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Updated November 2019
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Protein Info
Short Name:
C4orf21
Full Name:
Uncharacterized protein C4orf21
Alias:
Type:
Mass (Da):
119347
Number AA:
1062
UniProt ID:
Q86YA3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
S
Q
E
F
I
V
L
Y
T
H
Q
K
M
K
K
Site 2
S63
K
P
G
D
D
L
E
S
D
R
Y
L
I
T
V
Site 3
Y66
D
D
L
E
S
D
R
Y
L
I
T
V
E
E
V
Site 4
T69
E
S
D
R
Y
L
I
T
V
E
E
V
K
V
A
Site 5
S95
K
E
A
P
E
L
N
S
R
T
F
I
S
S
G
Site 6
T97
A
P
E
L
N
S
R
T
F
I
S
S
G
R
S
Site 7
S100
L
N
S
R
T
F
I
S
S
G
R
S
L
G
C
Site 8
S101
N
S
R
T
F
I
S
S
G
R
S
L
G
C
Q
Site 9
S104
T
F
I
S
S
G
R
S
L
G
C
Q
P
S
G
Site 10
S110
R
S
L
G
C
Q
P
S
G
L
K
R
K
F
T
Site 11
T117
S
G
L
K
R
K
F
T
G
F
Q
G
P
R
Q
Site 12
S134
K
K
M
V
I
M
E
S
G
E
S
A
A
S
H
Site 13
S137
V
I
M
E
S
G
E
S
A
A
S
H
E
A
K
Site 14
S140
E
S
G
E
S
A
A
S
H
E
A
K
K
T
G
Site 15
T146
A
S
H
E
A
K
K
T
G
P
T
I
F
S
P
Site 16
S152
K
T
G
P
T
I
F
S
P
F
C
S
M
P
P
Site 17
T163
S
M
P
P
L
F
P
T
V
G
K
K
D
V
N
Site 18
T181
A
D
P
E
N
I
V
T
Y
K
N
R
E
R
N
Site 19
S193
E
R
N
A
M
D
F
S
S
V
F
S
P
S
F
Site 20
S194
R
N
A
M
D
F
S
S
V
F
S
P
S
F
Q
Site 21
S197
M
D
F
S
S
V
F
S
P
S
F
Q
I
N
P
Site 22
Y212
E
V
L
C
E
E
N
Y
F
C
S
P
V
N
S
Site 23
S219
Y
F
C
S
P
V
N
S
G
N
K
L
S
D
S
Site 24
S224
V
N
S
G
N
K
L
S
D
S
L
L
T
N
E
Site 25
S226
S
G
N
K
L
S
D
S
L
L
T
N
E
P
V
Site 26
S237
N
E
P
V
K
R
D
S
L
A
S
H
Y
S
G
Site 27
S240
V
K
R
D
S
L
A
S
H
Y
S
G
V
S
Q
Site 28
Y242
R
D
S
L
A
S
H
Y
S
G
V
S
Q
N
I
Site 29
S243
D
S
L
A
S
H
Y
S
G
V
S
Q
N
I
R
Site 30
S246
A
S
H
Y
S
G
V
S
Q
N
I
R
S
K
A
Site 31
S261
Q
I
L
A
L
L
K
S
E
S
S
S
S
C
E
Site 32
S263
L
A
L
L
K
S
E
S
S
S
S
C
E
E
L
Site 33
S264
A
L
L
K
S
E
S
S
S
S
C
E
E
L
N
Site 34
S265
L
L
K
S
E
S
S
S
S
C
E
E
L
N
S
Site 35
S266
L
K
S
E
S
S
S
S
C
E
E
L
N
S
E
Site 36
S272
S
S
C
E
E
L
N
S
E
M
T
E
H
F
P
Site 37
Y295
K
I
A
T
K
P
K
Y
L
I
Q
Q
E
E
C
Site 38
T308
E
C
A
E
M
K
S
T
E
N
L
Y
Y
Q
H
Site 39
Y312
M
K
S
T
E
N
L
Y
Y
Q
H
Q
S
E
N
Site 40
Y313
K
S
T
E
N
L
Y
Y
Q
H
Q
S
E
N
T
Site 41
Y330
N
K
S
R
W
A
M
Y
L
S
S
Q
S
S
P
Site 42
S332
S
R
W
A
M
Y
L
S
S
Q
S
S
P
I
H
Site 43
S333
R
W
A
M
Y
L
S
S
Q
S
S
P
I
H
S
Site 44
S335
A
M
Y
L
S
S
Q
S
S
P
I
H
S
S
T
Site 45
S336
M
Y
L
S
S
Q
S
S
P
I
H
S
S
T
V
Site 46
S340
S
Q
S
S
P
I
H
S
S
T
V
D
G
N
D
Site 47
S341
Q
S
S
P
I
H
S
S
T
V
D
G
N
D
T
Site 48
T342
S
S
P
I
H
S
S
T
V
D
G
N
D
T
E
Site 49
T348
S
T
V
D
G
N
D
T
E
R
K
P
K
A
Q
Site 50
S367
N
S
N
L
K
D
L
S
L
Q
K
I
I
Q
F
Site 51
Y385
Y
A
E
E
R
K
K
Y
N
V
D
Q
S
V
G
Site 52
S390
K
K
Y
N
V
D
Q
S
V
G
N
N
D
P
S
Site 53
S397
S
V
G
N
N
D
P
S
W
N
Q
E
V
K
L
Site 54
S408
E
V
K
L
E
I
P
S
F
N
E
S
S
S
L
Site 55
S412
E
I
P
S
F
N
E
S
S
S
L
Q
V
T
C
Site 56
S414
P
S
F
N
E
S
S
S
L
Q
V
T
C
S
S
Site 57
T418
E
S
S
S
L
Q
V
T
C
S
S
A
E
N
D
Site 58
S420
S
S
L
Q
V
T
C
S
S
A
E
N
D
G
I
Site 59
S429
A
E
N
D
G
I
L
S
E
S
D
I
Q
E
D
Site 60
S431
N
D
G
I
L
S
E
S
D
I
Q
E
D
N
K
Site 61
S452
D
K
G
C
I
K
E
S
V
L
I
K
E
N
A
Site 62
Y472
C
G
T
L
E
K
E
Y
E
Q
S
E
S
S
L
Site 63
S475
L
E
K
E
Y
E
Q
S
E
S
S
L
P
E
L
Site 64
S477
K
E
Y
E
Q
S
E
S
S
L
P
E
L
K
H
Site 65
S478
E
Y
E
Q
S
E
S
S
L
P
E
L
K
H
L
Site 66
S489
L
K
H
L
Q
I
E
S
S
N
N
S
R
I
S
Site 67
S490
K
H
L
Q
I
E
S
S
N
N
S
R
I
S
D
Site 68
S493
Q
I
E
S
S
N
N
S
R
I
S
D
D
I
T
Site 69
S496
S
S
N
N
S
R
I
S
D
D
I
T
D
M
I
Site 70
T500
S
R
I
S
D
D
I
T
D
M
I
S
E
S
K
Site 71
S504
D
D
I
T
D
M
I
S
E
S
K
M
D
N
E
Site 72
S506
I
T
D
M
I
S
E
S
K
M
D
N
E
S
L
Site 73
S512
E
S
K
M
D
N
E
S
L
N
S
I
H
E
S
Site 74
S515
M
D
N
E
S
L
N
S
I
H
E
S
L
S
N
Site 75
S519
S
L
N
S
I
H
E
S
L
S
N
V
T
Q
P
Site 76
S521
N
S
I
H
E
S
L
S
N
V
T
Q
P
F
L
Site 77
T531
T
Q
P
F
L
E
V
T
F
N
L
N
N
F
E
Site 78
T542
N
N
F
E
T
S
D
T
E
E
E
S
Q
E
S
Site 79
S546
T
S
D
T
E
E
E
S
Q
E
S
N
K
I
S
Site 80
S549
T
E
E
E
S
Q
E
S
N
K
I
S
Q
D
S
Site 81
S553
S
Q
E
S
N
K
I
S
Q
D
S
E
S
W
V
Site 82
S556
S
N
K
I
S
Q
D
S
E
S
W
V
K
D
I
Site 83
S558
K
I
S
Q
D
S
E
S
W
V
K
D
I
L
V
Site 84
S594
E
H
L
P
F
L
T
S
V
S
D
K
P
T
V
Site 85
T600
T
S
V
S
D
K
P
T
V
T
F
P
V
K
E
Site 86
T602
V
S
D
K
P
T
V
T
F
P
V
K
E
T
L
Site 87
S611
P
V
K
E
T
L
P
S
Q
F
C
D
K
T
Y
Site 88
Y618
S
Q
F
C
D
K
T
Y
V
G
F
D
M
G
I
Site 89
Y638
T
G
K
E
I
E
E
Y
S
D
T
L
S
N
F
Site 90
S639
G
K
E
I
E
E
Y
S
D
T
L
S
N
F
E
Site 91
T641
E
I
E
E
Y
S
D
T
L
S
N
F
E
S
F
Site 92
S643
E
E
Y
S
D
T
L
S
N
F
E
S
F
K
W
Site 93
S647
D
T
L
S
N
F
E
S
F
K
W
T
D
A
V
Site 94
Y655
F
K
W
T
D
A
V
Y
G
D
N
K
E
D
A
Site 95
Y673
I
Q
E
V
R
I
N
Y
D
F
A
L
P
P
N
Site 96
S682
F
A
L
P
P
N
K
S
K
G
I
N
M
N
L
Site 97
S706
A
E
N
S
N
L
F
S
E
D
A
Q
P
Q
P
Site 98
S718
P
Q
P
F
I
L
G
S
D
L
D
K
N
D
E
Site 99
S730
N
D
E
H
V
L
P
S
T
S
S
S
D
N
S
Site 100
T731
D
E
H
V
L
P
S
T
S
S
S
D
N
S
V
Site 101
S732
E
H
V
L
P
S
T
S
S
S
D
N
S
V
Q
Site 102
S733
H
V
L
P
S
T
S
S
S
D
N
S
V
Q
L
Site 103
S734
V
L
P
S
T
S
S
S
D
N
S
V
Q
L
L
Site 104
S737
S
T
S
S
S
D
N
S
V
Q
L
L
N
T
N
Site 105
Y748
L
N
T
N
Q
N
H
Y
E
C
I
A
L
D
K
Site 106
S756
E
C
I
A
L
D
K
S
N
T
H
I
S
N
S
Site 107
T758
I
A
L
D
K
S
N
T
H
I
S
N
S
L
F
Site 108
S761
D
K
S
N
T
H
I
S
N
S
L
F
Y
P
L
Site 109
S763
S
N
T
H
I
S
N
S
L
F
Y
P
L
G
K
Site 110
Y766
H
I
S
N
S
L
F
Y
P
L
G
K
K
H
L
Site 111
S775
L
G
K
K
H
L
I
S
K
D
T
E
A
H
I
Site 112
T778
K
H
L
I
S
K
D
T
E
A
H
I
S
E
P
Site 113
S783
K
D
T
E
A
H
I
S
E
P
E
D
L
G
K
Site 114
S793
E
D
L
G
K
I
R
S
P
P
P
D
H
V
E
Site 115
Y810
T
A
R
E
G
K
Q
Y
W
N
P
R
N
S
S
Site 116
S816
Q
Y
W
N
P
R
N
S
S
E
L
S
G
L
V
Site 117
S817
Y
W
N
P
R
N
S
S
E
L
S
G
L
V
N
Site 118
S820
P
R
N
S
S
E
L
S
G
L
V
N
T
I
S
Site 119
S836
L
K
S
L
C
E
H
S
T
A
L
D
S
L
E
Site 120
T837
K
S
L
C
E
H
S
T
A
L
D
S
L
E
I
Site 121
S841
E
H
S
T
A
L
D
S
L
E
I
L
K
K
K
Site 122
T850
E
I
L
K
K
K
N
T
V
F
Q
Q
G
T
Q
Site 123
T859
F
Q
Q
G
T
Q
Q
T
Y
E
P
D
S
P
P
Site 124
Y860
Q
Q
G
T
Q
Q
T
Y
E
P
D
S
P
P
E
Site 125
S864
Q
Q
T
Y
E
P
D
S
P
P
E
V
R
K
P
Site 126
T874
E
V
R
K
P
F
I
T
V
V
S
P
K
S
P
Site 127
S877
K
P
F
I
T
V
V
S
P
K
S
P
H
L
H
Site 128
S880
I
T
V
V
S
P
K
S
P
H
L
H
K
D
S
Site 129
S887
S
P
H
L
H
K
D
S
Q
Q
I
L
K
E
D
Site 130
S899
K
E
D
E
V
E
L
S
E
P
L
Q
S
V
Q
Site 131
S904
E
L
S
E
P
L
Q
S
V
Q
F
S
S
S
G
Site 132
S908
P
L
Q
S
V
Q
F
S
S
S
G
S
K
E
E
Site 133
S910
Q
S
V
Q
F
S
S
S
G
S
K
E
E
T
A
Site 134
S912
V
Q
F
S
S
S
G
S
K
E
E
T
A
F
Q
Site 135
T916
S
S
G
S
K
E
E
T
A
F
Q
A
V
I
P
Site 136
T930
P
K
Q
I
E
R
K
T
C
D
P
K
P
V
E
Site 137
S946
Q
G
H
Q
V
K
G
S
A
T
S
G
V
M
V
Site 138
S957
G
V
M
V
R
G
H
S
S
Q
L
G
C
G
Q
Site 139
S958
V
M
V
R
G
H
S
S
Q
L
G
C
G
Q
F
Site 140
Y971
Q
F
P
D
S
T
E
Y
E
N
F
M
T
E
T
Site 141
T976
T
E
Y
E
N
F
M
T
E
T
P
E
L
P
S
Site 142
T978
Y
E
N
F
M
T
E
T
P
E
L
P
S
T
C
Site 143
T984
E
T
P
E
L
P
S
T
C
M
Q
I
D
F
L
Site 144
S995
I
D
F
L
Q
V
T
S
P
E
E
N
I
S
T
Site 145
S1001
T
S
P
E
E
N
I
S
T
L
S
P
V
S
T
Site 146
T1002
S
P
E
E
N
I
S
T
L
S
P
V
S
T
F
Site 147
S1004
E
E
N
I
S
T
L
S
P
V
S
T
F
S
L
Site 148
S1007
I
S
T
L
S
P
V
S
T
F
S
L
N
S
R
Site 149
T1008
S
T
L
S
P
V
S
T
F
S
L
N
S
R
D
Site 150
S1010
L
S
P
V
S
T
F
S
L
N
S
R
D
E
D
Site 151
S1023
E
D
F
M
V
E
F
S
E
T
S
L
K
A
R
Site 152
T1031
E
T
S
L
K
A
R
T
L
P
D
D
L
H
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation