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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HOOK3
Full Name:
Protein Hook homolog 3
Alias:
Golgi-associated microtubule-binding protein HOOK3; HHK3; HK3; Hook 3; Hook homolog 3
Type:
Adaptor/scaffold
Mass (Da):
83126
Number AA:
718
UniProt ID:
Q86VS8
International Prot ID:
IPI00031768
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005794
GO:0005801
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0008017
PhosphoSite+
KinaseNET
Biological Process:
GO:0000226
GO:0007017
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
E
R
A
E
L
C
E
S
L
L
T
W
I
Q
T
Site 2
Y52
L
Q
K
I
D
P
A
Y
F
D
E
N
W
L
N
Site 3
T99
G
Q
Q
I
N
D
F
T
L
P
D
V
N
L
I
Site 4
S110
V
N
L
I
G
E
H
S
D
A
A
E
L
G
R
Site 5
S159
T
A
I
Q
E
L
M
S
K
E
S
P
V
S
A
Site 6
S162
Q
E
L
M
S
K
E
S
P
V
S
A
G
N
D
Site 7
S165
M
S
K
E
S
P
V
S
A
G
N
D
A
Y
V
Site 8
Y171
V
S
A
G
N
D
A
Y
V
D
L
D
R
Q
L
Site 9
T181
L
D
R
Q
L
K
K
T
T
E
E
L
N
E
A
Site 10
S190
E
E
L
N
E
A
L
S
A
K
E
E
I
A
Q
Site 11
S214
A
A
L
Q
E
E
K
S
S
L
L
A
E
N
Q
Site 12
S215
A
L
Q
E
E
K
S
S
L
L
A
E
N
Q
V
Site 13
S230
L
M
E
R
L
N
Q
S
D
S
I
E
D
P
N
Site 14
S232
E
R
L
N
Q
S
D
S
I
E
D
P
N
S
P
Site 15
S238
D
S
I
E
D
P
N
S
P
A
G
R
R
H
L
Site 16
T258
L
E
Q
L
Q
E
E
T
F
R
L
E
A
A
K
Site 17
Y268
L
E
A
A
K
D
D
Y
R
I
R
C
E
E
L
Site 18
S280
E
E
L
E
K
E
I
S
E
L
R
Q
Q
N
D
Site 19
S309
E
I
D
V
L
R
H
S
S
D
K
V
S
K
L
Site 20
S310
I
D
V
L
R
H
S
S
D
K
V
S
K
L
E
Site 21
S314
R
H
S
S
D
K
V
S
K
L
E
G
Q
V
E
Site 22
S322
K
L
E
G
Q
V
E
S
Y
K
K
K
L
E
D
Site 23
T345
K
L
L
E
E
K
N
T
M
Y
M
Q
N
T
V
Site 24
Y347
L
E
E
K
N
T
M
Y
M
Q
N
T
V
S
L
Site 25
T351
N
T
M
Y
M
Q
N
T
V
S
L
E
E
E
L
Site 26
S353
M
Y
M
Q
N
T
V
S
L
E
E
E
L
R
K
Site 27
S366
R
K
A
N
A
A
R
S
Q
L
E
T
Y
K
R
Site 28
T370
A
A
R
S
Q
L
E
T
Y
K
R
Q
V
V
E
Site 29
Y371
A
R
S
Q
L
E
T
Y
K
R
Q
V
V
E
L
Site 30
S383
V
E
L
Q
N
R
L
S
E
E
S
K
K
A
D
Site 31
S386
Q
N
R
L
S
E
E
S
K
K
A
D
K
L
D
Site 32
Y396
A
D
K
L
D
F
E
Y
K
R
L
K
E
K
V
Site 33
S405
R
L
K
E
K
V
D
S
L
Q
K
E
K
D
R
Site 34
T415
K
E
K
D
R
L
R
T
E
R
D
S
L
K
E
Site 35
S419
R
L
R
T
E
R
D
S
L
K
E
T
I
E
E
Site 36
T423
E
R
D
S
L
K
E
T
I
E
E
L
R
C
V
Site 37
T438
Q
A
Q
E
G
Q
L
T
T
Q
G
L
M
P
L
Site 38
S447
Q
G
L
M
P
L
G
S
Q
E
S
S
D
S
L
Site 39
S451
P
L
G
S
Q
E
S
S
D
S
L
A
A
E
I
Site 40
S453
G
S
Q
E
S
S
D
S
L
A
A
E
I
V
T
Site 41
S484
L
K
L
N
Q
E
G
S
D
N
E
K
I
A
L
Site 42
S494
E
K
I
A
L
L
Q
S
L
L
D
D
A
N
L
Site 43
S522
Q
R
L
L
E
V
Q
S
Q
V
E
E
L
Q
K
Site 44
S530
Q
V
E
E
L
Q
K
S
L
Q
D
Q
G
S
K
Site 45
S536
K
S
L
Q
D
Q
G
S
K
A
E
D
S
V
L
Site 46
S541
Q
G
S
K
A
E
D
S
V
L
L
K
K
K
L
Site 47
S580
E
P
R
F
N
N
S
S
L
K
I
E
E
L
Q
Site 48
Y607
M
E
E
R
Y
K
K
Y
L
E
K
A
K
S
V
Site 49
S613
K
Y
L
E
K
A
K
S
V
I
R
T
L
D
P
Site 50
T617
K
A
K
S
V
I
R
T
L
D
P
K
Q
N
Q
Site 51
S646
E
R
D
R
L
F
H
S
L
E
K
E
Y
E
K
Site 52
Y651
F
H
S
L
E
K
E
Y
E
K
T
K
S
Q
R
Site 53
T654
L
E
K
E
Y
E
K
T
K
S
Q
R
E
M
E
Site 54
S656
K
E
Y
E
K
T
K
S
Q
R
E
M
E
E
K
Site 55
Y664
Q
R
E
M
E
E
K
Y
I
V
S
A
W
Y
N
Site 56
S687
A
A
E
D
R
L
A
S
T
G
S
G
Q
S
F
Site 57
T688
A
E
D
R
L
A
S
T
G
S
G
Q
S
F
L
Site 58
S690
D
R
L
A
S
T
G
S
G
Q
S
F
L
A
R
Site 59
S693
A
S
T
G
S
G
Q
S
F
L
A
R
Q
R
Q
Site 60
T702
L
A
R
Q
R
Q
A
T
S
S
R
R
S
Y
P
Site 61
S703
A
R
Q
R
Q
A
T
S
S
R
R
S
Y
P
G
Site 62
S704
R
Q
R
Q
A
T
S
S
R
R
S
Y
P
G
H
Site 63
S707
Q
A
T
S
S
R
R
S
Y
P
G
H
V
Q
P
Site 64
Y708
A
T
S
S
R
R
S
Y
P
G
H
V
Q
P
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation