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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
THOC6
Full Name:
THO complex subunit 6 homolog
Alias:
WD repeat-containing protein 58
Type:
Mass (Da):
37517
Number AA:
341
UniProt ID:
Q86W42
International Prot ID:
IPI00328985
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S58
F
S
L
S
S
A
L
S
S
E
A
K
E
E
S
Site 2
S59
S
L
S
S
A
L
S
S
E
A
K
E
E
S
K
Site 3
S65
S
S
E
A
K
E
E
S
K
K
P
V
V
T
F
Site 4
Y80
Q
A
H
D
G
P
V
Y
S
M
V
S
T
D
R
Site 5
S81
A
H
D
G
P
V
Y
S
M
V
S
T
D
R
H
Site 6
S84
G
P
V
Y
S
M
V
S
T
D
R
H
L
L
S
Site 7
T85
P
V
Y
S
M
V
S
T
D
R
H
L
L
S
A
Site 8
S91
S
T
D
R
H
L
L
S
A
G
D
G
E
V
K
Site 9
Y120
L
W
R
R
Q
P
P
Y
R
T
S
L
E
V
P
Site 10
S123
R
Q
P
P
Y
R
T
S
L
E
V
P
E
I
N
Site 11
T152
G
G
D
C
Q
L
H
T
M
D
L
E
T
G
T
Site 12
T159
T
M
D
L
E
T
G
T
F
T
R
V
L
R
G
Site 13
T168
T
R
V
L
R
G
H
T
D
Y
I
H
C
L
A
Site 14
S180
C
L
A
L
R
E
R
S
P
E
V
L
S
G
G
Site 15
S185
E
R
S
P
E
V
L
S
G
G
E
D
G
A
V
Site 16
T199
V
R
L
W
D
L
R
T
A
K
E
V
Q
T
I
Site 17
T242
C
G
G
G
P
A
L
T
L
W
H
L
R
S
S
Site 18
S249
T
L
W
H
L
R
S
S
T
P
T
T
I
F
P
Site 19
T252
H
L
R
S
S
T
P
T
T
I
F
P
I
R
A
Site 20
T253
L
R
S
S
T
P
T
T
I
F
P
I
R
A
P
Site 21
T265
R
A
P
Q
K
H
V
T
F
Y
Q
D
L
I
L
Site 22
Y267
P
Q
K
H
V
T
F
Y
Q
D
L
I
L
S
A
Site 23
S297
K
A
Q
V
P
G
S
S
P
G
L
L
S
L
S
Site 24
S302
G
S
S
P
G
L
L
S
L
S
L
N
Q
Q
P
Site 25
S304
S
P
G
L
L
S
L
S
L
N
Q
Q
P
A
A
Site 26
T318
A
P
E
C
K
V
L
T
A
A
G
N
S
C
R
Site 27
T330
S
C
R
V
D
V
F
T
N
L
G
Y
R
A
F
Site 28
Y334
D
V
F
T
N
L
G
Y
R
A
F
S
L
S
F
Site 29
S338
N
L
G
Y
R
A
F
S
L
S
F
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation