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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMC8
Full Name:
Transmembrane channel-like protein 8
Alias:
Epidermodysplasia verruciformis protein 2; EVER2; EVIN2; Transmembrane channel-like 8
Type:
Membrane protein, integral
Mass (Da):
81641
Number AA:
726
UniProt ID:
Q8IU68
International Prot ID:
IPI00302538
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
L
L
P
R
S
V
S
S
E
R
A
P
Site 2
S8
M
L
L
P
R
S
V
S
S
E
R
A
P
G
V
Site 3
S9
L
L
P
R
S
V
S
S
E
R
A
P
G
V
P
Site 4
S32
E
M
E
R
L
R
G
S
G
T
P
V
R
G
L
Site 5
T34
E
R
L
R
G
S
G
T
P
V
R
G
L
P
Y
Site 6
T60
R
E
P
A
G
V
Q
T
L
R
W
Q
R
W
Q
Site 7
T72
R
W
Q
R
R
R
Q
T
V
E
R
R
L
R
E
Site 8
T146
R
P
P
D
P
G
P
T
L
N
L
T
L
Q
C
Site 9
T150
P
G
P
T
L
N
L
T
L
Q
C
P
G
S
R
Site 10
S156
L
T
L
Q
C
P
G
S
R
Q
S
P
P
G
V
Site 11
S159
Q
C
P
G
S
R
Q
S
P
P
G
V
L
R
F
Site 12
T175
N
Q
L
W
H
V
L
T
G
R
A
F
T
N
T
Site 13
T182
T
G
R
A
F
T
N
T
Y
L
F
Y
G
A
Y
Site 14
Y183
G
R
A
F
T
N
T
Y
L
F
Y
G
A
Y
R
Site 15
Y189
T
Y
L
F
Y
G
A
Y
R
V
G
P
E
S
S
Site 16
S195
A
Y
R
V
G
P
E
S
S
S
V
Y
S
I
R
Site 17
S196
Y
R
V
G
P
E
S
S
S
V
Y
S
I
R
L
Site 18
S197
R
V
G
P
E
S
S
S
V
Y
S
I
R
L
A
Site 19
T232
V
K
G
L
P
Q
K
T
L
L
G
Q
G
Y
Q
Site 20
Y238
K
T
L
L
G
Q
G
Y
Q
A
P
L
S
A
K
Site 21
S243
Q
G
Y
Q
A
P
L
S
A
K
V
F
S
S
W
Site 22
T292
Q
Q
Q
T
R
A
Q
T
A
C
R
L
L
S
Y
Site 23
Y299
T
A
C
R
L
L
S
Y
L
R
V
N
V
L
N
Site 24
S315
L
L
V
V
G
A
I
S
A
I
F
W
A
T
K
Site 25
T321
I
S
A
I
F
W
A
T
K
Y
S
Q
D
N
K
Site 26
S324
I
F
W
A
T
K
Y
S
Q
D
N
K
E
E
S
Site 27
S331
S
Q
D
N
K
E
E
S
L
F
L
L
L
Q
Y
Site 28
Y364
F
L
V
Q
L
E
N
Y
P
P
N
T
E
V
N
Site 29
T368
L
E
N
Y
P
P
N
T
E
V
N
L
T
L
I
Site 30
S404
L
C
I
G
R
D
K
S
S
C
E
S
Y
G
Y
Site 31
Y409
D
K
S
S
C
E
S
Y
G
Y
N
V
C
D
Y
Site 32
Y428
N
S
V
G
E
E
L
Y
K
L
S
I
F
N
F
Site 33
Y512
L
T
F
Y
I
K
K
Y
T
L
L
K
N
S
R
Site 34
S518
K
Y
T
L
L
K
N
S
R
A
S
S
R
P
F
Site 35
S521
L
L
K
N
S
R
A
S
S
R
P
F
R
A
S
Site 36
S522
L
K
N
S
R
A
S
S
R
P
F
R
A
S
S
Site 37
S528
S
S
R
P
F
R
A
S
S
S
T
F
F
F
Q
Site 38
S529
S
R
P
F
R
A
S
S
S
T
F
F
F
Q
L
Site 39
Y593
I
G
Q
R
A
L
H
Y
L
G
S
H
A
F
S
Site 40
S647
W
H
L
V
E
D
L
S
R
L
L
P
E
P
G
Site 41
S656
L
L
P
E
P
G
P
S
D
S
P
G
P
K
Y
Site 42
S658
P
E
P
G
P
S
D
S
P
G
P
K
Y
P
A
Site 43
Y663
S
D
S
P
G
P
K
Y
P
A
S
Q
A
S
R
Site 44
S666
P
G
P
K
Y
P
A
S
Q
A
S
R
P
Q
S
Site 45
S669
K
Y
P
A
S
Q
A
S
R
P
Q
S
F
C
P
Site 46
S673
S
Q
A
S
R
P
Q
S
F
C
P
G
C
P
C
Site 47
S683
P
G
C
P
C
P
G
S
P
G
H
Q
A
P
R
Site 48
S694
Q
A
P
R
P
G
P
S
V
V
D
A
A
G
L
Site 49
S703
V
D
A
A
G
L
R
S
P
C
P
G
Q
H
G
Site 50
S714
G
Q
H
G
A
P
A
S
A
R
R
F
R
F
P
Site 51
S722
A
R
R
F
R
F
P
S
G
A
E
L
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation