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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLCZ1
Full Name:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Alias:
Phosphoinositide phospholipase C-zeta-1;Phospholipase C-zeta-1;Testis-development protein NYD-SP27
Type:
Mass (Da):
70411
Number AA:
608
UniProt ID:
Q86YW0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T24
G
K
I
N
L
E
K
T
Q
R
L
L
E
K
L
Site 2
T56
R
L
K
Q
G
R
I
T
I
E
E
F
R
A
I
Site 3
Y64
I
E
E
F
R
A
I
Y
R
I
I
T
H
R
E
Site 4
T68
R
A
I
Y
R
I
I
T
H
R
E
E
I
I
E
Site 5
T79
E
I
I
E
I
F
N
T
Y
S
E
N
R
K
I
Site 6
T97
S
N
L
A
Q
F
L
T
Q
E
Q
Y
A
A
E
Site 7
S106
E
Q
Y
A
A
E
M
S
K
A
I
A
F
E
I
Site 8
Y117
A
F
E
I
I
Q
K
Y
E
P
I
E
E
V
R
Site 9
S130
V
R
K
A
H
Q
M
S
L
E
G
F
T
R
Y
Site 10
Y137
S
L
E
G
F
T
R
Y
M
D
S
R
E
C
L
Site 11
S140
G
F
T
R
Y
M
D
S
R
E
C
L
L
F
K
Site 12
Y154
K
N
E
C
R
K
V
Y
Q
D
M
T
H
P
L
Site 13
Y164
M
T
H
P
L
N
D
Y
F
I
S
S
S
H
N
Site 14
S167
P
L
N
D
Y
F
I
S
S
S
H
N
T
Y
L
Site 15
S169
N
D
Y
F
I
S
S
S
H
N
T
Y
L
V
S
Site 16
T172
F
I
S
S
S
H
N
T
Y
L
V
S
D
Q
L
Site 17
Y173
I
S
S
S
H
N
T
Y
L
V
S
D
Q
L
L
Site 18
Y214
A
Q
N
E
P
V
V
Y
H
G
Y
T
L
T
S
Site 19
T218
P
V
V
Y
H
G
Y
T
L
T
S
K
L
L
F
Site 20
T220
V
Y
H
G
Y
T
L
T
S
K
L
L
F
K
T
Site 21
S221
Y
H
G
Y
T
L
T
S
K
L
L
F
K
T
V
Site 22
S240
H
K
Y
A
F
M
T
S
D
Y
P
V
V
L
S
Site 23
S247
S
D
Y
P
V
V
L
S
L
E
N
H
C
S
T
Site 24
S253
L
S
L
E
N
H
C
S
T
A
Q
Q
E
V
M
Site 25
S274
T
F
G
E
S
L
L
S
D
M
L
D
D
F
P
Site 26
T283
M
L
D
D
F
P
D
T
L
P
S
P
E
A
L
Site 27
S286
D
F
P
D
T
L
P
S
P
E
A
L
K
F
K
Site 28
T307
K
I
G
T
L
K
E
T
H
E
R
K
G
S
D
Site 29
S313
E
T
H
E
R
K
G
S
D
K
R
G
D
N
Q
Site 30
T324
G
D
N
Q
D
K
E
T
G
V
K
K
L
P
G
Site 31
S363
T
K
A
E
K
F
K
S
F
Q
H
S
R
L
Y
Site 32
Y370
S
F
Q
H
S
R
L
Y
Q
Q
F
N
E
N
N
Site 33
T382
E
N
N
S
I
G
E
T
Q
A
R
K
L
S
K
Site 34
S388
E
T
Q
A
R
K
L
S
K
L
R
V
H
E
F
Site 35
Y407
R
K
F
I
T
R
I
Y
P
K
A
T
R
A
D
Site 36
T411
T
R
I
Y
P
K
A
T
R
A
D
S
S
N
F
Site 37
S415
P
K
A
T
R
A
D
S
S
N
F
N
P
Q
E
Site 38
S455
K
F
L
D
N
G
G
S
G
Y
I
L
K
P
H
Site 39
Y457
L
D
N
G
G
S
G
Y
I
L
K
P
H
F
L
Site 40
S467
K
P
H
F
L
R
E
S
K
S
Y
F
N
P
S
Site 41
S469
H
F
L
R
E
S
K
S
Y
F
N
P
S
N
I
Site 42
Y470
F
L
R
E
S
K
S
Y
F
N
P
S
N
I
K
Site 43
S474
S
K
S
Y
F
N
P
S
N
I
K
E
G
M
P
Site 44
T497
S
G
I
Q
L
P
L
T
H
S
S
S
N
K
G
Site 45
S499
I
Q
L
P
L
T
H
S
S
S
N
K
G
D
S
Site 46
S501
L
P
L
T
H
S
S
S
N
K
G
D
S
L
V
Site 47
S533
V
I
K
K
N
A
F
S
P
R
W
N
E
T
F
Site 48
T572
N
E
F
L
G
Q
Y
T
L
P
L
L
C
M
N
Site 49
S589
Y
R
R
I
P
L
F
S
R
M
G
E
S
L
E
Site 50
S599
G
E
S
L
E
P
A
S
L
F
V
Y
V
W
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation