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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RHPN2
Full Name:
Rhophilin-2
Alias:
76 kDa RhoB effector protein; GTP-Rho-binding protein 2; P76RBE; RhoBP; Rhophilin, Rho GTPase binding protein 2
Type:
Vesicle protein
Mass (Da):
76993
Number AA:
686
UniProt ID:
Q8IUC4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y20
L
E
K
E
N
D
G
Y
F
R
K
G
C
N
P
Site 2
T31
G
C
N
P
L
A
Q
T
G
R
S
K
L
Q
N
Site 3
T55
L
K
A
V
R
M
R
T
G
A
E
N
L
L
K
Site 4
S67
L
L
K
V
A
T
N
S
K
V
R
E
Q
V
R
Site 5
S78
E
Q
V
R
L
E
L
S
F
V
N
S
D
L
Q
Site 6
S82
L
E
L
S
F
V
N
S
D
L
Q
M
L
K
E
Site 7
S97
E
L
E
G
L
N
I
S
V
G
V
Y
Q
N
T
Site 8
Y101
L
N
I
S
V
G
V
Y
Q
N
T
E
E
A
F
Site 9
T104
S
V
G
V
Y
Q
N
T
E
E
A
F
T
I
P
Site 10
Y137
K
D
F
I
L
E
H
Y
S
E
D
G
Y
L
Y
Site 11
Y142
E
H
Y
S
E
D
G
Y
L
Y
E
D
E
I
A
Site 12
Y144
Y
S
E
D
G
Y
L
Y
E
D
E
I
A
D
L
Site 13
T160
D
L
R
Q
A
C
R
T
P
S
R
D
E
A
G
Site 14
S162
R
Q
A
C
R
T
P
S
R
D
E
A
G
V
E
Site 15
S183
I
Q
L
G
F
V
E
S
R
F
F
P
P
T
R
Site 16
T189
E
S
R
F
F
P
P
T
R
Q
M
G
L
L
F
Site 17
T197
R
Q
M
G
L
L
F
T
W
Y
D
S
L
T
G
Site 18
T203
F
T
W
Y
D
S
L
T
G
V
P
V
S
Q
Q
Site 19
T238
G
T
R
C
D
R
Q
T
Q
A
G
L
E
S
A
Site 20
Y258
R
A
A
G
V
L
N
Y
L
K
D
T
F
T
H
Site 21
T262
V
L
N
Y
L
K
D
T
F
T
H
T
P
S
Y
Site 22
T264
N
Y
L
K
D
T
F
T
H
T
P
S
Y
D
M
Site 23
T266
L
K
D
T
F
T
H
T
P
S
Y
D
M
S
P
Site 24
S268
D
T
F
T
H
T
P
S
Y
D
M
S
P
A
M
Site 25
Y269
T
F
T
H
T
P
S
Y
D
M
S
P
A
M
L
Site 26
S296
E
S
V
F
E
K
I
S
L
P
G
I
R
N
E
Site 27
S329
Q
Q
L
H
A
A
M
S
Q
A
P
V
K
E
N
Site 28
Y339
P
V
K
E
N
I
P
Y
S
W
A
S
L
A
C
Site 29
Y386
E
K
C
L
S
Q
L
Y
D
H
M
P
E
G
L
Site 30
T394
D
H
M
P
E
G
L
T
P
L
A
T
L
K
N
Site 31
T398
E
G
L
T
P
L
A
T
L
K
N
D
Q
Q
R
Site 32
S411
Q
R
R
Q
L
G
K
S
H
L
R
R
A
M
A
Site 33
S423
A
M
A
H
H
E
E
S
V
R
E
A
S
L
C
Site 34
S428
E
E
S
V
R
E
A
S
L
C
K
K
L
R
S
Site 35
T453
A
Q
E
R
S
R
L
T
Y
A
Q
H
Q
E
E
Site 36
Y454
Q
E
R
S
R
L
T
Y
A
Q
H
Q
E
E
D
Site 37
T491
L
P
Q
F
S
K
L
T
V
T
D
F
F
Q
K
Site 38
S503
F
Q
K
L
G
P
L
S
V
F
S
A
N
K
R
Site 39
T512
F
S
A
N
K
R
W
T
P
P
R
S
I
R
F
Site 40
S516
K
R
W
T
P
P
R
S
I
R
F
T
A
E
E
Site 41
T520
P
P
R
S
I
R
F
T
A
E
E
G
D
L
G
Site 42
T529
E
E
G
D
L
G
F
T
L
R
G
N
A
P
V
Site 43
S548
L
D
P
Y
C
S
A
S
V
A
G
A
R
E
G
Site 44
S580
E
V
M
K
L
L
K
S
F
G
E
D
E
I
E
Site 45
S596
K
V
V
S
L
L
D
S
T
S
S
M
H
N
K
Site 46
S598
V
S
L
L
D
S
T
S
S
M
H
N
K
S
A
Site 47
S599
S
L
L
D
S
T
S
S
M
H
N
K
S
A
T
Site 48
S604
T
S
S
M
H
N
K
S
A
T
Y
S
V
G
M
Site 49
T606
S
M
H
N
K
S
A
T
Y
S
V
G
M
Q
K
Site 50
Y607
M
H
N
K
S
A
T
Y
S
V
G
M
Q
K
T
Site 51
S608
H
N
K
S
A
T
Y
S
V
G
M
Q
K
T
Y
Site 52
S616
V
G
M
Q
K
T
Y
S
M
I
C
L
A
I
D
Site 53
T628
A
I
D
D
D
D
K
T
D
K
T
K
K
I
S
Site 54
T631
D
D
D
K
T
D
K
T
K
K
I
S
K
K
L
Site 55
S635
T
D
K
T
K
K
I
S
K
K
L
S
F
L
S
Site 56
S639
K
K
I
S
K
K
L
S
F
L
S
W
G
T
N
Site 57
S642
S
K
K
L
S
F
L
S
W
G
T
N
K
N
R
Site 58
T645
L
S
F
L
S
W
G
T
N
K
N
R
Q
K
S
Site 59
S652
T
N
K
N
R
Q
K
S
A
S
T
L
C
L
P
Site 60
S654
K
N
R
Q
K
S
A
S
T
L
C
L
P
S
V
Site 61
T655
N
R
Q
K
S
A
S
T
L
C
L
P
S
V
G
Site 62
S674
Q
V
K
K
K
L
P
S
P
F
S
L
L
N
S
Site 63
S677
K
K
L
P
S
P
F
S
L
L
N
S
D
S
S
Site 64
S681
S
P
F
S
L
L
N
S
D
S
S
W
Y
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation