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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FCHSD1
Full Name:
FCH and double SH3 domains protein 1
Alias:
FCH and double SH3 domains 1; FCSD1; FLJ00007; nervous wreck 2; NWK2
Type:
Adaptor/scaffold
Mass (Da):
76940
Number AA:
UniProt ID:
Q86WN1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
L
R
F
L
E
Q
L
S
I
L
Q
T
W
Q
Q
Site 2
T27
E
Q
L
S
I
L
Q
T
W
Q
Q
R
E
A
D
Site 3
S41
D
L
L
E
D
I
R
S
Y
S
K
Q
R
A
A
Site 4
Y42
L
L
E
D
I
R
S
Y
S
K
Q
R
A
A
I
Site 5
S43
L
E
D
I
R
S
Y
S
K
Q
R
A
A
I
E
Site 6
Y53
R
A
A
I
E
R
E
Y
G
Q
A
L
Q
K
L
Site 7
S72
L
K
R
E
G
H
R
S
G
E
M
D
S
R
G
Site 8
S77
H
R
S
G
E
M
D
S
R
G
R
T
V
F
G
Site 9
T81
E
M
D
S
R
G
R
T
V
F
G
A
W
R
C
Site 10
T93
W
R
C
L
L
D
A
T
V
A
G
G
Q
T
R
Site 11
S104
G
Q
T
R
L
Q
A
S
D
R
Y
R
D
L
A
Site 12
Y107
R
L
Q
A
S
D
R
Y
R
D
L
A
G
G
T
Site 13
T127
E
Q
V
L
R
K
G
T
E
N
L
Q
R
A
Q
Site 14
S140
A
Q
A
E
V
L
Q
S
V
R
E
L
S
R
S
Site 15
S145
L
Q
S
V
R
E
L
S
R
S
R
K
L
Y
G
Site 16
S147
S
V
R
E
L
S
R
S
R
K
L
Y
G
Q
R
Site 17
Y151
L
S
R
S
R
K
L
Y
G
Q
R
E
R
V
W
Site 18
S175
V
Q
A
R
L
N
R
S
D
H
G
I
F
H
S
Site 19
S182
S
D
H
G
I
F
H
S
R
T
S
L
Q
K
L
Site 20
T184
H
G
I
F
H
S
R
T
S
L
Q
K
L
S
T
Site 21
S185
G
I
F
H
S
R
T
S
L
Q
K
L
S
T
K
Site 22
S190
R
T
S
L
Q
K
L
S
T
K
L
S
A
Q
S
Site 23
S194
Q
K
L
S
T
K
L
S
A
Q
S
A
Q
Y
S
Site 24
S201
S
A
Q
S
A
Q
Y
S
Q
Q
L
Q
A
A
R
Site 25
Y225
T
N
A
H
L
D
H
Y
Y
Q
E
E
L
P
A
Site 26
Y226
N
A
H
L
D
H
Y
Y
Q
E
E
L
P
A
L
Site 27
S239
A
L
L
K
A
L
V
S
E
L
S
E
H
L
R
Site 28
S242
K
A
L
V
S
E
L
S
E
H
L
R
D
P
L
Site 29
T250
E
H
L
R
D
P
L
T
S
L
S
H
T
E
L
Site 30
S251
H
L
R
D
P
L
T
S
L
S
H
T
E
L
E
Site 31
S253
R
D
P
L
T
S
L
S
H
T
E
L
E
A
A
Site 32
T255
P
L
T
S
L
S
H
T
E
L
E
A
A
E
V
Site 33
T274
A
H
R
G
E
Q
T
T
S
Q
V
S
W
E
Q
Site 34
S275
H
R
G
E
Q
T
T
S
Q
V
S
W
E
Q
D
Site 35
S294
L
Q
E
P
G
V
F
S
P
T
P
P
Q
Q
F
Site 36
T296
E
P
G
V
F
S
P
T
P
P
Q
Q
F
Q
P
Site 37
T333
E
K
E
V
Q
R
L
T
S
R
A
A
R
D
Y
Site 38
S334
K
E
V
Q
R
L
T
S
R
A
A
R
D
Y
K
Site 39
Y340
T
S
R
A
A
R
D
Y
K
I
Q
N
H
G
H
Site 40
S361
E
Q
R
R
Q
Q
A
S
E
R
E
A
P
S
I
Site 41
S378
R
L
Q
E
V
R
E
S
I
R
R
A
Q
V
S
Site 42
S385
S
I
R
R
A
Q
V
S
Q
V
K
G
A
A
R
Site 43
S425
V
E
Q
E
R
R
L
S
E
A
R
L
S
Q
R
Site 44
S430
R
L
S
E
A
R
L
S
Q
R
D
L
S
P
T
Site 45
S435
R
L
S
Q
R
D
L
S
P
T
A
E
D
A
E
Site 46
T437
S
Q
R
D
L
S
P
T
A
E
D
A
E
L
S
Site 47
S444
T
A
E
D
A
E
L
S
D
F
E
E
C
E
E
Site 48
T452
D
F
E
E
C
E
E
T
G
E
L
F
E
E
P
Site 49
Y479
P
A
H
V
V
F
R
Y
Q
A
G
R
E
D
E
Site 50
T488
A
G
R
E
D
E
L
T
I
T
E
G
E
W
L
Site 51
T490
R
E
D
E
L
T
I
T
E
G
E
W
L
E
V
Site 52
Y523
V
G
F
V
P
E
R
Y
L
N
F
P
D
L
S
Site 53
S530
Y
L
N
F
P
D
L
S
L
P
E
S
S
Q
D
Site 54
S534
P
D
L
S
L
P
E
S
S
Q
D
S
D
N
P
Site 55
S535
D
L
S
L
P
E
S
S
Q
D
S
D
N
P
C
Site 56
S538
L
P
E
S
S
Q
D
S
D
N
P
C
G
A
E
Site 57
S556
F
L
A
Q
A
L
Y
S
Y
T
G
Q
S
A
E
Site 58
S566
G
Q
S
A
E
E
L
S
F
P
E
G
A
L
I
Site 59
S617
P
P
G
P
P
E
L
S
D
P
E
Q
M
L
P
Site 60
S625
D
P
E
Q
M
L
P
S
P
S
P
P
S
F
S
Site 61
S627
E
Q
M
L
P
S
P
S
P
P
S
F
S
P
P
Site 62
S630
L
P
S
P
S
P
P
S
F
S
P
P
A
P
T
Site 63
S632
S
P
S
P
P
S
F
S
P
P
A
P
T
S
V
Site 64
S638
F
S
P
P
A
P
T
S
V
L
D
G
P
P
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation