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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IGFN1
Full Name:
Immunoglobulin-like and fibronectin type III domain-containing protein 1
Alias:
EEF1A2-binding protein 1;KY-interacting protein 1
Type:
Mass (Da):
137763
Number AA:
1251
UniProt ID:
Q86VF2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
G
K
L
R
K
S
H
I
P
G
V
S
I
Site 2
T28
E
I
P
E
G
C
S
T
P
D
F
E
Q
K
P
Site 3
S65
P
E
V
R
W
Q
N
S
K
G
D
L
S
D
S
Site 4
S70
Q
N
S
K
G
D
L
S
D
S
S
K
Y
K
I
Site 5
S72
S
K
G
D
L
S
D
S
S
K
Y
K
I
S
S
Site 6
S73
K
G
D
L
S
D
S
S
K
Y
K
I
S
S
S
Site 7
Y75
D
L
S
D
S
S
K
Y
K
I
S
S
S
P
G
Site 8
S78
D
S
S
K
Y
K
I
S
S
S
P
G
S
K
E
Site 9
S79
S
S
K
Y
K
I
S
S
S
P
G
S
K
E
H
Site 10
S80
S
K
Y
K
I
S
S
S
P
G
S
K
E
H
V
Site 11
S83
K
I
S
S
S
P
G
S
K
E
H
V
L
Q
I
Site 12
T98
N
K
L
T
G
E
D
T
D
L
Y
R
C
T
A
Site 13
Y101
T
G
E
D
T
D
L
Y
R
C
T
A
V
N
A
Site 14
T104
D
T
D
L
Y
R
C
T
A
V
N
A
Y
G
E
Site 15
Y179
M
T
A
D
R
K
D
Y
E
K
I
C
L
K
Y
Site 16
Y186
Y
E
K
I
C
L
K
Y
G
I
V
D
Y
R
G
Site 17
Y191
L
K
Y
G
I
V
D
Y
R
G
M
L
R
R
L
Site 18
Y212
Q
E
D
K
M
A
Q
Y
I
N
T
I
S
S
L
Site 19
S218
Q
Y
I
N
T
I
S
S
L
R
H
I
R
V
T
Site 20
T225
S
L
R
H
I
R
V
T
K
D
G
N
A
K
F
Site 21
S241
L
E
L
D
L
K
D
S
Q
S
K
I
Y
L
Y
Site 22
S243
L
D
L
K
D
S
Q
S
K
I
Y
L
Y
K
D
Site 23
Y246
K
D
S
Q
S
K
I
Y
L
Y
K
D
G
E
M
Site 24
Y248
S
Q
S
K
I
Y
L
Y
K
D
G
E
M
I
P
Site 25
Y256
K
D
G
E
M
I
P
Y
G
F
N
N
Q
T
K
Site 26
Y273
L
R
R
L
G
K
R
Y
E
F
Q
I
Q
D
L
Site 27
S285
Q
D
L
R
P
E
D
S
G
I
Y
Q
V
K
V
Site 28
S351
R
H
R
L
L
H
P
S
D
K
Y
E
V
Y
V
Site 29
Y354
L
L
H
P
S
D
K
Y
E
V
Y
V
S
P
D
Site 30
Y357
P
S
D
K
Y
E
V
Y
V
S
P
D
G
L
T
Site 31
S359
D
K
Y
E
V
Y
V
S
P
D
G
L
T
H
R
Site 32
T364
Y
V
S
P
D
G
L
T
H
R
L
V
V
R
G
Site 33
S375
V
V
R
G
A
R
F
S
D
M
G
P
Y
S
L
Site 34
Y380
R
F
S
D
M
G
P
Y
S
L
G
T
G
L
Y
Site 35
S381
F
S
D
M
G
P
Y
S
L
G
T
G
L
Y
T
Site 36
S405
G
K
D
K
D
L
Q
S
T
S
A
D
H
K
L
Site 37
S407
D
K
D
L
Q
S
T
S
A
D
H
K
L
Q
S
Site 38
S414
S
A
D
H
K
L
Q
S
R
R
S
G
K
D
G
Site 39
S417
H
K
L
Q
S
R
R
S
G
K
D
G
R
L
D
Site 40
Y426
K
D
G
R
L
D
I
Y
G
E
R
R
D
A
T
Site 41
T433
Y
G
E
R
R
D
A
T
R
S
S
T
S
R
Y
Site 42
S435
E
R
R
D
A
T
R
S
S
T
S
R
Y
K
P
Site 43
S436
R
R
D
A
T
R
S
S
T
S
R
Y
K
P
G
Site 44
T437
R
D
A
T
R
S
S
T
S
R
Y
K
P
G
T
Site 45
Y440
T
R
S
S
T
S
R
Y
K
P
G
T
G
S
F
Site 46
T444
T
S
R
Y
K
P
G
T
G
S
F
S
K
D
A
Site 47
S446
R
Y
K
P
G
T
G
S
F
S
K
D
A
Q
G
Site 48
S448
K
P
G
T
G
S
F
S
K
D
A
Q
G
P
M
Site 49
S459
Q
G
P
M
G
H
F
S
Q
G
L
A
D
M
E
Site 50
T487
T
S
D
L
G
P
G
T
W
F
K
D
G
V
K
Site 51
S511
K
Q
D
G
L
V
H
S
L
F
I
T
H
V
Q
Site 52
Y525
Q
G
T
Q
A
G
R
Y
T
F
V
A
G
D
Q
Site 53
T526
G
T
Q
A
G
R
Y
T
F
V
A
G
D
Q
Q
Site 54
S534
F
V
A
G
D
Q
Q
S
E
A
T
L
T
V
Q
Site 55
T539
Q
Q
S
E
A
T
L
T
V
Q
D
S
P
T
I
Site 56
T545
L
T
V
Q
D
S
P
T
I
A
P
D
V
T
E
Site 57
T551
P
T
I
A
P
D
V
T
E
K
L
R
E
P
L
Site 58
S592
D
G
A
E
V
V
G
S
S
D
R
E
A
Q
V
Site 59
S593
G
A
E
V
V
G
S
S
D
R
E
A
Q
V
D
Site 60
Y605
Q
V
D
L
G
D
G
Y
T
R
L
C
L
P
S
Site 61
S612
Y
T
R
L
C
L
P
S
A
G
R
K
D
C
G
Site 62
S622
R
K
D
C
G
Q
Y
S
V
T
L
R
S
E
G
Site 63
T624
D
C
G
Q
Y
S
V
T
L
R
S
E
G
G
S
Site 64
S627
Q
Y
S
V
T
L
R
S
E
G
G
S
V
Q
A
Site 65
S631
T
L
R
S
E
G
G
S
V
Q
A
E
L
T
L
Site 66
T637
G
S
V
Q
A
E
L
T
L
Q
V
I
D
K
P
Site 67
Y679
G
G
R
T
V
E
C
Y
V
V
E
R
R
Q
A
Site 68
S689
E
R
R
Q
A
G
R
S
T
W
L
K
V
G
E
Site 69
T690
R
R
Q
A
G
R
S
T
W
L
K
V
G
E
A
Site 70
S701
V
G
E
A
P
A
D
S
T
T
F
T
D
A
H
Site 71
T703
E
A
P
A
D
S
T
T
F
T
D
A
H
V
E
Site 72
T705
P
A
D
S
T
T
F
T
D
A
H
V
E
P
G
Site 73
Y715
H
V
E
P
G
R
K
Y
T
F
R
V
R
A
V
Site 74
T716
V
E
P
G
R
K
Y
T
F
R
V
R
A
V
T
Site 75
T723
T
F
R
V
R
A
V
T
S
E
G
A
G
E
A
Site 76
T761
S
A
S
S
Q
G
I
T
L
T
W
T
A
P
R
Site 77
T763
S
S
Q
G
I
T
L
T
W
T
A
P
R
G
P
Site 78
T765
Q
G
I
T
L
T
W
T
A
P
R
G
P
G
S
Site 79
S772
T
A
P
R
G
P
G
S
A
H
I
L
G
Y
L
Site 80
S787
I
E
R
R
K
K
G
S
N
T
W
T
A
V
N
Site 81
T791
K
K
G
S
N
T
W
T
A
V
N
D
Q
P
V
Site 82
T804
P
V
P
E
R
R
W
T
V
A
D
V
R
Q
G
Site 83
Y814
D
V
R
Q
G
C
Q
Y
E
F
R
V
T
A
V
Site 84
T819
C
Q
Y
E
F
R
V
T
A
V
A
P
S
G
P
Site 85
S824
R
V
T
A
V
A
P
S
G
P
G
E
P
G
P
Site 86
S833
P
G
E
P
G
P
P
S
D
A
V
F
A
R
D
Site 87
T854
L
V
R
N
L
Q
V
T
D
R
S
N
T
S
I
Site 88
S857
N
L
Q
V
T
D
R
S
N
T
S
I
T
L
S
Site 89
T859
Q
V
T
D
R
S
N
T
S
I
T
L
S
W
A
Site 90
S860
V
T
D
R
S
N
T
S
I
T
L
S
W
A
G
Site 91
T862
D
R
S
N
T
S
I
T
L
S
W
A
G
P
D
Site 92
S864
S
N
T
S
I
T
L
S
W
A
G
P
D
T
Q
Site 93
T870
L
S
W
A
G
P
D
T
Q
E
G
D
E
A
Q
Site 94
Y879
E
G
D
E
A
Q
G
Y
V
V
E
L
C
S
S
Site 95
S888
V
E
L
C
S
S
D
S
L
Q
W
L
P
C
H
Site 96
Y904
G
T
V
P
V
T
T
Y
T
A
K
G
L
R
P
Site 97
T920
E
G
Y
F
V
R
V
T
A
V
N
E
G
G
Q
Site 98
S928
A
V
N
E
G
G
Q
S
Q
P
S
A
L
D
T
Site 99
S931
E
G
G
Q
S
Q
P
S
A
L
D
T
L
V
Q
Site 100
S952
C
P
K
F
L
V
D
S
S
T
K
D
L
L
T
Site 101
T954
K
F
L
V
D
S
S
T
K
D
L
L
T
V
K
Site 102
T959
S
S
T
K
D
L
L
T
V
K
V
G
D
T
V
Site 103
T995
P
L
P
K
R
S
V
T
V
T
K
D
G
L
T
Site 104
T997
P
K
R
S
V
T
V
T
K
D
G
L
T
Q
L
Site 105
S1032
Q
G
K
E
V
A
H
S
F
R
I
R
V
A
A
Site 106
T1056
L
Q
E
N
V
P
G
T
V
T
A
E
W
E
P
Site 107
S1064
V
T
A
E
W
E
P
S
P
D
E
A
Q
D
V
Site 108
Y1075
A
Q
D
V
P
L
H
Y
A
V
F
T
R
S
S
Site 109
T1096
E
A
A
D
R
I
H
T
N
R
F
T
L
L
G
Site 110
Y1110
G
I
L
P
G
H
E
Y
H
F
R
V
V
A
K
Site 111
S1123
A
K
N
E
L
G
A
S
K
P
S
D
T
S
Q
Site 112
S1126
E
L
G
A
S
K
P
S
D
T
S
Q
P
W
C
Site 113
T1128
G
A
S
K
P
S
D
T
S
Q
P
W
C
I
P
Site 114
S1129
A
S
K
P
S
D
T
S
Q
P
W
C
I
P
R
Site 115
T1142
P
R
Q
R
D
R
F
T
V
K
A
P
C
Y
R
Site 116
Y1148
F
T
V
K
A
P
C
Y
R
E
P
D
L
S
Q
Site 117
S1154
C
Y
R
E
P
D
L
S
Q
K
P
R
F
L
V
Site 118
S1183
M
S
C
A
V
Q
G
S
P
R
P
H
V
T
W
Site 119
S1196
T
W
F
K
N
D
R
S
L
E
G
N
P
A
V
Site 120
S1220
S
L
T
I
P
S
V
S
P
K
D
S
G
E
Y
Site 121
S1224
P
S
V
S
P
K
D
S
G
E
Y
K
A
V
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation