KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ZNF227
Full Name:
Zinc finger protein 227
Alias:
Type:
Mass (Da):
92033
Number AA:
799
UniProt ID:
Q86WZ6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T43
E
L
R
L
L
D
L
T
Q
R
K
L
Y
R
D
Site 2
Y48
D
L
T
Q
R
K
L
Y
R
D
V
M
V
E
N
Site 3
S73
P
F
Q
P
D
M
V
S
Q
L
E
A
E
E
K
Site 4
T86
E
K
L
W
M
M
E
T
E
T
Q
R
S
S
K
Site 5
T88
L
W
M
M
E
T
E
T
Q
R
S
S
K
H
Q
Site 6
S92
E
T
E
T
Q
R
S
S
K
H
Q
N
K
M
E
Site 7
Y108
L
Q
K
F
A
L
K
Y
L
S
N
Q
E
L
S
Site 8
S110
K
F
A
L
K
Y
L
S
N
Q
E
L
S
C
W
Site 9
S136
R
C
L
Q
G
K
S
S
Q
L
L
Q
G
D
S
Site 10
S143
S
Q
L
L
Q
G
D
S
I
Q
V
S
E
N
E
Site 11
S147
Q
G
D
S
I
Q
V
S
E
N
E
N
N
I
M
Site 12
S161
M
N
P
K
G
D
S
S
I
Y
I
E
N
Q
E
Site 13
Y163
P
K
G
D
S
S
I
Y
I
E
N
Q
E
F
P
Site 14
T181
T
Q
H
S
C
G
N
T
Y
L
S
E
S
Q
I
Site 15
Y182
Q
H
S
C
G
N
T
Y
L
S
E
S
Q
I
Q
Site 16
S184
S
C
G
N
T
Y
L
S
E
S
Q
I
Q
S
R
Site 17
S186
G
N
T
Y
L
S
E
S
Q
I
Q
S
R
G
K
Site 18
S190
L
S
E
S
Q
I
Q
S
R
G
K
Q
I
D
V
Site 19
T219
P
F
H
E
H
I
K
T
D
T
E
P
K
P
C
Site 20
T221
H
E
H
I
K
T
D
T
E
P
K
P
C
K
G
Site 21
Y231
K
P
C
K
G
N
E
Y
G
K
I
I
S
D
G
Site 22
S239
G
K
I
I
S
D
G
S
N
Q
K
L
P
L
G
Site 23
S260
G
E
C
G
R
G
F
S
Y
S
P
R
L
P
L
Site 24
Y261
E
C
G
R
G
F
S
Y
S
P
R
L
P
L
H
Site 25
S262
C
G
R
G
F
S
Y
S
P
R
L
P
L
H
P
Site 26
S279
H
T
G
E
K
C
F
S
Q
S
S
H
L
R
T
Site 27
S281
G
E
K
C
F
S
Q
S
S
H
L
R
T
H
Q
Site 28
S282
E
K
C
F
S
Q
S
S
H
L
R
T
H
Q
R
Site 29
T286
S
Q
S
S
H
L
R
T
H
Q
R
I
H
P
G
Site 30
S309
S
G
D
C
F
N
K
S
S
F
H
S
Y
Q
S
Site 31
S313
F
N
K
S
S
F
H
S
Y
Q
S
N
H
T
G
Site 32
Y314
N
K
S
S
F
H
S
Y
Q
S
N
H
T
G
E
Site 33
S316
S
S
F
H
S
Y
Q
S
N
H
T
G
E
K
S
Site 34
Y324
N
H
T
G
E
K
S
Y
R
C
D
S
C
G
K
Site 35
S328
E
K
S
Y
R
C
D
S
C
G
K
G
F
S
S
Site 36
Y343
S
T
G
L
I
I
H
Y
R
T
H
T
G
E
K
Site 37
T345
G
L
I
I
H
Y
R
T
H
T
G
E
K
P
Y
Site 38
T347
I
I
H
Y
R
T
H
T
G
E
K
P
Y
K
C
Site 39
T375
Q
C
H
Q
R
V
H
T
E
E
K
P
Y
K
C
Site 40
Y380
V
H
T
E
E
K
P
Y
K
C
E
E
C
G
K
Site 41
Y408
V
H
R
G
E
K
P
Y
K
C
E
E
C
G
K
Site 42
T431
H
I
H
Q
R
V
H
T
G
E
K
P
Y
K
C
Site 43
Y436
V
H
T
G
E
K
P
Y
K
C
D
V
C
G
K
Site 44
S449
G
K
G
F
S
H
N
S
P
L
I
C
H
R
R
Site 45
T459
I
C
H
R
R
V
H
T
G
E
K
P
Y
K
C
Site 46
T487
H
I
H
F
R
V
H
T
G
E
K
P
Y
K
C
Site 47
Y492
V
H
T
G
E
K
P
Y
K
C
K
E
C
G
K
Site 48
S502
K
E
C
G
K
G
F
S
Q
A
S
N
L
Q
V
Site 49
T524
E
K
R
F
K
C
E
T
C
G
K
G
F
S
Q
Site 50
S530
E
T
C
G
K
G
F
S
Q
S
S
K
L
Q
T
Site 51
S532
C
G
K
G
F
S
Q
S
S
K
L
Q
T
H
Q
Site 52
T537
S
Q
S
S
K
L
Q
T
H
Q
R
V
H
T
G
Site 53
T543
Q
T
H
Q
R
V
H
T
G
E
K
P
Y
R
C
Site 54
S558
D
V
C
G
K
D
F
S
Y
S
S
N
L
K
L
Site 55
Y559
V
C
G
K
D
F
S
Y
S
S
N
L
K
L
H
Site 56
S560
C
G
K
D
F
S
Y
S
S
N
L
K
L
H
Q
Site 57
S561
G
K
D
F
S
Y
S
S
N
L
K
L
H
Q
V
Site 58
T571
K
L
H
Q
V
I
H
T
G
E
K
P
Y
K
C
Site 59
S586
E
E
C
G
K
G
F
S
W
R
S
N
L
H
A
Site 60
S589
G
K
G
F
S
W
R
S
N
L
H
A
H
Q
R
Site 61
S599
H
A
H
Q
R
V
H
S
G
E
K
P
Y
K
C
Site 62
S614
E
Q
C
D
K
S
F
S
Q
A
I
D
F
R
V
Site 63
T627
R
V
H
Q
R
V
H
T
G
E
K
P
Y
K
C
Site 64
Y632
V
H
T
G
E
K
P
Y
K
C
G
V
C
G
K
Site 65
S642
G
V
C
G
K
G
F
S
Q
S
S
G
L
Q
S
Site 66
S644
C
G
K
G
F
S
Q
S
S
G
L
Q
S
H
Q
Site 67
S649
S
Q
S
S
G
L
Q
S
H
Q
R
V
H
T
G
Site 68
T655
Q
S
H
Q
R
V
H
T
G
E
K
P
Y
K
C
Site 69
Y671
V
C
G
K
G
F
R
Y
S
S
Q
F
I
Y
H
Site 70
S673
G
K
G
F
R
Y
S
S
Q
F
I
Y
H
Q
R
Site 71
Y677
R
Y
S
S
Q
F
I
Y
H
Q
R
G
H
T
G
Site 72
T683
I
Y
H
Q
R
G
H
T
G
E
K
P
Y
K
C
Site 73
Y688
G
H
T
G
E
K
P
Y
K
C
E
E
C
G
K
Site 74
S700
C
G
K
G
F
G
R
S
L
N
L
R
H
H
Q
Site 75
T711
R
H
H
Q
R
V
H
T
G
E
K
P
H
I
C
Site 76
S726
E
E
C
G
K
A
F
S
L
P
S
N
L
R
V
Site 77
S729
G
K
A
F
S
L
P
S
N
L
R
V
H
L
G
Site 78
S754
E
E
C
G
K
G
F
S
Q
S
A
R
L
E
A
Site 79
S756
C
G
K
G
F
S
Q
S
A
R
L
E
A
H
Q
Site 80
T767
E
A
H
Q
R
V
H
T
G
E
K
P
Y
K
C
Site 81
S785
D
K
D
F
R
H
R
S
R
L
T
Y
H
Q
K
Site 82
T788
F
R
H
R
S
R
L
T
Y
H
Q
K
V
H
T
Site 83
Y789
R
H
R
S
R
L
T
Y
H
Q
K
V
H
T
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation