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Updated November 2019
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Protein Info
Short Name:
MYO18B
Full Name:
Myosin-XVIIIb
Alias:
BK125H2.1; MY18B; myosin 18B; myosin XVIIIb; Myosin-18B
Type:
Motor protein
Mass (Da):
285185
Number AA:
2567
UniProt ID:
Q8IUG5
International Prot ID:
IPI00306929
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0016459
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003774
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
K
I
R
E
E
D
K
S
P
P
P
S
S
P
P
Site 2
S24
E
D
K
S
P
P
P
S
S
P
P
P
L
F
S
Site 3
S25
D
K
S
P
P
P
S
S
P
P
P
L
F
S
V
Site 4
T45
I
K
Q
L
V
R
G
T
E
K
E
A
K
E
A
Site 5
S62
R
K
Q
L
A
V
A
S
P
E
R
E
I
P
E
Site 6
S71
E
R
E
I
P
E
I
S
I
S
Q
P
N
S
K
Site 7
S73
E
I
P
E
I
S
I
S
Q
P
N
S
K
S
S
Site 8
S77
I
S
I
S
Q
P
N
S
K
S
S
S
G
T
R
Site 9
S79
I
S
Q
P
N
S
K
S
S
S
G
T
R
S
G
Site 10
S81
Q
P
N
S
K
S
S
S
G
T
R
S
G
S
Q
Site 11
T83
N
S
K
S
S
S
G
T
R
S
G
S
Q
Q
I
Site 12
S85
K
S
S
S
G
T
R
S
G
S
Q
Q
I
S
Q
Site 13
S87
S
S
G
T
R
S
G
S
Q
Q
I
S
Q
D
D
Site 14
S91
R
S
G
S
Q
Q
I
S
Q
D
D
Q
S
S
S
Site 15
S96
Q
I
S
Q
D
D
Q
S
S
S
P
G
S
S
D
Site 16
S97
I
S
Q
D
D
Q
S
S
S
P
G
S
S
D
I
Site 17
S98
S
Q
D
D
Q
S
S
S
P
G
S
S
D
I
L
Site 18
S101
D
Q
S
S
S
P
G
S
S
D
I
L
G
K
E
Site 19
S102
Q
S
S
S
P
G
S
S
D
I
L
G
K
E
S
Site 20
S112
L
G
K
E
S
E
G
S
R
S
P
D
P
E
Q
Site 21
S114
K
E
S
E
G
S
R
S
P
D
P
E
Q
M
T
Site 22
T121
S
P
D
P
E
Q
M
T
S
I
N
G
E
K
A
Site 23
S122
P
D
P
E
Q
M
T
S
I
N
G
E
K
A
Q
Site 24
S133
E
K
A
Q
E
L
G
S
S
A
T
P
T
K
K
Site 25
S134
K
A
Q
E
L
G
S
S
A
T
P
T
K
K
T
Site 26
T136
Q
E
L
G
S
S
A
T
P
T
K
K
T
V
P
Site 27
T138
L
G
S
S
A
T
P
T
K
K
T
V
P
F
K
Site 28
T141
S
A
T
P
T
K
K
T
V
P
F
K
R
G
V
Site 29
S164
V
A
K
L
D
P
D
S
A
K
P
E
K
T
H
Site 30
S181
D
A
P
P
C
K
T
S
P
P
A
T
D
T
G
Site 31
T185
C
K
T
S
P
P
A
T
D
T
G
K
E
K
K
Site 32
T195
G
K
E
K
K
G
E
T
S
R
T
P
C
G
S
Site 33
S196
K
E
K
K
G
E
T
S
R
T
P
C
G
S
Q
Site 34
T198
K
K
G
E
T
S
R
T
P
C
G
S
Q
A
S
Site 35
S202
T
S
R
T
P
C
G
S
Q
A
S
T
E
I
L
Site 36
T206
P
C
G
S
Q
A
S
T
E
I
L
A
P
K
A
Site 37
T216
L
A
P
K
A
E
K
T
R
T
G
G
L
G
D
Site 38
T218
P
K
A
E
K
T
R
T
G
G
L
G
D
P
G
Site 39
T228
L
G
D
P
G
Q
G
T
V
A
L
K
K
G
E
Site 40
S239
K
K
G
E
E
G
Q
S
I
V
G
K
G
L
G
Site 41
T247
I
V
G
K
G
L
G
T
P
K
T
T
E
L
K
Site 42
T250
K
G
L
G
T
P
K
T
T
E
L
K
E
A
E
Site 43
T266
Q
G
K
D
R
Q
G
T
R
P
Q
A
Q
G
P
Site 44
T292
E
G
A
E
P
T
N
T
V
E
K
G
N
V
S
Site 45
S326
G
G
F
L
G
R
R
S
K
W
D
G
P
Q
N
Site 46
S343
D
K
E
G
V
L
L
S
K
A
E
K
T
G
E
Site 47
T353
E
K
T
G
E
P
Q
T
Q
M
E
K
T
S
Q
Site 48
S380
E
K
A
G
E
L
R
S
T
T
G
K
A
G
E
Site 49
T381
K
A
G
E
L
R
S
T
T
G
K
A
G
E
S
Site 50
T382
A
G
E
L
R
S
T
T
G
K
A
G
E
S
W
Site 51
S402
M
G
Q
P
Q
G
K
S
G
N
A
G
E
A
R
Site 52
S410
G
N
A
G
E
A
R
S
Q
T
E
K
G
C
E
Site 53
T412
A
G
E
A
R
S
Q
T
E
K
G
C
E
A
P
Site 54
S423
C
E
A
P
K
E
V
S
T
M
V
E
S
P
A
Site 55
T424
E
A
P
K
E
V
S
T
M
V
E
S
P
A
A
Site 56
S428
E
V
S
T
M
V
E
S
P
A
A
P
G
K
G
Site 57
S440
G
K
G
G
W
P
G
S
R
G
Q
E
A
E
E
Site 58
S450
Q
E
A
E
E
P
C
S
R
A
G
D
G
A
G
Site 59
T461
D
G
A
G
A
L
E
T
E
L
E
G
P
S
Q
Site 60
S502
K
G
G
Q
S
R
D
S
D
Q
A
P
E
D
R
Site 61
Y511
Q
A
P
E
D
R
W
Y
E
A
E
K
V
W
L
Site 62
T528
K
D
G
F
T
L
A
T
V
L
K
P
D
E
G
Site 63
T553
L
W
I
D
A
D
K
T
I
T
E
V
D
E
E
Site 64
S578
D
Q
V
E
D
L
A
S
L
I
S
V
N
E
S
Site 65
T590
N
E
S
S
V
L
N
T
L
L
Q
R
Y
K
A
Site 66
S617
V
L
Q
P
R
G
P
S
V
P
S
A
G
K
V
Site 67
S620
P
R
G
P
S
V
P
S
A
G
K
V
P
K
G
Site 68
Y644
G
S
M
A
Q
R
A
Y
W
A
L
L
N
Q
R
Site 69
S655
L
N
Q
R
R
D
Q
S
I
V
A
L
G
R
S
Site 70
T667
G
R
S
G
A
G
K
T
T
C
C
E
Q
V
L
Site 71
S689
G
S
V
D
G
R
V
S
V
E
K
I
R
A
T
Site 72
S707
L
R
A
F
G
S
V
S
M
A
H
S
R
S
A
Site 73
S711
G
S
V
S
M
A
H
S
R
S
A
T
R
F
S
Site 74
S713
V
S
M
A
H
S
R
S
A
T
R
F
S
M
V
Site 75
T715
M
A
H
S
R
S
A
T
R
F
S
M
V
M
S
Site 76
S718
S
R
S
A
T
R
F
S
M
V
M
S
L
D
F
Site 77
T728
M
S
L
D
F
N
A
T
G
R
I
T
A
A
Q
Site 78
T772
G
L
D
L
D
L
R
T
E
L
N
L
H
Q
M
Site 79
S782
N
L
H
Q
M
A
D
S
S
S
F
G
M
G
V
Site 80
S784
H
Q
M
A
D
S
S
S
F
G
M
G
V
W
S
Site 81
S818
E
M
L
G
I
S
E
S
E
Q
R
A
V
W
R
Site 82
T870
Y
E
E
L
N
T
A
T
F
K
H
H
L
R
Q
Site 83
T896
W
G
L
E
D
E
E
T
S
S
G
L
K
M
T
Site 84
S898
L
E
D
E
E
T
S
S
G
L
K
M
T
G
V
Site 85
S932
S
L
I
N
R
S
F
S
S
H
H
L
S
M
A
Site 86
S933
L
I
N
R
S
F
S
S
H
H
L
S
M
A
S
Site 87
S946
A
S
I
M
V
V
D
S
P
G
F
Q
N
P
R
Site 88
T962
Q
G
K
D
R
A
A
T
F
E
E
L
C
H
N
Site 89
Y980
E
R
L
Q
L
L
F
Y
Q
R
T
F
V
S
T
Site 90
T983
Q
L
L
F
Y
Q
R
T
F
V
S
T
L
Q
R
Site 91
T987
Y
Q
R
T
F
V
S
T
L
Q
R
Y
Q
E
E
Site 92
S1006
Q
F
D
L
P
D
P
S
P
G
T
T
V
A
V
Site 93
T1010
P
D
P
S
P
G
T
T
V
A
V
V
D
Q
N
Site 94
S1019
A
V
V
D
Q
N
P
S
Q
V
R
L
P
A
G
Site 95
S1049
E
V
H
V
E
G
S
S
D
S
V
V
L
E
R
Site 96
S1051
H
V
E
G
S
S
D
S
V
V
L
E
R
L
C
Site 97
S1071
G
A
G
T
E
G
S
S
A
L
R
T
C
E
Q
Site 98
S1072
G
A
G
T
E
G
S
S
A
L
R
T
C
E
Q
Site 99
T1076
E
G
S
S
A
L
R
T
C
E
Q
P
L
Q
C
Site 100
Y1096
L
G
W
D
P
V
R
Y
D
L
T
G
W
L
H
Site 101
T1099
D
P
V
R
Y
D
L
T
G
W
L
H
R
A
K
Site 102
S1110
H
R
A
K
P
N
L
S
A
L
D
A
P
Q
V
Site 103
S1121
A
P
Q
V
L
H
Q
S
K
R
E
E
L
R
S
Site 104
S1128
S
K
R
E
E
L
R
S
L
F
Q
A
R
A
K
Site 105
T1163
R
S
R
M
V
R
R
T
F
A
S
S
L
A
A
Site 106
S1166
M
V
R
R
T
F
A
S
S
L
A
A
V
R
R
Site 107
S1167
V
R
R
T
F
A
S
S
L
A
A
V
R
R
K
Site 108
S1178
V
R
R
K
A
P
C
S
Q
I
K
L
Q
M
D
Site 109
T1188
K
L
Q
M
D
A
L
T
S
M
I
K
R
S
R
Site 110
S1210
V
P
N
P
V
V
E
S
R
S
G
Q
E
S
P
Site 111
S1212
N
P
V
V
E
S
R
S
G
Q
E
S
P
P
P
Site 112
S1216
E
S
R
S
G
Q
E
S
P
P
P
P
Q
P
G
Site 113
Y1260
L
R
L
H
R
T
G
Y
A
D
H
M
G
L
T
Site 114
S1286
P
L
L
K
K
L
M
S
T
S
E
G
I
D
E
Site 115
T1287
L
L
K
K
L
M
S
T
S
E
G
I
D
E
R
Site 116
S1288
L
K
K
L
M
S
T
S
E
G
I
D
E
R
K
Site 117
T1303
A
V
E
E
L
L
E
T
L
D
L
E
K
K
A
Site 118
S1337
K
Q
R
E
K
L
V
S
Q
S
I
V
L
F
Q
Site 119
S1352
A
A
C
K
G
F
L
S
R
Q
E
F
K
K
L
Site 120
S1396
G
S
L
Q
P
L
L
S
A
T
I
G
T
E
Q
Site 121
T1412
R
A
K
E
E
E
L
T
T
L
R
R
K
L
E
Site 122
T1413
A
K
E
E
E
L
T
T
L
R
R
K
L
E
K
Site 123
S1421
L
R
R
K
L
E
K
S
E
K
L
R
N
E
L
Site 124
T1432
R
N
E
L
R
Q
N
T
D
L
L
E
S
K
I
Site 125
T1443
E
S
K
I
A
D
L
T
S
D
L
A
D
E
R
Site 126
S1444
S
K
I
A
D
L
T
S
D
L
A
D
E
R
F
Site 127
T1512
N
D
L
E
R
N
P
T
G
G
A
D
E
W
Q
Site 128
S1545
Q
C
E
E
R
L
D
S
E
L
T
A
R
K
E
Site 129
T1548
E
R
L
D
S
E
L
T
A
R
K
E
L
E
Q
Site 130
S1562
Q
K
L
G
E
L
Q
S
A
Y
D
G
A
K
K
Site 131
Y1564
L
G
E
L
Q
S
A
Y
D
G
A
K
K
M
A
Site 132
S1597
V
L
L
E
N
Q
Q
S
R
N
H
E
L
E
K
Site 133
T1631
K
G
L
R
E
K
V
T
Q
E
N
T
S
V
R
Site 134
S1636
K
V
T
Q
E
N
T
S
V
R
W
E
L
G
Q
Site 135
S1656
K
Q
K
E
Q
E
A
S
Q
L
K
Q
Q
V
E
Site 136
S1675
H
K
R
E
L
L
G
S
P
S
L
G
E
N
C
Site 137
S1677
R
E
L
L
G
S
P
S
L
G
E
N
C
V
A
Site 138
S1695
E
R
L
W
K
L
E
S
S
A
L
E
Q
Q
K
Site 139
S1705
L
E
Q
Q
K
I
Q
S
Q
Q
E
N
T
I
K
Site 140
S1749
E
L
E
D
V
R
Q
S
C
Q
K
R
L
H
Q
Site 141
Y1765
E
M
Q
L
E
Q
E
Y
E
E
K
Q
M
V
L
Site 142
T1807
L
R
R
D
L
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Site 143
T1826
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Site 144
S1827
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Site 145
S1829
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D
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Site 146
S1838
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Site 147
S1843
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Site 148
T1853
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A
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Site 149
S1863
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L
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A
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L
E
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M
H
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E
N
Site 150
S1866
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D
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Site 151
S1876
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N
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L
Y
Site 152
Y1883
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K
A
Site 153
Y1954
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Site 154
S2008
I
K
M
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A
A
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Site 155
T2012
E
E
L
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A
A
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R
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Site 156
S2013
E
L
S
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A
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Site 157
S2015
S
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A
A
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Site 158
S2020
S
E
S
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Y
Y
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Site 159
S2021
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S
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Q
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Y
Y
Q
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Site 160
Y2023
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Q
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Y
Y
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R
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Site 161
Y2024
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R
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Y
Y
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Site 162
S2046
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Site 163
Y2055
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A
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Site 164
T2065
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Site 165
T2068
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Site 166
T2072
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Site 167
S2073
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Q
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Site 168
S2089
A
A
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A
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Site 169
S2090
A
L
E
E
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A
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S
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Site 170
S2092
E
E
V
A
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D
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T
Site 171
T2094
V
A
S
S
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S
D
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A
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Site 172
S2096
S
S
D
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D
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A
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C
Site 173
T2099
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D
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C
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Site 174
S2105
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A
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K
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M
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Site 175
S2106
T
A
V
D
C
G
S
S
G
R
K
E
M
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N
Site 176
S2115
R
K
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M
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N
V
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P
E
Site 177
S2118
M
D
N
V
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Site 178
S2119
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N
V
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Q
Site 179
S2124
L
S
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Q
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W
L
S
C
Site 180
S2127
Q
P
E
G
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Q
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W
L
S
C
T
L
S
Site 181
S2134
S
W
L
S
C
T
L
S
L
A
T
D
T
M
R
Site 182
T2139
T
L
S
L
A
T
D
T
M
R
T
P
S
R
Q
Site 183
T2142
L
A
T
D
T
M
R
T
P
S
R
Q
S
A
T
Site 184
S2144
T
D
T
M
R
T
P
S
R
Q
S
A
T
S
S
Site 185
S2147
M
R
T
P
S
R
Q
S
A
T
S
S
R
I
L
Site 186
T2149
T
P
S
R
Q
S
A
T
S
S
R
I
L
S
P
Site 187
S2150
P
S
R
Q
S
A
T
S
S
R
I
L
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P
R
Site 188
S2151
S
R
Q
S
A
T
S
S
R
I
L
S
P
R
I
Site 189
S2155
A
T
S
S
R
I
L
S
P
R
I
N
E
E
A
Site 190
T2165
I
N
E
E
A
G
D
T
E
R
T
Q
S
A
L
Site 191
S2170
G
D
T
E
R
T
Q
S
A
L
A
L
S
R
A
Site 192
S2175
T
Q
S
A
L
A
L
S
R
A
R
S
T
N
V
Site 193
S2179
L
A
L
S
R
A
R
S
T
N
V
H
S
K
T
Site 194
T2180
A
L
S
R
A
R
S
T
N
V
H
S
K
T
S
Site 195
T2186
S
T
N
V
H
S
K
T
S
G
D
K
P
V
S
Site 196
S2193
T
S
G
D
K
P
V
S
P
H
F
V
R
R
Q
Site 197
Y2202
H
F
V
R
R
Q
K
Y
C
H
F
G
D
G
E
Site 198
S2217
V
L
A
V
Q
R
K
S
T
E
R
L
E
P
A
Site 199
T2218
L
A
V
Q
R
K
S
T
E
R
L
E
P
A
S
Site 200
S2225
T
E
R
L
E
P
A
S
S
P
L
A
S
R
S
Site 201
S2226
E
R
L
E
P
A
S
S
P
L
A
S
R
S
T
Site 202
S2230
P
A
S
S
P
L
A
S
R
S
T
N
T
S
P
Site 203
S2232
S
S
P
L
A
S
R
S
T
N
T
S
P
L
S
Site 204
T2233
S
P
L
A
S
R
S
T
N
T
S
P
L
S
R
Site 205
S2236
A
S
R
S
T
N
T
S
P
L
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R
E
K
L
Site 206
S2239
S
T
N
T
S
P
L
S
R
E
K
L
P
S
P
Site 207
S2245
L
S
R
E
K
L
P
S
P
S
A
A
L
S
E
Site 208
S2247
R
E
K
L
P
S
P
S
A
A
L
S
E
F
V
Site 209
S2251
P
S
P
S
A
A
L
S
E
F
V
E
G
L
R
Site 210
S2268
R
A
Q
R
G
Q
G
S
T
L
G
L
E
D
W
Site 211
T2269
A
Q
R
G
Q
G
S
T
L
G
L
E
D
W
P
Site 212
T2277
L
G
L
E
D
W
P
T
L
P
I
Y
Q
T
T
Site 213
Y2281
D
W
P
T
L
P
I
Y
Q
T
T
G
A
S
T
Site 214
T2283
P
T
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P
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Y
Q
T
T
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A
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L
R
Site 215
T2284
T
L
P
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T
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R
Site 216
T2288
Y
Q
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T
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A
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R
G
R
A
G
Site 217
S2296
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R
R
G
R
A
G
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G
N
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S
L
Site 218
S2302
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S
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G
N
L
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G
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K
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Site 219
S2309
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L
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K
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G
A
Site 220
S2325
G
G
L
L
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L
K
C
I
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S
D
Site 221
S2330
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T
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K
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V
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G
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Site 222
S2331
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K
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Site 223
T2338
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D
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T
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K
Site 224
S2344
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T
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L
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Q
F
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Site 225
T2346
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L
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K
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Site 226
S2349
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K
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L
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Site 227
S2350
K
S
K
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S
C
E
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L
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E
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Site 228
S2353
T
Q
F
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E
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L
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P
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Site 229
S2357
S
C
E
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L
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P
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M
G
R
K
Site 230
S2360
S
L
L
E
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S
M
G
R
K
L
S
S
Site 231
S2366
P
S
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G
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T
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R
D
Site 232
S2367
S
M
G
R
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L
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S
P
T
T
P
R
D
M
Site 233
T2370
R
K
L
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S
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T
T
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R
D
M
L
L
S
Site 234
S2377
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P
R
D
M
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L
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T
L
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R
R
Site 235
T2379
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D
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T
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R
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R
C
Site 236
S2389
P
R
R
R
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E
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D
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G
C
Site 237
S2390
R
R
R
C
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S
V
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D
A
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C
P
Site 238
S2421
L
M
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E
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K
L
Site 239
S2425
P
L
G
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F
S
W
K
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P
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L
D
Site 240
S2430
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F
S
W
K
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P
S
L
D
Y
E
R
K
T
Site 241
Y2433
W
K
L
P
S
L
D
Y
E
R
K
T
K
V
D
Site 242
T2437
S
L
D
Y
E
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K
T
K
V
D
F
D
D
F
Site 243
T2453
P
A
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T
P
T
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L
A
G
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Site 244
T2455
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R
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P
T
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A
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A
K
Site 245
S2456
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K
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A
G
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A
K
G
Site 246
S2460
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P
T
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A
G
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A
K
G
G
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D
G
Site 247
S2468
A
K
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G
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G
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S
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H
F
Site 248
S2472
Q
D
G
S
Q
R
S
S
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F
E
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E
E
Site 249
S2483
E
T
E
E
A
N
R
S
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Site 250
T2490
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F
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K
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P
E
Site 251
S2495
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K
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K
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K
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D
P
Site 252
S2506
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D
S
S
S
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S
G
Site 253
S2508
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P
A
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D
S
S
S
S
S
G
S
I
Site 254
S2509
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A
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S
S
S
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S
G
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I
V
Site 255
S2510
A
H
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D
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S
S
S
S
G
S
I
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S
Site 256
S2511
H
L
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S
S
S
G
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S
F
Site 257
S2512
L
S
D
S
S
S
S
S
G
S
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F
K
Site 258
S2514
D
S
S
S
S
S
G
S
I
V
S
F
K
S
A
Site 259
S2517
S
S
S
G
S
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V
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F
K
S
A
D
S
I
Site 260
S2520
G
S
I
V
S
F
K
S
A
D
S
I
K
S
R
Site 261
S2523
V
S
F
K
S
A
D
S
I
K
S
R
P
G
I
Site 262
S2526
K
S
A
D
S
I
K
S
R
P
G
I
P
R
L
Site 263
S2542
G
D
G
G
E
R
T
S
P
E
R
R
E
P
G
Site 264
T2550
P
E
R
R
E
P
G
T
G
R
K
D
D
D
V
Site 265
S2559
R
K
D
D
D
V
A
S
I
M
K
K
Y
L
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation