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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CADPS2
Full Name:
Calcium-dependent secretion activator 2
Alias:
Ca2+-dependent activator protein for secretion 2; Calcium-dependent secretion activator 2
Type:
Mass (Da):
147735
Number AA:
1296
UniProt ID:
Q86UW7
International Prot ID:
IPI00384264
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0031410
GO:0045202
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0008289
PhosphoSite+
KinaseNET
Biological Process:
GO:0006887
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
L
D
P
S
S
S
E
E
E
S
D
Site 2
S6
_
_
M
L
D
P
S
S
S
E
E
E
S
D
E
Site 3
S7
_
M
L
D
P
S
S
S
E
E
E
S
D
E
G
Site 4
S11
P
S
S
S
E
E
E
S
D
E
G
L
E
E
E
Site 5
S56
G
G
G
G
A
A
R
S
V
S
P
S
P
S
V
Site 6
S58
G
G
A
A
R
S
V
S
P
S
P
S
V
L
S
Site 7
S60
A
A
R
S
V
S
P
S
P
S
V
L
S
E
G
Site 8
S62
R
S
V
S
P
S
P
S
V
L
S
E
G
R
D
Site 9
S65
S
P
S
P
S
V
L
S
E
G
R
D
E
P
Q
Site 10
Y150
C
N
A
V
R
S
Y
Y
E
V
F
L
K
S
D
Site 11
S165
R
V
A
R
M
V
Q
S
G
G
C
S
A
N
D
Site 12
S169
M
V
Q
S
G
G
C
S
A
N
D
F
R
E
V
Site 13
S187
N
I
E
K
R
V
R
S
L
P
E
I
D
G
L
Site 14
S195
L
P
E
I
D
G
L
S
K
E
T
V
L
S
S
Site 15
S201
L
S
K
E
T
V
L
S
S
W
I
A
K
Y
D
Site 16
S202
S
K
E
T
V
L
S
S
W
I
A
K
Y
D
A
Site 17
Y207
L
S
S
W
I
A
K
Y
D
A
I
Y
R
G
E
Site 18
Y211
I
A
K
Y
D
A
I
Y
R
G
E
E
D
L
C
Site 19
Y258
K
L
E
H
Q
L
L
Y
N
A
C
Q
L
D
N
Site 20
Y305
A
K
D
M
E
N
M
Y
I
E
E
L
R
S
S
Site 21
S326
N
L
E
S
L
P
V
S
K
G
G
P
E
F
K
Site 22
S340
K
L
Q
K
L
K
R
S
Q
N
S
A
F
L
D
Site 23
S357
D
E
N
E
I
Q
L
S
K
S
D
V
V
L
S
Site 24
S359
N
E
I
Q
L
S
K
S
D
V
V
L
S
F
T
Site 25
T366
S
D
V
V
L
S
F
T
L
E
I
V
I
M
E
Site 26
T389
P
N
R
I
V
Y
C
T
M
E
V
E
G
E
K
Site 27
T399
V
E
G
E
K
L
Q
T
D
Q
A
E
A
S
R
Site 28
T411
A
S
R
P
Q
W
G
T
Q
G
D
F
T
T
T
Site 29
T416
W
G
T
Q
G
D
F
T
T
T
H
P
R
P
V
Site 30
T417
G
T
Q
G
D
F
T
T
T
H
P
R
P
V
V
Site 31
Y449
E
L
G
R
V
I
L
Y
P
T
S
N
S
S
K
Site 32
T451
G
R
V
I
L
Y
P
T
S
N
S
S
K
S
A
Site 33
S452
R
V
I
L
Y
P
T
S
N
S
S
K
S
A
E
Site 34
S455
L
Y
P
T
S
N
S
S
K
S
A
E
L
H
R
Site 35
S457
P
T
S
N
S
S
K
S
A
E
L
H
R
M
V
Site 36
S469
R
M
V
V
P
K
N
S
Q
D
S
D
L
K
I
Site 37
Y493
A
H
M
K
H
S
G
Y
L
Y
A
L
G
Q
K
Site 38
Y495
M
K
H
S
G
Y
L
Y
A
L
G
Q
K
V
W
Site 39
Y509
W
K
R
W
K
K
R
Y
F
V
L
V
Q
V
S
Site 40
S530
C
S
Y
R
E
K
K
S
E
P
Q
E
L
M
Q
Site 41
Y545
L
E
G
Y
T
V
D
Y
T
D
P
H
P
G
L
Site 42
T546
E
G
Y
T
V
D
Y
T
D
P
H
P
G
L
Q
Site 43
T567
N
A
V
K
E
G
D
T
V
I
F
A
S
D
D
Site 44
S572
G
D
T
V
I
F
A
S
D
D
E
Q
D
R
I
Site 45
Y586
I
L
W
V
Q
A
M
Y
R
A
T
G
Q
S
Y
Site 46
T589
V
Q
A
M
Y
R
A
T
G
Q
S
Y
K
P
V
Site 47
S592
M
Y
R
A
T
G
Q
S
Y
K
P
V
P
A
I
Site 48
T654
F
R
I
L
Q
R
Q
T
L
D
H
R
L
N
D
Site 49
Y663
D
H
R
L
N
D
S
Y
S
C
L
G
W
F
S
Site 50
Y684
L
D
E
Y
C
A
R
Y
G
V
R
G
C
H
R
Site 51
T735
N
R
P
D
G
I
G
T
V
S
V
E
E
K
E
Site 52
S737
P
D
G
I
G
T
V
S
V
E
E
K
E
R
F
Site 53
S752
E
E
I
K
E
R
L
S
S
L
L
E
N
Q
I
Site 54
S753
E
I
K
E
R
L
S
S
L
L
E
N
Q
I
S
Site 55
Y764
N
Q
I
S
H
F
R
Y
C
F
P
F
G
R
P
Site 56
Y815
E
K
A
A
L
I
N
Y
T
R
L
T
E
Y
A
Site 57
T819
L
I
N
Y
T
R
L
T
E
Y
A
K
I
E
E
Site 58
Y821
N
Y
T
R
L
T
E
Y
A
K
I
E
E
T
M
Site 59
S832
E
E
T
M
N
Q
A
S
P
A
R
K
L
E
E
Site 60
T889
L
F
T
V
D
M
D
T
A
L
E
A
Q
P
Q
Site 61
S898
L
E
A
Q
P
Q
D
S
W
D
S
F
P
L
F
Site 62
S901
Q
P
Q
D
S
W
D
S
F
P
L
F
Q
L
L
Site 63
T916
N
N
F
L
R
N
D
T
L
L
C
N
G
K
F
Site 64
Y938
F
V
P
L
V
V
R
Y
V
D
L
M
E
S
S
Site 65
S945
Y
V
D
L
M
E
S
S
I
A
Q
S
I
H
R
Site 66
S949
M
E
S
S
I
A
Q
S
I
H
R
G
F
E
Q
Site 67
S991
L
P
Q
I
P
N
I
S
T
A
S
W
M
P
S
Site 68
T992
P
Q
I
P
N
I
S
T
A
S
W
M
P
S
L
Site 69
S994
I
P
N
I
S
T
A
S
W
M
P
S
L
Y
E
Site 70
S998
S
T
A
S
W
M
P
S
L
Y
E
S
T
N
G
Site 71
Y1000
A
S
W
M
P
S
L
Y
E
S
T
N
G
S
A
Site 72
S1002
W
M
P
S
L
Y
E
S
T
N
G
S
A
T
S
Site 73
S1006
L
Y
E
S
T
N
G
S
A
T
S
E
D
L
F
Site 74
S1009
S
T
N
G
S
A
T
S
E
D
L
F
W
K
L
Site 75
T1058
A
C
V
K
R
T
R
T
A
F
E
L
K
L
Q
Site 76
Y1107
D
G
G
Q
E
Q
Q
Y
H
S
K
I
D
D
L
Site 77
S1139
S
V
L
E
G
V
L
S
K
L
S
R
Y
D
E
Site 78
S1142
E
G
V
L
S
K
L
S
R
Y
D
E
G
T
F
Site 79
T1148
L
S
R
Y
D
E
G
T
F
F
S
S
I
L
S
Site 80
Y1164
T
V
K
A
A
A
K
Y
V
D
V
P
K
P
G
Site 81
Y1178
G
M
D
L
A
D
T
Y
I
M
F
V
R
Q
N
Site 82
Y1198
E
K
V
N
E
E
M
Y
I
E
K
L
F
D
Q
Site 83
Y1207
E
K
L
F
D
Q
W
Y
S
S
S
M
K
V
I
Site 84
T1241
L
I
K
I
V
K
K
T
Y
R
D
F
R
L
Q
Site 85
T1254
L
Q
G
V
L
E
G
T
L
N
S
K
T
Y
D
Site 86
T1259
E
G
T
L
N
S
K
T
Y
D
T
V
H
R
R
Site 87
Y1260
G
T
L
N
S
K
T
Y
D
T
V
H
R
R
L
Site 88
T1262
L
N
S
K
T
Y
D
T
V
H
R
R
L
T
V
Site 89
T1268
D
T
V
H
R
R
L
T
V
E
E
A
T
A
S
Site 90
S1275
T
V
E
E
A
T
A
S
V
S
E
G
G
G
L
Site 91
S1277
E
E
A
T
A
S
V
S
E
G
G
G
L
Q
G
Site 92
T1286
G
G
G
L
Q
G
I
T
M
K
D
S
D
E
E
Site 93
S1290
Q
G
I
T
M
K
D
S
D
E
E
E
E
G
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation