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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CCDC125
Full Name:
Coiled-coil domain-containing protein 125
Alias:
CC125; Coiled-coil domain containing 125; KENAE; Protein kenae
Type:
Mass (Da):
58660
Number AA:
UniProt ID:
Q86Z20
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
K
V
A
R
S
S
S
E
S
D
V
Q
Site 2
S8
M
S
K
V
A
R
S
S
S
E
S
D
V
Q
L
Site 3
S9
S
K
V
A
R
S
S
S
E
S
D
V
Q
L
W
Site 4
S11
V
A
R
S
S
S
E
S
D
V
Q
L
W
E
T
Site 5
T24
E
T
E
E
D
D
M
T
E
G
D
L
G
Y
G
Site 6
Y30
M
T
E
G
D
L
G
Y
G
L
G
R
K
P
G
Site 7
Y40
G
R
K
P
G
G
I
Y
E
I
E
F
S
H
R
Site 8
S45
G
I
Y
E
I
E
F
S
H
R
S
R
K
R
S
Site 9
S48
E
I
E
F
S
H
R
S
R
K
R
S
D
G
K
Site 10
S52
S
H
R
S
R
K
R
S
D
G
K
N
F
S
P
Site 11
S58
R
S
D
G
K
N
F
S
P
P
P
F
P
R
K
Site 12
S73
G
E
E
R
N
E
A
S
F
Q
Y
S
K
H
K
Site 13
S77
N
E
A
S
F
Q
Y
S
K
H
K
S
Q
Q
D
Site 14
S81
F
Q
Y
S
K
H
K
S
Q
Q
D
T
F
P
Q
Site 15
T85
K
H
K
S
Q
Q
D
T
F
P
Q
V
S
R
I
Site 16
S93
F
P
Q
V
S
R
I
S
N
Y
R
R
Q
S
S
Site 17
Y95
Q
V
S
R
I
S
N
Y
R
R
Q
S
S
T
V
Site 18
S99
I
S
N
Y
R
R
Q
S
S
T
V
D
S
N
S
Site 19
S100
S
N
Y
R
R
Q
S
S
T
V
D
S
N
S
E
Site 20
T101
N
Y
R
R
Q
S
S
T
V
D
S
N
S
E
L
Site 21
S104
R
Q
S
S
T
V
D
S
N
S
E
L
S
N
E
Site 22
S106
S
S
T
V
D
S
N
S
E
L
S
N
E
E
L
Site 23
S109
V
D
S
N
S
E
L
S
N
E
E
L
R
Q
C
Site 24
T129
E
E
V
E
M
L
K
T
E
L
E
A
S
Q
R
Site 25
S134
L
K
T
E
L
E
A
S
Q
R
Q
L
R
G
K
Site 26
S174
K
T
M
E
Q
N
R
S
L
E
K
E
I
N
A
Site 27
Y204
E
E
S
W
I
Q
K
Y
D
R
L
N
C
E
N
Site 28
S230
E
E
I
K
M
L
K
S
D
N
A
V
L
N
Q
Site 29
S290
G
P
G
G
N
P
C
S
C
A
R
M
A
A
S
Site 30
S315
E
L
E
I
L
Q
K
S
K
E
E
A
Y
V
M
Site 31
Y320
Q
K
S
K
E
E
A
Y
V
M
A
D
A
F
R
Site 32
T345
N
D
Q
A
L
Q
L
T
Q
M
D
K
M
H
K
Site 33
S370
L
K
E
D
G
F
P
S
P
R
S
K
K
T
F
Site 34
S373
D
G
F
P
S
P
R
S
K
K
T
F
G
Q
R
Site 35
T376
P
S
P
R
S
K
K
T
F
G
Q
R
L
L
G
Site 36
S387
R
L
L
G
M
L
P
S
E
N
S
S
K
R
M
Site 37
S390
G
M
L
P
S
E
N
S
S
K
R
M
E
D
Q
Site 38
S391
M
L
P
S
E
N
S
S
K
R
M
E
D
Q
D
Site 39
S399
K
R
M
E
D
Q
D
S
P
Q
E
V
L
K
M
Site 40
S425
L
A
H
Q
R
K
V
S
Y
M
L
A
R
A
L
Site 41
T437
R
A
L
E
D
K
D
T
A
S
N
E
N
K
E
Site 42
S439
L
E
D
K
D
T
A
S
N
E
N
K
E
K
N
Site 43
T461
F
N
N
P
W
R
K
T
S
E
F
S
V
L
G
Site 44
S462
N
N
P
W
R
K
T
S
E
F
S
V
L
G
D
Site 45
Y496
H
S
Q
I
D
P
N
Y
R
T
L
K
R
S
H
Site 46
T498
Q
I
D
P
N
Y
R
T
L
K
R
S
H
S
L
Site 47
S502
N
Y
R
T
L
K
R
S
H
S
L
P
S
S
I
Site 48
S504
R
T
L
K
R
S
H
S
L
P
S
S
I
I
F
Site 49
S507
K
R
S
H
S
L
P
S
S
I
I
F
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation