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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PACS2
Full Name:
Phosphofurin acidic cluster sorting protein 2
Alias:
KIAA0602; PACS1L; PACS1-like protein; PACS-2
Type:
Mass (Da):
97702
Number AA:
889
UniProt ID:
Q86VP3
International Prot ID:
IPI00029041
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005788
GO:0005739
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
A
T
W
E
V
D
G
S
S
P
S
C
V
P
R
Site 2
S34
T
W
E
V
D
G
S
S
P
S
C
V
P
R
L
Site 3
S36
E
V
D
G
S
S
P
S
C
V
P
R
L
C
S
Site 4
S71
I
A
V
K
M
Q
G
S
K
R
I
L
R
S
H
Site 5
S77
G
S
K
R
I
L
R
S
H
E
I
V
L
P
P
Site 6
S85
H
E
I
V
L
P
P
S
G
Q
V
E
T
D
L
Site 7
Y121
M
L
Q
R
R
K
R
Y
K
N
R
T
I
L
G
Site 8
T125
R
K
R
Y
K
N
R
T
I
L
G
Y
K
T
L
Site 9
Y129
K
N
R
T
I
L
G
Y
K
T
L
A
A
G
S
Site 10
S154
S
E
G
G
Q
V
L
S
L
C
S
S
I
K
E
Site 11
S175
E
I
W
I
A
S
L
S
S
Q
P
I
D
H
E
Site 12
S184
Q
P
I
D
H
E
D
S
T
M
Q
A
G
P
K
Site 13
T185
P
I
D
H
E
D
S
T
M
Q
A
G
P
K
A
Site 14
S194
Q
A
G
P
K
A
K
S
T
D
N
Y
S
E
E
Site 15
T195
A
G
P
K
A
K
S
T
D
N
Y
S
E
E
E
Site 16
Y198
K
A
K
S
T
D
N
Y
S
E
E
E
Y
E
S
Site 17
S199
A
K
S
T
D
N
Y
S
E
E
E
Y
E
S
F
Site 18
Y203
D
N
Y
S
E
E
E
Y
E
S
F
S
S
E
Q
Site 19
S205
Y
S
E
E
E
Y
E
S
F
S
S
E
Q
E
A
Site 20
S208
E
E
Y
E
S
F
S
S
E
Q
E
A
S
D
D
Site 21
S213
F
S
S
E
Q
E
A
S
D
D
A
V
Q
G
Q
Site 22
S238
K
P
K
K
Q
R
R
S
I
V
R
T
T
S
M
Site 23
T242
Q
R
R
S
I
V
R
T
T
S
M
T
R
Q
Q
Site 24
T243
R
R
S
I
V
R
T
T
S
M
T
R
Q
Q
N
Site 25
S244
R
S
I
V
R
T
T
S
M
T
R
Q
Q
N
F
Site 26
T246
I
V
R
T
T
S
M
T
R
Q
Q
N
F
K
Q
Site 27
S265
L
L
R
R
F
K
V
S
D
E
V
L
D
S
E
Site 28
S271
V
S
D
E
V
L
D
S
E
Q
D
P
A
E
H
Site 29
Y290
E
E
D
L
D
L
L
Y
D
T
L
D
M
E
H
Site 30
T292
D
L
D
L
L
Y
D
T
L
D
M
E
H
P
S
Site 31
S299
T
L
D
M
E
H
P
S
D
S
G
P
D
M
E
Site 32
S301
D
M
E
H
P
S
D
S
G
P
D
M
E
D
D
Site 33
S310
P
D
M
E
D
D
D
S
V
L
S
T
P
K
P
Site 34
S313
E
D
D
D
S
V
L
S
T
P
K
P
K
L
R
Site 35
T314
D
D
D
S
V
L
S
T
P
K
P
K
L
R
P
Site 36
Y322
P
K
P
K
L
R
P
Y
F
E
G
L
S
H
S
Site 37
S327
R
P
Y
F
E
G
L
S
H
S
S
S
Q
T
E
Site 38
S329
Y
F
E
G
L
S
H
S
S
S
Q
T
E
I
G
Site 39
S330
F
E
G
L
S
H
S
S
S
Q
T
E
I
G
S
Site 40
S331
E
G
L
S
H
S
S
S
Q
T
E
I
G
S
I
Site 41
T333
L
S
H
S
S
S
Q
T
E
I
G
S
I
H
S
Site 42
S337
S
S
Q
T
E
I
G
S
I
H
S
A
R
S
H
Site 43
S340
T
E
I
G
S
I
H
S
A
R
S
H
K
E
P
Site 44
S343
G
S
I
H
S
A
R
S
H
K
E
P
P
S
P
Site 45
S349
R
S
H
K
E
P
P
S
P
A
D
V
P
E
K
Site 46
S359
D
V
P
E
K
T
R
S
L
G
G
R
Q
P
S
Site 47
S366
S
L
G
G
R
Q
P
S
D
S
V
S
D
T
V
Site 48
S368
G
G
R
Q
P
S
D
S
V
S
D
T
V
A
L
Site 49
S370
R
Q
P
S
D
S
V
S
D
T
V
A
L
G
V
Site 50
S390
H
P
G
Q
P
E
D
S
P
E
A
E
A
S
T
Site 51
S396
D
S
P
E
A
E
A
S
T
L
D
V
F
T
E
Site 52
T397
S
P
E
A
E
A
S
T
L
D
V
F
T
E
R
Site 53
T402
A
S
T
L
D
V
F
T
E
R
L
P
P
S
G
Site 54
S408
F
T
E
R
L
P
P
S
G
R
I
T
K
T
E
Site 55
T414
P
S
G
R
I
T
K
T
E
S
L
V
I
P
S
Site 56
S416
G
R
I
T
K
T
E
S
L
V
I
P
S
T
R
Site 57
S421
T
E
S
L
V
I
P
S
T
R
S
E
G
K
Q
Site 58
T422
E
S
L
V
I
P
S
T
R
S
E
G
K
Q
A
Site 59
S435
Q
A
G
R
R
G
R
S
T
S
L
K
E
R
Q
Site 60
T436
A
G
R
R
G
R
S
T
S
L
K
E
R
Q
A
Site 61
S437
G
R
R
G
R
S
T
S
L
K
E
R
Q
A
A
Site 62
S453
P
Q
N
E
R
A
N
S
L
D
N
E
R
C
P
Site 63
S464
E
R
C
P
D
A
R
S
Q
L
Q
I
P
R
K
Site 64
T472
Q
L
Q
I
P
R
K
T
V
Y
D
Q
L
N
H
Site 65
Y474
Q
I
P
R
K
T
V
Y
D
Q
L
N
H
I
L
Site 66
S483
Q
L
N
H
I
L
I
S
D
D
Q
L
P
E
N
Site 67
T547
N
C
N
S
Q
P
P
T
P
V
K
I
A
V
A
Site 68
S572
R
L
F
V
E
Q
L
S
H
K
T
P
D
W
L
Site 69
T575
V
E
Q
L
S
H
K
T
P
D
W
L
G
Y
M
Site 70
Y597
G
S
H
P
V
A
R
Y
L
G
S
V
D
Y
R
Site 71
S600
P
V
A
R
Y
L
G
S
V
D
Y
R
Y
N
N
Site 72
Y603
R
Y
L
G
S
V
D
Y
R
Y
N
N
F
F
Q
Site 73
Y605
L
G
S
V
D
Y
R
Y
N
N
F
F
Q
D
L
Site 74
T630
A
Q
S
A
V
Q
D
T
P
D
I
V
S
R
I
Site 75
T658
P
I
A
E
A
M
L
T
Y
K
Q
K
S
P
D
Site 76
S663
M
L
T
Y
K
Q
K
S
P
D
E
E
S
S
Q
Site 77
S669
K
S
P
D
E
E
S
S
Q
K
F
I
P
F
V
Site 78
S688
V
G
I
V
E
P
S
S
A
T
S
G
D
S
D
Site 79
T690
I
V
E
P
S
S
A
T
S
G
D
S
D
D
A
Site 80
S691
V
E
P
S
S
A
T
S
G
D
S
D
D
A
A
Site 81
S694
S
S
A
T
S
G
D
S
D
D
A
A
P
S
G
Site 82
S700
D
S
D
D
A
A
P
S
G
S
G
T
L
S
S
Site 83
S702
D
D
A
A
P
S
G
S
G
T
L
S
S
T
P
Site 84
T704
A
A
P
S
G
S
G
T
L
S
S
T
P
P
S
Site 85
S706
P
S
G
S
G
T
L
S
S
T
P
P
S
A
S
Site 86
S707
S
G
S
G
T
L
S
S
T
P
P
S
A
S
P
Site 87
T708
G
S
G
T
L
S
S
T
P
P
S
A
S
P
A
Site 88
S711
T
L
S
S
T
P
P
S
A
S
P
A
A
K
E
Site 89
S713
S
S
T
P
P
S
A
S
P
A
A
K
E
A
S
Site 90
S720
S
P
A
A
K
E
A
S
P
T
P
P
S
S
P
Site 91
T722
A
A
K
E
A
S
P
T
P
P
S
S
P
S
V
Site 92
S725
E
A
S
P
T
P
P
S
S
P
S
V
S
G
G
Site 93
S726
A
S
P
T
P
P
S
S
P
S
V
S
G
G
L
Site 94
S728
P
T
P
P
S
S
P
S
V
S
G
G
L
S
S
Site 95
S730
P
P
S
S
P
S
V
S
G
G
L
S
S
P
S
Site 96
S734
P
S
V
S
G
G
L
S
S
P
S
Q
G
V
G
Site 97
S735
S
V
S
G
G
L
S
S
P
S
Q
G
V
G
A
Site 98
S737
S
G
G
L
S
S
P
S
Q
G
V
G
A
E
L
Site 99
T779
T
K
N
T
L
K
C
T
F
R
S
L
Q
V
S
Site 100
S782
T
L
K
C
T
F
R
S
L
Q
V
S
R
L
P
Site 101
S786
T
F
R
S
L
Q
V
S
R
L
P
S
S
G
E
Site 102
S790
L
Q
V
S
R
L
P
S
S
G
E
A
A
A
T
Site 103
S791
Q
V
S
R
L
P
S
S
G
E
A
A
A
T
P
Site 104
T803
A
T
P
T
M
S
M
T
V
V
T
K
E
K
N
Site 105
S827
A
K
D
K
D
V
E
S
K
S
Q
C
I
E
G
Site 106
S829
D
K
D
V
E
S
K
S
Q
C
I
E
G
I
S
Site 107
S836
S
Q
C
I
E
G
I
S
R
L
I
C
T
A
R
Site 108
T841
G
I
S
R
L
I
C
T
A
R
Q
Q
Q
N
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation