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Updated November 2019
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Protein Info
Short Name:
ZC3H18
Full Name:
Zinc finger CCCH domain-containing protein 18
Alias:
NHN1; Nuclear protein NHN1; ZCH18; Zinc finger CCCH-type containing 18
Type:
Unknown function
Mass (Da):
106378
Number AA:
953
UniProt ID:
Q86VM9
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
D
V
A
E
S
P
E
R
D
P
H
S
Site 2
S13
S
P
E
R
D
P
H
S
P
E
D
E
E
Q
P
Site 3
S24
E
E
Q
P
Q
G
L
S
D
D
D
I
L
R
D
Site 4
S32
D
D
D
I
L
R
D
S
G
S
D
Q
D
L
D
Site 5
S34
D
I
L
R
D
S
G
S
D
Q
D
L
D
G
A
Site 6
S46
D
G
A
G
V
R
A
S
D
L
E
D
E
E
S
Site 7
S53
S
D
L
E
D
E
E
S
A
A
R
G
P
S
Q
Site 8
S59
E
S
A
A
R
G
P
S
Q
E
E
E
D
N
H
Site 9
S67
Q
E
E
E
D
N
H
S
D
E
E
D
R
A
S
Site 10
S74
S
D
E
E
D
R
A
S
E
P
K
S
Q
D
Q
Site 11
S78
D
R
A
S
E
P
K
S
Q
D
Q
D
S
E
V
Site 12
S83
P
K
S
Q
D
Q
D
S
E
V
N
E
L
S
R
Site 13
S89
D
S
E
V
N
E
L
S
R
G
P
T
S
S
P
Site 14
T93
N
E
L
S
R
G
P
T
S
S
P
C
E
E
E
Site 15
S94
E
L
S
R
G
P
T
S
S
P
C
E
E
E
G
Site 16
S95
L
S
R
G
P
T
S
S
P
C
E
E
E
G
D
Site 17
T109
D
E
G
E
E
D
R
T
S
D
L
R
D
E
A
Site 18
S110
E
G
E
E
D
R
T
S
D
L
R
D
E
A
S
Site 19
S117
S
D
L
R
D
E
A
S
S
V
T
R
E
L
D
Site 20
S118
D
L
R
D
E
A
S
S
V
T
R
E
L
D
E
Site 21
Y130
L
D
E
H
E
L
D
Y
D
E
E
V
P
E
E
Site 22
T162
D
E
E
K
G
E
G
T
P
R
E
E
G
K
A
Site 23
S173
E
G
K
A
G
V
Q
S
V
G
E
K
E
S
L
Site 24
S214
E
G
E
V
K
D
P
S
D
R
K
V
R
P
R
Site 25
T223
R
K
V
R
P
R
P
T
C
R
F
F
M
K
G
Site 26
Y251
G
V
N
D
K
G
N
Y
S
L
I
T
K
A
D
Site 27
S252
V
N
D
K
G
N
Y
S
L
I
T
K
A
D
P
Site 28
T297
P
P
P
P
E
P
P
T
E
S
A
W
E
R
G
Site 29
T316
K
E
V
L
K
K
A
T
I
R
K
E
Q
E
P
Site 30
T331
D
F
E
E
K
R
F
T
V
T
I
G
E
D
E
Site 31
S353
E
V
F
R
D
W
N
S
R
I
P
R
D
V
R
Site 32
T362
I
P
R
D
V
R
D
T
V
L
E
P
Y
A
D
Site 33
Y367
R
D
T
V
L
E
P
Y
A
D
P
Y
Y
D
Y
Site 34
Y371
L
E
P
Y
A
D
P
Y
Y
D
Y
E
I
E
R
Site 35
Y372
E
P
Y
A
D
P
Y
Y
D
Y
E
I
E
R
F
Site 36
Y374
Y
A
D
P
Y
Y
D
Y
E
I
E
R
F
W
R
Site 37
Y385
R
F
W
R
G
G
Q
Y
E
N
F
R
V
Q
Y
Site 38
Y392
Y
E
N
F
R
V
Q
Y
T
E
T
E
P
Y
H
Site 39
Y398
Q
Y
T
E
T
E
P
Y
H
N
Y
R
E
R
E
Site 40
Y401
E
T
E
P
Y
H
N
Y
R
E
R
E
R
E
R
Site 41
S487
K
G
K
P
K
P
R
S
P
Q
P
P
S
R
Q
Site 42
S492
P
R
S
P
Q
P
P
S
R
Q
A
E
P
P
K
Site 43
S522
W
K
D
P
W
R
R
S
K
S
P
K
K
K
L
Site 44
S524
D
P
W
R
R
S
K
S
P
K
K
K
L
G
V
Site 45
S532
P
K
K
K
L
G
V
S
V
S
P
S
R
A
R
Site 46
S534
K
K
L
G
V
S
V
S
P
S
R
A
R
R
R
Site 47
S536
L
G
V
S
V
S
P
S
R
A
R
R
R
R
K
Site 48
T544
R
A
R
R
R
R
K
T
S
A
S
S
A
S
A
Site 49
S545
A
R
R
R
R
K
T
S
A
S
S
A
S
A
S
Site 50
S547
R
R
R
K
T
S
A
S
S
A
S
A
S
N
S
Site 51
S548
R
R
K
T
S
A
S
S
A
S
A
S
N
S
S
Site 52
S550
K
T
S
A
S
S
A
S
A
S
N
S
S
R
S
Site 53
S552
S
A
S
S
A
S
A
S
N
S
S
R
S
S
S
Site 54
S554
S
S
A
S
A
S
N
S
S
R
S
S
S
R
S
Site 55
S555
S
A
S
A
S
N
S
S
R
S
S
S
R
S
S
Site 56
S557
S
A
S
N
S
S
R
S
S
S
R
S
S
S
Y
Site 57
S558
A
S
N
S
S
R
S
S
S
R
S
S
S
Y
S
Site 58
S559
S
N
S
S
R
S
S
S
R
S
S
S
Y
S
G
Site 59
S561
S
S
R
S
S
S
R
S
S
S
Y
S
G
S
G
Site 60
S562
S
R
S
S
S
R
S
S
S
Y
S
G
S
G
S
Site 61
S563
R
S
S
S
R
S
S
S
Y
S
G
S
G
S
S
Site 62
Y564
S
S
S
R
S
S
S
Y
S
G
S
G
S
S
R
Site 63
S565
S
S
R
S
S
S
Y
S
G
S
G
S
S
R
S
Site 64
S567
R
S
S
S
Y
S
G
S
G
S
S
R
S
R
S
Site 65
S569
S
S
Y
S
G
S
G
S
S
R
S
R
S
R
S
Site 66
S570
R
S
R
S
R
S
F
S
S
S
P
S
P
S
P
Site 67
S572
R
S
R
S
F
S
S
S
P
S
P
S
P
T
P
Site 68
S574
R
S
F
S
S
S
P
S
P
S
P
T
P
S
P
Site 69
S576
F
S
S
S
P
S
P
S
P
T
P
S
P
H
R
Site 70
S577
S
R
S
R
S
R
S
S
S
Y
S
S
Y
S
S
Site 71
S578
R
S
R
S
R
S
S
S
Y
S
S
Y
S
S
R
Site 72
Y579
S
R
S
R
S
S
S
Y
S
S
Y
S
S
R
S
Site 73
S580
P
S
P
S
P
T
P
S
P
H
R
P
S
I
R
Site 74
S581
S
R
S
S
S
Y
S
S
Y
S
S
R
S
S
R
Site 75
Y582
R
S
S
S
Y
S
S
Y
S
S
R
S
S
R
H
Site 76
S583
S
S
S
Y
S
S
Y
S
S
R
S
S
R
H
S
Site 77
S584
S
S
Y
S
S
Y
S
S
R
S
S
R
H
S
S
Site 78
S586
Y
S
S
Y
S
S
R
S
S
R
H
S
S
F
S
Site 79
S587
S
S
Y
S
S
R
S
S
R
H
S
S
F
S
G
Site 80
S590
S
S
R
S
S
R
H
S
S
F
S
G
S
R
S
Site 81
S591
S
R
S
S
R
H
S
S
F
S
G
S
R
S
R
Site 82
S593
S
S
R
H
S
S
F
S
G
S
R
S
R
S
R
Site 83
S595
R
H
S
S
F
S
G
S
R
S
R
S
R
S
F
Site 84
S597
S
S
F
S
G
S
R
S
R
S
R
S
F
S
S
Site 85
S599
F
S
G
S
R
S
R
S
R
S
F
S
S
S
P
Site 86
S601
G
S
R
S
R
S
R
S
F
S
S
S
P
S
P
Site 87
S603
R
S
R
S
R
S
F
S
S
S
P
S
P
S
P
Site 88
S604
S
R
S
R
S
F
S
S
S
P
S
P
S
P
T
Site 89
S605
R
S
R
S
F
S
S
S
P
S
P
S
P
T
P
Site 90
S607
R
S
F
S
S
S
P
S
P
S
P
T
P
S
P
Site 91
S609
F
S
S
S
P
S
P
S
P
T
P
S
P
H
R
Site 92
T611
S
S
P
S
P
S
P
T
P
S
P
H
R
P
S
Site 93
S613
P
S
P
S
P
T
P
S
P
H
R
P
S
I
R
Site 94
S618
T
P
S
P
H
R
P
S
I
R
T
K
G
E
P
Site 95
T621
P
H
R
P
S
I
R
T
K
G
E
P
A
P
P
Site 96
S636
P
G
K
A
G
E
K
S
V
K
K
P
A
P
P
Site 97
T652
A
P
P
Q
A
T
K
T
T
A
P
V
P
E
P
Site 98
T653
P
P
Q
A
T
K
T
T
A
P
V
P
E
P
T
Site 99
T677
R
K
E
R
P
A
R
T
P
P
R
R
R
T
L
Site 100
T683
R
T
P
P
R
R
R
T
L
S
G
S
G
S
G
Site 101
S685
P
P
R
R
R
T
L
S
G
S
G
S
G
S
G
Site 102
S687
R
R
R
T
L
S
G
S
G
S
G
S
G
S
S
Site 103
S689
R
T
L
S
G
S
G
S
G
S
G
S
S
Y
S
Site 104
S691
L
S
G
S
G
S
G
S
G
S
S
Y
S
G
S
Site 105
S693
G
S
G
S
G
S
G
S
S
Y
S
G
S
S
S
Site 106
S694
S
G
S
G
S
G
S
S
Y
S
G
S
S
S
R
Site 107
Y695
G
S
G
S
G
S
S
Y
S
G
S
S
S
R
S
Site 108
S696
S
G
S
G
S
S
Y
S
G
S
S
S
R
S
R
Site 109
S698
S
G
S
S
Y
S
G
S
S
S
R
S
R
S
L
Site 110
S699
G
S
S
Y
S
G
S
S
S
R
S
R
S
L
S
Site 111
S700
S
S
Y
S
G
S
S
S
R
S
R
S
L
S
V
Site 112
S702
Y
S
G
S
S
S
R
S
R
S
L
S
V
S
S
Site 113
S704
G
S
S
S
R
S
R
S
L
S
V
S
S
V
S
Site 114
S706
S
S
R
S
R
S
L
S
V
S
S
V
S
S
V
Site 115
S708
R
S
R
S
L
S
V
S
S
V
S
S
V
S
S
Site 116
S709
S
R
S
L
S
V
S
S
V
S
S
V
S
S
A
Site 117
S714
V
S
S
V
S
S
V
S
S
A
T
S
S
S
S
Site 118
S715
S
S
V
S
S
V
S
S
A
T
S
S
S
S
S
Site 119
T717
V
S
S
V
S
S
A
T
S
S
S
S
S
A
H
Site 120
S718
S
S
V
S
S
A
T
S
S
S
S
S
A
H
S
Site 121
S719
S
V
S
S
A
T
S
S
S
S
S
A
H
S
V
Site 122
S720
V
S
S
A
T
S
S
S
S
S
A
H
S
V
D
Site 123
S721
S
S
A
T
S
S
S
S
S
A
H
S
V
D
S
Site 124
S722
S
A
T
S
S
S
S
S
A
H
S
V
D
S
E
Site 125
S725
S
S
S
S
S
A
H
S
V
D
S
E
D
M
Y
Site 126
S728
S
S
A
H
S
V
D
S
E
D
M
Y
A
D
L
Site 127
Y732
S
V
D
S
E
D
M
Y
A
D
L
A
S
P
V
Site 128
S737
D
M
Y
A
D
L
A
S
P
V
S
S
A
S
S
Site 129
S740
A
D
L
A
S
P
V
S
S
A
S
S
R
S
P
Site 130
S741
D
L
A
S
P
V
S
S
A
S
S
R
S
P
A
Site 131
S743
A
S
P
V
S
S
A
S
S
R
S
P
A
P
A
Site 132
S744
S
P
V
S
S
A
S
S
R
S
P
A
P
A
Q
Site 133
S746
V
S
S
A
S
S
R
S
P
A
P
A
Q
T
R
Site 134
S759
T
R
K
E
K
G
K
S
K
K
E
D
G
V
K
Site 135
S774
E
E
K
R
K
R
D
S
S
T
Q
P
P
K
S
Site 136
S775
E
K
R
K
R
D
S
S
T
Q
P
P
K
S
A
Site 137
T776
K
R
K
R
D
S
S
T
Q
P
P
K
S
A
K
Site 138
S781
S
S
T
Q
P
P
K
S
A
K
P
P
A
G
G
Site 139
S790
K
P
P
A
G
G
K
S
S
Q
Q
P
S
T
P
Site 140
S791
P
P
A
G
G
K
S
S
Q
Q
P
S
T
P
Q
Site 141
S795
G
K
S
S
Q
Q
P
S
T
P
Q
Q
A
P
P
Site 142
T796
K
S
S
Q
Q
P
S
T
P
Q
Q
A
P
P
G
Site 143
T809
P
G
Q
P
Q
Q
G
T
F
V
A
H
K
E
I
Site 144
T819
A
H
K
E
I
K
L
T
L
L
N
K
A
A
D
Site 145
S829
N
K
A
A
D
K
G
S
R
K
R
Y
E
P
S
Site 146
Y833
D
K
G
S
R
K
R
Y
E
P
S
D
K
D
R
Site 147
S836
S
R
K
R
Y
E
P
S
D
K
D
R
Q
S
P
Site 148
S842
P
S
D
K
D
R
Q
S
P
P
P
A
K
R
P
Site 149
T851
P
P
A
K
R
P
N
T
S
P
D
R
G
S
R
Site 150
S852
P
A
K
R
P
N
T
S
P
D
R
G
S
R
D
Site 151
S857
K
S
G
G
R
L
G
S
P
K
P
E
R
Q
R
Site 152
S862
R
G
S
R
D
R
K
S
G
G
R
L
G
S
P
Site 153
S868
K
S
G
G
R
L
G
S
P
K
P
E
R
Q
R
Site 154
S893
A
D
R
K
R
Q
L
S
P
Q
S
K
S
S
S
Site 155
S896
K
R
Q
L
S
P
Q
S
K
S
S
S
K
V
T
Site 156
S898
Q
L
S
P
Q
S
K
S
S
S
K
V
T
S
V
Site 157
S899
L
S
P
Q
S
K
S
S
S
K
V
T
S
V
P
Site 158
S900
S
P
Q
S
K
S
S
S
K
V
T
S
V
P
G
Site 159
T903
S
K
S
S
S
K
V
T
S
V
P
G
K
A
S
Site 160
S904
K
S
S
S
K
V
T
S
V
P
G
K
A
S
D
Site 161
S910
T
S
V
P
G
K
A
S
D
P
G
A
A
S
T
Site 162
S916
A
S
D
P
G
A
A
S
T
K
S
G
K
A
S
Site 163
T917
S
D
P
G
A
A
S
T
K
S
G
K
A
S
T
Site 164
S919
P
G
A
A
S
T
K
S
G
K
A
S
T
L
S
Site 165
S923
S
T
K
S
G
K
A
S
T
L
S
R
R
E
E
Site 166
T924
T
K
S
G
K
A
S
T
L
S
R
R
E
E
L
Site 167
S926
S
G
K
A
S
T
L
S
R
R
E
E
L
L
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation