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Updated November 2019
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Protein Info
Short Name:
CASZ1
Full Name:
Zinc finger protein castor homolog 1
Alias:
Castor-related protein
Type:
Mass (Da):
190130
Number AA:
1759
UniProt ID:
Q86V15
International Prot ID:
IPI00103440
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
T
A
E
G
T
R
C
T
D
P
P
A
G
K
P
Site 2
S52
E
K
R
A
D
A
G
S
H
T
E
G
S
P
S
Site 3
S57
A
G
S
H
T
E
G
S
P
S
Q
P
R
D
Q
Site 4
S59
S
H
T
E
G
S
P
S
Q
P
R
D
Q
E
R
Site 5
S67
Q
P
R
D
Q
E
R
S
G
P
E
S
G
A
A
Site 6
S71
Q
E
R
S
G
P
E
S
G
A
A
R
A
P
R
Site 7
S79
G
A
A
R
A
P
R
S
E
E
D
K
R
R
A
Site 8
S97
K
W
V
N
G
E
Y
S
E
E
P
A
P
T
P
Site 9
T103
Y
S
E
E
P
A
P
T
P
V
L
G
R
I
A
Site 10
Y122
E
L
P
P
E
G
V
Y
M
V
Q
P
Q
G
C
Site 11
S151
G
A
L
E
E
K
D
S
D
G
A
A
S
K
E
Site 12
S156
K
D
S
D
G
A
A
S
K
E
D
S
G
P
S
Site 13
S160
G
A
A
S
K
E
D
S
G
P
S
T
R
Q
A
Site 14
S163
S
K
E
D
S
G
P
S
T
R
Q
A
S
G
E
Site 15
T164
K
E
D
S
G
P
S
T
R
Q
A
S
G
E
A
Site 16
S168
G
P
S
T
R
Q
A
S
G
E
A
S
S
L
R
Site 17
S172
R
Q
A
S
G
E
A
S
S
L
R
D
Y
A
A
Site 18
S173
Q
A
S
G
E
A
S
S
L
R
D
Y
A
A
S
Site 19
Y177
E
A
S
S
L
R
D
Y
A
A
S
T
M
T
E
Site 20
S180
S
L
R
D
Y
A
A
S
T
M
T
E
F
L
G
Site 21
T183
D
Y
A
A
S
T
M
T
E
F
L
G
M
F
G
Site 22
Y191
E
F
L
G
M
F
G
Y
D
D
Q
N
T
R
D
Site 23
T196
F
G
Y
D
D
Q
N
T
R
D
E
L
A
R
K
Site 24
S205
D
E
L
A
R
K
I
S
F
E
K
L
H
A
G
Site 25
T214
E
K
L
H
A
G
S
T
P
E
A
A
T
S
S
Site 26
S220
S
T
P
E
A
A
T
S
S
M
L
P
T
S
E
Site 27
S221
T
P
E
A
A
T
S
S
M
L
P
T
S
E
D
Site 28
T225
A
T
S
S
M
L
P
T
S
E
D
T
L
S
K
Site 29
S226
T
S
S
M
L
P
T
S
E
D
T
L
S
K
R
Site 30
T229
M
L
P
T
S
E
D
T
L
S
K
R
A
R
F
Site 31
S231
P
T
S
E
D
T
L
S
K
R
A
R
F
S
K
Site 32
S237
L
S
K
R
A
R
F
S
K
Y
E
E
Y
I
R
Site 33
Y239
K
R
A
R
F
S
K
Y
E
E
Y
I
R
K
L
Site 34
Y242
R
F
S
K
Y
E
E
Y
I
R
K
L
K
A
G
Site 35
S253
L
K
A
G
E
Q
L
S
W
P
A
P
S
T
K
Site 36
S280
L
P
G
L
R
L
P
S
S
T
A
H
L
E
T
Site 37
S281
P
G
L
R
L
P
S
S
T
A
H
L
E
T
K
Site 38
T282
G
L
R
L
P
S
S
T
A
H
L
E
T
K
A
Site 39
T290
A
H
L
E
T
K
A
T
I
L
P
L
P
S
H
Site 40
S299
L
P
L
P
S
H
S
S
V
Q
M
Q
N
L
V
Site 41
S310
Q
N
L
V
A
R
A
S
K
Y
D
F
F
I
Q
Site 42
S331
N
L
R
P
Q
N
G
S
T
Y
K
K
P
S
K
Site 43
Y333
R
P
Q
N
G
S
T
Y
K
K
P
S
K
Y
D
Site 44
Y339
T
Y
K
K
P
S
K
Y
D
L
E
N
V
K
Y
Site 45
Y346
Y
D
L
E
N
V
K
Y
L
H
L
F
K
P
G
Site 46
S356
L
F
K
P
G
E
G
S
P
D
M
G
G
A
I
Site 47
T367
G
G
A
I
A
F
K
T
G
K
V
G
R
P
S
Site 48
S374
T
G
K
V
G
R
P
S
K
Y
D
V
R
G
I
Site 49
Y376
K
V
G
R
P
S
K
Y
D
V
R
G
I
Q
K
Site 50
T392
G
P
A
K
V
P
P
T
P
S
L
A
P
A
P
Site 51
S419
P
G
P
E
P
P
A
S
L
S
F
N
T
P
E
Site 52
S421
P
E
P
P
A
S
L
S
F
N
T
P
E
Y
L
Site 53
T424
P
A
S
L
S
F
N
T
P
E
Y
L
K
S
T
Site 54
Y427
L
S
F
N
T
P
E
Y
L
K
S
T
F
S
K
Site 55
S430
N
T
P
E
Y
L
K
S
T
F
S
K
T
D
S
Site 56
T431
T
P
E
Y
L
K
S
T
F
S
K
T
D
S
I
Site 57
S433
E
Y
L
K
S
T
F
S
K
T
D
S
I
T
T
Site 58
T435
L
K
S
T
F
S
K
T
D
S
I
T
T
G
T
Site 59
S437
S
T
F
S
K
T
D
S
I
T
T
G
T
V
S
Site 60
T440
S
K
T
D
S
I
T
T
G
T
V
S
T
V
K
Site 61
T442
T
D
S
I
T
T
G
T
V
S
T
V
K
N
G
Site 62
Y467
D
V
N
I
Y
Q
K
Y
I
A
R
F
S
G
S
Site 63
Y490
A
Y
Q
Y
R
E
H
Y
H
C
L
D
P
E
C
Site 64
Y499
C
L
D
P
E
C
N
Y
Q
R
F
T
S
K
Q
Site 65
Y512
K
Q
D
V
I
R
H
Y
N
M
H
K
K
R
D
Site 66
S530
Q
H
G
F
M
R
F
S
P
L
D
D
C
S
V
Site 67
Y538
P
L
D
D
C
S
V
Y
Y
H
G
C
H
L
N
Site 68
Y539
L
D
D
C
S
V
Y
Y
H
G
C
H
L
N
G
Site 69
Y551
L
N
G
K
S
T
H
Y
H
C
M
Q
V
G
C
Site 70
Y562
Q
V
G
C
N
K
V
Y
T
S
T
S
D
V
M
Site 71
S566
N
K
V
Y
T
S
T
S
D
V
M
T
H
E
N
Site 72
T570
T
S
T
S
D
V
M
T
H
E
N
F
H
K
K
Site 73
T592
G
F
Q
R
F
R
A
T
E
D
C
G
T
A
D
Site 74
Y603
G
T
A
D
C
Q
F
Y
G
Q
K
T
T
H
F
Site 75
Y633
D
I
E
K
H
K
S
Y
H
I
K
D
D
A
Y
Site 76
Y640
Y
H
I
K
D
D
A
Y
A
K
D
G
F
K
K
Site 77
Y649
K
D
G
F
K
K
F
Y
K
Y
E
E
C
K
Y
Site 78
Y651
G
F
K
K
F
Y
K
Y
E
E
C
K
Y
E
G
Site 79
Y656
Y
K
Y
E
E
C
K
Y
E
G
C
V
Y
S
K
Site 80
Y661
C
K
Y
E
G
C
V
Y
S
K
A
T
N
H
F
Site 81
T682
C
G
F
T
F
T
S
T
S
Q
M
T
S
H
K
Site 82
S683
G
F
T
F
T
S
T
S
Q
M
T
S
H
K
R
Site 83
S687
T
S
T
S
Q
M
T
S
H
K
R
K
H
E
R
Site 84
S699
H
E
R
R
H
I
R
S
S
G
A
L
G
L
P
Site 85
S700
E
R
R
H
I
R
S
S
G
A
L
G
L
P
P
Site 86
T715
S
L
L
G
A
K
D
T
E
H
E
E
S
S
N
Site 87
S720
K
D
T
E
H
E
E
S
S
N
D
D
L
V
D
Site 88
S721
D
T
E
H
E
E
S
S
N
D
D
L
V
D
F
Site 89
S729
N
D
D
L
V
D
F
S
A
L
S
S
K
N
S
Site 90
S732
L
V
D
F
S
A
L
S
S
K
N
S
S
L
S
Site 91
S733
V
D
F
S
A
L
S
S
K
N
S
S
L
S
A
Site 92
S736
S
A
L
S
S
K
N
S
S
L
S
A
S
P
T
Site 93
S737
A
L
S
S
K
N
S
S
L
S
A
S
P
T
S
Site 94
S739
S
S
K
N
S
S
L
S
A
S
P
T
S
Q
Q
Site 95
S741
K
N
S
S
L
S
A
S
P
T
S
Q
Q
S
S
Site 96
T743
S
S
L
S
A
S
P
T
S
Q
Q
S
S
A
S
Site 97
S744
S
L
S
A
S
P
T
S
Q
Q
S
S
A
S
L
Site 98
S748
S
P
T
S
Q
Q
S
S
A
S
L
A
A
A
T
Site 99
S750
T
S
Q
Q
S
S
A
S
L
A
A
A
T
A
A
Site 100
S763
A
A
T
E
A
G
P
S
A
T
K
P
P
N
S
Site 101
S770
S
A
T
K
P
P
N
S
K
I
S
G
L
L
P
Site 102
T797
L
S
N
S
G
L
P
T
P
T
P
Y
F
P
I
Site 103
S812
L
A
G
R
G
S
T
S
L
P
V
G
T
P
S
Site 104
S831
V
S
S
G
S
A
A
S
A
T
P
D
T
P
T
Site 105
T833
S
G
S
A
A
S
A
T
P
D
T
P
T
L
V
Site 106
S842
D
T
P
T
L
V
A
S
G
A
G
D
S
A
P
Site 107
S874
S
A
S
K
G
L
I
S
P
M
M
A
R
L
A
Site 108
S888
A
A
A
A
L
K
P
S
A
T
F
D
P
G
S
Site 109
T890
A
A
L
K
P
S
A
T
F
D
P
G
S
G
Q
Site 110
S895
S
A
T
F
D
P
G
S
G
Q
Q
V
T
P
A
Site 111
T900
P
G
S
G
Q
Q
V
T
P
A
R
F
P
P
A
Site 112
S916
V
K
P
E
P
G
E
S
T
G
A
P
G
P
H
Site 113
T917
K
P
E
P
G
E
S
T
G
A
P
G
P
H
E
Site 114
S926
A
P
G
P
H
E
A
S
Q
D
R
S
L
D
L
Site 115
S930
H
E
A
S
Q
D
R
S
L
D
L
T
V
K
E
Site 116
T934
Q
D
R
S
L
D
L
T
V
K
E
P
S
N
E
Site 117
S955
P
A
N
S
S
L
L
S
S
L
M
N
K
M
S
Site 118
S956
A
N
S
S
L
L
S
S
L
M
N
K
M
S
Q
Site 119
S962
S
S
L
M
N
K
M
S
Q
G
N
P
G
L
G
Site 120
S970
Q
G
N
P
G
L
G
S
L
L
N
I
K
A
E
Site 121
S981
I
K
A
E
A
E
G
S
P
A
A
E
P
S
P
Site 122
S987
G
S
P
A
A
E
P
S
P
F
L
G
K
A
V
Site 123
Y1009
L
A
E
P
W
K
V
Y
L
R
R
F
G
T
K
Site 124
T1015
V
Y
L
R
R
F
G
T
K
D
F
C
D
G
Q
Site 125
T1067
G
G
A
A
K
G
N
T
E
A
A
F
P
A
S
Site 126
T1078
F
P
A
S
A
A
E
T
K
P
P
M
A
P
S
Site 127
S1085
T
K
P
P
M
A
P
S
S
P
P
V
P
P
V
Site 128
S1086
K
P
P
M
A
P
S
S
P
P
V
P
P
V
T
Site 129
S1106
S
L
E
G
P
A
P
S
P
A
S
V
P
S
T
Site 130
S1109
G
P
A
P
S
P
A
S
V
P
S
T
P
T
L
Site 131
T1113
S
P
A
S
V
P
S
T
P
T
L
L
A
W
K
Site 132
S1135
Q
M
P
Q
I
P
A
S
V
P
H
L
P
A
S
Site 133
T1146
L
P
A
S
P
L
A
T
T
S
L
E
N
A
K
Site 134
S1148
A
S
P
L
A
T
T
S
L
E
N
A
K
P
Q
Site 135
Y1191
C
L
F
G
N
C
K
Y
V
C
K
T
S
G
K
Site 136
S1201
K
T
S
G
K
A
E
S
H
C
L
D
H
I
N
Site 137
Y1222
N
V
R
D
Q
F
A
Y
Y
S
L
Q
C
L
C
Site 138
Y1242
E
F
R
M
R
G
H
Y
H
C
L
R
T
G
C
Site 139
Y1279
R
A
A
N
G
F
K
Y
F
T
K
R
E
E
C
Site 140
T1281
A
N
G
F
K
Y
F
T
K
R
E
E
C
G
R
Site 141
Y1293
C
G
R
L
G
C
K
Y
N
Q
V
S
S
H
F
Site 142
S1339
N
F
D
R
V
P
P
S
Q
G
P
P
G
L
M
Site 143
T1350
P
G
L
M
D
A
E
T
D
E
C
M
D
Y
T
Site 144
Y1356
E
T
D
E
C
M
D
Y
T
G
C
S
P
G
A
Site 145
S1360
C
M
D
Y
T
G
C
S
P
G
A
M
S
S
E
Site 146
S1365
G
C
S
P
G
A
M
S
S
E
S
S
T
M
D
Site 147
S1366
C
S
P
G
A
M
S
S
E
S
S
T
M
D
R
Site 148
S1368
P
G
A
M
S
S
E
S
S
T
M
D
R
S
C
Site 149
S1369
G
A
M
S
S
E
S
S
T
M
D
R
S
C
S
Site 150
T1370
A
M
S
S
E
S
S
T
M
D
R
S
C
S
S
Site 151
S1374
E
S
S
T
M
D
R
S
C
S
S
T
P
V
G
Site 152
S1376
S
T
M
D
R
S
C
S
S
T
P
V
G
N
E
Site 153
S1377
T
M
D
R
S
C
S
S
T
P
V
G
N
E
S
Site 154
T1378
M
D
R
S
C
S
S
T
P
V
G
N
E
S
T
Site 155
S1397
T
I
S
M
P
T
A
S
G
A
K
K
R
F
W
Site 156
S1410
F
W
I
I
E
D
M
S
P
F
G
K
R
R
K
Site 157
T1418
P
F
G
K
R
R
K
T
A
S
S
R
K
M
L
Site 158
S1420
G
K
R
R
K
T
A
S
S
R
K
M
L
D
E
Site 159
S1421
K
R
R
K
T
A
S
S
R
K
M
L
D
E
G
Site 160
Y1440
G
F
R
R
F
D
L
Y
E
D
C
K
D
A
A
Site 161
Y1457
F
S
L
K
V
T
H
Y
H
C
T
R
E
N
C
Site 162
S1498
D
F
K
R
F
K
A
S
L
S
R
H
F
A
D
Site 163
S1500
K
R
F
K
A
S
L
S
R
H
F
A
D
C
P
Site 164
T1525
L
R
C
R
F
R
C
T
D
S
T
K
V
T
A
Site 165
T1528
R
F
R
C
T
D
S
T
K
V
T
A
H
R
K
Site 166
S1544
H
G
K
Q
D
V
I
S
A
A
G
F
R
Q
F
Site 167
S1554
G
F
R
Q
F
S
S
S
A
D
C
A
V
P
D
Site 168
S1586
R
H
T
V
V
G
M
S
Q
M
D
S
H
K
R
Site 169
S1590
V
G
M
S
Q
M
D
S
H
K
R
K
H
E
K
Site 170
S1619
P
P
I
S
L
D
G
S
L
S
L
G
A
E
P
Site 171
T1717
D
D
D
E
D
L
R
T
D
S
E
E
S
L
P
Site 172
S1719
D
E
D
L
R
T
D
S
E
E
S
L
P
E
A
Site 173
T1754
G
A
P
G
P
A
P
T
A
A
S
S
P
_
_
Site 174
S1758
P
A
P
T
A
A
S
S
P
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation