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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
C17orf28
Full Name:
UPF0663 transmembrane protein C17orf28
Alias:
Chromosome 17 open reading frame 28; CQ028; DMC1; Downregulated in multiple cancer 1; Down-regulated in multiple cancers-1
Type:
DNA binding protein
Mass (Da):
88740
Number AA:
UniProt ID:
Q8IV36
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
V
I
Q
L
T
T
K
T
Q
P
V
E
A
T
D
Site 2
S62
I
R
A
V
R
E
E
S
P
S
N
L
A
T
L
Site 3
S64
A
V
R
E
E
S
P
S
N
L
A
T
L
C
Y
Site 4
T68
E
S
P
S
N
L
A
T
L
C
Y
K
A
V
E
Site 5
S83
K
L
V
Q
G
A
E
S
G
C
H
S
E
K
E
Site 6
S87
G
A
E
S
G
C
H
S
E
K
E
K
Q
I
V
Site 7
T121
W
R
G
F
F
W
S
T
V
P
G
A
G
R
G
Site 8
S144
H
A
R
P
L
A
E
S
L
L
L
A
I
A
D
Site 9
T159
L
L
F
C
P
D
F
T
V
Q
S
H
R
R
S
Site 10
S162
C
P
D
F
T
V
Q
S
H
R
R
S
T
V
D
Site 11
S166
T
V
Q
S
H
R
R
S
T
V
D
S
A
E
D
Site 12
T167
V
Q
S
H
R
R
S
T
V
D
S
A
E
D
V
Site 13
S170
H
R
R
S
T
V
D
S
A
E
D
V
H
S
L
Site 14
S176
D
S
A
E
D
V
H
S
L
D
S
C
E
Y
I
Site 15
Y182
H
S
L
D
S
C
E
Y
I
W
E
A
G
V
G
Site 16
S193
A
G
V
G
F
A
H
S
P
Q
P
N
Y
I
H
Site 17
Y198
A
H
S
P
Q
P
N
Y
I
H
D
M
N
R
M
Site 18
Y220
T
C
F
S
E
A
M
Y
L
P
P
A
P
E
S
Site 19
S227
Y
L
P
P
A
P
E
S
G
S
T
N
P
W
V
Site 20
S229
P
P
A
P
E
S
G
S
T
N
P
W
V
Q
F
Site 21
T230
P
A
P
E
S
G
S
T
N
P
W
V
Q
F
F
Site 22
Y264
C
A
Y
D
P
V
G
Y
G
I
P
Y
N
H
L
Site 23
S274
P
Y
N
H
L
L
F
S
D
Y
R
E
P
L
V
Site 24
Y276
N
H
L
L
F
S
D
Y
R
E
P
L
V
E
E
Site 25
S296
I
V
T
L
D
H
D
S
A
S
S
A
S
P
T
Site 26
S298
T
L
D
H
D
S
A
S
S
A
S
P
T
V
D
Site 27
S299
L
D
H
D
S
A
S
S
A
S
P
T
V
D
G
Site 28
S301
H
D
S
A
S
S
A
S
P
T
V
D
G
T
T
Site 29
T303
S
A
S
S
A
S
P
T
V
D
G
T
T
T
G
Site 30
T307
A
S
P
T
V
D
G
T
T
T
G
T
A
M
D
Site 31
Y328
P
E
N
L
F
V
N
Y
L
S
R
I
H
R
E
Site 32
S350
K
G
I
A
R
L
L
S
N
P
L
L
Q
T
Y
Site 33
T356
L
S
N
P
L
L
Q
T
Y
L
P
N
S
T
K
Site 34
Y357
S
N
P
L
L
Q
T
Y
L
P
N
S
T
K
K
Site 35
S361
L
Q
T
Y
L
P
N
S
T
K
K
I
Q
F
H
Site 36
S414
N
D
A
R
A
D
Q
S
R
V
G
L
M
H
I
Site 37
S430
V
F
I
L
L
L
L
S
G
E
R
N
F
G
V
Site 38
Y443
G
V
R
L
N
K
P
Y
S
I
R
V
P
M
D
Site 39
S444
V
R
L
N
K
P
Y
S
I
R
V
P
M
D
I
Site 40
S497
N
V
S
P
Y
L
K
S
L
S
M
V
T
A
N
Site 41
S499
S
P
Y
L
K
S
L
S
M
V
T
A
N
K
L
Site 42
Y542
V
F
N
N
I
I
Q
Y
Q
F
D
G
N
S
N
Site 43
Y552
D
G
N
S
N
L
V
Y
A
I
I
R
K
R
S
Site 44
T569
H
Q
L
A
N
L
P
T
D
P
P
T
I
H
K
Site 45
T573
N
L
P
T
D
P
P
T
I
H
K
A
L
Q
R
Site 46
T584
A
L
Q
R
R
R
R
T
P
E
P
L
S
R
T
Site 47
S589
R
R
T
P
E
P
L
S
R
T
G
S
Q
E
G
Site 48
T591
T
P
E
P
L
S
R
T
G
S
Q
E
G
T
S
Site 49
S593
E
P
L
S
R
T
G
S
Q
E
G
T
S
M
E
Site 50
T597
R
T
G
S
Q
E
G
T
S
M
E
G
S
R
P
Site 51
S598
T
G
S
Q
E
G
T
S
M
E
G
S
R
P
A
Site 52
S602
E
G
T
S
M
E
G
S
R
P
A
A
P
A
E
Site 53
T627
T
P
G
I
D
K
L
T
E
K
S
Q
V
S
E
Site 54
S630
I
D
K
L
T
E
K
S
Q
V
S
E
D
G
T
Site 55
T637
S
Q
V
S
E
D
G
T
L
R
S
L
E
P
E
Site 56
S640
S
E
D
G
T
L
R
S
L
E
P
E
P
Q
Q
Site 57
S648
L
E
P
E
P
Q
Q
S
L
E
D
G
S
P
A
Site 58
S653
Q
Q
S
L
E
D
G
S
P
A
K
G
E
P
S
Site 59
S660
S
P
A
K
G
E
P
S
Q
A
W
R
E
Q
R
Site 60
S670
W
R
E
Q
R
R
P
S
T
S
S
A
S
G
Q
Site 61
T671
R
E
Q
R
R
P
S
T
S
S
A
S
G
Q
W
Site 62
S672
E
Q
R
R
P
S
T
S
S
A
S
G
Q
W
S
Site 63
S673
Q
R
R
P
S
T
S
S
A
S
G
Q
W
S
P
Site 64
S675
R
P
S
T
S
S
A
S
G
Q
W
S
P
T
P
Site 65
S679
S
S
A
S
G
Q
W
S
P
T
P
E
W
V
L
Site 66
T681
A
S
G
Q
W
S
P
T
P
E
W
V
L
S
W
Site 67
S687
P
T
P
E
W
V
L
S
W
K
S
K
L
P
L
Site 68
S690
E
W
V
L
S
W
K
S
K
L
P
L
Q
T
I
Site 69
Y747
H
P
I
L
I
R
K
Y
Q
A
N
S
G
T
A
Site 70
Y766
T
Y
M
W
G
V
I
Y
L
R
N
V
D
P
P
Site 71
T778
D
P
P
V
W
Y
D
T
D
V
K
L
F
E
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation