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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RNF135
Full Name:
E3 ubiquitin-protein ligase RNF135
Alias:
RIG-I E3 ubiquitin ligase;RING finger protein 135;Riplet
Type:
Mass (Da):
47888
Number AA:
432
UniProt ID:
Q8IUD6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T76
Q
P
H
L
R
K
N
T
L
L
Q
D
L
A
D
Site 2
Y85
L
Q
D
L
A
D
K
Y
R
R
A
A
R
E
I
Site 3
S106
A
H
C
P
C
P
G
S
S
S
L
S
S
A
A
Site 4
S107
H
C
P
C
P
G
S
S
S
L
S
S
A
A
A
Site 5
S108
C
P
C
P
G
S
S
S
L
S
S
A
A
A
R
Site 6
S110
C
P
G
S
S
S
L
S
S
A
A
A
R
P
R
Site 7
S111
P
G
S
S
S
L
S
S
A
A
A
R
P
R
R
Site 8
S159
L
Q
N
Q
R
P
L
S
E
S
G
P
D
N
E
Site 9
S161
N
Q
R
P
L
S
E
S
G
P
D
N
E
L
S
Site 10
S168
S
G
P
D
N
E
L
S
I
L
G
K
A
F
S
Site 11
T192
P
K
L
V
T
S
D
T
A
A
G
K
I
R
D
Site 12
S214
I
Q
E
K
L
Q
E
S
V
T
W
K
E
A
P
Site 13
S234
G
E
L
L
E
A
P
S
S
S
S
C
P
L
P
Site 14
S235
E
L
L
E
A
P
S
S
S
S
C
P
L
P
D
Site 15
S236
L
L
E
A
P
S
S
S
S
C
P
L
P
D
Q
Site 16
S244
S
C
P
L
P
D
Q
S
H
P
A
L
R
R
A
Site 17
S252
H
P
A
L
R
R
A
S
R
F
A
Q
W
A
I
Site 18
T262
A
Q
W
A
I
H
P
T
F
N
L
K
S
L
S
Site 19
S267
H
P
T
F
N
L
K
S
L
S
C
S
L
E
G
Site 20
S269
T
F
N
L
K
S
L
S
C
S
L
E
G
S
K
Site 21
S271
N
L
K
S
L
S
C
S
L
E
G
S
K
D
S
Site 22
S275
L
S
C
S
L
E
G
S
K
D
S
R
T
V
T
Site 23
S278
S
L
E
G
S
K
D
S
R
T
V
T
V
S
H
Site 24
T280
E
G
S
K
D
S
R
T
V
T
V
S
H
R
P
Site 25
T282
S
K
D
S
R
T
V
T
V
S
H
R
P
Q
P
Site 26
S284
D
S
R
T
V
T
V
S
H
R
P
Q
P
Y
R
Site 27
S300
N
C
E
R
F
S
T
S
Q
V
L
C
S
Q
A
Site 28
S305
S
T
S
Q
V
L
C
S
Q
A
L
S
S
G
K
Site 29
S309
V
L
C
S
Q
A
L
S
S
G
K
H
Y
W
E
Site 30
Y314
A
L
S
S
G
K
H
Y
W
E
V
D
T
R
N
Site 31
S335
G
V
A
S
W
E
M
S
R
D
Q
V
L
G
R
Site 32
T366
A
W
H
M
V
K
E
T
V
L
G
S
D
R
P
Site 33
S370
V
K
E
T
V
L
G
S
D
R
P
G
V
V
G
Site 34
Y390
E
E
G
K
L
A
F
Y
S
V
D
N
Q
E
K
Site 35
S391
E
G
K
L
A
F
Y
S
V
D
N
Q
E
K
L
Site 36
Y400
D
N
Q
E
K
L
L
Y
E
C
T
I
S
A
S
Site 37
Y417
L
Y
P
A
F
W
L
Y
G
L
H
P
G
N
Y
Site 38
Y424
Y
G
L
H
P
G
N
Y
L
I
I
K
Q
V
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation