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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AACS
Full Name:
Acetoacetyl-CoA synthetase
Alias:
Acyl-CoA synthetase family member 1;Protein sur-5 homolog
Type:
Mass (Da):
75144
Number AA:
672
UniProt ID:
Q86V21
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T27
E
P
D
S
K
K
N
T
Q
M
D
R
F
R
A
Site 2
Y47
C
G
L
A
L
E
S
Y
D
D
L
Y
H
W
S
Site 3
Y51
L
E
S
Y
D
D
L
Y
H
W
S
V
E
S
Y
Site 4
Y101
F
K
G
S
R
L
N
Y
A
E
N
L
L
R
H
Site 5
Y117
E
N
D
R
V
A
L
Y
I
A
R
E
G
K
E
Site 6
Y159
K
G
D
R
V
V
G
Y
L
P
N
S
E
H
A
Site 7
S184
G
A
I
W
S
S
T
S
P
D
F
G
V
N
G
Site 8
S197
N
G
V
L
D
R
F
S
Q
I
Q
P
K
L
I
Site 9
Y212
F
S
V
E
A
V
V
Y
N
G
K
E
H
N
H
Site 10
Y241
K
K
V
V
V
I
P
Y
V
S
S
R
E
N
I
Site 11
S251
S
R
E
N
I
D
L
S
K
I
P
N
S
V
F
Site 12
T307
M
V
H
S
A
G
G
T
L
I
Q
H
L
K
E
Site 13
T406
H
S
L
Q
M
L
H
T
I
L
S
T
G
S
P
Site 14
S412
H
T
I
L
S
T
G
S
P
L
K
A
Q
S
Y
Site 15
S418
G
S
P
L
K
A
Q
S
Y
E
Y
V
Y
R
C
Site 16
Y419
S
P
L
K
A
Q
S
Y
E
Y
V
Y
R
C
I
Site 17
Y421
L
K
A
Q
S
Y
E
Y
V
Y
R
C
I
K
S
Site 18
Y423
A
Q
S
Y
E
Y
V
Y
R
C
I
K
S
S
I
Site 19
Y455
H
N
F
S
L
P
V
Y
K
G
E
I
Q
A
R
Site 20
T488
E
S
G
E
L
V
C
T
K
P
I
P
C
Q
P
Site 21
Y507
N
D
E
N
G
N
K
Y
R
K
A
Y
F
S
K
Site 22
Y511
G
N
K
Y
R
K
A
Y
F
S
K
F
P
G
I
Site 23
Y524
G
I
W
A
H
G
D
Y
C
R
I
N
P
K
T
Site 24
T531
Y
C
R
I
N
P
K
T
G
G
I
V
M
L
G
Site 25
T543
M
L
G
R
S
D
G
T
L
N
P
N
G
V
R
Site 26
S553
P
N
G
V
R
F
G
S
S
E
I
Y
N
I
V
Site 27
Y557
R
F
G
S
S
E
I
Y
N
I
V
E
S
F
E
Site 28
S562
E
I
Y
N
I
V
E
S
F
E
E
V
E
D
S
Site 29
S569
S
F
E
E
V
E
D
S
L
C
V
P
Q
Y
N
Site 30
Y575
D
S
L
C
V
P
Q
Y
N
K
Y
R
E
E
R
Site 31
Y578
C
V
P
Q
Y
N
K
Y
R
E
E
R
V
I
L
Site 32
T629
E
T
K
G
I
P
Y
T
L
N
G
K
K
V
E
Site 33
S655
V
E
Q
G
G
A
F
S
N
P
E
T
L
D
L
Site 34
T659
G
A
F
S
N
P
E
T
L
D
L
Y
R
D
I
Site 35
Y663
N
P
E
T
L
D
L
Y
R
D
I
P
E
L
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation