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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NLRP14
Full Name:
NACHT, LRR and PYD domains-containing protein 14
Alias:
Nucleotide-binding oligomerization domain protein 5
Type:
Mass (Da):
124733
Number AA:
1093
UniProt ID:
Q86W24
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
D
S
S
S
S
S
F
F
P
D
F
Site 2
S8
M
A
D
S
S
S
S
S
F
F
P
D
F
G
L
Site 3
Y18
P
D
F
G
L
L
L
Y
L
E
E
L
N
K
E
Site 4
T29
L
N
K
E
E
L
N
T
F
K
L
F
L
K
E
Site 5
T37
F
K
L
F
L
K
E
T
M
E
P
E
H
G
L
Site 6
T45
M
E
P
E
H
G
L
T
P
W
N
E
V
K
K
Site 7
Y65
L
A
N
L
M
K
K
Y
Y
P
G
E
K
A
W
Site 8
Y66
A
N
L
M
K
K
Y
Y
P
G
E
K
A
W
S
Site 9
S73
Y
P
G
E
K
A
W
S
V
S
L
K
I
F
G
Site 10
S75
G
E
K
A
W
S
V
S
L
K
I
F
G
K
M
Site 11
S98
A
K
E
E
I
N
W
S
A
Q
T
I
G
P
D
Site 12
T124
E
A
V
L
G
D
G
T
E
Y
R
N
R
I
K
Site 13
Y126
V
L
G
D
G
T
E
Y
R
N
R
I
K
E
K
Site 14
T137
I
K
E
K
F
C
I
T
W
D
K
K
S
L
A
Site 15
S142
C
I
T
W
D
K
K
S
L
A
G
K
P
E
D
Site 16
Y206
D
W
A
E
G
S
L
Y
Q
Q
R
F
K
Y
V
Site 17
Y212
L
Y
Q
Q
R
F
K
Y
V
F
Y
L
N
G
R
Site 18
Y215
Q
R
F
K
Y
V
F
Y
L
N
G
R
E
I
N
Site 19
S228
I
N
Q
L
K
E
R
S
F
A
Q
L
I
S
K
Site 20
S239
L
I
S
K
D
W
P
S
T
E
G
P
I
E
E
Site 21
T240
I
S
K
D
W
P
S
T
E
G
P
I
E
E
I
Site 22
S302
K
V
M
L
P
E
A
S
L
L
V
T
T
R
L
Site 23
T306
P
E
A
S
L
L
V
T
T
R
L
T
T
S
K
Site 24
T310
L
L
V
T
T
R
L
T
T
S
K
R
L
K
Q
Site 25
T311
L
V
T
T
R
L
T
T
S
K
R
L
K
Q
L
Site 26
S312
V
T
T
R
L
T
T
S
K
R
L
K
Q
L
L
Site 27
Y324
Q
L
L
K
N
H
H
Y
V
E
L
L
G
M
S
Site 28
Y338
S
E
D
A
R
E
E
Y
I
Y
Q
F
F
E
D
Site 29
Y340
D
A
R
E
E
Y
I
Y
Q
F
F
E
D
K
R
Site 30
S355
W
A
M
K
V
F
S
S
L
K
S
N
E
M
L
Site 31
S358
K
V
F
S
S
L
K
S
N
E
M
L
F
S
M
Site 32
T390
M
E
K
G
G
D
V
T
L
T
C
Q
T
T
T
Site 33
S415
F
T
P
V
D
G
G
S
P
S
L
P
N
Q
A
Site 34
S417
P
V
D
G
G
S
P
S
L
P
N
Q
A
Q
L
Site 35
Y440
K
G
I
W
T
M
T
Y
V
F
Y
R
E
N
L
Site 36
T453
N
L
R
R
L
G
L
T
Q
S
D
V
S
S
F
Site 37
S455
R
R
L
G
L
T
Q
S
D
V
S
S
F
M
D
Site 38
S463
D
V
S
S
F
M
D
S
N
I
I
Q
K
D
A
Site 39
Y472
I
I
Q
K
D
A
E
Y
E
N
C
Y
V
F
T
Site 40
Y476
D
A
E
Y
E
N
C
Y
V
F
T
H
L
H
V
Site 41
S504
S
W
E
A
G
N
P
S
C
Q
P
F
E
D
L
Site 42
S513
Q
P
F
E
D
L
K
S
L
L
Q
S
T
S
Y
Site 43
S517
D
L
K
S
L
L
Q
S
T
S
Y
K
D
P
H
Site 44
S519
K
S
L
L
Q
S
T
S
Y
K
D
P
H
L
T
Site 45
Y520
S
L
L
Q
S
T
S
Y
K
D
P
H
L
T
Q
Site 46
T547
R
V
K
Q
L
E
R
T
F
N
C
K
M
S
L
Site 47
S553
R
T
F
N
C
K
M
S
L
K
I
K
S
K
L
Site 48
S570
C
M
E
V
L
G
N
S
D
Y
S
P
S
Q
L
Site 49
Y572
E
V
L
G
N
S
D
Y
S
P
S
Q
L
G
F
Site 50
S573
V
L
G
N
S
D
Y
S
P
S
Q
L
G
F
L
Site 51
S575
G
N
S
D
Y
S
P
S
Q
L
G
F
L
E
L
Site 52
Y587
L
E
L
F
H
C
L
Y
E
T
Q
D
K
A
F
Site 53
T646
F
E
K
K
I
L
K
T
S
L
P
T
N
T
W
Site 54
S647
E
K
K
I
L
K
T
S
L
P
T
N
T
W
D
Site 55
T671
D
L
C
S
V
L
H
T
N
E
H
L
R
E
L
Site 56
Y681
H
L
R
E
L
D
L
Y
H
S
N
L
D
K
S
Site 57
S683
R
E
L
D
L
Y
H
S
N
L
D
K
S
A
M
Site 58
S722
P
D
G
C
Q
D
I
S
T
S
L
I
H
N
K
Site 59
T723
D
G
C
Q
D
I
S
T
S
L
I
H
N
K
N
Site 60
S724
G
C
Q
D
I
S
T
S
L
I
H
N
K
N
L
Site 61
S739
M
H
L
D
L
K
G
S
D
I
G
D
N
G
V
Site 62
S748
I
G
D
N
G
V
K
S
L
C
E
A
L
K
H
Site 63
T762
H
P
E
C
K
L
Q
T
L
R
L
E
S
C
N
Site 64
Y816
A
L
R
H
P
K
C
Y
L
E
R
L
S
L
E
Site 65
S821
K
C
Y
L
E
R
L
S
L
E
S
C
G
L
T
Site 66
S824
L
E
R
L
S
L
E
S
C
G
L
T
E
A
G
Site 67
T846
L
I
S
N
K
R
L
T
H
L
C
L
A
D
N
Site 68
S864
D
G
G
V
K
L
M
S
D
A
L
Q
H
A
Q
Site 69
T885
V
L
R
R
C
H
F
T
S
L
S
S
E
Y
L
Site 70
S886
L
R
R
C
H
F
T
S
L
S
S
E
Y
L
S
Site 71
S888
R
C
H
F
T
S
L
S
S
E
Y
L
S
T
S
Site 72
S889
C
H
F
T
S
L
S
S
E
Y
L
S
T
S
L
Site 73
S893
S
L
S
S
E
Y
L
S
T
S
L
L
H
N
K
Site 74
S895
S
S
E
Y
L
S
T
S
L
L
H
N
K
S
L
Site 75
S901
T
S
L
L
H
N
K
S
L
T
H
L
D
L
G
Site 76
T903
L
L
H
N
K
S
L
T
H
L
D
L
G
S
N
Site 77
Y983
I
L
C
D
A
L
R
Y
P
N
C
N
I
Q
R
Site 78
T1022
R
L
I
K
M
N
L
T
Q
N
T
L
G
Y
E
Site 79
Y1035
Y
E
G
I
V
K
L
Y
K
V
L
K
S
P
K
Site 80
S1040
K
L
Y
K
V
L
K
S
P
K
C
K
L
Q
V
Site 81
Y1081
I
I
K
P
D
C
N
Y
H
N
E
E
D
V
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation