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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DTX2
Full Name:
Protein deltex-2
Alias:
Deltex 2; Deltex2; RING finger protein 58; RNF58
Type:
Transcription, coactivator/corepressor
Mass (Da):
67246
Number AA:
622
UniProt ID:
Q86UW9
International Prot ID:
IPI00292746
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007219
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y75
A
D
P
S
L
A
P
Y
I
I
D
L
P
S
W
Site 2
T89
W
T
Q
F
R
Q
D
T
G
T
M
R
A
V
R
Site 3
T91
Q
F
R
Q
D
T
G
T
M
R
A
V
R
R
H
Site 4
S104
R
H
L
F
P
Q
H
S
A
P
G
R
G
V
V
Site 5
S120
E
W
L
S
D
D
G
S
W
T
A
Y
E
A
S
Site 6
Y124
D
D
G
S
W
T
A
Y
E
A
S
V
C
D
Y
Site 7
Y131
Y
E
A
S
V
C
D
Y
L
E
Q
Q
V
A
R
Site 8
Y152
L
A
P
L
G
Y
N
Y
T
V
N
Y
T
T
H
Site 9
T153
A
P
L
G
Y
N
Y
T
V
N
Y
T
T
H
T
Site 10
Y156
G
Y
N
Y
T
V
N
Y
T
T
H
T
Q
T
N
Site 11
T162
N
Y
T
T
H
T
Q
T
N
K
T
S
S
F
C
Site 12
S166
H
T
Q
T
N
K
T
S
S
F
C
R
S
V
R
Site 13
S167
T
Q
T
N
K
T
S
S
F
C
R
S
V
R
R
Site 14
S171
K
T
S
S
F
C
R
S
V
R
R
Q
A
G
P
Site 15
Y180
R
R
Q
A
G
P
P
Y
P
V
T
T
I
I
A
Site 16
S203
C
S
C
H
Q
C
L
S
G
S
R
T
G
P
V
Site 17
S205
C
H
Q
C
L
S
G
S
R
T
G
P
V
S
G
Site 18
T207
Q
C
L
S
G
S
R
T
G
P
V
S
G
R
Y
Site 19
S211
G
S
R
T
G
P
V
S
G
R
Y
R
H
S
M
Site 20
Y214
T
G
P
V
S
G
R
Y
R
H
S
M
T
N
L
Site 21
S217
V
S
G
R
Y
R
H
S
M
T
N
L
P
A
Y
Site 22
T219
G
R
Y
R
H
S
M
T
N
L
P
A
Y
P
V
Site 23
Y224
S
M
T
N
L
P
A
Y
P
V
P
Q
H
P
P
Site 24
S236
H
P
P
H
R
T
A
S
V
F
G
T
H
Q
A
Site 25
T240
R
T
A
S
V
F
G
T
H
Q
A
F
A
P
Y
Site 26
Y247
T
H
Q
A
F
A
P
Y
N
K
P
S
L
S
G
Site 27
S251
F
A
P
Y
N
K
P
S
L
S
G
A
R
S
A
Site 28
S253
P
Y
N
K
P
S
L
S
G
A
R
S
A
P
R
Site 29
S257
P
S
L
S
G
A
R
S
A
P
R
L
N
T
T
Site 30
T263
R
S
A
P
R
L
N
T
T
N
A
W
G
A
A
Site 31
S273
A
W
G
A
A
P
P
S
L
G
S
Q
P
L
Y
Site 32
S276
A
A
P
P
S
L
G
S
Q
P
L
Y
R
S
S
Site 33
Y280
S
L
G
S
Q
P
L
Y
R
S
S
L
S
H
L
Site 34
S282
G
S
Q
P
L
Y
R
S
S
L
S
H
L
G
P
Site 35
S283
S
Q
P
L
Y
R
S
S
L
S
H
L
G
P
Q
Site 36
S285
P
L
Y
R
S
S
L
S
H
L
G
P
Q
H
L
Site 37
S296
P
Q
H
L
P
P
G
S
S
T
S
G
A
V
S
Site 38
S297
Q
H
L
P
P
G
S
S
T
S
G
A
V
S
A
Site 39
S303
S
S
T
S
G
A
V
S
A
S
L
P
S
G
P
Site 40
S305
T
S
G
A
V
S
A
S
L
P
S
G
P
S
S
Site 41
S308
A
V
S
A
S
L
P
S
G
P
S
S
S
P
G
Site 42
S311
A
S
L
P
S
G
P
S
S
S
P
G
S
V
P
Site 43
S312
S
L
P
S
G
P
S
S
S
P
G
S
V
P
A
Site 44
S313
L
P
S
G
P
S
S
S
P
G
S
V
P
A
T
Site 45
S316
G
P
S
S
S
P
G
S
V
P
A
T
V
P
M
Site 46
T320
S
P
G
S
V
P
A
T
V
P
M
Q
M
P
K
Site 47
T359
L
S
R
A
P
Q
P
T
S
P
P
A
S
R
L
Site 48
S360
S
R
A
P
Q
P
T
S
P
P
A
S
R
L
A
Site 49
S364
Q
P
T
S
P
P
A
S
R
L
A
S
K
S
H
Site 50
S368
P
P
A
S
R
L
A
S
K
S
H
G
S
V
K
Site 51
S370
A
S
R
L
A
S
K
S
H
G
S
V
K
R
L
Site 52
S373
L
A
S
K
S
H
G
S
V
K
R
L
R
K
M
Site 53
S381
V
K
R
L
R
K
M
S
V
K
G
A
T
P
K
Site 54
T386
K
M
S
V
K
G
A
T
P
K
P
E
P
E
P
Site 55
T429
A
S
G
Y
S
D
V
T
D
S
K
A
I
G
S
Site 56
S431
G
Y
S
D
V
T
D
S
K
A
I
G
S
L
A
Site 57
S471
D
G
S
L
Q
C
P
S
C
K
T
I
Y
G
E
Site 58
Y476
C
P
S
C
K
T
I
Y
G
E
K
T
G
T
Q
Site 59
T482
I
Y
G
E
K
T
G
T
Q
P
Q
G
K
M
E
Site 60
S496
E
V
L
R
F
Q
M
S
L
P
G
H
E
D
C
Site 61
T529
P
N
P
G
K
P
F
T
A
R
G
F
P
R
Q
Site 62
Y538
R
G
F
P
R
Q
C
Y
L
P
D
N
A
Q
G
Site 63
T563
W
K
R
R
L
I
F
T
V
G
T
S
S
T
T
Site 64
S568
I
F
T
V
G
T
S
S
T
T
G
E
T
D
T
Site 65
T575
S
T
T
G
E
T
D
T
V
V
W
N
E
I
H
Site 66
T592
T
E
M
D
R
N
I
T
G
H
G
Y
P
D
P
Site 67
Y596
R
N
I
T
G
H
G
Y
P
D
P
N
Y
L
Q
Site 68
Y601
H
G
Y
P
D
P
N
Y
L
Q
N
V
L
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation