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Updated November 2019
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Protein Info
Short Name:
FAM124A
Full Name:
Protein FAM124A
Alias:
Type:
Mass (Da):
60104
Number AA:
546
UniProt ID:
Q86V42
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
E
E
D
D
C
V
D
S
G
A
E
T
G
G
S
Site 2
T21
C
V
D
S
G
A
E
T
G
G
S
D
Y
S
H
Site 3
S24
S
G
A
E
T
G
G
S
D
Y
S
H
L
S
S
Site 4
Y26
A
E
T
G
G
S
D
Y
S
H
L
S
S
T
S
Site 5
S27
E
T
G
G
S
D
Y
S
H
L
S
S
T
S
S
Site 6
S30
G
S
D
Y
S
H
L
S
S
T
S
S
E
L
S
Site 7
S31
S
D
Y
S
H
L
S
S
T
S
S
E
L
S
V
Site 8
S33
Y
S
H
L
S
S
T
S
S
E
L
S
V
E
E
Site 9
S34
S
H
L
S
S
T
S
S
E
L
S
V
E
E
A
Site 10
S37
S
S
T
S
S
E
L
S
V
E
E
A
Q
D
P
Site 11
S82
D
L
P
L
F
R
V
S
E
R
R
A
S
R
R
Site 12
S87
R
V
S
E
R
R
A
S
R
R
R
R
K
P
P
Site 13
T122
Q
I
L
Q
L
H
R
T
L
Q
Q
P
P
W
R
Site 14
Y143
V
H
G
R
F
L
P
Y
L
P
C
S
Q
D
F
Site 15
Y177
E
I
V
R
F
T
V
Y
C
R
Y
D
N
Y
A
Site 16
Y180
R
F
T
V
Y
C
R
Y
D
N
Y
A
D
S
L
Site 17
Y183
V
Y
C
R
Y
D
N
Y
A
D
S
L
R
F
Y
Site 18
Y190
Y
A
D
S
L
R
F
Y
Q
L
I
L
R
R
S
Site 19
S197
Y
Q
L
I
L
R
R
S
P
S
Q
K
K
A
D
Site 20
S199
L
I
L
R
R
S
P
S
Q
K
K
A
D
F
C
Site 21
S221
L
D
V
D
I
Q
F
S
L
K
R
L
P
C
D
Site 22
S237
C
P
V
P
T
D
S
S
V
L
E
F
R
V
R
Site 23
S258
P
L
L
P
N
P
C
S
P
I
S
E
G
R
W
Site 24
S261
P
N
P
C
S
P
I
S
E
G
R
W
Q
T
E
Site 25
T267
I
S
E
G
R
W
Q
T
E
D
H
D
G
N
K
Site 26
S296
P
G
R
V
H
H
A
S
E
K
K
R
H
S
T
Site 27
S302
A
S
E
K
K
R
H
S
T
P
L
P
S
T
A
Site 28
T303
S
E
K
K
R
H
S
T
P
L
P
S
T
A
V
Site 29
S307
R
H
S
T
P
L
P
S
T
A
V
P
S
H
T
Site 30
T308
H
S
T
P
L
P
S
T
A
V
P
S
H
T
P
Site 31
S312
L
P
S
T
A
V
P
S
H
T
P
G
S
S
Q
Site 32
T314
S
T
A
V
P
S
H
T
P
G
S
S
Q
Q
S
Site 33
S317
V
P
S
H
T
P
G
S
S
Q
Q
S
P
L
N
Site 34
S318
P
S
H
T
P
G
S
S
Q
Q
S
P
L
N
S
Site 35
S321
T
P
G
S
S
Q
Q
S
P
L
N
S
P
H
P
Site 36
S325
S
Q
Q
S
P
L
N
S
P
H
P
G
P
I
R
Site 37
T333
P
H
P
G
P
I
R
T
G
L
P
P
G
H
Q
Site 38
S349
E
F
A
G
R
A
N
S
T
P
N
P
P
W
S
Site 39
T350
F
A
G
R
A
N
S
T
P
N
P
P
W
S
F
Site 40
S356
S
T
P
N
P
P
W
S
F
Q
R
S
K
S
L
Site 41
S360
P
P
W
S
F
Q
R
S
K
S
L
F
C
L
P
Site 42
S362
W
S
F
Q
R
S
K
S
L
F
C
L
P
T
G
Site 43
S372
C
L
P
T
G
G
P
S
L
A
S
S
A
E
P
Site 44
S376
G
G
P
S
L
A
S
S
A
E
P
Q
W
F
S
Site 45
T385
E
P
Q
W
F
S
N
T
G
A
P
G
H
R
A
Site 46
S393
G
A
P
G
H
R
A
S
E
W
R
H
G
H
L
Site 47
S402
W
R
H
G
H
L
L
S
I
D
D
L
E
G
A
Site 48
T416
A
Q
E
T
D
V
D
T
G
L
R
L
S
S
S
Site 49
S422
D
T
G
L
R
L
S
S
S
D
L
S
V
V
S
Site 50
S429
S
S
D
L
S
V
V
S
A
Y
S
A
P
S
R
Site 51
S432
L
S
V
V
S
A
Y
S
A
P
S
R
F
C
S
Site 52
S435
V
S
A
Y
S
A
P
S
R
F
C
S
T
V
E
Site 53
S439
S
A
P
S
R
F
C
S
T
V
E
T
P
L
P
Site 54
T443
R
F
C
S
T
V
E
T
P
L
P
S
E
R
C
Site 55
S447
T
V
E
T
P
L
P
S
E
R
C
S
S
H
W
Site 56
S451
P
L
P
S
E
R
C
S
S
H
W
A
A
H
K
Site 57
S452
L
P
S
E
R
C
S
S
H
W
A
A
H
K
D
Site 58
T467
S
R
E
G
P
L
P
T
V
S
R
V
T
T
E
Site 59
S469
E
G
P
L
P
T
V
S
R
V
T
T
E
A
S
Site 60
T472
L
P
T
V
S
R
V
T
T
E
A
S
W
A
S
Site 61
T473
P
T
V
S
R
V
T
T
E
A
S
W
A
S
L
Site 62
S476
S
R
V
T
T
E
A
S
W
A
S
L
P
F
F
Site 63
S479
T
T
E
A
S
W
A
S
L
P
F
F
T
K
R
Site 64
T484
W
A
S
L
P
F
F
T
K
R
S
S
S
S
S
Site 65
S487
L
P
F
F
T
K
R
S
S
S
S
S
A
T
A
Site 66
S488
P
F
F
T
K
R
S
S
S
S
S
A
T
A
R
Site 67
S489
F
F
T
K
R
S
S
S
S
S
A
T
A
R
A
Site 68
S491
T
K
R
S
S
S
S
S
A
T
A
R
A
A
P
Site 69
T493
R
S
S
S
S
S
A
T
A
R
A
A
P
P
A
Site 70
S502
R
A
A
P
P
A
P
S
T
S
T
L
T
D
S
Site 71
S504
A
P
P
A
P
S
T
S
T
L
T
D
S
S
P
Site 72
T505
P
P
A
P
S
T
S
T
L
T
D
S
S
P
Q
Site 73
T507
A
P
S
T
S
T
L
T
D
S
S
P
Q
L
P
Site 74
S509
S
T
S
T
L
T
D
S
S
P
Q
L
P
C
D
Site 75
S510
T
S
T
L
T
D
S
S
P
Q
L
P
C
D
T
Site 76
T517
S
P
Q
L
P
C
D
T
P
K
V
K
Q
T
D
Site 77
S533
D
M
P
P
P
P
G
S
A
G
P
G
D
N
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation