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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ITIH5
Full Name:
Inter-alpha-trypsin inhibitor heavy chain H5
Alias:
Type:
Mass (Da):
104576
Number AA:
942
UniProt ID:
Q86UX2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
G
L
S
L
C
V
G
S
Q
E
E
A
Q
S
W
Site 2
S23
G
S
Q
E
E
A
Q
S
W
G
H
S
S
E
Q
Site 3
S27
E
A
Q
S
W
G
H
S
S
E
Q
D
G
L
R
Site 4
S28
A
Q
S
W
G
H
S
S
E
Q
D
G
L
R
V
Site 5
T47
R
L
L
Q
R
L
K
T
K
P
L
M
T
E
F
Site 6
S58
M
T
E
F
S
V
K
S
T
I
I
S
R
Y
A
Site 7
S78
C
R
M
L
N
R
A
S
E
D
Q
D
I
E
F
Site 8
Y107
M
L
I
G
D
K
V
Y
Q
G
E
I
T
E
R
Site 9
T112
K
V
Y
Q
G
E
I
T
E
R
E
K
K
S
G
Site 10
S118
I
T
E
R
E
K
K
S
G
D
R
V
K
E
K
Site 11
T129
V
K
E
K
R
N
K
T
T
E
E
N
G
E
K
Site 12
S144
G
T
E
I
F
R
A
S
A
V
I
P
S
K
D
Site 13
S158
D
K
A
A
F
F
L
S
Y
E
E
L
L
Q
R
Site 14
Y170
L
Q
R
R
L
G
K
Y
E
H
S
I
S
V
R
Site 15
S173
R
L
G
K
Y
E
H
S
I
S
V
R
P
Q
Q
Site 16
S175
G
K
Y
E
H
S
I
S
V
R
P
Q
Q
L
S
Site 17
S182
S
V
R
P
Q
Q
L
S
G
R
L
S
V
D
V
Site 18
S186
Q
Q
L
S
G
R
L
S
V
D
V
N
I
L
E
Site 19
S208
E
V
L
P
L
H
N
S
R
Q
R
G
S
G
R
Site 20
S213
H
N
S
R
Q
R
G
S
G
R
G
E
D
D
S
Site 21
S220
S
G
R
G
E
D
D
S
G
P
P
P
S
T
V
Site 22
S225
D
D
S
G
P
P
P
S
T
V
I
N
Q
N
E
Site 23
T226
D
S
G
P
P
P
S
T
V
I
N
Q
N
E
T
Site 24
Y262
L
G
D
F
I
I
R
Y
D
V
N
R
E
Q
S
Site 25
S269
Y
D
V
N
R
E
Q
S
I
G
D
I
Q
V
L
Site 26
Y283
L
N
G
Y
F
V
H
Y
F
A
P
K
D
L
P
Site 27
T309
S
S
A
S
M
V
G
T
K
L
R
Q
T
K
D
Site 28
T314
V
G
T
K
L
R
Q
T
K
D
A
L
F
T
I
Site 29
S332
L
R
P
Q
D
R
F
S
I
I
G
F
S
N
R
Site 30
S349
V
W
K
D
H
L
I
S
V
T
P
D
S
I
R
Site 31
T351
K
D
H
L
I
S
V
T
P
D
S
I
R
D
G
Site 32
S354
L
I
S
V
T
P
D
S
I
R
D
G
K
V
Y
Site 33
Y361
S
I
R
D
G
K
V
Y
I
H
H
M
S
P
T
Site 34
S366
K
V
Y
I
H
H
M
S
P
T
G
G
T
D
I
Site 35
T458
S
L
E
N
C
G
L
T
R
R
V
H
E
E
E
Site 36
S469
H
E
E
E
D
A
G
S
Q
L
I
G
F
Y
D
Site 37
Y475
G
S
Q
L
I
G
F
Y
D
E
I
R
T
P
L
Site 38
T480
G
F
Y
D
E
I
R
T
P
L
L
S
D
I
R
Site 39
S484
E
I
R
T
P
L
L
S
D
I
R
I
D
Y
P
Site 40
Y490
L
S
D
I
R
I
D
Y
P
P
S
S
V
V
Q
Site 41
S493
I
R
I
D
Y
P
P
S
S
V
V
Q
A
T
K
Site 42
S494
R
I
D
Y
P
P
S
S
V
V
Q
A
T
K
T
Site 43
T499
P
S
S
V
V
Q
A
T
K
T
L
F
P
N
Y
Site 44
T501
S
V
V
Q
A
T
K
T
L
F
P
N
Y
F
N
Site 45
Y506
T
K
T
L
F
P
N
Y
F
N
G
S
E
I
I
Site 46
T531
D
H
L
H
V
E
V
T
A
S
N
S
K
K
F
Site 47
T543
K
K
F
I
I
L
K
T
D
V
P
V
R
P
Q
Site 48
T557
Q
K
A
G
K
D
V
T
G
S
P
R
P
G
G
Site 49
S559
A
G
K
D
V
T
G
S
P
R
P
G
G
D
G
Site 50
T570
G
G
D
G
E
G
D
T
N
H
I
E
R
L
W
Site 51
S578
N
H
I
E
R
L
W
S
Y
L
T
T
K
E
L
Site 52
Y579
H
I
E
R
L
W
S
Y
L
T
T
K
E
L
L
Site 53
T581
E
R
L
W
S
Y
L
T
T
K
E
L
L
S
S
Site 54
T582
R
L
W
S
Y
L
T
T
K
E
L
L
S
S
W
Site 55
S588
T
T
K
E
L
L
S
S
W
L
Q
S
D
D
E
Site 56
S592
L
L
S
S
W
L
Q
S
D
D
E
P
E
K
E
Site 57
S620
R
F
L
T
P
F
T
S
M
K
L
R
G
P
V
Site 58
S640
L
E
E
A
H
G
M
S
A
A
M
G
P
E
P
Site 59
S651
G
P
E
P
V
V
Q
S
V
R
G
A
G
T
Q
Site 60
Y667
G
P
L
L
K
K
P
Y
Q
P
R
I
K
I
S
Site 61
T676
P
R
I
K
I
S
K
T
S
V
D
G
D
P
H
Site 62
S677
R
I
K
I
S
K
T
S
V
D
G
D
P
H
F
Site 63
S711
G
D
I
L
R
L
V
S
D
H
R
D
S
G
V
Site 64
S716
L
V
S
D
H
R
D
S
G
V
T
V
N
G
E
Site 65
T719
D
H
R
D
S
G
V
T
V
N
G
E
L
I
G
Site 66
T739
N
G
H
K
K
Q
R
T
Y
L
R
T
I
T
I
Site 67
Y740
G
H
K
K
Q
R
T
Y
L
R
T
I
T
I
L
Site 68
T743
K
Q
R
T
Y
L
R
T
I
T
I
L
I
N
K
Site 69
T745
R
T
Y
L
R
T
I
T
I
L
I
N
K
P
E
Site 70
Y755
I
N
K
P
E
R
S
Y
L
E
I
T
P
S
R
Site 71
T759
E
R
S
Y
L
E
I
T
P
S
R
V
I
L
D
Site 72
Y827
Q
R
H
H
L
G
F
Y
I
A
N
S
E
G
L
Site 73
S836
A
N
S
E
G
L
S
S
N
C
H
G
L
L
G
Site 74
T853
L
N
Q
D
A
R
L
T
E
D
P
A
G
P
S
Site 75
T880
E
G
P
E
A
V
L
T
V
K
G
H
Q
V
P
Site 76
Y896
V
W
K
Q
R
K
I
Y
N
G
E
E
Q
I
D
Site 77
Y919
A
K
L
I
D
G
E
Y
K
D
Y
L
A
F
H
Site 78
Y922
I
D
G
E
Y
K
D
Y
L
A
F
H
P
F
D
Site 79
T930
L
A
F
H
P
F
D
T
G
M
T
L
G
Q
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation