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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PARG
Full Name:
Poly(ADP-ribose) glycohydrolase
Alias:
poly (ADP-ribose) glycohydrolase; Poly(ADP-ribose) glycohydrolase: Poly(ADP-ribose) glycohydrolase: Poly(ADP-ribose) glycohydrolase
Type:
EC 3.2.1.143; Hydrolase
Mass (Da):
111110
Number AA:
976
UniProt ID:
Q86W56
International Prot ID:
IPI00759749
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0004649
GO:0004553
GO:0004649
PhosphoSite+
KinaseNET
Biological Process:
GO:0005975
GO:0006974
GO:0009581
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
R
P
R
W
G
A
A
T
T
S
P
A
A
S
D
Site 2
S22
R
W
G
A
A
T
T
S
P
A
A
S
D
A
R
Site 3
S26
A
T
T
S
P
A
A
S
D
A
R
S
F
P
S
Site 4
S30
P
A
A
S
D
A
R
S
F
P
S
R
Q
R
R
Site 5
S33
S
D
A
R
S
F
P
S
R
Q
R
R
V
L
D
Site 6
S54
Q
F
R
V
P
P
S
S
P
A
C
V
P
G
R
Site 7
S68
R
A
G
Q
H
R
G
S
A
T
S
L
V
F
K
Site 8
S71
Q
H
R
G
S
A
T
S
L
V
F
K
Q
K
T
Site 9
T85
T
I
T
S
W
M
D
T
K
G
I
K
T
A
E
Site 10
T90
M
D
T
K
G
I
K
T
A
E
S
E
S
L
D
Site 11
S93
K
G
I
K
T
A
E
S
E
S
L
D
S
K
E
Site 12
S95
I
K
T
A
E
S
E
S
L
D
S
K
E
N
N
Site 13
S98
A
E
S
E
S
L
D
S
K
E
N
N
N
T
R
Site 14
T104
D
S
K
E
N
N
N
T
R
I
E
S
M
M
S
Site 15
S108
N
N
N
T
R
I
E
S
M
M
S
S
V
Q
K
Site 16
S112
R
I
E
S
M
M
S
S
V
Q
K
D
N
F
Y
Site 17
Y119
S
V
Q
K
D
N
F
Y
Q
H
N
V
E
K
L
Site 18
S133
L
E
N
V
S
Q
L
S
L
D
K
S
P
T
E
Site 19
S137
S
Q
L
S
L
D
K
S
P
T
E
K
S
T
Q
Site 20
T139
L
S
L
D
K
S
P
T
E
K
S
T
Q
Y
L
Site 21
S142
D
K
S
P
T
E
K
S
T
Q
Y
L
N
Q
H
Site 22
Y145
P
T
E
K
S
T
Q
Y
L
N
Q
H
Q
T
A
Site 23
T164
W
Q
N
E
G
K
H
T
E
Q
L
L
E
S
E
Site 24
T174
L
L
E
S
E
P
Q
T
V
T
L
V
P
E
Q
Site 25
T176
E
S
E
P
Q
T
V
T
L
V
P
E
Q
F
S
Site 26
S190
S
N
A
N
I
D
R
S
P
Q
N
D
D
H
S
Site 27
S197
S
P
Q
N
D
D
H
S
D
T
D
S
E
E
N
Site 28
T199
Q
N
D
D
H
S
D
T
D
S
E
E
N
R
D
Site 29
S201
D
D
H
S
D
T
D
S
E
E
N
R
D
N
Q
Site 30
S233
E
Q
A
R
E
A
K
S
H
Q
K
C
S
K
S
Site 31
S240
S
H
Q
K
C
S
K
S
C
D
P
G
E
D
C
Site 32
S249
D
P
G
E
D
C
A
S
C
Q
Q
D
E
I
D
Site 33
S261
E
I
D
V
V
P
E
S
P
L
S
D
V
G
S
Site 34
S264
V
V
P
E
S
P
L
S
D
V
G
S
E
D
V
Site 35
S268
S
P
L
S
D
V
G
S
E
D
V
G
T
G
P
Site 36
T273
V
G
S
E
D
V
G
T
G
P
K
N
D
N
K
Site 37
S286
N
K
L
T
R
Q
E
S
C
L
G
N
S
P
P
Site 38
S291
Q
E
S
C
L
G
N
S
P
P
F
E
K
E
S
Site 39
S298
S
P
P
F
E
K
E
S
E
P
E
S
P
M
D
Site 40
S302
E
K
E
S
E
P
E
S
P
M
D
V
D
N
S
Site 41
S309
S
P
M
D
V
D
N
S
K
N
S
C
Q
D
S
Site 42
S312
D
V
D
N
S
K
N
S
C
Q
D
S
E
A
D
Site 43
S316
S
K
N
S
C
Q
D
S
E
A
D
E
E
T
S
Site 44
S323
S
E
A
D
E
E
T
S
P
G
F
D
E
Q
E
Site 45
S334
D
E
Q
E
D
G
S
S
S
Q
T
A
N
K
P
Site 46
S335
E
Q
E
D
G
S
S
S
Q
T
A
N
K
P
S
Site 47
T337
E
D
G
S
S
S
Q
T
A
N
K
P
S
R
F
Site 48
Y357
D
I
E
F
R
K
R
Y
S
T
K
G
G
E
V
Site 49
S358
I
E
F
R
K
R
Y
S
T
K
G
G
E
V
R
Site 50
T359
E
F
R
K
R
Y
S
T
K
G
G
E
V
R
L
Site 51
S391
A
K
L
P
G
N
I
S
S
L
N
V
E
C
R
Site 52
S392
K
L
P
G
N
I
S
S
L
N
V
E
C
R
N
Site 53
S400
L
N
V
E
C
R
N
S
K
Q
H
G
K
K
D
Site 54
T430
R
R
K
E
Q
W
E
T
K
H
Q
R
T
E
R
Site 55
T435
W
E
T
K
H
Q
R
T
E
R
K
I
P
K
Y
Site 56
Y442
T
E
R
K
I
P
K
Y
V
P
P
H
L
S
P
Site 57
S448
K
Y
V
P
P
H
L
S
P
D
K
K
W
L
G
Site 58
T456
P
D
K
K
W
L
G
T
P
I
E
E
M
R
R
Site 59
S477
R
L
P
L
L
R
P
S
A
N
H
T
V
T
I
Site 60
T481
L
R
P
S
A
N
H
T
V
T
I
R
V
D
L
Site 61
T483
P
S
A
N
H
T
V
T
I
R
V
D
L
L
R
Site 62
T500
E
V
P
K
P
F
P
T
H
Y
K
D
L
W
D
Site 63
Y502
P
K
P
F
P
T
H
Y
K
D
L
W
D
N
K
Site 64
Y521
P
C
S
E
Q
N
L
Y
P
V
E
D
E
N
G
Site 65
T541
S
R
W
E
L
I
Q
T
A
L
L
N
K
F
T
Site 66
T548
T
A
L
L
N
K
F
T
R
P
Q
N
L
K
D
Site 67
Y560
L
K
D
A
I
L
K
Y
N
V
A
Y
S
K
K
Site 68
Y590
E
A
E
A
Q
H
L
Y
Q
S
I
L
P
D
M
Site 69
S622
L
K
Q
K
M
N
H
S
I
T
M
S
Q
E
Q
Site 70
S626
M
N
H
S
I
T
M
S
Q
E
Q
I
A
S
L
Site 71
T641
L
A
N
A
F
F
C
T
F
P
R
R
N
A
K
Site 72
S651
R
R
N
A
K
M
K
S
E
Y
S
S
Y
P
D
Site 73
S655
K
M
K
S
E
Y
S
S
Y
P
D
I
N
F
N
Site 74
Y656
M
K
S
E
Y
S
S
Y
P
D
I
N
F
N
R
Site 75
S669
N
R
L
F
E
G
R
S
S
R
K
P
E
K
L
Site 76
S670
R
L
F
E
G
R
S
S
R
K
P
E
K
L
K
Site 77
T678
R
K
P
E
K
L
K
T
L
F
C
Y
F
R
R
Site 78
Y682
K
L
K
T
L
F
C
Y
F
R
R
V
T
E
K
Site 79
T687
F
C
Y
F
R
R
V
T
E
K
K
P
T
G
L
Site 80
T692
R
V
T
E
K
K
P
T
G
L
V
T
F
T
R
Site 81
T696
K
K
P
T
G
L
V
T
F
T
R
Q
S
L
E
Site 82
S701
L
V
T
F
T
R
Q
S
L
E
D
F
P
E
W
Site 83
T716
E
R
C
E
K
P
L
T
R
L
H
V
T
Y
E
Site 84
Y722
L
T
R
L
H
V
T
Y
E
G
T
I
E
E
N
Site 85
T786
E
C
L
I
I
T
G
T
E
Q
Y
S
E
Y
T
Site 86
Y795
Q
Y
S
E
Y
T
G
Y
A
E
T
Y
R
W
S
Site 87
Y799
Y
T
G
Y
A
E
T
Y
R
W
S
R
S
H
E
Site 88
S802
Y
A
E
T
Y
R
W
S
R
S
H
E
D
G
S
Site 89
S804
E
T
Y
R
W
S
R
S
H
E
D
G
S
E
R
Site 90
S809
S
R
S
H
E
D
G
S
E
R
D
D
W
Q
R
Site 91
Y832
D
A
L
H
F
R
R
Y
L
D
Q
F
V
P
E
Site 92
S863
G
V
S
S
E
N
L
S
A
V
A
T
G
N
W
Site 93
Y899
A
A
E
R
D
V
V
Y
F
T
F
G
D
S
E
Site 94
T901
E
R
D
V
V
Y
F
T
F
G
D
S
E
L
M
Site 95
Y912
S
E
L
M
R
D
I
Y
S
M
H
I
F
L
T
Site 96
S913
E
L
M
R
D
I
Y
S
M
H
I
F
L
T
E
Site 97
T919
Y
S
M
H
I
F
L
T
E
R
K
L
T
V
G
Site 98
T924
F
L
T
E
R
K
L
T
V
G
D
V
Y
K
L
Site 99
Y936
Y
K
L
L
L
R
Y
Y
N
E
E
C
R
N
C
Site 100
S944
N
E
E
C
R
N
C
S
T
P
G
P
D
I
K
Site 101
T945
E
E
C
R
N
C
S
T
P
G
P
D
I
K
L
Site 102
T966
A
V
E
S
C
A
E
T
A
D
H
S
G
Q
R
Site 103
S970
C
A
E
T
A
D
H
S
G
Q
R
T
G
T
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation