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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KBTBD6
Full Name:
Kelch repeat and BTB domain-containing protein 6
Alias:
Type:
Mass (Da):
76138
Number AA:
674
UniProt ID:
Q86V97
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
S
R
E
D
A
P
R
S
R
R
L
A
S
P
R
Site 2
S15
P
R
S
R
R
L
A
S
P
R
G
G
K
R
P
Site 3
S31
K
I
H
K
P
T
V
S
A
F
F
T
G
P
E
Site 4
T35
P
T
V
S
A
F
F
T
G
P
E
E
L
K
D
Site 5
T43
G
P
E
E
L
K
D
T
A
H
S
A
A
L
L
Site 6
T78
T
P
G
S
G
P
G
T
G
R
L
F
P
C
N
Site 7
Y105
S
M
F
T
G
G
M
Y
E
S
Q
Q
A
S
V
Site 8
S107
F
T
G
G
M
Y
E
S
Q
Q
A
S
V
T
M
Site 9
S121
M
H
D
V
D
A
E
S
F
E
V
L
V
D
Y
Site 10
S135
Y
C
Y
T
G
R
V
S
L
S
E
A
N
V
E
Site 11
S137
Y
T
G
R
V
S
L
S
E
A
N
V
E
R
L
Site 12
Y145
E
A
N
V
E
R
L
Y
A
A
S
D
M
L
Q
Site 13
S148
V
E
R
L
Y
A
A
S
D
M
L
Q
L
E
Y
Site 14
Y155
S
D
M
L
Q
L
E
Y
V
R
E
A
C
A
S
Site 15
S162
Y
V
R
E
A
C
A
S
F
L
A
R
R
L
D
Site 16
S190
F
G
H
R
K
L
R
S
Q
A
Q
S
Y
I
A
Site 17
S194
K
L
R
S
Q
A
Q
S
Y
I
A
Q
N
F
K
Site 18
S204
A
Q
N
F
K
Q
L
S
H
M
G
S
I
R
E
Site 19
S208
K
Q
L
S
H
M
G
S
I
R
E
E
T
L
A
Site 20
S230
L
A
V
L
R
L
D
S
L
D
V
E
S
E
Q
Site 21
S235
L
D
S
L
D
V
E
S
E
Q
T
V
C
H
V
Site 22
S257
A
P
K
E
R
G
P
S
A
A
E
V
F
K
C
Site 23
Y277
F
T
E
E
D
Q
D
Y
L
E
G
L
L
T
K
Site 24
T283
D
Y
L
E
G
L
L
T
K
P
I
V
K
K
Y
Site 25
Y290
T
K
P
I
V
K
K
Y
C
L
D
V
I
E
G
Site 26
Y303
E
G
A
L
Q
M
R
Y
G
D
L
L
Y
K
S
Site 27
Y308
M
R
Y
G
D
L
L
Y
K
S
L
V
P
V
P
Site 28
S310
Y
G
D
L
L
Y
K
S
L
V
P
V
P
N
S
Site 29
S317
S
L
V
P
V
P
N
S
S
S
S
S
S
S
S
Site 30
S318
L
V
P
V
P
N
S
S
S
S
S
S
S
S
N
Site 31
S319
V
P
V
P
N
S
S
S
S
S
S
S
S
N
S
Site 32
S320
P
V
P
N
S
S
S
S
S
S
S
S
N
S
L
Site 33
S321
V
P
N
S
S
S
S
S
S
S
S
N
S
L
V
Site 34
S322
P
N
S
S
S
S
S
S
S
S
N
S
L
V
S
Site 35
S323
N
S
S
S
S
S
S
S
S
N
S
L
V
S
A
Site 36
S324
S
S
S
S
S
S
S
S
N
S
L
V
S
A
A
Site 37
S326
S
S
S
S
S
S
N
S
L
V
S
A
A
E
N
Site 38
S329
S
S
S
N
S
L
V
S
A
A
E
N
P
P
Q
Site 39
Y367
D
P
Y
S
G
D
L
Y
K
V
P
S
P
L
T
Site 40
Y396
I
S
P
D
H
D
I
Y
L
A
A
Q
P
R
T
Site 41
Y408
P
R
T
D
L
W
V
Y
K
P
A
Q
N
S
W
Site 42
Y438
A
Y
L
N
G
Y
I
Y
I
L
G
G
R
D
P
Site 43
T447
L
G
G
R
D
P
I
T
G
V
K
L
K
E
V
Site 44
Y457
K
L
K
E
V
E
C
Y
N
V
K
R
N
Q
W
Site 45
Y487
M
V
I
R
D
Y
L
Y
A
L
N
S
K
R
M
Site 46
Y537
D
I
P
V
M
K
V
Y
N
P
V
R
A
E
W
Site 47
Y559
L
V
S
E
T
N
N
Y
R
I
I
K
H
G
Q
Site 48
S573
Q
K
L
L
L
I
T
S
R
T
P
Q
W
K
K
Site 49
T575
L
L
L
I
T
S
R
T
P
Q
W
K
K
N
R
Site 50
Y586
K
K
N
R
V
T
V
Y
E
Y
D
I
R
G
D
Site 51
Y588
N
R
V
T
V
Y
E
Y
D
I
R
G
D
Q
W
Site 52
S621
L
S
A
R
V
Y
P
S
C
L
E
P
G
Q
S
Site 53
S628
S
C
L
E
P
G
Q
S
F
L
T
E
E
E
E
Site 54
S638
T
E
E
E
E
I
P
S
E
S
S
T
E
W
D
Site 55
S641
E
E
I
P
S
E
S
S
T
E
W
D
L
G
G
Site 56
T642
E
I
P
S
E
S
S
T
E
W
D
L
G
G
F
Site 57
S650
E
W
D
L
G
G
F
S
E
P
D
S
E
S
G
Site 58
S654
G
G
F
S
E
P
D
S
E
S
G
S
S
S
S
Site 59
S656
F
S
E
P
D
S
E
S
G
S
S
S
S
L
S
Site 60
S658
E
P
D
S
E
S
G
S
S
S
S
L
S
D
D
Site 61
S659
P
D
S
E
S
G
S
S
S
S
L
S
D
D
D
Site 62
S660
D
S
E
S
G
S
S
S
S
L
S
D
D
D
F
Site 63
S661
S
E
S
G
S
S
S
S
L
S
D
D
D
F
W
Site 64
S663
S
G
S
S
S
S
L
S
D
D
D
F
W
V
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation