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Updated November 2019
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Protein Info
Short Name:
SGK223
Full Name:
Tyrosine-protein kinase SgK223
Alias:
EC 2.7.10.2; FLJ00269; SG223; Sugen kinase 223
Type:
EC 2.7.10.2; Protein kinase, Ser/Thr (non-receptor); Other group; NKF3 family
Mass (Da):
149688
Number AA:
1406
UniProt ID:
Q86YV5
International Prot ID:
IPI00166578
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004715
GO:0004672
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0006468
GO:0006793
Phosida
TranscriptoNet
STRING
Kinexus Products
Tyrosine-protein kinase SgK223; Homologue of rat pragma of Rnd2 Y413 phosphosite-specific antibody AB-PK810#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK810#Tyrosine-protein kinase SgK223 / Homologue of rat pragma of Rnd2 (E410-S416, human) pY413 phosphopeptide - Powder PE-04APO99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APO99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
N
P
E
S
L
K
M
S
A
C
S
D
F
V
E
Site 2
S53
P
P
Q
P
R
A
G
S
L
P
P
P
P
R
L
Site 3
S76
L
E
D
E
G
V
N
S
S
P
Y
S
K
P
T
Site 4
S77
E
D
E
G
V
N
S
S
P
Y
S
K
P
T
I
Site 5
Y79
E
G
V
N
S
S
P
Y
S
K
P
T
I
A
V
Site 6
S80
G
V
N
S
S
P
Y
S
K
P
T
I
A
V
K
Site 7
T83
S
S
P
Y
S
K
P
T
I
A
V
K
P
T
M
Site 8
T89
P
T
I
A
V
K
P
T
M
M
S
S
E
A
S
Site 9
S92
A
V
K
P
T
M
M
S
S
E
A
S
D
V
W
Site 10
S93
V
K
P
T
M
M
S
S
E
A
S
D
V
W
T
Site 11
S96
T
M
M
S
S
E
A
S
D
V
W
T
E
A
N
Site 12
T100
S
E
A
S
D
V
W
T
E
A
N
L
S
A
E
Site 13
S109
A
N
L
S
A
E
V
S
Q
V
I
W
R
R
A
Site 14
Y132
Q
E
D
A
P
V
V
Y
L
G
S
F
R
G
V
Site 15
S146
V
Q
K
P
A
G
P
S
T
S
P
D
G
N
S
Site 16
T147
Q
K
P
A
G
P
S
T
S
P
D
G
N
S
R
Site 17
S148
K
P
A
G
P
S
T
S
P
D
G
N
S
R
C
Site 18
S153
S
T
S
P
D
G
N
S
R
C
P
P
A
Y
T
Site 19
Y159
N
S
R
C
P
P
A
Y
T
M
V
G
L
H
N
Site 20
T160
S
R
C
P
P
A
Y
T
M
V
G
L
H
N
L
Site 21
S181
N
I
A
F
H
P
V
S
F
P
E
E
K
A
V
Site 22
S194
A
V
H
K
E
K
P
S
F
P
Y
Q
D
R
P
Site 23
Y197
K
E
K
P
S
F
P
Y
Q
D
R
P
S
T
Q
Site 24
S202
F
P
Y
Q
D
R
P
S
T
Q
E
S
F
R
Q
Site 25
T203
P
Y
Q
D
R
P
S
T
Q
E
S
F
R
Q
K
Site 26
S206
D
R
P
S
T
Q
E
S
F
R
Q
K
L
A
A
Site 27
S219
A
A
F
A
G
T
T
S
G
C
H
Q
G
P
G
Site 28
S231
G
P
G
P
L
R
E
S
L
P
S
E
D
D
S
Site 29
S234
P
L
R
E
S
L
P
S
E
D
D
S
D
Q
R
Site 30
S238
S
L
P
S
E
D
D
S
D
Q
R
C
S
P
S
Site 31
S243
D
D
S
D
Q
R
C
S
P
S
G
D
S
E
G
Site 32
S245
S
D
Q
R
C
S
P
S
G
D
S
E
G
G
E
Site 33
S248
R
C
S
P
S
G
D
S
E
G
G
E
Y
C
S
Site 34
Y253
G
D
S
E
G
G
E
Y
C
S
I
L
D
C
C
Site 35
S263
I
L
D
C
C
P
G
S
P
V
A
K
A
A
S
Site 36
S270
S
P
V
A
K
A
A
S
Q
T
A
G
S
R
G
Site 37
S275
A
A
S
Q
T
A
G
S
R
G
R
H
G
G
R
Site 38
S285
R
H
G
G
R
D
C
S
P
T
C
W
E
Q
G
Site 39
S306
E
Q
E
K
R
G
P
S
F
P
K
E
C
C
S
Site 40
S313
S
F
P
K
E
C
C
S
Q
G
P
T
A
H
P
Site 41
T317
E
C
C
S
Q
G
P
T
A
H
P
S
C
L
G
Site 42
S321
Q
G
P
T
A
H
P
S
C
L
G
P
K
K
L
Site 43
T331
G
P
K
K
L
S
L
T
S
E
A
A
I
S
S
Site 44
S332
P
K
K
L
S
L
T
S
E
A
A
I
S
S
D
Site 45
S338
T
S
E
A
A
I
S
S
D
G
L
S
C
G
S
Site 46
S342
A
I
S
S
D
G
L
S
C
G
S
G
S
G
S
Site 47
S345
S
D
G
L
S
C
G
S
G
S
G
S
G
S
G
Site 48
S347
G
L
S
C
G
S
G
S
G
S
G
S
G
A
S
Site 49
S349
S
C
G
S
G
S
G
S
G
S
G
A
S
S
P
Site 50
S351
G
S
G
S
G
S
G
S
G
A
S
S
P
F
V
Site 51
S354
S
G
S
G
S
G
A
S
S
P
F
V
P
H
L
Site 52
S355
G
S
G
S
G
A
S
S
P
F
V
P
H
L
E
Site 53
S363
P
F
V
P
H
L
E
S
D
Y
C
S
L
M
K
Site 54
Y365
V
P
H
L
E
S
D
Y
C
S
L
M
K
E
P
Site 55
S367
H
L
E
S
D
Y
C
S
L
M
K
E
P
A
P
Site 56
T386
D
P
G
C
P
G
V
T
P
S
R
C
L
G
L
Site 57
T394
P
S
R
C
L
G
L
T
G
E
P
Q
P
P
A
Site 58
Y413
A
T
Q
P
E
P
I
Y
A
E
S
T
K
R
K
Tyrosine-protein kinase SgK223; Homologue of rat pragma of Rnd2 Y413 phosphosite-specific antibody AB-PK810#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK810#Tyrosine-protein kinase SgK223 / Homologue of rat pragma of Rnd2 (E410-S416, human) pY413 phosphopeptide - Powder PE-04APO99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APO99
Site 59
S416
P
E
P
I
Y
A
E
S
T
K
R
K
K
A
A
Site 60
T417
E
P
I
Y
A
E
S
T
K
R
K
K
A
A
P
Site 61
S429
A
A
P
V
P
S
K
S
Q
A
K
I
E
H
A
Site 62
S457
A
W
A
Q
K
A
A
S
G
W
G
R
D
S
P
Site 63
S463
A
S
G
W
G
R
D
S
P
D
P
T
P
Q
V
Site 64
T467
G
R
D
S
P
D
P
T
P
Q
V
S
A
T
I
Site 65
T487
H
P
E
E
D
H
R
T
I
Y
L
S
S
P
D
Site 66
Y489
E
E
D
H
R
T
I
Y
L
S
S
P
D
S
A
Site 67
S491
D
H
R
T
I
Y
L
S
S
P
D
S
A
V
G
Site 68
S492
H
R
T
I
Y
L
S
S
P
D
S
A
V
G
V
Site 69
S507
Q
W
P
R
G
P
V
S
Q
N
S
E
V
G
E
Site 70
S510
R
G
P
V
S
Q
N
S
E
V
G
E
E
E
T
Site 71
S518
E
V
G
E
E
E
T
S
A
G
Q
G
L
S
S
Site 72
S524
T
S
A
G
Q
G
L
S
S
R
E
S
H
A
H
Site 73
S525
S
A
G
Q
G
L
S
S
R
E
S
H
A
H
S
Site 74
S528
Q
G
L
S
S
R
E
S
H
A
H
S
A
S
E
Site 75
S532
S
R
E
S
H
A
H
S
A
S
E
S
K
P
K
Site 76
S534
E
S
H
A
H
S
A
S
E
S
K
P
K
E
R
Site 77
S536
H
A
H
S
A
S
E
S
K
P
K
E
R
P
A
Site 78
S549
P
A
I
P
P
K
L
S
K
S
S
P
V
G
S
Site 79
S551
I
P
P
K
L
S
K
S
S
P
V
G
S
P
V
Site 80
S552
P
P
K
L
S
K
S
S
P
V
G
S
P
V
S
Site 81
S556
S
K
S
S
P
V
G
S
P
V
S
P
S
A
G
Site 82
S559
S
P
V
G
S
P
V
S
P
S
A
G
G
P
P
Site 83
S561
V
G
S
P
V
S
P
S
A
G
G
P
P
V
S
Site 84
S577
L
A
D
L
S
D
G
S
C
G
G
S
S
I
G
Site 85
S581
S
D
G
S
C
G
G
S
S
I
G
P
Q
P
P
Site 86
S582
D
G
S
C
G
G
S
S
I
G
P
Q
P
P
S
Site 87
S589
S
I
G
P
Q
P
P
S
Q
G
P
A
D
P
A
Site 88
S598
G
P
A
D
P
A
P
S
C
R
T
N
G
V
A
Site 89
S607
R
T
N
G
V
A
I
S
D
P
S
R
C
P
Q
Site 90
S610
G
V
A
I
S
D
P
S
R
C
P
Q
P
A
A
Site 91
S618
R
C
P
Q
P
A
A
S
S
A
S
E
Q
R
R
Site 92
S621
Q
P
A
A
S
S
A
S
E
Q
R
R
P
R
F
Site 93
S651
E
V
E
Q
E
L
L
S
H
S
W
G
R
E
T
Site 94
S653
E
Q
E
L
L
S
H
S
W
G
R
E
T
K
N
Site 95
T658
S
H
S
W
G
R
E
T
K
N
G
P
T
D
H
Site 96
S666
K
N
G
P
T
D
H
S
N
S
T
T
W
H
R
Site 97
S668
G
P
T
D
H
S
N
S
T
T
W
H
R
L
H
Site 98
T670
T
D
H
S
N
S
T
T
W
H
R
L
H
P
T
Site 99
T677
T
W
H
R
L
H
P
T
D
G
S
S
G
Q
N
Site 100
S680
R
L
H
P
T
D
G
S
S
G
Q
N
S
K
V
Site 101
S681
L
H
P
T
D
G
S
S
G
Q
N
S
K
V
G
Site 102
S685
D
G
S
S
G
Q
N
S
K
V
G
T
G
M
S
Site 103
T689
G
Q
N
S
K
V
G
T
G
M
S
K
S
A
S
Site 104
S692
S
K
V
G
T
G
M
S
K
S
A
S
F
A
F
Site 105
S694
V
G
T
G
M
S
K
S
A
S
F
A
F
E
F
Site 106
S696
T
G
M
S
K
S
A
S
F
A
F
E
F
P
K
Site 107
S706
F
E
F
P
K
D
R
S
G
I
E
T
F
S
P
Site 108
T710
K
D
R
S
G
I
E
T
F
S
P
P
P
P
P
Site 109
S712
R
S
G
I
E
T
F
S
P
P
P
P
P
P
K
Site 110
S720
P
P
P
P
P
P
K
S
R
H
L
L
K
M
N
Site 111
S729
H
L
L
K
M
N
K
S
S
S
D
L
E
K
V
Site 112
S731
L
K
M
N
K
S
S
S
D
L
E
K
V
S
Q
Site 113
S737
S
S
D
L
E
K
V
S
Q
G
S
A
E
S
L
Site 114
S740
L
E
K
V
S
Q
G
S
A
E
S
L
S
P
S
Site 115
S743
V
S
Q
G
S
A
E
S
L
S
P
S
F
R
G
Site 116
S745
Q
G
S
A
E
S
L
S
P
S
F
R
G
V
H
Site 117
S747
S
A
E
S
L
S
P
S
F
R
G
V
H
V
S
Site 118
S754
S
F
R
G
V
H
V
S
F
T
T
G
S
T
D
Site 119
S759
H
V
S
F
T
T
G
S
T
D
S
L
A
S
D
Site 120
S762
F
T
T
G
S
T
D
S
L
A
S
D
S
R
T
Site 121
S765
G
S
T
D
S
L
A
S
D
S
R
T
C
S
D
Site 122
S767
T
D
S
L
A
S
D
S
R
T
C
S
D
G
G
Site 123
T769
S
L
A
S
D
S
R
T
C
S
D
G
G
P
S
Site 124
S771
A
S
D
S
R
T
C
S
D
G
G
P
S
S
E
Site 125
S777
C
S
D
G
G
P
S
S
E
L
A
H
S
P
T
Site 126
S782
P
S
S
E
L
A
H
S
P
T
N
S
G
K
K
Site 127
T784
S
E
L
A
H
S
P
T
N
S
G
K
K
L
F
Site 128
S786
L
A
H
S
P
T
N
S
G
K
K
L
F
A
P
Site 129
S798
F
A
P
V
P
F
P
S
G
S
T
E
D
V
S
Site 130
S800
P
V
P
F
P
S
G
S
T
E
D
V
S
P
S
Site 131
T801
V
P
F
P
S
G
S
T
E
D
V
S
P
S
G
Site 132
S805
S
G
S
T
E
D
V
S
P
S
G
P
Q
Q
P
Site 133
S807
S
T
E
D
V
S
P
S
G
P
Q
Q
P
P
P
Site 134
S822
L
P
Q
K
K
I
V
S
R
A
A
S
S
P
D
Site 135
S826
K
I
V
S
R
A
A
S
S
P
D
G
F
F
W
Site 136
S837
G
F
F
W
T
Q
G
S
P
K
P
G
T
A
S
Site 137
T842
Q
G
S
P
K
P
G
T
A
S
P
K
L
N
L
Site 138
S844
S
P
K
P
G
T
A
S
P
K
L
N
L
S
H
Site 139
S850
A
S
P
K
L
N
L
S
H
S
E
T
N
V
H
Site 140
S852
P
K
L
N
L
S
H
S
E
T
N
V
H
D
E
Site 141
T854
L
N
L
S
H
S
E
T
N
V
H
D
E
S
H
Site 142
S860
E
T
N
V
H
D
E
S
H
F
S
Y
S
L
S
Site 143
S863
V
H
D
E
S
H
F
S
Y
S
L
S
P
G
N
Site 144
Y864
H
D
E
S
H
F
S
Y
S
L
S
P
G
N
R
Site 145
S865
D
E
S
H
F
S
Y
S
L
S
P
G
N
R
H
Site 146
S867
S
H
F
S
Y
S
L
S
P
G
N
R
H
H
P
Site 147
S877
N
R
H
H
P
V
F
S
S
S
D
P
L
E
K
Site 148
S879
H
H
P
V
F
S
S
S
D
P
L
E
K
A
F
Site 149
S907
G
N
R
G
G
C
G
S
P
G
L
Q
C
K
G
Site 150
S917
L
Q
C
K
G
A
P
S
A
S
S
S
Q
L
S
Site 151
S919
C
K
G
A
P
S
A
S
S
S
Q
L
S
V
S
Site 152
S920
K
G
A
P
S
A
S
S
S
Q
L
S
V
S
S
Site 153
S921
G
A
P
S
A
S
S
S
Q
L
S
V
S
S
Q
Site 154
S924
S
A
S
S
S
Q
L
S
V
S
S
Q
A
S
T
Site 155
S926
S
S
S
Q
L
S
V
S
S
Q
A
S
T
G
S
Site 156
S927
S
S
Q
L
S
V
S
S
Q
A
S
T
G
S
T
Site 157
S930
L
S
V
S
S
Q
A
S
T
G
S
T
Q
L
Q
Site 158
T931
S
V
S
S
Q
A
S
T
G
S
T
Q
L
Q
L
Site 159
S933
S
S
Q
A
S
T
G
S
T
Q
L
Q
L
H
G
Site 160
T934
S
Q
A
S
T
G
S
T
Q
L
Q
L
H
G
L
Site 161
S943
L
Q
L
H
G
L
L
S
N
I
S
S
K
E
G
Site 162
S946
H
G
L
L
S
N
I
S
S
K
E
G
T
Y
A
Site 163
S947
G
L
L
S
N
I
S
S
K
E
G
T
Y
A
K
Site 164
T951
N
I
S
S
K
E
G
T
Y
A
K
L
G
G
L
Site 165
Y952
I
S
S
K
E
G
T
Y
A
K
L
G
G
L
Y
Site 166
Y1008
C
D
S
G
D
A
I
Y
Y
C
A
T
C
S
E
Site 167
Y1009
D
S
G
D
A
I
Y
Y
C
A
T
C
S
E
D
Site 168
S1019
T
C
S
E
D
P
G
S
T
Y
A
V
K
I
C
Site 169
Y1021
S
E
D
P
G
S
T
Y
A
V
K
I
C
K
A
Site 170
T1033
C
K
A
P
E
P
K
T
V
S
Y
C
S
P
S
Site 171
S1035
A
P
E
P
K
T
V
S
Y
C
S
P
S
V
P
Site 172
Y1036
P
E
P
K
T
V
S
Y
C
S
P
S
V
P
V
Site 173
S1038
P
K
T
V
S
Y
C
S
P
S
V
P
V
H
F
Site 174
S1064
S
V
P
S
S
M
L
S
S
P
D
A
P
K
D
Site 175
S1065
V
P
S
S
M
L
S
S
P
D
A
P
K
D
P
Site 176
S1101
E
V
P
H
Q
T
A
S
D
F
V
R
D
S
A
Site 177
S1107
A
S
D
F
V
R
D
S
A
A
S
H
Q
T
E
Site 178
S1110
F
V
R
D
S
A
A
S
H
Q
T
E
P
E
A
Site 179
Y1118
H
Q
T
E
P
E
A
Y
E
R
R
V
C
F
L
Site 180
S1193
P
P
A
G
G
T
L
S
P
A
A
G
P
A
S
Site 181
S1200
S
P
A
A
G
P
A
S
P
E
G
P
R
E
K
Site 182
S1226
K
A
K
Q
K
P
G
S
T
P
N
L
Q
Q
K
Site 183
T1227
A
K
Q
K
P
G
S
T
P
N
L
Q
Q
K
K
Site 184
S1235
P
N
L
Q
Q
K
K
S
Q
A
R
L
A
P
E
Site 185
S1247
A
P
E
I
V
S
A
S
Q
Y
R
K
F
D
E
Site 186
Y1249
E
I
V
S
A
S
Q
Y
R
K
F
D
E
F
Q
Site 187
Y1282
A
Q
L
R
E
R
D
Y
R
Q
E
D
L
P
P
Site 188
Y1387
E
D
W
L
C
C
Q
Y
L
A
S
A
E
P
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation