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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RALGPS2
Full Name:
Ras-specific guanine nucleotide-releasing factor RalGPS2
Alias:
FLJ10244; FLJ25604; KIAA0351; Ral GEF with PH domain and SH3 binding motif 2; Ral GEF with PH domain and SH3-binding motif 2; RalA exchange factor RalGPS2
Type:
Guanine nucleotide exchange factor, Ras
Mass (Da):
65167
Number AA:
583
UniProt ID:
Q86X27
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005085
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007264
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
S
S
V
N
I
A
A
T
A
S
E
K
S
S
S
Site 2
S18
V
N
I
A
A
T
A
S
E
K
S
S
S
S
E
Site 3
S21
A
A
T
A
S
E
K
S
S
S
S
E
S
L
S
Site 4
S22
A
T
A
S
E
K
S
S
S
S
E
S
L
S
D
Site 5
S23
T
A
S
E
K
S
S
S
S
E
S
L
S
D
K
Site 6
S24
A
S
E
K
S
S
S
S
E
S
L
S
D
K
G
Site 7
S26
E
K
S
S
S
S
E
S
L
S
D
K
G
S
E
Site 8
S28
S
S
S
S
E
S
L
S
D
K
G
S
E
L
K
Site 9
S32
E
S
L
S
D
K
G
S
E
L
K
K
S
F
D
Site 10
S37
K
G
S
E
L
K
K
S
F
D
A
V
V
F
D
Site 11
T49
V
F
D
V
L
K
V
T
P
E
E
Y
A
G
Q
Site 12
S74
A
I
Q
P
D
E
L
S
S
C
G
W
N
K
K
Site 13
Y84
G
W
N
K
K
E
K
Y
S
S
A
P
N
A
V
Site 14
S86
N
K
K
E
K
Y
S
S
A
P
N
A
V
A
F
Site 15
S122
K
I
R
A
E
V
L
S
H
Y
I
K
T
A
K
Site 16
Y124
R
A
E
V
L
S
H
Y
I
K
T
A
K
K
L
Site 17
Y132
I
K
T
A
K
K
L
Y
E
L
N
N
L
H
A
Site 18
T158
P
I
F
R
L
T
K
T
W
A
L
L
S
R
K
Site 19
S163
T
K
T
W
A
L
L
S
R
K
D
K
T
T
F
Site 20
T168
L
L
S
R
K
D
K
T
T
F
E
K
L
E
Y
Site 21
T169
L
S
R
K
D
K
T
T
F
E
K
L
E
Y
V
Site 22
Y175
T
T
F
E
K
L
E
Y
V
M
S
K
E
D
N
Site 23
S178
E
K
L
E
Y
V
M
S
K
E
D
N
Y
K
R
Site 24
Y183
V
M
S
K
E
D
N
Y
K
R
L
R
D
Y
I
Site 25
Y189
N
Y
K
R
L
R
D
Y
I
S
S
L
K
M
T
Site 26
S191
K
R
L
R
D
Y
I
S
S
L
K
M
T
P
C
Site 27
S192
R
L
R
D
Y
I
S
S
L
K
M
T
P
C
I
Site 28
Y211
I
Y
L
S
D
L
T
Y
I
D
S
A
Y
P
S
Site 29
S214
S
D
L
T
Y
I
D
S
A
Y
P
S
T
G
S
Site 30
S218
Y
I
D
S
A
Y
P
S
T
G
S
I
L
E
N
Site 31
S240
N
N
I
L
R
I
I
S
D
L
Q
Q
S
C
E
Site 32
Y248
D
L
Q
Q
S
C
E
Y
D
I
P
M
L
P
H
Site 33
Y259
M
L
P
H
V
Q
K
Y
L
N
S
V
Q
Y
I
Site 34
Y265
K
Y
L
N
S
V
Q
Y
I
E
E
L
Q
K
F
Site 35
Y278
K
F
V
E
D
D
N
Y
K
L
S
L
K
I
E
Site 36
S281
E
D
D
N
Y
K
L
S
L
K
I
E
P
G
T
Site 37
T288
S
L
K
I
E
P
G
T
S
T
P
R
S
A
A
Site 38
S289
L
K
I
E
P
G
T
S
T
P
R
S
A
A
S
Site 39
T290
K
I
E
P
G
T
S
T
P
R
S
A
A
S
R
Site 40
S293
P
G
T
S
T
P
R
S
A
A
S
R
E
D
L
Site 41
S296
S
T
P
R
S
A
A
S
R
E
D
L
V
G
P
Site 42
S308
V
G
P
E
V
G
A
S
P
Q
S
G
R
K
S
Site 43
S311
E
V
G
A
S
P
Q
S
G
R
K
S
V
A
A
Site 44
S315
S
P
Q
S
G
R
K
S
V
A
A
E
G
A
L
Site 45
T326
E
G
A
L
L
P
Q
T
P
P
S
P
R
N
L
Site 46
S329
L
L
P
Q
T
P
P
S
P
R
N
L
I
P
H
Site 47
S343
H
G
H
R
K
C
H
S
L
G
Y
N
F
I
H
Site 48
T354
N
F
I
H
K
M
N
T
A
E
F
K
S
A
T
Site 49
S359
M
N
T
A
E
F
K
S
A
T
F
P
N
A
G
Site 50
T361
T
A
E
F
K
S
A
T
F
P
N
A
G
P
R
Site 51
S374
P
R
H
L
L
D
D
S
V
M
E
P
H
A
P
Site 52
S388
P
S
R
G
Q
A
E
S
S
T
L
S
S
G
I
Site 53
S389
S
R
G
Q
A
E
S
S
T
L
S
S
G
I
S
Site 54
T390
R
G
Q
A
E
S
S
T
L
S
S
G
I
S
I
Site 55
S392
Q
A
E
S
S
T
L
S
S
G
I
S
I
G
S
Site 56
S393
A
E
S
S
T
L
S
S
G
I
S
I
G
S
S
Site 57
S396
S
T
L
S
S
G
I
S
I
G
S
S
D
G
S
Site 58
S399
S
S
G
I
S
I
G
S
S
D
G
S
E
L
S
Site 59
S400
S
G
I
S
I
G
S
S
D
G
S
E
L
S
E
Site 60
S403
S
I
G
S
S
D
G
S
E
L
S
E
E
T
S
Site 61
S406
S
S
D
G
S
E
L
S
E
E
T
S
W
P
A
Site 62
S410
S
E
L
S
E
E
T
S
W
P
A
F
E
R
N
Site 63
Y420
A
F
E
R
N
R
L
Y
H
S
L
G
P
V
T
Site 64
S422
E
R
N
R
L
Y
H
S
L
G
P
V
T
R
V
Site 65
Y434
T
R
V
A
R
N
G
Y
R
S
H
M
K
A
S
Site 66
S436
V
A
R
N
G
Y
R
S
H
M
K
A
S
S
S
Site 67
S441
Y
R
S
H
M
K
A
S
S
S
A
E
S
E
D
Site 68
S442
R
S
H
M
K
A
S
S
S
A
E
S
E
D
L
Site 69
S443
S
H
M
K
A
S
S
S
A
E
S
E
D
L
A
Site 70
S446
K
A
S
S
S
A
E
S
E
D
L
A
V
H
L
Site 71
T468
Q
G
V
L
R
R
K
T
L
L
K
E
G
K
K
Site 72
T477
L
K
E
G
K
K
P
T
V
A
S
W
T
K
Y
Site 73
S500
L
F
Y
Y
A
A
K
S
L
K
A
T
E
R
K
Site 74
T504
A
A
K
S
L
K
A
T
E
R
K
H
F
K
S
Site 75
S511
T
E
R
K
H
F
K
S
T
S
N
K
N
V
S
Site 76
S513
R
K
H
F
K
S
T
S
N
K
N
V
S
V
I
Site 77
T539
H
P
D
L
F
L
L
T
D
S
E
K
G
N
S
Site 78
S541
D
L
F
L
L
T
D
S
E
K
G
N
S
Y
K
Site 79
Y547
D
S
E
K
G
N
S
Y
K
F
Q
A
G
N
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation