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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GEFT
Full Name:
Rho guanine nucleotide exchange factor 25
Alias:
Guanine nucleotide exchange factor GEFT;Rac/Cdc42/Rho exchange factor GEFT;RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT;p63RhoGEF
Type:
Mass (Da):
63843
Number AA:
580
UniProt ID:
Q86VW2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S34
F
A
R
G
G
R
E
S
Y
S
I
A
G
S
E
Site 2
Y35
A
R
G
G
R
E
S
Y
S
I
A
G
S
E
G
Site 3
S36
R
G
G
R
E
S
Y
S
I
A
G
S
E
G
S
Site 4
S40
E
S
Y
S
I
A
G
S
E
G
S
I
S
A
S
Site 5
S59
L
A
A
P
S
G
P
S
S
G
L
S
S
G
P
Site 6
S60
A
A
P
S
G
P
S
S
G
L
S
S
G
P
C
Site 7
S63
S
G
P
S
S
G
L
S
S
G
P
C
S
P
G
Site 8
S64
G
P
S
S
G
L
S
S
G
P
C
S
P
G
P
Site 9
S68
G
L
S
S
G
P
C
S
P
G
P
P
G
P
V
Site 10
S76
P
G
P
P
G
P
V
S
G
L
R
R
W
L
D
Site 11
S85
L
R
R
W
L
D
H
S
K
H
C
L
S
V
E
Site 12
S90
D
H
S
K
H
C
L
S
V
E
T
E
A
D
S
Site 13
S97
S
V
E
T
E
A
D
S
G
Q
A
G
P
Y
E
Site 14
Y103
D
S
G
Q
A
G
P
Y
E
N
W
M
L
E
P
Site 15
T135
L
E
G
P
G
D
K
T
Q
P
P
E
E
E
T
Site 16
S144
P
P
E
E
E
T
L
S
Q
A
P
E
S
E
E
Site 17
S149
T
L
S
Q
A
P
E
S
E
E
E
Q
K
K
K
Site 18
S161
K
K
K
A
L
E
R
S
M
Y
V
L
S
E
L
Site 19
Y163
K
A
L
E
R
S
M
Y
V
L
S
E
L
V
E
Site 20
S166
E
R
S
M
Y
V
L
S
E
L
V
E
T
E
K
Site 21
T171
V
L
S
E
L
V
E
T
E
K
M
Y
V
D
D
Site 22
Y175
L
V
E
T
E
K
M
Y
V
D
D
L
G
Q
I
Site 23
S198
A
A
Q
G
V
P
E
S
L
R
G
R
D
R
I
Site 24
Y220
I
Y
E
W
H
R
D
Y
F
L
Q
E
L
Q
R
Site 25
Y249
H
E
R
R
L
H
M
Y
V
V
Y
C
Q
N
K
Site 26
Y252
R
L
H
M
Y
V
V
Y
C
Q
N
K
P
K
S
Site 27
S264
P
K
S
E
H
V
V
S
E
F
G
D
S
Y
F
Site 28
S269
V
V
S
E
F
G
D
S
Y
F
E
E
L
R
Q
Site 29
Y270
V
S
E
F
G
D
S
Y
F
E
E
L
R
Q
Q
Site 30
Y298
P
V
Q
R
I
M
K
Y
Q
L
L
L
K
D
F
Site 31
Y308
L
L
K
D
F
L
K
Y
Y
N
R
A
G
M
D
Site 32
Y309
L
K
D
F
L
K
Y
Y
N
R
A
G
M
D
T
Site 33
T316
Y
N
R
A
G
M
D
T
A
D
L
E
Q
A
V
Site 34
T338
K
R
C
N
D
M
M
T
L
G
R
L
R
G
F
Site 35
T350
R
G
F
E
G
K
L
T
A
Q
G
K
L
L
G
Site 36
T360
G
K
L
L
G
Q
D
T
F
W
V
T
E
P
E
Site 37
S373
P
E
A
G
G
L
L
S
S
R
G
R
E
R
R
Site 38
S374
E
A
G
G
L
L
S
S
R
G
R
E
R
R
V
Site 39
T402
G
G
G
V
R
G
G
T
Q
P
G
Y
V
Y
K
Site 40
Y406
R
G
G
T
Q
P
G
Y
V
Y
K
N
S
I
K
Site 41
S411
P
G
Y
V
Y
K
N
S
I
K
V
S
C
L
G
Site 42
S415
Y
K
N
S
I
K
V
S
C
L
G
L
E
G
N
Site 43
T433
D
P
C
R
F
A
L
T
S
R
G
P
E
G
G
Site 44
S434
P
C
R
F
A
L
T
S
R
G
P
E
G
G
I
Site 45
Y444
P
E
G
G
I
Q
R
Y
V
L
Q
A
A
D
P
Site 46
S454
Q
A
A
D
P
A
I
S
Q
A
W
I
K
H
V
Site 47
S467
H
V
A
Q
I
L
E
S
Q
R
D
F
L
N
A
Site 48
S477
D
F
L
N
A
L
Q
S
P
I
E
Y
Q
R
R
Site 49
Y481
A
L
Q
S
P
I
E
Y
Q
R
R
E
S
Q
T
Site 50
S486
I
E
Y
Q
R
R
E
S
Q
T
N
S
L
G
R
Site 51
T488
Y
Q
R
R
E
S
Q
T
N
S
L
G
R
P
R
Site 52
S490
R
R
E
S
Q
T
N
S
L
G
R
P
R
G
P
Site 53
S501
P
R
G
P
G
V
G
S
P
G
R
I
Q
L
G
Site 54
S514
L
G
D
Q
A
Q
G
S
T
H
T
P
I
N
G
Site 55
T517
Q
A
Q
G
S
T
H
T
P
I
N
G
S
L
P
Site 56
S556
I
P
Q
A
P
H
D
S
P
P
V
S
P
T
P
Site 57
S560
P
H
D
S
P
P
V
S
P
T
P
K
T
P
P
Site 58
T562
D
S
P
P
V
S
P
T
P
K
T
P
P
C
Q
Site 59
T565
P
V
S
P
T
P
K
T
P
P
C
Q
A
R
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation