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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MIB1
Full Name:
E3 ubiquitin-protein ligase MIB1
Alias:
DAPK-interacting 1; DIP1; DIP-1; KIAA1323; MIB; Mind bomb homolog 1; Mindbomb 1; Ubiquitin ligase protein MIB1; Zinc finger ZZ type with ankyrin repeat domain protein 2; ZZANK2; ZZZ6
Type:
Ubiquitin ligase; Ligase; Ubiquitin conjugating system; EC 6.3.2.-
Mass (Da):
110136
Number AA:
1006
UniProt ID:
Q86YT6
International Prot ID:
IPI00183054
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0004842
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007219
GO:0019941
GO:0016567
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T38
G
G
E
G
H
V
G
T
V
R
S
F
E
S
P
Site 2
S41
G
H
V
G
T
V
R
S
F
E
S
P
E
E
V
Site 3
Y60
D
N
G
T
A
A
N
Y
R
C
S
G
A
Y
D
Site 4
S63
T
A
A
N
Y
R
C
S
G
A
Y
D
L
R
I
Site 5
Y66
N
Y
R
C
S
G
A
Y
D
L
R
I
L
D
S
Site 6
S73
Y
D
L
R
I
L
D
S
A
P
T
G
I
K
H
Site 7
Y106
K
C
A
E
C
T
N
Y
D
L
C
T
V
C
Y
Site 8
Y125
H
H
L
R
H
R
F
Y
R
I
T
T
P
G
S
Site 9
T128
R
H
R
F
Y
R
I
T
T
P
G
S
E
R
V
Site 10
T129
H
R
F
Y
R
I
T
T
P
G
S
E
R
V
L
Site 11
S132
Y
R
I
T
T
P
G
S
E
R
V
L
L
E
S
Site 12
S139
S
E
R
V
L
L
E
S
R
R
K
S
K
K
I
Site 13
S143
L
L
E
S
R
R
K
S
K
K
I
T
A
R
G
Site 14
T147
R
R
K
S
K
K
I
T
A
R
G
I
F
A
G
Site 15
T179
N
G
R
R
G
K
V
T
E
I
Q
D
W
S
A
Site 16
S185
V
T
E
I
Q
D
W
S
A
S
S
P
H
S
A
Site 17
S187
E
I
Q
D
W
S
A
S
S
P
H
S
A
A
Y
Site 18
S188
I
Q
D
W
S
A
S
S
P
H
S
A
A
Y
V
Site 19
S191
W
S
A
S
S
P
H
S
A
A
Y
V
L
W
D
Site 20
Y194
S
S
P
H
S
A
A
Y
V
L
W
D
N
G
A
Site 21
Y205
D
N
G
A
K
N
L
Y
R
V
G
F
E
G
M
Site 22
S225
V
Q
D
A
K
G
G
S
F
Y
R
D
H
C
P
Site 23
S263
L
D
L
E
I
V
Q
S
L
Q
H
G
H
G
G
Site 24
T284
E
T
L
T
T
T
G
T
V
C
G
I
D
E
D
Site 25
Y298
D
H
D
I
V
V
Q
Y
P
S
G
N
R
W
T
Site 26
T305
Y
P
S
G
N
R
W
T
F
N
P
A
V
L
T
Site 27
S331
Q
G
A
E
G
G
T
S
Q
F
Q
V
G
D
L
Site 28
Y376
V
G
R
V
Q
Q
I
Y
S
D
S
D
L
K
V
Site 29
S377
G
R
V
Q
Q
I
Y
S
D
S
D
L
K
V
E
Site 30
S379
V
Q
Q
I
Y
S
D
S
D
L
K
V
E
V
C
Site 31
S398
T
Y
N
P
A
A
V
S
K
V
A
S
A
G
S
Site 32
S402
A
A
V
S
K
V
A
S
A
G
S
A
I
S
N
Site 33
S405
S
K
V
A
S
A
G
S
A
I
S
N
A
S
G
Site 34
S408
A
S
A
G
S
A
I
S
N
A
S
G
E
R
L
Site 35
S411
G
S
A
I
S
N
A
S
G
E
R
L
S
Q
L
Site 36
S416
N
A
S
G
E
R
L
S
Q
L
L
K
K
L
F
Site 37
S428
K
L
F
E
T
Q
E
S
G
D
L
N
E
E
L
Site 38
S520
I
E
V
L
H
R
G
S
A
D
L
N
A
R
N
Site 39
T532
A
R
N
K
R
R
Q
T
P
L
H
I
A
V
N
Site 40
S557
L
D
F
G
C
H
P
S
L
Q
D
S
E
G
D
Site 41
S561
C
H
P
S
L
Q
D
S
E
G
D
T
P
L
H
Site 42
T565
L
Q
D
S
E
G
D
T
P
L
H
D
A
I
S
Site 43
S572
T
P
L
H
D
A
I
S
K
K
R
D
D
I
L
Site 44
T590
L
E
A
G
A
D
V
T
I
T
N
N
N
G
F
Site 45
T592
A
G
A
D
V
T
I
T
N
N
N
G
F
N
A
Site 46
Y633
D
E
K
K
D
D
G
Y
T
A
L
H
L
A
A
Site 47
T701
I
Q
D
K
D
G
D
T
P
L
H
E
A
L
R
Site 48
T711
H
E
A
L
R
H
H
T
L
S
Q
L
R
Q
L
Site 49
S713
A
L
R
H
H
T
L
S
Q
L
R
Q
L
Q
D
Site 50
S751
T
Q
G
A
E
K
K
S
A
A
S
I
A
C
F
Site 51
S767
A
A
N
G
A
D
L
S
I
R
N
K
K
G
Q
Site 52
S775
I
R
N
K
K
G
Q
S
P
L
D
L
C
P
D
Site 53
S803
K
V
S
G
Q
V
G
S
R
S
P
S
M
I
S
Site 54
S805
S
G
Q
V
G
S
R
S
P
S
M
I
S
N
D
Site 55
S807
Q
V
G
S
R
S
P
S
M
I
S
N
D
S
E
Site 56
S810
S
R
S
P
S
M
I
S
N
D
S
E
T
L
E
Site 57
S813
P
S
M
I
S
N
D
S
E
T
L
E
E
C
M
Site 58
T815
M
I
S
N
D
S
E
T
L
E
E
C
M
V
C
Site 59
S918
I
M
C
C
G
G
K
S
S
E
D
A
T
D
D
Site 60
T923
G
K
S
S
E
D
A
T
D
D
I
S
S
G
N
Site 61
S927
E
D
A
T
D
D
I
S
S
G
N
I
P
V
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation