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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRIM50
Full Name:
E3 ubiquitin-protein ligase TRIM50
Alias:
Tripartite motif-containing protein 50
Type:
Mass (Da):
54774
Number AA:
487
UniProt ID:
Q86XT4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S64
R
Q
A
V
D
G
S
S
S
L
P
N
V
S
L
Site 2
S97
V
H
H
R
N
P
L
S
L
F
C
E
K
D
Q
Site 3
S116
G
L
C
G
L
L
G
S
H
Q
H
H
P
V
T
Site 4
T123
S
H
Q
H
H
P
V
T
P
V
S
T
V
Y
S
Site 5
S126
H
H
P
V
T
P
V
S
T
V
Y
S
R
M
K
Site 6
Y129
V
T
P
V
S
T
V
Y
S
R
M
K
E
E
L
Site 7
S130
T
P
V
S
T
V
Y
S
R
M
K
E
E
L
A
Site 8
S168
R
T
R
I
V
N
E
S
D
V
F
S
W
V
I
Site 9
S172
V
N
E
S
D
V
F
S
W
V
I
R
R
E
F
Site 10
S207
H
T
R
G
L
V
A
S
L
D
M
Q
L
E
Q
Site 11
S246
K
F
I
R
K
F
H
S
M
A
S
R
A
E
M
Site 12
S264
R
P
L
E
G
A
F
S
P
I
S
F
K
P
G
Site 13
S267
E
G
A
F
S
P
I
S
F
K
P
G
L
H
Q
Site 14
T280
H
Q
A
D
I
K
L
T
V
W
K
R
L
F
R
Site 15
S327
L
L
A
Q
R
R
A
S
Q
P
E
R
F
D
Y
Site 16
Y334
S
Q
P
E
R
F
D
Y
S
T
C
V
L
A
S
Site 17
S335
Q
P
E
R
F
D
Y
S
T
C
V
L
A
S
R
Site 18
T336
P
E
R
F
D
Y
S
T
C
V
L
A
S
R
G
Site 19
S345
V
L
A
S
R
G
F
S
C
G
R
H
Y
W
E
Site 20
Y350
G
F
S
C
G
R
H
Y
W
E
V
V
V
G
S
Site 21
T369
R
L
G
V
I
K
G
T
A
S
R
K
G
K
L
Site 22
S371
G
V
I
K
G
T
A
S
R
K
G
K
L
N
R
Site 23
S379
R
K
G
K
L
N
R
S
P
E
H
G
V
W
L
Site 24
Y395
G
L
K
E
G
R
V
Y
E
A
F
A
C
P
R
Site 25
Y417
H
P
H
R
I
G
L
Y
L
H
Y
E
Q
G
E
Site 26
Y420
R
I
G
L
Y
L
H
Y
E
Q
G
E
L
T
F
Site 27
T426
H
Y
E
Q
G
E
L
T
F
F
D
A
D
R
P
Site 28
Y440
P
D
D
L
R
P
L
Y
T
F
Q
A
D
F
Q
Site 29
T441
D
D
L
R
P
L
Y
T
F
Q
A
D
F
Q
G
Site 30
Y451
A
D
F
Q
G
K
L
Y
P
I
L
D
T
C
W
Site 31
S465
W
H
E
R
G
S
N
S
L
P
M
V
L
P
P
Site 32
S474
P
M
V
L
P
P
P
S
G
P
G
P
L
S
P
Site 33
S480
P
S
G
P
G
P
L
S
P
E
Q
P
T
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation