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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NLRP8
Full Name:
NACHT, LRR and PYD domains-containing protein 8
Alias:
CLR19.2; NACHT, LRR and PYD containing 8; NALP8; NLR family, pyrin domain containing 8; NOD16; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 8; PAN4
Type:
Mass (Da):
119430
Number AA:
UniProt ID:
Q86W28
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
S
D
V
N
P
P
S
D
T
P
I
P
F
S
Site 2
T10
D
V
N
P
P
S
D
T
P
I
P
F
S
S
S
Site 3
S15
S
D
T
P
I
P
F
S
S
S
S
T
H
S
S
Site 4
S16
D
T
P
I
P
F
S
S
S
S
T
H
S
S
H
Site 5
S17
T
P
I
P
F
S
S
S
S
T
H
S
S
H
I
Site 6
S18
P
I
P
F
S
S
S
S
T
H
S
S
H
I
P
Site 7
T19
I
P
F
S
S
S
S
T
H
S
S
H
I
P
P
Site 8
S21
F
S
S
S
S
T
H
S
S
H
I
P
P
W
T
Site 9
S22
S
S
S
S
T
H
S
S
H
I
P
P
W
T
F
Site 10
T28
S
S
H
I
P
P
W
T
F
S
C
Y
P
G
S
Site 11
S35
T
F
S
C
Y
P
G
S
P
C
E
N
G
V
M
Site 12
Y44
C
E
N
G
V
M
L
Y
M
R
N
V
S
H
E
Site 13
S49
M
L
Y
M
R
N
V
S
H
E
E
L
Q
R
F
Site 14
T62
R
F
K
Q
L
L
L
T
E
L
S
T
G
T
M
Site 15
T72
S
T
G
T
M
P
I
T
W
D
Q
V
E
T
A
Site 16
T127
E
I
N
A
I
L
P
T
L
E
P
E
D
L
N
Site 17
Y153
E
S
G
K
I
R
R
Y
K
S
N
V
M
E
K
Site 18
S155
G
K
I
R
R
Y
K
S
N
V
M
E
K
F
F
Site 19
Y179
G
N
Q
R
D
F
F
Y
Q
G
V
H
R
H
E
Site 20
Y188
G
V
H
R
H
E
E
Y
L
P
C
L
L
L
P
Site 21
T205
P
Q
G
R
Q
P
K
T
V
A
I
Q
G
A
P
Site 22
T251
H
C
Q
E
V
N
Q
T
T
D
Q
S
F
S
E
Site 23
S255
V
N
Q
T
T
D
Q
S
F
S
E
L
I
E
Q
Site 24
S267
I
E
Q
K
W
P
G
S
Q
D
L
V
S
K
I
Site 25
S272
P
G
S
Q
D
L
V
S
K
I
M
S
K
P
D
Site 26
S293
D
G
F
E
E
L
T
S
T
L
I
D
R
L
E
Site 27
T294
G
F
E
E
L
T
S
T
L
I
D
R
L
E
D
Site 28
S303
I
D
R
L
E
D
L
S
E
D
W
R
Q
K
L
Site 29
T359
V
T
L
P
G
F
N
T
M
E
K
I
K
Y
F
Site 30
Y369
K
I
K
Y
F
Q
M
Y
F
G
H
T
E
E
G
Site 31
S381
E
E
G
D
Q
V
L
S
F
A
M
E
N
T
I
Site 32
T417
M
E
R
G
N
N
L
T
Q
S
C
P
N
A
T
Site 33
S419
R
G
N
N
L
T
Q
S
C
P
N
A
T
S
V
Site 34
S425
Q
S
C
P
N
A
T
S
V
F
V
R
Y
I
S
Site 35
T437
Y
I
S
S
L
F
P
T
R
A
E
N
F
S
R
Site 36
S443
P
T
R
A
E
N
F
S
R
K
I
H
Q
A
Q
Site 37
S534
L
K
N
F
H
V
L
S
H
V
N
I
Q
R
L
Site 38
S544
N
I
Q
R
L
I
A
S
P
R
G
S
K
S
Y
Site 39
S548
L
I
A
S
P
R
G
S
K
S
Y
L
S
H
M
Site 40
S550
A
S
P
R
G
S
K
S
Y
L
S
H
M
G
L
Site 41
Y551
S
P
R
G
S
K
S
Y
L
S
H
M
G
L
F
Site 42
S553
R
G
S
K
S
Y
L
S
H
M
G
L
F
L
F
Site 43
S580
Q
S
F
Q
C
K
V
S
F
G
N
K
R
K
L
Site 44
S601
L
H
K
C
D
P
P
S
P
G
S
G
V
P
Q
Site 45
S604
C
D
P
P
S
P
G
S
G
V
P
Q
L
F
Y
Site 46
Y611
S
G
V
P
Q
L
F
Y
C
L
H
E
I
R
E
Site 47
S623
I
R
E
E
A
F
V
S
Q
A
L
N
D
Y
H
Site 48
Y654
F
C
L
K
R
C
Q
Y
L
H
E
V
E
L
T
Site 49
S673
F
M
N
V
W
K
L
S
S
S
S
H
P
G
S
Site 50
S674
M
N
V
W
K
L
S
S
S
S
H
P
G
S
E
Site 51
S675
N
V
W
K
L
S
S
S
S
H
P
G
S
E
A
Site 52
S676
V
W
K
L
S
S
S
S
H
P
G
S
E
A
P
Site 53
S680
S
S
S
S
H
P
G
S
E
A
P
E
S
N
G
Site 54
S685
P
G
S
E
A
P
E
S
N
G
L
H
R
W
W
Site 55
T709
N
D
K
L
E
V
L
T
M
T
N
S
V
L
G
Site 56
S744
L
L
L
R
R
V
N
S
T
M
L
N
Q
D
L
Site 57
T745
L
L
R
R
V
N
S
T
M
L
N
Q
D
L
I
Site 58
T756
Q
D
L
I
G
V
L
T
G
N
Q
H
L
R
Y
Site 59
Y763
T
G
N
Q
H
L
R
Y
L
E
I
Q
H
V
E
Site 60
T801
R
L
E
D
C
L
A
T
P
R
I
W
T
D
L
Site 61
T806
L
A
T
P
R
I
W
T
D
L
G
N
N
L
Q
Site 62
T820
Q
G
N
G
H
L
K
T
L
I
L
R
K
N
S
Site 63
S827
T
L
I
L
R
K
N
S
L
E
N
C
G
A
Y
Site 64
S845
V
A
Q
L
E
R
L
S
I
E
N
C
N
L
T
Site 65
T852
S
I
E
N
C
N
L
T
Q
L
T
C
E
S
L
Site 66
S861
L
T
C
E
S
L
A
S
C
L
R
Q
S
K
M
Site 67
T870
L
R
Q
S
K
M
L
T
H
L
S
L
A
E
N
Site 68
S873
S
K
M
L
T
H
L
S
L
A
E
N
A
L
K
Site 69
T925
S
A
L
C
K
N
K
T
L
K
S
L
D
L
S
Site 70
S928
C
K
N
K
T
L
K
S
L
D
L
S
F
N
S
Site 71
S932
T
L
K
S
L
D
L
S
F
N
S
L
K
D
D
Site 72
S935
S
L
D
L
S
F
N
S
L
K
D
D
G
V
I
Site 73
T954
A
L
K
N
P
D
C
T
L
Q
I
L
E
L
E
Site 74
S989
H
L
R
H
L
D
L
S
K
N
A
I
G
V
Y
Site 75
S1006
L
T
L
C
E
A
F
S
S
Q
K
K
R
E
E
Site 76
S1007
T
L
C
E
A
F
S
S
Q
K
K
R
E
E
V
Site 77
T1025
I
P
A
W
T
R
I
T
S
F
S
P
T
P
H
Site 78
S1026
P
A
W
T
R
I
T
S
F
S
P
T
P
H
P
Site 79
S1028
W
T
R
I
T
S
F
S
P
T
P
H
P
P
D
Site 80
T1030
R
I
T
S
F
S
P
T
P
H
P
P
D
F
T
Site 81
S1040
P
P
D
F
T
G
K
S
D
C
L
S
Q
I
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation