KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ARMC8
Full Name:
Armadillo repeat-containing protein 8
Alias:
armadillo repeat containing 8; armadillo repeat-containing 8; DKFZP434A043; HSPC056
Type:
Unknown function
Mass (Da):
75491
Number AA:
673
UniProt ID:
Q8IUR7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
P
I
R
M
S
V
L
S
E
V
T
A
S
S
R
Site 2
S20
V
L
S
E
V
T
A
S
S
R
H
Y
V
D
R
Site 3
Y24
V
T
A
S
S
R
H
Y
V
D
R
L
F
D
P
Site 4
T77
L
Q
Q
E
T
S
S
T
E
L
K
T
E
C
A
Site 5
S100
G
T
E
N
N
V
K
S
L
L
D
C
H
I
I
Site 6
T134
R
C
L
R
T
I
F
T
S
P
V
T
P
E
E
Site 7
T145
T
P
E
E
L
L
Y
T
D
A
T
V
I
P
H
Site 8
S158
P
H
L
M
A
L
L
S
R
S
R
Y
T
Q
E
Site 9
Y162
A
L
L
S
R
S
R
Y
T
Q
E
Y
I
C
Q
Site 10
T163
L
L
S
R
S
R
Y
T
Q
E
Y
I
C
Q
I
Site 11
Y166
R
S
R
Y
T
Q
E
Y
I
C
Q
I
F
S
H
Site 12
T255
K
P
I
E
M
Q
L
T
S
A
K
C
L
T
Y
Site 13
T261
L
T
S
A
K
C
L
T
Y
M
C
R
A
G
A
Site 14
Y262
T
S
A
K
C
L
T
Y
M
C
R
A
G
A
I
Site 15
S289
P
C
L
V
R
M
C
S
K
E
R
L
L
E
E
Site 16
T303
E
R
V
E
G
A
E
T
L
A
Y
L
I
E
P
Site 17
Y306
E
G
A
E
T
L
A
Y
L
I
E
P
D
V
E
Site 18
S336
A
D
Y
F
K
Y
P
S
S
V
S
A
I
T
D
Site 19
S337
D
Y
F
K
Y
P
S
S
V
S
A
I
T
D
I
Site 20
Y365
R
Q
A
A
F
K
L
Y
A
S
L
G
A
N
D
Site 21
T391
N
M
M
D
R
I
V
T
G
L
S
E
S
S
V
Site 22
S394
D
R
I
V
T
G
L
S
E
S
S
V
K
V
R
Site 23
S396
I
V
T
G
L
S
E
S
S
V
K
V
R
L
A
Site 24
S397
V
T
G
L
S
E
S
S
V
K
V
R
L
A
A
Site 25
S410
A
A
V
R
C
L
H
S
L
S
R
S
V
Q
Q
Site 26
S412
V
R
C
L
H
S
L
S
R
S
V
Q
Q
L
R
Site 27
S414
C
L
H
S
L
S
R
S
V
Q
Q
L
R
T
S
Site 28
S421
S
V
Q
Q
L
R
T
S
F
Q
D
H
A
V
W
Site 29
S460
L
L
L
E
F
S
P
S
K
E
P
I
L
E
S
Site 30
S512
A
D
I
L
R
S
L
S
T
E
Q
L
F
R
L
Site 31
S540
G
L
L
R
N
L
L
S
T
R
P
H
I
D
K
Site 32
T541
L
L
R
N
L
L
S
T
R
P
H
I
D
K
I
Site 33
Y605
D
I
L
Q
K
I
K
Y
Y
M
G
H
S
H
V
Site 34
Y606
I
L
Q
K
I
K
Y
Y
M
G
H
S
H
V
K
Site 35
S633
I
W
N
E
E
E
G
S
Q
E
R
Q
D
K
L
Site 36
S653
V
D
I
L
H
K
L
S
Q
S
P
D
S
N
L
Site 37
S655
I
L
H
K
L
S
Q
S
P
D
S
N
L
C
D
Site 38
S658
K
L
S
Q
S
P
D
S
N
L
C
D
K
A
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation