KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PPARGC1B
Full Name:
Peroxisome proliferator-activated receptor gamma coactivator 1-beta
Alias:
PERC; Peroxisome proliferative activated receptor, gamma, coactivator 1, beta; Peroxisome proliferator-activated receptor gamma, coactivator 1 beta; PGC1B; PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PRGC2
Type:
Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Mass (Da):
113222
Number AA:
1023
UniProt ID:
Q86YN6
International Prot ID:
IPI00152517
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016592
Uniprot
OncoNet
Molecular Function:
GO:0050682
GO:0003723
GO:0016455
PhosphoSite+
KinaseNET
Biological Process:
GO:0030520
GO:0045944
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T25
F
L
N
Y
L
A
D
T
Q
G
G
G
S
G
E
Site 2
Y36
G
S
G
E
E
Q
L
Y
A
D
F
P
E
L
D
Site 3
S45
D
F
P
E
L
D
L
S
Q
L
D
A
S
D
F
Site 4
S50
D
L
S
Q
L
D
A
S
D
F
D
S
A
T
C
Site 5
T56
A
S
D
F
D
S
A
T
C
F
G
E
L
Q
W
Site 6
T70
W
C
P
E
N
S
E
T
E
P
N
Q
Y
S
P
Site 7
Y75
S
E
T
E
P
N
Q
Y
S
P
D
D
S
E
L
Site 8
S76
E
T
E
P
N
Q
Y
S
P
D
D
S
E
L
F
Site 9
S80
N
Q
Y
S
P
D
D
S
E
L
F
Q
I
D
S
Site 10
S87
S
E
L
F
Q
I
D
S
E
N
E
A
L
L
A
Site 11
T99
L
L
A
E
L
T
K
T
L
D
D
I
P
E
D
Site 12
S126
G
D
A
L
S
C
T
S
A
S
P
A
P
S
S
Site 13
S128
A
L
S
C
T
S
A
S
P
A
P
S
S
A
P
Site 14
S132
T
S
A
S
P
A
P
S
S
A
P
P
S
P
A
Site 15
S133
S
A
S
P
A
P
S
S
A
P
P
S
P
A
P
Site 16
S137
A
P
S
S
A
P
P
S
P
A
P
E
K
P
S
Site 17
T163
L
Q
K
L
L
L
A
T
S
Y
P
T
S
S
S
Site 18
S164
Q
K
L
L
L
A
T
S
Y
P
T
S
S
S
D
Site 19
Y165
K
L
L
L
A
T
S
Y
P
T
S
S
S
D
T
Site 20
S168
L
A
T
S
Y
P
T
S
S
S
D
T
Q
K
E
Site 21
S170
T
S
Y
P
T
S
S
S
D
T
Q
K
E
G
T
Site 22
T172
Y
P
T
S
S
S
D
T
Q
K
E
G
T
A
W
Site 23
S186
W
R
Q
A
G
L
R
S
K
S
Q
R
P
C
V
Site 24
S188
Q
A
G
L
R
S
K
S
Q
R
P
C
V
K
A
Site 25
S197
R
P
C
V
K
A
D
S
T
Q
D
K
K
A
P
Site 26
T198
P
C
V
K
A
D
S
T
Q
D
K
K
A
P
M
Site 27
S208
K
K
A
P
M
M
Q
S
Q
S
R
S
C
T
E
Site 28
S212
M
M
Q
S
Q
S
R
S
C
T
E
L
H
K
H
Site 29
T214
Q
S
Q
S
R
S
C
T
E
L
H
K
H
L
T
Site 30
S239
L
Q
P
P
C
L
Q
S
P
R
L
P
A
K
E
Site 31
S256
E
P
G
E
D
C
P
S
P
Q
P
A
P
A
S
Site 32
S263
S
P
Q
P
A
P
A
S
P
R
D
S
L
A
L
Site 33
S267
A
P
A
S
P
R
D
S
L
A
L
G
R
A
D
Site 34
S280
A
D
P
G
A
P
V
S
Q
E
D
M
Q
A
M
Site 35
Y297
L
I
R
Y
M
H
T
Y
C
L
P
Q
R
K
L
Site 36
T308
Q
R
K
L
P
P
Q
T
P
E
P
L
P
K
A
Site 37
S317
E
P
L
P
K
A
C
S
N
P
S
Q
Q
V
R
Site 38
S320
P
K
A
C
S
N
P
S
Q
Q
V
R
S
R
P
Site 39
S325
N
P
S
Q
Q
V
R
S
R
P
W
S
R
H
H
Site 40
S329
Q
V
R
S
R
P
W
S
R
H
H
S
K
A
S
Site 41
S333
R
P
W
S
R
H
H
S
K
A
S
W
A
E
F
Site 42
S336
S
R
H
H
S
K
A
S
W
A
E
F
S
I
L
Site 43
S356
Q
D
V
L
C
D
V
S
K
P
Y
R
L
A
T
Site 44
T363
S
K
P
Y
R
L
A
T
P
V
Y
A
S
L
T
Site 45
Y366
Y
R
L
A
T
P
V
Y
A
S
L
T
P
R
S
Site 46
S368
L
A
T
P
V
Y
A
S
L
T
P
R
S
R
P
Site 47
T370
T
P
V
Y
A
S
L
T
P
R
S
R
P
R
P
Site 48
S373
Y
A
S
L
T
P
R
S
R
P
R
P
P
K
D
Site 49
S381
R
P
R
P
P
K
D
S
Q
A
S
P
G
R
P
Site 50
S384
P
P
K
D
S
Q
A
S
P
G
R
P
S
S
V
Site 51
S389
Q
A
S
P
G
R
P
S
S
V
E
E
V
R
I
Site 52
S390
A
S
P
G
R
P
S
S
V
E
E
V
R
I
A
Site 53
S399
E
E
V
R
I
A
A
S
P
K
S
T
G
P
R
Site 54
S402
R
I
A
A
S
P
K
S
T
G
P
R
P
S
L
Site 55
T403
I
A
A
S
P
K
S
T
G
P
R
P
S
L
R
Site 56
S408
K
S
T
G
P
R
P
S
L
R
P
L
R
L
E
Site 57
T463
P
G
R
G
L
P
W
T
K
L
G
R
K
L
E
Site 58
S471
K
L
G
R
K
L
E
S
S
V
C
P
V
R
R
Site 59
S472
L
G
R
K
L
E
S
S
V
C
P
V
R
R
S
Site 60
S479
S
V
C
P
V
R
R
S
R
R
L
N
P
E
L
Site 61
S524
D
V
E
R
E
L
G
S
P
T
D
E
D
S
G
Site 62
T526
E
R
E
L
G
S
P
T
D
E
D
S
G
Q
D
Site 63
S530
G
S
P
T
D
E
D
S
G
Q
D
Q
Q
L
L
Site 64
S547
P
Q
I
P
A
L
E
S
P
C
E
S
G
C
G
Site 65
S551
A
L
E
S
P
C
E
S
G
C
G
D
M
D
E
Site 66
S561
G
D
M
D
E
D
P
S
C
P
Q
L
P
P
R
Site 67
S570
P
Q
L
P
P
R
D
S
P
R
C
L
M
L
A
Site 68
S581
L
M
L
A
L
S
Q
S
D
P
T
F
G
K
K
Site 69
T584
A
L
S
Q
S
D
P
T
F
G
K
K
S
F
E
Site 70
S589
D
P
T
F
G
K
K
S
F
E
Q
T
L
T
V
Site 71
T593
G
K
K
S
F
E
Q
T
L
T
V
E
L
C
G
Site 72
T595
K
S
F
E
Q
T
L
T
V
E
L
C
G
T
A
Site 73
T608
T
A
G
L
T
P
P
T
T
P
P
Y
K
P
T
Site 74
T609
A
G
L
T
P
P
T
T
P
P
Y
K
P
T
E
Site 75
Y612
T
P
P
T
T
P
P
Y
K
P
T
E
E
D
P
Site 76
S627
F
K
P
D
I
K
H
S
L
G
K
E
I
A
L
Site 77
S643
L
P
S
P
E
G
L
S
L
K
A
T
P
G
A
Site 78
T647
E
G
L
S
L
K
A
T
P
G
A
A
H
K
L
Site 79
S662
P
K
K
H
P
E
R
S
E
L
L
S
H
L
R
Site 80
S666
P
E
R
S
E
L
L
S
H
L
R
H
A
T
A
Site 81
T672
L
S
H
L
R
H
A
T
A
Q
P
A
S
Q
A
Site 82
S677
H
A
T
A
Q
P
A
S
Q
A
G
Q
K
R
P
Site 83
S686
A
G
Q
K
R
P
F
S
C
S
F
G
D
H
D
Site 84
Y694
C
S
F
G
D
H
D
Y
C
Q
V
L
R
P
E
Site 85
S711
L
Q
R
K
V
L
R
S
W
E
P
S
G
V
H
Site 86
S715
V
L
R
S
W
E
P
S
G
V
H
L
E
D
W
Site 87
S742
P
G
R
E
E
D
R
S
C
D
A
G
A
P
P
Site 88
T753
G
A
P
P
K
D
S
T
L
L
R
D
H
E
I
Site 89
S763
R
D
H
E
I
R
A
S
L
T
K
H
F
G
L
Site 90
S782
L
E
E
E
D
L
A
S
C
K
S
P
E
Y
D
Site 91
S785
E
D
L
A
S
C
K
S
P
E
Y
D
T
V
F
Site 92
Y788
A
S
C
K
S
P
E
Y
D
T
V
F
E
D
S
Site 93
T790
C
K
S
P
E
Y
D
T
V
F
E
D
S
S
S
Site 94
S795
Y
D
T
V
F
E
D
S
S
S
S
S
G
E
S
Site 95
S796
D
T
V
F
E
D
S
S
S
S
S
G
E
S
S
Site 96
S797
T
V
F
E
D
S
S
S
S
S
G
E
S
S
F
Site 97
S798
V
F
E
D
S
S
S
S
S
G
E
S
S
F
L
Site 98
S799
F
E
D
S
S
S
S
S
G
E
S
S
F
L
P
Site 99
S802
S
S
S
S
S
G
E
S
S
F
L
P
E
E
E
Site 100
S803
S
S
S
S
G
E
S
S
F
L
P
E
E
E
E
Site 101
S825
E
D
D
E
E
E
D
S
G
V
S
P
T
C
S
Site 102
S828
E
E
E
D
S
G
V
S
P
T
C
S
D
H
C
Site 103
T830
E
D
S
G
V
S
P
T
C
S
D
H
C
P
Y
Site 104
S832
S
G
V
S
P
T
C
S
D
H
C
P
Y
Q
S
Site 105
Y837
T
C
S
D
H
C
P
Y
Q
S
P
P
S
K
A
Site 106
S839
S
D
H
C
P
Y
Q
S
P
P
S
K
A
N
R
Site 107
S842
C
P
Y
Q
S
P
P
S
K
A
N
R
Q
L
C
Site 108
S850
K
A
N
R
Q
L
C
S
R
S
R
S
S
S
G
Site 109
S852
N
R
Q
L
C
S
R
S
R
S
S
S
G
S
S
Site 110
S854
Q
L
C
S
R
S
R
S
S
S
G
S
S
P
C
Site 111
S855
L
C
S
R
S
R
S
S
S
G
S
S
P
C
H
Site 112
S856
C
S
R
S
R
S
S
S
G
S
S
P
C
H
S
Site 113
S858
R
S
R
S
S
S
G
S
S
P
C
H
S
W
S
Site 114
S859
S
R
S
S
S
G
S
S
P
C
H
S
W
S
P
Site 115
S863
S
G
S
S
P
C
H
S
W
S
P
A
T
R
R
Site 116
S865
S
S
P
C
H
S
W
S
P
A
T
R
R
N
F
Site 117
S876
R
R
N
F
R
C
E
S
R
G
P
C
S
D
R
Site 118
S881
C
E
S
R
G
P
C
S
D
R
T
P
S
I
R
Site 119
T884
R
G
P
C
S
D
R
T
P
S
I
R
H
A
R
Site 120
S886
P
C
S
D
R
T
P
S
I
R
H
A
R
K
R
Site 121
Y905
I
G
E
G
R
V
V
Y
I
Q
N
L
S
S
D
Site 122
S910
V
V
Y
I
Q
N
L
S
S
D
M
S
S
R
E
Site 123
S911
V
Y
I
Q
N
L
S
S
D
M
S
S
R
E
L
Site 124
S914
Q
N
L
S
S
D
M
S
S
R
E
L
K
R
R
Site 125
S915
N
L
S
S
D
M
S
S
R
E
L
K
R
R
F
Site 126
Y943
R
N
R
R
G
E
K
Y
G
F
I
T
Y
R
C
Site 127
T947
G
E
K
Y
G
F
I
T
Y
R
C
S
E
H
A
Site 128
Y948
E
K
Y
G
F
I
T
Y
R
C
S
E
H
A
A
Site 129
S971
L
R
K
R
N
E
P
S
F
Q
L
S
Y
G
G
Site 130
S975
N
E
P
S
F
Q
L
S
Y
G
G
L
R
H
F
Site 131
Y987
R
H
F
C
W
P
R
Y
T
D
Y
D
S
N
S
Site 132
Y990
C
W
P
R
Y
T
D
Y
D
S
N
S
E
E
A
Site 133
S992
P
R
Y
T
D
Y
D
S
N
S
E
E
A
L
P
Site 134
S994
Y
T
D
Y
D
S
N
S
E
E
A
L
P
A
S
Site 135
S1001
S
E
E
A
L
P
A
S
G
K
S
K
Y
E
A
Site 136
Y1006
P
A
S
G
K
S
K
Y
E
A
M
D
F
D
S
Site 137
S1013
Y
E
A
M
D
F
D
S
L
L
K
E
A
Q
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation