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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RFX6
Full Name:
DNA-binding protein RFX6
Alias:
Regulatory factor X 6;Regulatory factor X domain-containing protein 1
Type:
Mass (Da):
102461
Number AA:
928
UniProt ID:
Q8HWS3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
K
V
P
E
L
E
D
T
F
L
Q
A
Q
P
A
Site 2
S21
A
Q
P
A
P
Q
L
S
P
G
I
Q
E
D
C
Site 3
Y46
V
Y
P
E
E
T
V
Y
L
A
A
E
G
Q
P
Site 4
S74
E
L
P
G
A
V
K
S
E
M
H
L
N
N
G
Site 5
S95
E
D
A
D
N
H
D
S
K
T
K
A
A
D
Q
Site 6
T97
A
D
N
H
D
S
K
T
K
A
A
D
Q
Y
L
Site 7
Y103
K
T
K
A
A
D
Q
Y
L
S
Q
K
K
T
I
Site 8
S105
K
A
A
D
Q
Y
L
S
Q
K
K
T
I
T
Q
Site 9
T109
Q
Y
L
S
Q
K
K
T
I
T
Q
I
V
K
D
Site 10
T124
K
K
K
Q
T
Q
L
T
L
Q
W
L
E
E
N
Site 11
Y149
R
C
I
L
Y
A
H
Y
L
D
F
C
R
K
E
Site 12
T165
L
E
P
A
C
A
A
T
F
G
K
T
I
R
Q
Site 13
T178
R
Q
K
F
P
L
L
T
T
R
R
L
G
T
R
Site 14
T184
L
T
T
R
R
L
G
T
R
G
H
S
K
Y
H
Site 15
Y190
G
T
R
G
H
S
K
Y
H
Y
Y
G
I
G
I
Site 16
Y192
R
G
H
S
K
Y
H
Y
Y
G
I
G
I
K
E
Site 17
S200
Y
G
I
G
I
K
E
S
S
A
Y
Y
H
S
V
Site 18
S201
G
I
G
I
K
E
S
S
A
Y
Y
H
S
V
Y
Site 19
Y203
G
I
K
E
S
S
A
Y
Y
H
S
V
Y
S
G
Site 20
Y204
I
K
E
S
S
A
Y
Y
H
S
V
Y
S
G
K
Site 21
S206
E
S
S
A
Y
Y
H
S
V
Y
S
G
K
G
L
Site 22
Y208
S
A
Y
Y
H
S
V
Y
S
G
K
G
L
T
R
Site 23
S209
A
Y
Y
H
S
V
Y
S
G
K
G
L
T
R
F
Site 24
S217
G
K
G
L
T
R
F
S
G
S
K
L
K
N
E
Site 25
S219
G
L
T
R
F
S
G
S
K
L
K
N
E
G
G
Site 26
T228
L
K
N
E
G
G
F
T
R
K
Y
S
L
S
S
Site 27
Y231
E
G
G
F
T
R
K
Y
S
L
S
S
K
T
G
Site 28
S232
G
G
F
T
R
K
Y
S
L
S
S
K
T
G
T
Site 29
S234
F
T
R
K
Y
S
L
S
S
K
T
G
T
L
L
Site 30
T239
S
L
S
S
K
T
G
T
L
L
P
E
F
P
S
Site 31
S246
T
L
L
P
E
F
P
S
A
Q
H
L
V
Y
Q
Site 32
Y252
P
S
A
Q
H
L
V
Y
Q
G
C
I
S
K
D
Site 33
T263
I
S
K
D
K
V
D
T
L
I
M
M
Y
K
T
Site 34
T334
T
D
V
L
I
P
A
T
M
Q
E
M
P
E
S
Site 35
S341
T
M
Q
E
M
P
E
S
L
L
A
D
I
R
N
Site 36
T369
E
N
L
P
E
A
L
T
D
K
K
I
P
I
V
Site 37
S381
P
I
V
R
R
F
V
S
S
L
K
R
Q
T
S
Site 38
S382
I
V
R
R
F
V
S
S
L
K
R
Q
T
S
F
Site 39
T387
V
S
S
L
K
R
Q
T
S
F
L
H
L
A
Q
Site 40
S388
S
S
L
K
R
Q
T
S
F
L
H
L
A
Q
I
Site 41
S430
S
Q
A
L
L
T
I
S
G
S
T
D
T
E
S
Site 42
T435
T
I
S
G
S
T
D
T
E
S
G
I
Y
T
E
Site 43
S437
S
G
S
T
D
T
E
S
G
I
Y
T
E
H
D
Site 44
Y440
T
D
T
E
S
G
I
Y
T
E
H
D
S
I
T
Site 45
T441
D
T
E
S
G
I
Y
T
E
H
D
S
I
T
V
Site 46
S445
G
I
Y
T
E
H
D
S
I
T
V
F
Q
E
L
Site 47
T447
Y
T
E
H
D
S
I
T
V
F
Q
E
L
K
D
Site 48
T461
D
L
L
K
K
N
A
T
V
E
A
F
I
E
W
Site 49
S481
E
Q
R
V
I
K
T
S
K
Q
N
G
R
S
L
Site 50
T511
A
R
V
M
H
N
L
T
L
N
N
A
S
S
F
Site 51
S516
N
L
T
L
N
N
A
S
S
F
G
S
F
H
L
Site 52
Y531
I
R
M
L
L
D
E
Y
I
L
L
A
M
E
T
Site 53
T538
Y
I
L
L
A
M
E
T
Q
F
N
N
D
K
E
Site 54
Y555
L
Q
N
L
L
D
K
Y
M
K
N
S
D
A
S
Site 55
S562
Y
M
K
N
S
D
A
S
K
A
A
F
T
A
S
Site 56
T567
D
A
S
K
A
A
F
T
A
S
P
S
S
C
F
Site 57
S572
A
F
T
A
S
P
S
S
C
F
L
A
N
R
N
Site 58
S582
L
A
N
R
N
K
G
S
M
V
S
S
D
A
V
Site 59
S586
N
K
G
S
M
V
S
S
D
A
V
K
N
E
S
Site 60
S593
S
D
A
V
K
N
E
S
H
V
E
T
T
Y
L
Site 61
T597
K
N
E
S
H
V
E
T
T
Y
L
P
L
P
S
Site 62
T598
N
E
S
H
V
E
T
T
Y
L
P
L
P
S
S
Site 63
Y599
E
S
H
V
E
T
T
Y
L
P
L
P
S
S
Q
Site 64
S604
T
T
Y
L
P
L
P
S
S
Q
P
G
G
L
G
Site 65
S605
T
Y
L
P
L
P
S
S
Q
P
G
G
L
G
P
Site 66
T628
N
T
D
N
M
P
L
T
G
Q
M
E
L
S
Q
Site 67
S646
H
L
M
T
P
P
I
S
P
A
M
A
S
R
G
Site 68
S651
P
I
S
P
A
M
A
S
R
G
S
V
I
N
Q
Site 69
S654
P
A
M
A
S
R
G
S
V
I
N
Q
G
P
M
Site 70
S676
G
P
V
L
S
A
P
S
H
C
S
T
Y
P
E
Site 71
S679
L
S
A
P
S
H
C
S
T
Y
P
E
P
I
Y
Site 72
T680
S
A
P
S
H
C
S
T
Y
P
E
P
I
Y
P
Site 73
Y681
A
P
S
H
C
S
T
Y
P
E
P
I
Y
P
T
Site 74
Y686
S
T
Y
P
E
P
I
Y
P
T
L
P
Q
A
N
Site 75
Y697
P
Q
A
N
H
D
F
Y
S
T
S
S
N
Y
Q
Site 76
Y703
F
Y
S
T
S
S
N
Y
Q
T
V
F
R
A
Q
Site 77
T705
S
T
S
S
N
Y
Q
T
V
F
R
A
Q
P
H
Site 78
S713
V
F
R
A
Q
P
H
S
T
S
G
L
Y
P
H
Site 79
Y718
P
H
S
T
S
G
L
Y
P
H
H
T
E
H
G
Site 80
S736
A
W
T
E
Q
Q
L
S
R
D
F
F
S
G
S
Site 81
S741
Q
L
S
R
D
F
F
S
G
S
C
A
G
S
P
Site 82
S743
S
R
D
F
F
S
G
S
C
A
G
S
P
Y
N
Site 83
S747
F
S
G
S
C
A
G
S
P
Y
N
S
R
P
P
Site 84
Y749
G
S
C
A
G
S
P
Y
N
S
R
P
P
S
S
Site 85
S751
C
A
G
S
P
Y
N
S
R
P
P
S
S
Y
G
Site 86
S755
P
Y
N
S
R
P
P
S
S
Y
G
P
S
L
Q
Site 87
S756
Y
N
S
R
P
P
S
S
Y
G
P
S
L
Q
A
Site 88
Y757
N
S
R
P
P
S
S
Y
G
P
S
L
Q
A
Q
Site 89
S760
P
P
S
S
Y
G
P
S
L
Q
A
Q
D
S
H
Site 90
S766
P
S
L
Q
A
Q
D
S
H
N
M
Q
F
L
N
Site 91
S776
M
Q
F
L
N
T
G
S
F
N
F
L
S
N
T
Site 92
T783
S
F
N
F
L
S
N
T
G
A
A
S
C
Q
G
Site 93
T792
A
A
S
C
Q
G
A
T
L
P
P
N
S
P
N
Site 94
S797
G
A
T
L
P
P
N
S
P
N
G
Y
Y
G
S
Site 95
Y801
P
P
N
S
P
N
G
Y
Y
G
S
N
I
N
Y
Site 96
Y802
P
N
S
P
N
G
Y
Y
G
S
N
I
N
Y
P
Site 97
S804
S
P
N
G
Y
Y
G
S
N
I
N
Y
P
E
S
Site 98
Y808
Y
Y
G
S
N
I
N
Y
P
E
S
H
R
L
G
Site 99
S811
S
N
I
N
Y
P
E
S
H
R
L
G
S
M
V
Site 100
S816
P
E
S
H
R
L
G
S
M
V
N
Q
H
V
S
Site 101
S826
N
Q
H
V
S
V
I
S
S
I
R
S
L
P
P
Site 102
S827
Q
H
V
S
V
I
S
S
I
R
S
L
P
P
Y
Site 103
Y834
S
I
R
S
L
P
P
Y
S
D
I
H
D
P
L
Site 104
S835
I
R
S
L
P
P
Y
S
D
I
H
D
P
L
N
Site 105
S847
P
L
N
I
L
D
D
S
G
R
K
Q
T
S
S
Site 106
T852
D
D
S
G
R
K
Q
T
S
S
F
Y
T
D
T
Site 107
S854
S
G
R
K
Q
T
S
S
F
Y
T
D
T
S
S
Site 108
Y856
R
K
Q
T
S
S
F
Y
T
D
T
S
S
P
V
Site 109
T857
K
Q
T
S
S
F
Y
T
D
T
S
S
P
V
A
Site 110
T859
T
S
S
F
Y
T
D
T
S
S
P
V
A
C
R
Site 111
S860
S
S
F
Y
T
D
T
S
S
P
V
A
C
R
T
Site 112
S861
S
F
Y
T
D
T
S
S
P
V
A
C
R
T
P
Site 113
S873
R
T
P
V
L
A
S
S
L
Q
T
P
I
P
S
Site 114
S880
S
L
Q
T
P
I
P
S
S
S
S
Q
C
M
Y
Site 115
S881
L
Q
T
P
I
P
S
S
S
S
Q
C
M
Y
G
Site 116
S883
T
P
I
P
S
S
S
S
Q
C
M
Y
G
T
S
Site 117
Y887
S
S
S
S
Q
C
M
Y
G
T
S
N
Q
Y
P
Site 118
Y893
M
Y
G
T
S
N
Q
Y
P
A
Q
E
T
L
D
Site 119
S901
P
A
Q
E
T
L
D
S
H
G
T
S
S
R
E
Site 120
S905
T
L
D
S
H
G
T
S
S
R
E
M
V
S
S
Site 121
S906
L
D
S
H
G
T
S
S
R
E
M
V
S
S
L
Site 122
S912
S
S
R
E
M
V
S
S
L
P
P
I
N
T
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation