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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IQGAP3
Full Name:
Ras GTPase-activating-like protein IQGAP3
Alias:
IQ motif containing GTPase activating 3; IQ motif containing GTPase activating protein 3; IQGA3; ras GTPase-activating-like IQGAP3
Type:
GTPase activating protein, Ras
Mass (Da):
184699
Number AA:
1631
UniProt ID:
Q86VI3
International Prot ID:
IPI00514068
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005099
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
GO:0051056
GO:0007264
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
A
G
P
G
W
A
A
Y
E
R
L
T
A
E
E
Site 2
T17
W
A
A
Y
E
R
L
T
A
E
E
M
D
E
Q
Site 3
Y31
Q
R
R
Q
N
V
A
Y
Q
Y
L
C
R
L
E
Site 4
Y33
R
Q
N
V
A
Y
Q
Y
L
C
R
L
E
E
A
Site 5
S54
C
L
K
E
E
L
P
S
P
V
E
L
E
E
S
Site 6
S61
S
P
V
E
L
E
E
S
L
R
N
G
V
L
L
Site 7
Y86
V
V
P
L
K
K
I
Y
D
V
E
Q
L
R
Y
Site 8
Y93
Y
D
V
E
Q
L
R
Y
Q
A
T
G
L
H
F
Site 9
T96
E
Q
L
R
Y
Q
A
T
G
L
H
F
R
H
T
Site 10
T121
A
H
I
G
L
P
S
T
F
F
P
E
T
T
D
Site 11
Y130
F
P
E
T
T
D
I
Y
D
K
K
N
M
P
R
Site 12
Y140
K
N
M
P
R
V
V
Y
C
I
H
A
L
S
L
Site 13
Y162
A
P
Q
I
H
D
L
Y
G
K
V
K
F
T
A
Site 14
T168
L
Y
G
K
V
K
F
T
A
E
E
L
S
N
M
Site 15
S177
E
E
L
S
N
M
A
S
E
L
A
K
Y
G
L
Site 16
T226
E
R
G
V
V
E
D
T
L
A
A
L
Q
N
P
Site 17
Y275
D
R
E
S
Q
D
I
Y
D
H
Y
L
T
Q
A
Site 18
Y278
S
Q
D
I
Y
D
H
Y
L
T
Q
A
E
I
Q
Site 19
S308
D
D
A
L
E
R
Q
S
P
E
A
L
L
K
A
Site 20
Y334
R
R
D
F
A
D
W
Y
L
E
Q
L
N
S
D
Site 21
S340
W
Y
L
E
Q
L
N
S
D
R
E
Q
K
A
Q
Site 22
T396
R
R
R
V
A
A
D
T
V
K
E
L
M
C
P
Site 23
Y411
E
A
Q
L
P
P
V
Y
P
V
A
S
S
M
Y
Site 24
S464
R
D
A
S
G
F
W
S
S
L
V
N
P
A
T
Site 25
S465
D
A
S
G
F
W
S
S
L
V
N
P
A
T
G
Site 26
Y484
E
G
E
N
A
Q
R
Y
F
D
A
L
L
K
L
Site 27
S503
G
M
G
E
D
F
L
S
W
N
D
L
Q
A
T
Site 28
T510
S
W
N
D
L
Q
A
T
V
S
Q
V
N
A
Q
Site 29
S512
N
D
L
Q
A
T
V
S
Q
V
N
A
Q
T
Q
Site 30
S539
N
E
A
L
D
K
G
S
P
E
K
T
L
S
A
Site 31
T543
D
K
G
S
P
E
K
T
L
S
A
L
L
L
P
Site 32
T603
V
V
R
A
N
Q
D
T
N
T
A
Q
R
M
A
Site 33
T605
R
A
N
Q
D
T
N
T
A
Q
R
M
A
L
G
Site 34
T628
K
E
G
K
A
A
Q
T
E
R
V
L
R
N
P
Site 35
Y650
V
P
D
C
A
N
G
Y
Q
R
A
L
E
S
A
Site 36
Y681
D
M
K
D
G
T
A
Y
Y
F
H
L
Q
T
F
Site 37
Y682
M
K
D
G
T
A
Y
Y
F
H
L
Q
T
F
Q
Site 38
S712
L
T
R
E
E
I
Q
S
A
V
T
K
V
T
A
Site 39
Y721
V
T
K
V
T
A
A
Y
D
R
Q
Q
L
W
K
Site 40
Y774
I
Q
A
H
W
R
G
Y
R
Q
R
K
I
Y
L
Site 41
Y780
G
Y
R
Q
R
K
I
Y
L
E
W
L
Q
Y
F
Site 42
Y810
M
W
A
A
R
R
Q
Y
L
R
R
L
H
Y
F
Site 43
Y816
Q
Y
L
R
R
L
H
Y
F
Q
K
N
V
N
S
Site 44
Y840
A
R
K
A
Q
D
D
Y
R
I
L
V
H
A
P
Site 45
S852
H
A
P
H
P
P
L
S
V
V
R
R
F
A
H
Site 46
S864
F
A
H
L
L
N
Q
S
Q
Q
D
F
L
A
E
Site 47
S887
E
V
V
R
K
I
R
S
N
Q
Q
L
E
Q
D
Site 48
S917
I
T
L
Q
E
V
V
S
H
C
K
K
L
T
K
Site 49
T923
V
S
H
C
K
K
L
T
K
R
N
K
E
Q
L
Site 50
S931
K
R
N
K
E
Q
L
S
D
M
M
V
L
D
K
Site 51
S944
D
K
Q
K
G
L
K
S
L
S
K
E
K
R
Q
Site 52
S946
Q
K
G
L
K
S
L
S
K
E
K
R
Q
K
L
Site 53
Y956
K
R
Q
K
L
E
A
Y
Q
H
L
F
Y
L
L
Site 54
Y961
E
A
Y
Q
H
L
F
Y
L
L
Q
T
Q
P
I
Site 55
Y994
E
A
V
I
F
S
L
Y
N
Y
A
S
S
R
R
Site 56
Y996
V
I
F
S
L
Y
N
Y
A
S
S
R
R
E
A
Site 57
S998
F
S
L
Y
N
Y
A
S
S
R
R
E
A
Y
L
Site 58
S999
S
L
Y
N
Y
A
S
S
R
R
E
A
Y
L
L
Site 59
Y1004
A
S
S
R
R
E
A
Y
L
L
L
Q
L
F
K
Site 60
S1020
A
L
Q
E
E
I
K
S
K
V
E
Q
P
Q
D
Site 61
T1030
E
Q
P
Q
D
V
V
T
G
N
P
T
V
V
R
Site 62
Y1043
V
R
L
V
V
R
F
Y
R
N
G
R
G
Q
S
Site 63
S1050
Y
R
N
G
R
G
Q
S
A
L
Q
E
I
L
G
Site 64
S1070
V
L
E
D
K
V
L
S
V
H
T
D
P
V
H
Site 65
Y1098
G
Q
R
S
H
L
P
Y
D
V
T
P
E
Q
A
Site 66
T1101
S
H
L
P
Y
D
V
T
P
E
Q
A
L
S
H
Site 67
S1107
V
T
P
E
Q
A
L
S
H
P
E
V
Q
R
R
Site 68
T1134
D
K
F
L
L
A
I
T
S
S
V
D
Q
I
P
Site 69
S1135
K
F
L
L
A
I
T
S
S
V
D
Q
I
P
Y
Site 70
S1136
F
L
L
A
I
T
S
S
V
D
Q
I
P
Y
G
Site 71
Y1142
S
S
V
D
Q
I
P
Y
G
M
R
Y
V
A
K
Site 72
T1163
A
E
K
F
P
D
A
T
D
S
E
V
Y
K
V
Site 73
S1165
K
F
P
D
A
T
D
S
E
V
Y
K
V
V
G
Site 74
Y1168
D
A
T
D
S
E
V
Y
K
V
V
G
N
L
L
Site 75
Y1238
H
L
R
V
L
N
D
Y
L
E
E
T
H
L
K
Site 76
Y1268
E
R
F
A
V
D
E
Y
S
D
M
V
A
V
A
Site 77
S1269
R
F
A
V
D
E
Y
S
D
M
V
A
V
A
K
Site 78
T1289
T
V
G
E
L
V
N
T
H
R
L
L
L
E
H
Site 79
T1335
S
I
A
A
D
G
H
T
D
L
S
K
L
E
V
Site 80
S1338
A
D
G
H
T
D
L
S
K
L
E
V
S
L
T
Site 81
S1343
D
L
S
K
L
E
V
S
L
T
L
T
N
K
F
Site 82
T1345
S
K
L
E
V
S
L
T
L
T
N
K
F
E
G
Site 83
S1360
L
E
A
D
A
D
D
S
N
T
R
S
L
L
L
Site 84
T1362
A
D
A
D
D
S
N
T
R
S
L
L
L
S
T
Site 85
S1364
A
D
D
S
N
T
R
S
L
L
L
S
T
K
Q
Site 86
S1368
N
T
R
S
L
L
L
S
T
K
Q
L
L
A
D
Site 87
S1390
D
T
L
K
E
I
L
S
L
S
A
S
R
E
Q
Site 88
S1392
L
K
E
I
L
S
L
S
A
S
R
E
Q
E
A
Site 89
S1394
E
I
L
S
L
S
A
S
R
E
Q
E
A
A
H
Site 90
S1406
A
A
H
K
Q
L
M
S
R
R
Q
A
C
T
A
Site 91
T1415
R
Q
A
C
T
A
Q
T
P
E
P
L
R
R
H
Site 92
S1424
E
P
L
R
R
H
R
S
L
T
A
H
S
L
L
Site 93
T1426
L
R
R
H
R
S
L
T
A
H
S
L
L
P
L
Site 94
S1429
H
R
S
L
T
A
H
S
L
L
P
L
A
E
K
Site 95
Y1459
L
V
S
A
R
N
G
Y
Q
G
L
V
D
E
L
Site 96
T1499
Q
G
L
S
T
K
T
T
F
Y
E
E
Q
G
D
Site 97
Y1501
L
S
T
K
T
T
F
Y
E
E
Q
G
D
Y
Y
Site 98
Y1507
F
Y
E
E
Q
G
D
Y
Y
S
Q
Y
I
R
A
Site 99
Y1508
Y
E
E
Q
G
D
Y
Y
S
Q
Y
I
R
A
C
Site 100
S1509
E
E
Q
G
D
Y
Y
S
Q
Y
I
R
A
C
L
Site 101
Y1511
Q
G
D
Y
Y
S
Q
Y
I
R
A
C
L
D
H
Site 102
S1523
L
D
H
L
A
P
D
S
K
S
S
G
K
G
K
Site 103
S1525
H
L
A
P
D
S
K
S
S
G
K
G
K
K
Q
Site 104
S1526
L
A
P
D
S
K
S
S
G
K
G
K
K
Q
P
Site 105
S1534
G
K
G
K
K
Q
P
S
L
H
Y
T
A
A
Q
Site 106
Y1537
K
K
Q
P
S
L
H
Y
T
A
A
Q
L
L
E
Site 107
T1538
K
Q
P
S
L
H
Y
T
A
A
Q
L
L
E
K
Site 108
S1557
E
I
E
D
L
P
A
S
H
F
R
N
V
I
F
Site 109
T1567
R
N
V
I
F
D
I
T
P
G
D
E
A
G
K
Site 110
Y1593
M
E
R
F
Q
L
H
Y
Q
D
L
L
Q
L
Q
Site 111
Y1601
Q
D
L
L
Q
L
Q
Y
E
G
V
A
V
M
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation