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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDX42
Full Name:
ATP-dependent RNA helicase DDX42
Alias:
DEAD box protein 42; RHELP; RNA helicase-like protein; RNA helicase-related protein; RNAHP; SF3b125; Splicing factor 3B-associated 125 kDa protein
Type:
Enzyme - Helicase
Mass (Da):
102975
Number AA:
938
UniProt ID:
Q86XP3
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015030
GO:0016607
GO:0016607
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
W
N
K
G
G
P
G
T
K
R
G
F
G
F
G
Site 2
S22
G
F
G
G
F
A
I
S
A
G
K
K
E
E
P
Site 3
S35
E
P
K
L
P
Q
Q
S
H
S
A
F
G
A
T
Site 4
S37
K
L
P
Q
Q
S
H
S
A
F
G
A
T
S
S
Site 5
T42
S
H
S
A
F
G
A
T
S
S
S
S
G
F
G
Site 6
S43
H
S
A
F
G
A
T
S
S
S
S
G
F
G
K
Site 7
S44
S
A
F
G
A
T
S
S
S
S
G
F
G
K
S
Site 8
S45
A
F
G
A
T
S
S
S
S
G
F
G
K
S
A
Site 9
S46
F
G
A
T
S
S
S
S
G
F
G
K
S
A
P
Site 10
S51
S
S
S
G
F
G
K
S
A
P
P
Q
L
P
S
Site 11
S58
S
A
P
P
Q
L
P
S
F
Y
K
I
G
S
K
Site 12
Y60
P
P
Q
L
P
S
F
Y
K
I
G
S
K
R
A
Site 13
S64
P
S
F
Y
K
I
G
S
K
R
A
N
F
D
E
Site 14
Y75
N
F
D
E
E
N
A
Y
F
E
D
E
E
E
D
Site 15
S83
F
E
D
E
E
E
D
S
S
N
V
D
L
P
Y
Site 16
S84
E
D
E
E
E
D
S
S
N
V
D
L
P
Y
I
Site 17
Y90
S
S
N
V
D
L
P
Y
I
P
A
E
N
S
P
Site 18
S96
P
Y
I
P
A
E
N
S
P
T
R
Q
Q
F
H
Site 19
T98
I
P
A
E
N
S
P
T
R
Q
Q
F
H
S
K
Site 20
S104
P
T
R
Q
Q
F
H
S
K
P
V
D
S
D
S
Site 21
S109
F
H
S
K
P
V
D
S
D
S
D
D
D
P
L
Site 22
S111
S
K
P
V
D
S
D
S
D
D
D
P
L
E
A
Site 23
Y160
E
E
D
D
Q
E
A
Y
F
R
Y
M
A
E
N
Site 24
Y183
E
E
E
D
N
L
E
Y
D
S
D
G
N
P
I
Site 25
S185
E
D
N
L
E
Y
D
S
D
G
N
P
I
A
P
Site 26
T193
D
G
N
P
I
A
P
T
K
K
I
I
D
P
L
Site 27
S206
P
L
P
P
I
D
H
S
E
I
D
Y
P
P
F
Site 28
Y210
I
D
H
S
E
I
D
Y
P
P
F
E
K
N
F
Site 29
Y218
P
P
F
E
K
N
F
Y
N
E
H
E
E
I
T
Site 30
T228
H
E
E
I
T
N
L
T
P
Q
Q
L
I
D
L
Site 31
S244
H
K
L
N
L
R
V
S
G
A
A
P
P
R
P
Site 32
S253
A
A
P
P
R
P
G
S
S
F
A
H
F
G
F
Site 33
S254
A
P
P
R
P
G
S
S
F
A
H
F
G
F
D
Site 34
S271
L
M
H
Q
I
R
K
S
E
Y
T
Q
P
T
P
Site 35
Y273
H
Q
I
R
K
S
E
Y
T
Q
P
T
P
I
Q
Site 36
T274
Q
I
R
K
S
E
Y
T
Q
P
T
P
I
Q
C
Site 37
T277
K
S
E
Y
T
Q
P
T
P
I
Q
C
Q
G
V
Site 38
Y353
C
K
R
F
G
K
A
Y
N
L
R
S
V
A
V
Site 39
S357
G
K
A
Y
N
L
R
S
V
A
V
Y
G
G
G
Site 40
Y361
N
L
R
S
V
A
V
Y
G
G
G
S
M
W
E
Site 41
S402
A
T
N
L
Q
R
V
S
Y
L
V
F
D
E
A
Site 42
Y403
T
N
L
Q
R
V
S
Y
L
V
F
D
E
A
D
Site 43
Y419
M
F
D
M
G
F
E
Y
Q
V
R
S
I
A
S
Site 44
S423
G
F
E
Y
Q
V
R
S
I
A
S
H
V
R
P
Site 45
T434
H
V
R
P
D
R
Q
T
L
L
F
S
A
T
F
Site 46
T440
Q
T
L
L
F
S
A
T
F
R
K
K
I
E
K
Site 47
T472
G
E
A
N
E
D
V
T
Q
I
V
E
I
L
H
Site 48
S535
L
H
G
D
M
D
Q
S
E
R
N
K
V
I
S
Site 49
S542
S
E
R
N
K
V
I
S
D
F
K
K
K
D
I
Site 50
T555
D
I
P
V
L
V
A
T
D
V
A
A
R
G
L
Site 51
Y573
S
I
K
T
V
I
N
Y
D
V
A
R
D
I
D
Site 52
T581
D
V
A
R
D
I
D
T
H
T
H
R
I
G
R
Site 53
T583
A
R
D
I
D
T
H
T
H
R
I
G
R
T
G
Site 54
Y599
A
G
E
K
G
V
A
Y
T
L
L
T
P
K
D
Site 55
S641
Q
N
A
W
F
R
K
S
R
F
K
G
G
K
G
Site 56
Y660
I
G
G
G
G
L
G
Y
R
E
R
P
G
L
G
Site 57
S668
R
E
R
P
G
L
G
S
E
N
M
D
R
G
N
Site 58
Y682
N
N
N
V
M
S
N
Y
E
A
Y
K
P
S
T
Site 59
Y707
K
A
A
F
Q
S
Q
Y
K
S
H
F
V
A
A
Site 60
S709
A
F
Q
S
Q
Y
K
S
H
F
V
A
A
S
L
Site 61
S715
K
S
H
F
V
A
A
S
L
S
N
Q
K
A
G
Site 62
S717
H
F
V
A
A
S
L
S
N
Q
K
A
G
S
S
Site 63
S723
L
S
N
Q
K
A
G
S
S
A
A
G
A
S
G
Site 64
S729
G
S
S
A
A
G
A
S
G
W
T
S
A
G
S
Site 65
S736
S
G
W
T
S
A
G
S
L
N
S
V
P
T
N
Site 66
S739
T
S
A
G
S
L
N
S
V
P
T
N
S
A
Q
Site 67
S744
L
N
S
V
P
T
N
S
A
Q
Q
G
H
N
S
Site 68
S751
S
A
Q
Q
G
H
N
S
P
D
S
P
V
T
S
Site 69
S754
Q
G
H
N
S
P
D
S
P
V
T
S
A
A
K
Site 70
T757
N
S
P
D
S
P
V
T
S
A
A
K
G
I
P
Site 71
S758
S
P
D
S
P
V
T
S
A
A
K
G
I
P
G
Site 72
T769
G
I
P
G
F
G
N
T
G
N
I
S
G
A
P
Site 73
S773
F
G
N
T
G
N
I
S
G
A
P
V
T
Y
P
Site 74
T778
N
I
S
G
A
P
V
T
Y
P
S
A
G
A
Q
Site 75
S781
G
A
P
V
T
Y
P
S
A
G
A
Q
G
V
N
Site 76
S792
Q
G
V
N
N
T
A
S
G
N
N
S
R
E
G
Site 77
S796
N
T
A
S
G
N
N
S
R
E
G
T
G
G
S
Site 78
T800
G
N
N
S
R
E
G
T
G
G
S
N
G
K
R
Site 79
S803
S
R
E
G
T
G
G
S
N
G
K
R
E
R
Y
Site 80
Y810
S
N
G
K
R
E
R
Y
T
E
N
R
G
S
S
Site 81
T811
N
G
K
R
E
R
Y
T
E
N
R
G
S
S
R
Site 82
S816
R
Y
T
E
N
R
G
S
S
R
H
S
H
G
E
Site 83
S817
Y
T
E
N
R
G
S
S
R
H
S
H
G
E
T
Site 84
S820
N
R
G
S
S
R
H
S
H
G
E
T
G
N
R
Site 85
T824
S
R
H
S
H
G
E
T
G
N
R
H
S
D
S
Site 86
S829
G
E
T
G
N
R
H
S
D
S
P
R
H
G
D
Site 87
S831
T
G
N
R
H
S
D
S
P
R
H
G
D
G
G
Site 88
Y844
G
G
R
H
G
D
G
Y
R
H
P
E
S
S
S
Site 89
S849
D
G
Y
R
H
P
E
S
S
S
R
H
T
D
G
Site 90
S850
G
Y
R
H
P
E
S
S
S
R
H
T
D
G
H
Site 91
T854
P
E
S
S
S
R
H
T
D
G
H
R
H
G
E
Site 92
S867
G
E
N
R
H
G
G
S
A
G
R
H
G
E
N
Site 93
S894
K
E
A
F
N
R
E
S
K
M
E
P
K
M
E
Site 94
S914
S
K
M
D
K
V
D
S
K
T
D
K
T
A
D
Site 95
T916
M
D
K
V
D
S
K
T
D
K
T
A
D
G
F
Site 96
S934
E
P
P
K
R
K
K
S
R
W
D
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation