PhosphoNET

           
Protein Info 
   
Short Name:  SPPL2C
Full Name:  Signal peptide peptidase-like 2C
Alias:  Intramembrane protease 5
Type: 
Mass (Da):  74503
Number AA:  684
UniProt ID:  Q8IUH8
International Prot ID: 
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:      PhosphoSite+ KinaseNET
Biological Process:      Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S17VGFLLLISTVAGGKY
Site 2Y38SENWSKDYCILFSSD
Site 3T48LFSSDYITLPRDLHH
Site 4Y62HAPLLPLYDGTKAPW
Site 5T65LLPLYDGTKAPWCPG
Site 6S75PWCPGEDSPHQAQLR
Site 7S83PHQAQLRSPSQRPLR
Site 8S85QAQLRSPSQRPLRQT
Site 9T92SQRPLRQTTAMVMRG
Site 10T93QRPLRQTTAMVMRGN
Site 11S125LLIVSRVSDQQCSDT
Site 12T133DQQCSDTTLAPQDPR
Site 13T208GGYWAGLTEANRLQR
Site 14S224RARRGGGSGGHHQLQ
Site 15S305SPLVCHLSLRQYQRP
Site 16Y309CHLSLRQYQRPPHSL
Site 17S315QYQRPPHSLWASLPL
Site 18T371LHRVRLPTLKNCSSF
Site 19S414VALGPAESSSHERLP
Site 20S416LGPAESSSHERLPMV
Site 21S523AACRQELSLFWTGQG
Site 22T527QELSLFWTGQGRAKM
Site 23S542CGLGCAPSAGSRQKQ
Site 24T557EGAADAHTASTLERG
Site 25T565ASTLERGTSRGAGDL
Site 26S566STLERGTSRGAGDLD
Site 27S574RGAGDLDSNPGEDTT
Site 28T581SNPGEDTTEIVTISE
Site 29T592TISENEATNPEDRSD
Site 30S598ATNPEDRSDSSEGWS
Site 31S600NPEDRSDSSEGWSDA
Site 32S601PEDRSDSSEGWSDAH
Site 33S605SDSSEGWSDAHLDPN
Site 34S645MPLMPPPSELGHVHA
Site 35S677KGLKVRKSMSTQAPL
Site 36S679LKVRKSMSTQAPL__
Site 37T680KVRKSMSTQAPL___
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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