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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NRAP
Full Name:
Nebulin-related-anchoring protein
Alias:
Nebulin-related anchoring protein; N-RAP
Type:
Adaptor/scaffold
Mass (Da):
197070
Number AA:
UniProt ID:
Q86VF7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005916
GO:0005927
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0051371
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
Q
P
C
S
R
C
G
Y
G
V
Y
P
A
E
K
Site 2
Y14
S
R
C
G
Y
G
V
Y
P
A
E
K
I
S
C
Site 3
Y53
V
S
H
Q
K
K
P
Y
C
H
A
H
N
P
K
Site 4
T63
A
H
N
P
K
N
N
T
F
T
S
V
Y
H
T
Site 5
S66
P
K
N
N
T
F
T
S
V
Y
H
T
P
L
N
Site 6
Y68
N
N
T
F
T
S
V
Y
H
T
P
L
N
L
N
Site 7
T70
T
F
T
S
V
Y
H
T
P
L
N
L
N
V
R
Site 8
T78
P
L
N
L
N
V
R
T
F
P
E
A
I
S
G
Site 9
Y123
P
L
A
N
E
R
A
Y
W
T
G
Y
G
E
G
Site 10
S152
R
M
V
E
A
R
K
S
L
G
E
E
Y
T
E
Site 11
Y161
G
E
E
Y
T
E
D
Y
E
Q
P
R
G
K
G
Site 12
S169
E
Q
P
R
G
K
G
S
F
P
A
M
I
T
P
Site 13
T175
G
S
F
P
A
M
I
T
P
A
Y
Q
R
A
K
Site 14
Y178
P
A
M
I
T
P
A
Y
Q
R
A
K
K
A
N
Site 15
S189
K
K
A
N
Q
L
A
S
Q
V
E
Y
K
R
G
Site 16
Y193
Q
L
A
S
Q
V
E
Y
K
R
G
H
D
E
R
Site 17
S202
R
G
H
D
E
R
I
S
R
F
S
T
V
V
D
Site 18
S205
D
E
R
I
S
R
F
S
T
V
V
D
T
P
E
Site 19
T206
E
R
I
S
R
F
S
T
V
V
D
T
P
E
L
Site 20
T210
R
F
S
T
V
V
D
T
P
E
L
L
R
S
K
Site 21
S216
D
T
P
E
L
L
R
S
K
A
G
A
Q
L
Q
Site 22
S224
K
A
G
A
Q
L
Q
S
D
V
R
Y
T
E
D
Site 23
Y228
Q
L
Q
S
D
V
R
Y
T
E
D
Y
E
Q
Q
Site 24
T229
L
Q
S
D
V
R
Y
T
E
D
Y
E
Q
Q
R
Site 25
Y232
D
V
R
Y
T
E
D
Y
E
Q
Q
R
G
K
G
Site 26
S240
E
Q
Q
R
G
K
G
S
F
P
A
M
I
T
P
Site 27
Y249
P
A
M
I
T
P
A
Y
Q
I
A
K
R
A
N
Site 28
Y264
E
L
A
S
D
V
R
Y
H
Q
Q
Y
Q
K
E
Site 29
Y268
D
V
R
Y
H
Q
Q
Y
Q
K
E
M
R
G
M
Site 30
T287
I
G
A
E
G
I
L
T
R
E
C
A
D
Q
Y
Site 31
Y294
T
R
E
C
A
D
Q
Y
G
Q
G
Y
P
E
E
Site 32
Y298
A
D
Q
Y
G
Q
G
Y
P
E
E
Y
E
E
H
Site 33
Y302
G
Q
G
Y
P
E
E
Y
E
E
H
R
G
K
G
Site 34
S310
E
E
H
R
G
K
G
S
F
P
A
M
I
T
P
Site 35
T316
G
S
F
P
A
M
I
T
P
A
Y
Q
N
A
K
Site 36
Y319
P
A
M
I
T
P
A
Y
Q
N
A
K
K
A
H
Site 37
Y334
E
L
A
S
D
I
K
Y
R
Q
D
F
N
K
M
Site 38
S349
K
G
A
A
H
Y
H
S
L
P
A
Q
D
N
L
Site 39
Y373
K
L
V
S
E
V
E
Y
K
K
D
L
E
S
S
Site 40
S379
E
Y
K
K
D
L
E
S
S
R
G
H
S
I
N
Site 41
S384
L
E
S
S
R
G
H
S
I
N
Y
C
E
T
P
Site 42
Y387
S
R
G
H
S
I
N
Y
C
E
T
P
Q
F
R
Site 43
S397
T
P
Q
F
R
N
V
S
K
I
S
K
F
T
S
Site 44
S404
S
K
I
S
K
F
T
S
D
N
K
Y
K
E
N
Site 45
Y408
K
F
T
S
D
N
K
Y
K
E
N
Y
Q
N
H
Site 46
Y412
D
N
K
Y
K
E
N
Y
Q
N
H
M
R
G
R
Site 47
Y420
Q
N
H
M
R
G
R
Y
E
G
V
G
M
D
R
Site 48
T429
G
V
G
M
D
R
R
T
L
H
A
M
K
V
G
Site 49
Y444
S
L
A
S
N
V
A
Y
K
A
D
Y
K
H
D
Site 50
Y448
N
V
A
Y
K
A
D
Y
K
H
D
I
V
D
Y
Site 51
Y455
Y
K
H
D
I
V
D
Y
N
Y
P
A
T
L
T
Site 52
Y457
H
D
I
V
D
Y
N
Y
P
A
T
L
T
P
S
Site 53
T460
V
D
Y
N
Y
P
A
T
L
T
P
S
Y
Q
T
Site 54
T462
Y
N
Y
P
A
T
L
T
P
S
Y
Q
T
A
M
Site 55
S464
Y
P
A
T
L
T
P
S
Y
Q
T
A
M
K
L
Site 56
Y465
P
A
T
L
T
P
S
Y
Q
T
A
M
K
L
V
Site 57
Y479
V
P
L
K
D
A
N
Y
R
Q
S
I
D
K
L
Site 58
S482
K
D
A
N
Y
R
Q
S
I
D
K
L
K
Y
S
Site 59
Y488
Q
S
I
D
K
L
K
Y
S
S
V
T
D
T
P
Site 60
S490
I
D
K
L
K
Y
S
S
V
T
D
T
P
Q
I
Site 61
T494
K
Y
S
S
V
T
D
T
P
Q
I
V
Q
A
K
Site 62
S508
K
I
N
A
Q
Q
L
S
H
V
N
Y
R
A
D
Site 63
Y512
Q
Q
L
S
H
V
N
Y
R
A
D
Y
E
K
N
Site 64
Y516
H
V
N
Y
R
A
D
Y
E
K
N
K
L
N
Y
Site 65
Y523
Y
E
K
N
K
L
N
Y
T
L
P
Q
D
V
P
Site 66
T537
P
Q
L
V
K
A
K
T
N
A
K
L
F
S
E
Site 67
Y547
K
L
F
S
E
V
K
Y
K
E
G
W
E
K
T
Site 68
Y583
E
L
A
S
N
I
K
Y
K
E
E
Y
E
K
T
Site 69
Y587
N
I
K
Y
K
E
E
Y
E
K
T
K
G
K
A
Site 70
T590
Y
K
E
E
Y
E
K
T
K
G
K
A
M
G
T
Site 71
S600
K
A
M
G
T
A
D
S
R
L
L
H
S
L
Q
Site 72
S605
A
D
S
R
L
L
H
S
L
Q
I
A
K
M
S
Site 73
Y617
K
M
S
S
E
V
E
Y
K
K
G
F
E
E
S
Site 74
S624
Y
K
K
G
F
E
E
S
K
T
R
F
H
L
P
Site 75
T626
K
G
F
E
E
S
K
T
R
F
H
L
P
M
D
Site 76
T645
R
H
A
K
K
A
Q
T
L
A
S
D
L
D
Y
Site 77
Y652
T
L
A
S
D
L
D
Y
R
K
K
L
H
E
Y
Site 78
T660
R
K
K
L
H
E
Y
T
V
L
P
E
D
M
K
Site 79
T668
V
L
P
E
D
M
K
T
Q
W
A
K
K
A
Y
Site 80
S679
K
K
A
Y
G
L
Q
S
E
L
Q
Y
K
A
D
Site 81
Y683
G
L
Q
S
E
L
Q
Y
K
A
D
L
A
W
M
Site 82
S714
K
K
A
G
Q
L
V
S
E
K
N
Y
R
Q
R
Site 83
Y718
Q
L
V
S
E
K
N
Y
R
Q
R
V
D
E
L
Site 84
T728
R
V
D
E
L
K
F
T
S
V
T
D
S
S
Q
Site 85
S729
V
D
E
L
K
F
T
S
V
T
D
S
S
Q
M
Site 86
S733
K
F
T
S
V
T
D
S
S
Q
M
E
H
A
K
Site 87
S734
F
T
S
V
T
D
S
S
Q
M
E
H
A
K
K
Site 88
S742
Q
M
E
H
A
K
K
S
Q
E
L
Q
S
G
V
Site 89
Y751
E
L
Q
S
G
V
A
Y
K
A
G
N
E
Q
S
Site 90
Y762
N
E
Q
S
V
H
Q
Y
T
I
S
K
D
E
P
Site 91
S765
S
V
H
Q
Y
T
I
S
K
D
E
P
L
F
L
Site 92
S782
R
A
N
A
A
N
L
S
E
K
L
Y
K
S
S
Site 93
Y786
A
N
L
S
E
K
L
Y
K
S
S
W
E
N
Q
Site 94
S788
L
S
E
K
L
Y
K
S
S
W
E
N
Q
K
A
Site 95
S818
K
A
K
R
D
L
A
S
E
V
K
Y
K
E
D
Site 96
Y822
D
L
A
S
E
V
K
Y
K
E
D
Y
E
R
S
Site 97
Y826
E
V
K
Y
K
E
D
Y
E
R
S
R
G
K
L
Site 98
S843
A
K
D
V
Q
G
D
S
Q
M
S
H
S
L
Q
Site 99
S846
V
Q
G
D
S
Q
M
S
H
S
L
Q
M
S
K
Site 100
S848
G
D
S
Q
M
S
H
S
L
Q
M
S
K
L
Q
Site 101
S852
M
S
H
S
L
Q
M
S
K
L
Q
S
E
L
E
Site 102
S856
L
Q
M
S
K
L
Q
S
E
L
E
Y
K
K
G
Site 103
Y860
K
L
Q
S
E
L
E
Y
K
K
G
F
E
D
T
Site 104
S869
K
G
F
E
D
T
K
S
Q
C
H
V
S
L
D
Site 105
Y895
H
L
A
T
D
V
G
Y
K
T
A
E
H
H
F
Site 106
T903
K
T
A
E
H
H
F
T
A
L
P
T
D
M
K
Site 107
S922
K
K
A
Y
G
L
Q
S
D
N
Q
Y
R
A
D
Site 108
Y926
G
L
Q
S
D
N
Q
Y
R
A
D
V
K
W
M
Site 109
S943
M
G
W
V
A
T
G
S
L
N
V
E
Q
A
K
Site 110
S957
K
K
A
G
E
L
I
S
E
K
K
Y
R
Q
H
Site 111
Y961
E
L
I
S
E
K
K
Y
R
Q
H
P
D
A
L
Site 112
S972
P
D
A
L
K
F
T
S
I
K
D
T
P
E
M
Site 113
T976
K
F
T
S
I
K
D
T
P
E
M
V
Q
A
R
Site 114
S985
E
M
V
Q
A
R
I
S
Y
T
Q
A
V
D
R
Site 115
Y986
M
V
Q
A
R
I
S
Y
T
Q
A
V
D
R
L
Site 116
Y994
T
Q
A
V
D
R
L
Y
R
E
Q
G
E
N
I
Site 117
T1006
E
N
I
K
H
H
Y
T
P
T
A
D
L
P
E
Site 118
Y1029
M
N
I
S
E
T
R
Y
K
E
S
W
S
K
L
Site 119
S1032
S
E
T
R
Y
K
E
S
W
S
K
L
R
D
G
Site 120
S1034
T
R
Y
K
E
S
W
S
K
L
R
D
G
G
Y
Site 121
Y1041
S
K
L
R
D
G
G
Y
K
L
R
L
D
A
L
Site 122
S1056
P
F
Q
A
A
K
A
S
G
E
I
I
S
D
Y
Site 123
Y1063
S
G
E
I
I
S
D
Y
K
Y
K
E
A
F
E
Site 124
Y1065
E
I
I
S
D
Y
K
Y
K
E
A
F
E
K
M
Site 125
S1081
G
Q
M
L
G
S
R
S
L
E
D
D
I
S
L
Site 126
S1087
R
S
L
E
D
D
I
S
L
A
H
S
V
Y
A
Site 127
S1091
D
D
I
S
L
A
H
S
V
Y
A
T
S
L
Q
Site 128
T1095
L
A
H
S
V
Y
A
T
S
L
Q
S
D
V
N
Site 129
S1096
A
H
S
V
Y
A
T
S
L
Q
S
D
V
N
Y
Site 130
Y1103
S
L
Q
S
D
V
N
Y
K
K
G
F
E
H
S
Site 131
S1110
Y
K
K
G
F
E
H
S
K
A
Q
F
H
L
P
Site 132
S1134
K
K
A
Q
T
L
A
S
N
Q
D
Y
K
H
P
Site 133
Y1138
T
L
A
S
N
Q
D
Y
K
H
P
L
P
Q
Y
Site 134
Y1145
Y
K
H
P
L
P
Q
Y
T
S
L
A
E
D
L
Site 135
S1147
H
P
L
P
Q
Y
T
S
L
A
E
D
L
R
L
Site 136
S1155
L
A
E
D
L
R
L
S
C
A
K
K
A
H
K
Site 137
Y1169
K
L
Q
S
E
N
L
Y
R
S
D
L
N
F
M
Site 138
S1171
Q
S
E
N
L
Y
R
S
D
L
N
F
M
R
G
Site 139
S1200
K
K
A
S
E
L
I
S
E
S
K
Y
R
Q
H
Site 140
Y1204
E
L
I
S
E
S
K
Y
R
Q
H
P
H
S
F
Site 141
S1210
K
Y
R
Q
H
P
H
S
F
K
Y
T
A
V
T
Site 142
Y1213
Q
H
P
H
S
F
K
Y
T
A
V
T
D
T
P
Site 143
T1214
H
P
H
S
F
K
Y
T
A
V
T
D
T
P
N
Site 144
T1217
S
F
K
Y
T
A
V
T
D
T
P
N
L
L
H
Site 145
T1219
K
Y
T
A
V
T
D
T
P
N
L
L
H
A
K
Site 146
T1232
A
K
F
S
N
Q
I
T
N
E
R
L
Y
K
A
Site 147
Y1237
Q
I
T
N
E
R
L
Y
K
A
A
G
E
D
A
Site 148
Y1248
G
E
D
A
R
H
E
Y
T
M
T
L
G
L
P
Site 149
T1251
A
R
H
E
Y
T
M
T
L
G
L
P
E
F
I
Site 150
T1262
P
E
F
I
R
A
K
T
N
A
A
N
L
S
D
Site 151
S1268
K
T
N
A
A
N
L
S
D
A
R
Y
K
E
S
Site 152
Y1272
A
N
L
S
D
A
R
Y
K
E
S
W
R
N
L
Site 153
S1275
S
D
A
R
Y
K
E
S
W
R
N
L
R
A
Q
Site 154
S1299
P
F
Q
A
A
R
A
S
G
D
I
A
S
D
F
Site 155
S1304
R
A
S
G
D
I
A
S
D
F
L
Y
R
H
D
Site 156
Y1308
D
I
A
S
D
F
L
Y
R
H
D
F
V
K
E
Site 157
S1324
G
K
L
I
G
P
Q
S
V
R
D
D
P
R
I
Site 158
S1342
R
R
M
G
Q
L
Q
S
E
L
Q
Y
R
R
G
Site 159
Y1346
Q
L
Q
S
E
L
Q
Y
R
R
G
A
T
S
S
Site 160
T1351
L
Q
Y
R
R
G
A
T
S
S
Q
A
Q
F
H
Site 161
S1352
Q
Y
R
R
G
A
T
S
S
Q
A
Q
F
H
L
Site 162
S1353
Y
R
R
G
A
T
S
S
Q
A
Q
F
H
L
P
Site 163
Y1381
A
L
A
S
D
H
D
Y
R
T
Q
Y
H
K
F
Site 164
Y1385
D
H
D
Y
R
T
Q
Y
H
K
F
T
A
L
P
Site 165
T1389
R
T
Q
Y
H
K
F
T
A
L
P
E
D
L
K
Site 166
S1408
K
K
A
H
A
L
Q
S
E
L
R
Y
K
S
D
Site 167
Y1412
A
L
Q
S
E
L
R
Y
K
S
D
L
I
G
M
Site 168
S1414
Q
S
E
L
R
Y
K
S
D
L
I
G
M
K
G
Site 169
S1429
I
G
W
L
A
L
R
S
P
Q
M
E
S
A
K
Site 170
S1443
K
K
A
G
E
L
I
S
E
T
K
Y
R
K
K
Site 171
Y1447
E
L
I
S
E
T
K
Y
R
K
K
P
D
S
I
Site 172
S1453
K
Y
R
K
K
P
D
S
I
K
F
T
T
V
V
Site 173
T1457
K
P
D
S
I
K
F
T
T
V
V
D
S
P
D
Site 174
T1458
P
D
S
I
K
F
T
T
V
V
D
S
P
D
L
Site 175
S1462
K
F
T
T
V
V
D
S
P
D
L
V
H
A
K
Site 176
Y1480
M
H
C
N
E
R
M
Y
R
S
G
D
A
E
S
Site 177
S1482
C
N
E
R
M
Y
R
S
G
D
A
E
S
L
H
Site 178
S1487
Y
R
S
G
D
A
E
S
L
H
R
Y
T
L
I
Site 179
Y1491
D
A
E
S
L
H
R
Y
T
L
I
P
D
H
P
Site 180
T1492
A
E
S
L
H
R
Y
T
L
I
P
D
H
P
D
Site 181
T1501
I
P
D
H
P
D
F
T
R
A
R
L
N
A
L
Site 182
S1511
R
L
N
A
L
H
L
S
D
K
V
Y
R
N
S
Site 183
Y1515
L
H
L
S
D
K
V
Y
R
N
S
W
E
Q
T
Site 184
S1518
S
D
K
V
Y
R
N
S
W
E
Q
T
R
A
G
Site 185
T1522
Y
R
N
S
W
E
Q
T
R
A
G
S
Y
D
F
Site 186
S1526
W
E
Q
T
R
A
G
S
Y
D
F
R
L
D
A
Site 187
T1538
L
D
A
I
P
F
Q
T
A
R
A
S
R
E
I
Site 188
S1542
P
F
Q
T
A
R
A
S
R
E
I
A
S
D
F
Site 189
S1547
R
A
S
R
E
I
A
S
D
F
R
Y
K
E
A
Site 190
Y1551
E
I
A
S
D
F
R
Y
K
E
A
F
L
R
D
Site 191
S1567
G
L
Q
I
G
Y
R
S
V
D
D
D
P
R
M
Site 192
S1585
L
N
V
G
R
L
Q
S
D
N
E
Y
K
K
D
Site 193
Y1589
R
L
Q
S
D
N
E
Y
K
K
D
F
A
K
S
Site 194
S1596
Y
K
K
D
F
A
K
S
R
S
Q
F
H
S
S
Site 195
S1598
K
D
F
A
K
S
R
S
Q
F
H
S
S
T
D
Site 196
S1602
K
S
R
S
Q
F
H
S
S
T
D
Q
P
G
L
Site 197
T1604
R
S
Q
F
H
S
S
T
D
Q
P
G
L
L
Q
Site 198
S1615
G
L
L
Q
A
K
R
S
Q
Q
L
A
S
D
V
Site 199
Y1624
Q
L
A
S
D
V
H
Y
R
Q
P
L
P
Q
P
Site 200
T1632
R
Q
P
L
P
Q
P
T
C
D
P
E
Q
L
G
Site 201
S1651
Q
K
A
H
Q
L
Q
S
D
V
K
Y
K
S
D
Site 202
Y1655
Q
L
Q
S
D
V
K
Y
K
S
D
L
N
L
T
Site 203
S1657
Q
S
D
V
K
Y
K
S
D
L
N
L
T
R
G
Site 204
T1668
L
T
R
G
V
G
W
T
P
P
G
S
Y
K
V
Site 205
S1672
V
G
W
T
P
P
G
S
Y
K
V
E
M
A
R
Site 206
S1709
V
E
A
G
D
H
Q
S
G
E
V
N
P
D
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation