E
D
R
S
T
S
P
R
D
D
E
Site 76
T606
Y
S
C
E
D
R
S
T
S
P
R
D
D
E
D
Site 77
S607
S
C
E
D
R
S
T
S
P
R
D
D
E
D
I
Site 78
S616
R
D
D
E
D
I
I
S
E
K
E
E
N
I
L
Site 79
S624
E
K
E
E
N
I
L
S
L
S
L
K
H
L
E
Site 80
S626
E
E
N
I
L
S
L
S
L
K
H
L
E
F
T
Site 81
T633
S
L
K
H
L
E
F
T
E
E
K
N
L
D
V
Site 82
T641
E
E
K
N
L
D
V
T
K
E
T
M
L
P
E
Site 83
Y652
M
L
P
E
N
V
A
Y
L
S
N
A
D
L
N
Site 84
S654
P
E
N
V
A
Y
L
S
N
A
D
L
N
K
R
Site 85
S666
N
K
R
R
K
E
I
S
D
M
N
P
S
I
Q
Site 86
T680
Q
S
A
L
I
L
E
T
P
H
M
Y
F
S
D
Site 87
Y684
I
L
E
T
P
H
M
Y
F
S
D
S
E
S
K
Site 88
S686
E
T
P
H
M
Y
F
S
D
S
E
S
K
L
Q
Site 89
S688
P
H
M
Y
F
S
D
S
E
S
K
L
Q
A
T
Site 90
S690
M
Y
F
S
D
S
E
S
K
L
Q
A
T
D
K
Site 91
S698
K
L
Q
A
T
D
K
S
E
N
E
Q
I
E
M
Site 92
T714
A
V
K
G
Y
S
K
T
D
T
D
S
S
M
E
Site 93
T716
K
G
Y
S
K
T
D
T
D
S
S
M
E
R
V
Site 94
S718
Y
S
K
T
D
T
D
S
S
M
E
R
V
S
P
Site 95
S719
S
K
T
D
T
D
S
S
M
E
R
V
S
P
S
Site 96
S724
D
S
S
M
E
R
V
S
P
S
T
C
C
S
E
Site 97
S726
S
M
E
R
V
S
P
S
T
C
C
S
E
N
N
Site 98
T727
M
E
R
V
S
P
S
T
C
C
S
E
N
N
Q
Site 99
S750
G
P
L
Q
N
E
K
S
S
P
G
E
I
V
E
Site 100
S751
P
L
Q
N
E
K
S
S
P
G
E
I
V
E
E
Site 101
T761
E
I
V
E
E
R
A
T
V
T
K
K
A
F
G
Site 102
S772
K
A
F
G
K
Q
K
S
K
S
T
L
E
K
F
Site 103
S774
F
G
K
Q
K
S
K
S
T
L
E
K
F
P
R
Site 104
T796
G
D
W
P
V
D
K
T
I
G
Q
R
T
K
R
Site 105
T807
R
T
K
R
N
R
K
T
E
K
T
S
S
V
Q
Site 106
T810
R
N
R
K
T
E
K
T
S
S
V
Q
S
D
K
Site 107
S811
N
R
K
T
E
K
T
S
S
V
Q
S
D
K
K
Site 108
S812
R
K
T
E
K
T
S
S
V
Q
S
D
K
K
Y
Site 109
S815
E
K
T
S
S
V
Q
S
D
K
K
Y
N
Y
P
Site 110
Y819
S
V
Q
S
D
K
K
Y
N
Y
P
Q
S
H
K
Site 111
Y821
Q
S
D
K
K
Y
N
Y
P
Q
S
H
K
L
V
Site 112
S824
K
K
Y
N
Y
P
Q
S
H
K
L
V
N
S
V
Site 113
S830
Q
S
H
K
L
V
N
S
V
S
V
N
T
D
C
Site 114
S832
H
K
L
V
N
S
V
S
V
N
T
D
C
V
Q
Site 115
S843
D
C
V
Q
Q
R
G
S
P
H
E
S
V
E
D
Site 116
S847
Q
R
G
S
P
H
E
S
V
E
D
G
R
K
S
Site 117
S854
S
V
E
D
G
R
K
S
Q
C
D
D
A
S
E
Site 118
S860
K
S
Q
C
D
D
A
S
E
P
L
N
S
Y
K
Site 119
S865
D
A
S
E
P
L
N
S
Y
K
Y
D
A
Y
K
Site 120
Y868
E
P
L
N
S
Y
K
Y
D
A
Y
K
N
I
D
Site 121
Y871
N
S
Y
K
Y
D
A
Y
K
N
I
D
K
N
S
Site 122
S887
N
I
M
G
D
W
P
S
S
D
S
L
A
Q
R
Site 123
S888
I
M
G
D
W
P
S
S
D
S
L
A
Q
R
E
Site 124
S890
G
D
W
P
S
S
D
S
L
A
Q
R
E
H
R
Site 125
S898
L
A
Q
R
E
H
R
S
R
M
P
K
T
G
L
Site 126
T903
H
R
S
R
M
P
K
T
G
L
S
E
P
N
L
Site 127
S906
R
M
P
K
T
G
L
S
E
P
N
L
E
I
G
Site 128
S935
E
A
C
W
G
T
S
S
Q
K
L
K
T
L
G
Site 129
T940
T
S
S
Q
K
L
K
T
L
G
S
S
N
L
G
Site 130
S943
Q
K
L
K
T
L
G
S
S
N
L
G
S
S
E
Site 131
S944
K
L
K
T
L
G
S
S
N
L
G
S
S
E
M
Site 132
S948
L
G
S
S
N
L
G
S
S
E
M
L
L
S
E
Site 133
S949
G
S
S
N
L
G
S
S
E
M
L
L
S
E
M
Site 134
S954
G
S
S
E
M
L
L
S
E
M
T
C
E
S
Q
Site 135
S960
L
S
E
M
T
C
E
S
Q
T
C
L
S
K
K
Site 136
S965
C
E
S
Q
T
C
L
S
K
K
S
H
G
Q
H
Site 137
S974
K
S
H
G
Q
H
T
S
L
P
L
T
F
T
N
Site 138
T978
Q
H
T
S
L
P
L
T
F
T
N
S
A
P
T
Site 139
T994
S
G
V
V
E
P
Q
T
L
A
E
C
Q
E
Q
Site 140
S1034
K
I
E
K
N
K
I
S
I
S
D
S
I
K
V
Site 141
S1036
E
K
N
K
I
S
I
S
D
S
I
K
V
L
T
Site 142
S1038
N
K
I
S
I
S
D
S
I
K
V
L
T
G
R
Site 143
T1043
S
D
S
I
K
V
L
T
G
R
L
D
G
F
K
Site 144
S1060
V
F
N
I
N
T
K
S
D
V
Q
E
A
I
P
Site 145
Y1068
D
V
Q
E
A
I
P
Y
R
V
M
Y
D
K
S
Site 146
Y1072
A
I
P
Y
R
V
M
Y
D
K
S
T
F
V
E
Site 147
S1075
Y
R
V
M
Y
D
K
S
T
F
V
E
E
S
E
Site 148
T1076
R
V
M
Y
D
K
S
T
F
V
E
E
S
E
L
Site 149
S1081
K
S
T
F
V
E
E
S
E
L
T
S
A
D
E
Site 150
T1084
F
V
E
E
S
E
L
T
S
A
D
E
S
E
N
Site 151
S1085
V
E
E
S
E
L
T
S
A
D
E
S
E
N
L
Site 152
S1089
E
L
T
S
A
D
E
S
E
N
L
N
I
L
C
Site 153
Y1111
L
E
A
L
K
D
L
Y
E
R
C
N
K
D
I
Site 154
S1128
A
T
S
L
L
L
D
S
E
T
K
L
C
E
D
Site 155
T1130
S
L
L
L
D
S
E
T
K
L
C
E
D
T
E
Site 156
S1144
E
F
E
N
F
Q
K
S
C
D
G
S
Q
I
G
Site 157
S1148
F
Q
K
S
C
D
G
S
Q
I
G
P
F
S
L
Site 158
S1154
G
S
Q
I
G
P
F
S
L
G
L
N
L
K
E
Site 159
S1164
L
N
L
K
E
I
I
S
Q
R
G
T
L
E
N
Site 160
T1168
E
I
I
S
Q
R
G
T
L
E
N
S
N
S
P
Site 161
S1172
Q
R
G
T
L
E
N
S
N
S
P
V
P
E
F
Site 162
S1174
G
T
L
E
N
S
N
S
P
V
P
E
F
S
H
Site 163
S1180
N
S
P
V
P
E
F
S
H
G
I
G
I
S
N
Site 164
S1186
F
S
H
G
I
G
I
S
N
A
D
S
Q
S
T
Site 165
S1190
I
G
I
S
N
A
D
S
Q
S
T
C
D
A
E
Site 166
S1192
I
S
N
A
D
S
Q
S
T
C
D
A
E
R
G
Site 167
S1201
C
D
A
E
R
G
N
S
E
Q
A
E
M
R
A
Site 168
T1210
Q
A
E
M
R
A
V
T
P
E
N
H
E
S
M
Site 169
S1216
V
T
P
E
N
H
E
S
M
T
S
I
F
P
S
Site 170
S1219
E
N
H
E
S
M
T
S
I
F
P
S
A
A
V
Site 171
S1238
N
N
D
I
L
P
N
S
Q
E
E
L
L
Y
S
Site 172
Y1244
N
S
Q
E
E
L
L
Y
S
S
K
Q
S
F
P
Site 173
S1245
S
Q
E
E
L
L
Y
S
S
K
Q
S
F
P
G
Site 174
S1246
Q
E
E
L
L
Y
S
S
K
Q
S
F
P
G
I
Site 175
T1258
P
G
I
L
K
A
T
T
P
K
D
M
S
E
T
Site 176
S1280
E
T
G
D
N
I
H
S
P
S
H
F
S
D
I
Site 177
Y1304
L
E
L
N
E
E
I
Y
F
T
D
S
L
E
I
Site 178
T1306
L
N
E
E
I
Y
F
T
D
S
L
E
I
K
R
Site 179
S1308
E
E
I
Y
F
T
D
S
L
E
I
K
R
N
E
Site 180
Y1321
N
E
N
F
P
K
D
Y
V
K
F
S
D
E
E
Site 181
S1325
P
K
D
Y
V
K
F
S
D
E
E
E
F
M
N
Site 182
S1353
S
S
L
S
A
G
V
S
G
E
D
K
T
E
I
Site 183
T1358
G
V
S
G
E
D
K
T
E
I
L
N
P
T
P
Site 184
T1364
K
T
E
I
L
N
P
T
P
A
M
A
K
S
L
Site 185
S1437
R
Q
R
Q
E
E
V
S
C
G
K
F
M
Q
D
Site 186
S1446
G
K
F
M
Q
D
P
S
L
V
G
H
T
G
L
Site 187
S1460
L
D
N
P
E
Q
K
S
S
Q
R
T
G
K
K
Site 188
S1461
D
N
P
E
Q
K
S
S
Q
R
T
G
K
K
L
Site 189
T1471
T
G
K
K
L
L
K
T
L
T
A
S
E
M
L
Site 190
T1486
P
L
L
D
H
W
N
T
Q
T
K
K
V
S
L
Site 191
T1488
L
D
H
W
N
T
Q
T
K
K
V
S
L
R
E
Site 192
S1492
N
T
Q
T
K
K
V
S
L
R
E
I
M
S
E
Site 193
S1498
V
S
L
R
E
I
M
S
E
E
I
A
L
Q
E
Site 194
T1513
K
H
N
L
K
R
E
T
L
M
F
E
K
D
C
Site 195
Y1550
D
I
F
K
D
H
N
Y
S
L
E
H
T
V
Q
Site 196
S1591
T
S
H
T
G
Q
K
S
K
E
K
K
P
K
K
Site 197
T1605
K
L
K
E
T
E
E
T
P
S
E
L
S
F
Q
Site 198
S1607
K
E
T
E
E
T
P
S
E
L
S
F
Q
D
F
Site 199
S1610
E
E
T
P
S
E
L
S
F
Q
D
F
E
Y
P
Site 200
Y1616
L
S
F
Q
D
F
E
Y
P
D
Y
D
D
Y
R
Site 201
Y1619
Q
D
F
E
Y
P
D
Y
D
D
Y
R
A
E
A
Site 202
Y1622
E
Y
P
D
Y
D
D
Y
R
A
E
A
F
L
H
Site 203
S1638
Q
K
R
M
E
C
Y
S
K
A
K
E
A
Y
R
Site 204
T1653
I
G
K
K
N
V
A
T
F
Y
A
Q
Q
G
T
Site 205
Y1655
K
K
N
V
A
T
F
Y
A
Q
Q
G
T
L
H
Site 206
Y1724
K
Q
N
G
G
K
P
Y
L
S
V
I
T
G
R
Site 207
S1726
N
G
G
K
P
Y
L
S
V
I
T
G
R
G
N
Site 208
S1735
I
T
G
R
G
N
H
S
Q
G
G
V
A
R
I
Site 209
S1754
I
K
Y
L
I
S
H
S
F
R
F
S
E
I
K
Site 210
S1758
I
S
H
S
F
R
F
S
E
I
K
P
G
C
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation