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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DZIP3
Full Name:
E3 ubiquitin-protein ligase DZIP3
Alias:
DAZ interacting protein 3, zinc finger; DAZ-interacting protein 3; hRUL138; RNA-binding ubiquitin ligase of 138 kDa; ubiquitin ligase protein DZIP3; UURF2; UURF2 ubiquitin ligase; zinc finger DAZ interacting protein 3
Type:
RNA binding protein; Ligase; EC 6.3.2.-; Ubiquitin conjugating system
Mass (Da):
138600
Number AA:
UniProt ID:
Q86Y13
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0031593
GO:0004842
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0000209
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S81
K
F
L
Q
E
D
F
S
F
Q
T
M
Q
R
E
Site 2
S93
Q
R
E
V
A
A
N
S
Q
N
G
E
E
I
V
Site 3
Y124
R
N
I
Q
A
G
N
Y
T
A
H
Q
I
N
I
Site 4
Y141
Y
L
T
L
L
F
L
Y
G
V
A
L
T
E
R
Site 5
T146
F
L
Y
G
V
A
L
T
E
R
G
K
K
E
D
Site 6
Y154
E
R
G
K
K
E
D
Y
T
E
A
E
N
K
F
Site 7
T155
R
G
K
K
E
D
Y
T
E
A
E
N
K
F
L
Site 8
S205
G
L
L
E
F
H
K
S
L
Q
E
I
G
D
K
Site 9
T222
H
W
F
D
I
D
P
T
E
D
E
D
L
P
T
Site 10
T229
T
E
D
E
D
L
P
T
T
F
K
D
L
L
N
Site 11
T230
E
D
E
D
L
P
T
T
F
K
D
L
L
N
N
Site 12
T242
L
N
N
F
I
K
T
T
E
S
N
I
M
K
Q
Site 13
T250
E
S
N
I
M
K
Q
T
I
C
S
Y
L
D
C
Site 14
Y254
M
K
Q
T
I
C
S
Y
L
D
C
E
R
S
C
Site 15
S260
S
Y
L
D
C
E
R
S
C
E
A
D
I
L
K
Site 16
Y271
D
I
L
K
N
T
S
Y
K
G
F
F
Q
L
M
Site 17
Y300
K
K
F
K
N
L
K
Y
P
G
E
N
D
Q
S
Site 18
S307
Y
P
G
E
N
D
Q
S
F
S
G
K
K
C
L
Site 19
Y346
E
V
V
R
K
D
E
Y
I
T
I
E
N
L
G
Site 20
S361
A
S
Y
R
K
L
I
S
L
K
I
T
D
T
D
Site 21
T365
K
L
I
S
L
K
I
T
D
T
D
I
R
P
K
Site 22
T367
I
S
L
K
I
T
D
T
D
I
R
P
K
I
S
Site 23
Y435
H
K
N
V
L
E
S
Y
Y
N
H
L
W
T
N
Site 24
Y436
K
N
V
L
E
S
Y
Y
N
H
L
W
T
N
H
Site 25
Y453
G
G
S
W
H
L
L
Y
P
P
N
K
E
L
P
Site 26
S462
P
N
K
E
L
P
Q
S
K
Q
F
D
L
C
L
Site 27
S493
G
W
N
M
E
P
P
S
S
D
I
S
K
S
A
Site 28
S494
W
N
M
E
P
P
S
S
D
I
S
K
S
A
D
Site 29
S497
E
P
P
S
S
D
I
S
K
S
A
D
I
L
R
Site 30
S499
P
S
S
D
I
S
K
S
A
D
I
L
R
L
C
Site 31
Y508
D
I
L
R
L
C
K
Y
R
D
I
L
L
S
E
Site 32
T522
E
I
L
M
N
G
L
T
E
S
Q
F
N
S
I
Site 33
S528
L
T
E
S
Q
F
N
S
I
W
K
K
V
S
D
Site 34
S559
E
N
P
I
E
N
I
S
L
D
Y
H
Q
L
S
Site 35
Y568
D
Y
H
Q
L
S
V
Y
L
G
I
P
V
P
E
Site 36
S592
Q
Q
G
I
A
L
Q
S
I
T
G
S
Q
R
I
Site 37
S596
A
L
Q
S
I
T
G
S
Q
R
I
E
I
E
E
Site 38
S612
Q
N
E
E
E
E
L
S
P
P
L
M
E
Y
N
Site 39
Y618
L
S
P
P
L
M
E
Y
N
I
N
V
K
S
H
Site 40
T638
A
E
I
N
K
D
G
T
S
I
P
S
E
S
S
Site 41
S639
E
I
N
K
D
G
T
S
I
P
S
E
S
S
T
Site 42
S642
K
D
G
T
S
I
P
S
E
S
S
T
E
S
L
Site 43
S644
G
T
S
I
P
S
E
S
S
T
E
S
L
K
D
Site 44
T646
S
I
P
S
E
S
S
T
E
S
L
K
D
L
Q
Site 45
S648
P
S
E
S
S
T
E
S
L
K
D
L
Q
E
V
Site 46
S657
K
D
L
Q
E
V
K
S
K
Q
R
K
K
K
K
Site 47
T665
K
Q
R
K
K
K
K
T
K
N
K
K
N
K
D
Site 48
Y680
S
K
E
D
Q
V
P
Y
V
V
E
K
E
E
Q
Site 49
S697
K
E
Q
A
N
P
H
S
V
S
R
L
I
K
D
Site 50
S707
R
L
I
K
D
D
A
S
D
V
Q
E
D
S
A
Site 51
S713
A
S
D
V
Q
E
D
S
A
M
E
D
K
F
Y
Site 52
Y720
S
A
M
E
D
K
F
Y
S
L
D
E
L
H
I
Site 53
S721
A
M
E
D
K
F
Y
S
L
D
E
L
H
I
L
Site 54
Y743
A
G
K
V
T
T
D
Y
G
E
T
E
K
E
R
Site 55
Y758
L
A
R
Q
R
Q
L
Y
K
L
H
Y
Q
C
E
Site 56
Y762
R
Q
L
Y
K
L
H
Y
Q
C
E
D
F
K
R
Site 57
T773
D
F
K
R
Q
L
R
T
V
T
F
R
W
Q
E
Site 58
T775
K
R
Q
L
R
T
V
T
F
R
W
Q
E
N
Q
Site 59
S794
K
K
D
K
I
I
A
S
L
N
Q
Q
V
A
F
Site 60
S828
K
N
L
K
E
Q
L
S
M
K
R
S
Q
W
E
Site 61
S832
E
Q
L
S
M
K
R
S
Q
W
E
M
E
K
H
Site 62
T847
N
L
E
S
T
M
K
T
Y
V
S
K
L
N
A
Site 63
Y848
L
E
S
T
M
K
T
Y
V
S
K
L
N
A
E
Site 64
S857
S
K
L
N
A
E
T
S
R
A
L
T
A
E
V
Site 65
Y865
R
A
L
T
A
E
V
Y
F
L
Q
C
R
R
D
Site 66
S898
R
V
T
H
M
A
A
S
N
L
E
S
L
Q
L
Site 67
Y930
I
A
F
L
R
T
Q
Y
N
E
Q
I
N
K
V
Site 68
S957
Q
L
P
P
P
P
P
S
P
E
I
L
M
Q
Q
Site 69
S974
G
R
P
L
V
K
E
S
F
F
R
P
I
L
T
Site 70
S1022
V
G
D
A
V
P
P
S
A
G
L
R
S
D
P
Site 71
S1027
P
P
S
A
G
L
R
S
D
P
S
I
M
N
W
Site 72
S1030
A
G
L
R
S
D
P
S
I
M
N
W
E
R
I
Site 73
T1043
R
I
T
D
R
L
K
T
A
F
P
Q
Q
T
R
Site 74
Y1064
L
R
K
L
K
D
A
Y
G
K
S
L
S
E
L
Site 75
S1067
L
K
D
A
Y
G
K
S
L
S
E
L
T
F
D
Site 76
S1069
D
A
Y
G
K
S
L
S
E
L
T
F
D
E
I
Site 77
T1072
G
K
S
L
S
E
L
T
F
D
E
I
V
C
K
Site 78
S1081
D
E
I
V
C
K
I
S
Q
F
I
D
P
K
K
Site 79
S1089
Q
F
I
D
P
K
K
S
Q
S
Q
G
K
S
V
Site 80
S1091
I
D
P
K
K
S
Q
S
Q
G
K
S
V
S
N
Site 81
S1095
K
S
Q
S
Q
G
K
S
V
S
N
V
N
C
V
Site 82
S1097
Q
S
Q
G
K
S
V
S
N
V
N
C
V
S
P
Site 83
S1103
V
S
N
V
N
C
V
S
P
S
H
S
P
S
Q
Site 84
S1105
N
V
N
C
V
S
P
S
H
S
P
S
Q
P
D
Site 85
S1107
N
C
V
S
P
S
H
S
P
S
Q
P
D
A
A
Site 86
S1109
V
S
P
S
H
S
P
S
Q
P
D
A
A
Q
P
Site 87
T1125
K
P
A
W
R
P
L
T
S
Q
G
P
A
T
W
Site 88
S1126
P
A
W
R
P
L
T
S
Q
G
P
A
T
W
E
Site 89
T1131
L
T
S
Q
G
P
A
T
W
E
G
A
S
N
P
Site 90
S1161
N
L
S
P
E
N
L
S
V
L
P
C
A
H
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation