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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
THEX1
Full Name:
3'-5' exoribonuclease 1
Alias:
3'-5' exonuclease ERI1; 3'EXO; 3'hExo; End-specific exonuclease; Enhanced RNAi three prime mRNA exonuclease 1; Eri-1 homolog; Exoribonuclease 1; HEXO; Histone mRNA 3'; Histone mRNA 3' end-specific exoribonuclease; Three prime histone mRNA exonuclease 1
Type:
EC 3.1.-.-; Hydrolase
Mass (Da):
40064
Number AA:
349
UniProt ID:
Q8IV48
International Prot ID:
IPI00216873
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0008408
GO:0000287
GO:0019843
PhosphoSite+
KinaseNET
Biological Process:
GO:0031047
GO:0031125
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
E
D
P
Q
S
K
E
P
A
G
E
A
Site 2
S21
V
A
L
A
L
L
E
S
P
R
P
E
G
G
E
Site 3
S34
G
E
E
P
P
R
P
S
P
E
E
T
Q
Q
C
Site 4
T38
P
R
P
S
P
E
E
T
Q
Q
C
K
F
D
G
Site 5
S51
D
G
Q
E
T
K
G
S
K
F
I
T
S
S
A
Site 6
T55
T
K
G
S
K
F
I
T
S
S
A
S
D
F
S
Site 7
S56
K
G
S
K
F
I
T
S
S
A
S
D
F
S
D
Site 8
S57
G
S
K
F
I
T
S
S
A
S
D
F
S
D
P
Site 9
S59
K
F
I
T
S
S
A
S
D
F
S
D
P
V
Y
Site 10
S62
T
S
S
A
S
D
F
S
D
P
V
Y
K
E
I
Site 11
Y66
S
D
F
S
D
P
V
Y
K
E
I
A
I
T
N
Site 12
S80
N
G
C
I
N
R
M
S
K
E
E
L
R
A
K
Site 13
S89
E
E
L
R
A
K
L
S
E
F
K
L
E
T
R
Site 14
Y110
K
K
R
L
K
N
Y
Y
K
K
Q
K
L
M
L
Site 15
S120
Q
K
L
M
L
K
E
S
N
F
A
D
S
Y
Y
Site 16
Y126
E
S
N
F
A
D
S
Y
Y
D
Y
I
C
I
I
Site 17
Y127
S
N
F
A
D
S
Y
Y
D
Y
I
C
I
I
D
Site 18
T169
H
T
L
E
I
E
D
T
F
Q
Q
Y
V
R
P
Site 19
Y173
I
E
D
T
F
Q
Q
Y
V
R
P
E
I
N
T
Site 20
T180
Y
V
R
P
E
I
N
T
Q
L
S
D
F
C
I
Site 21
T202
D
Q
V
D
R
A
D
T
F
P
Q
V
L
K
K
Site 22
Y223
L
K
E
L
G
T
K
Y
K
Y
S
L
L
T
D
Site 23
S226
L
G
T
K
Y
K
Y
S
L
L
T
D
G
S
W
Site 24
S232
Y
S
L
L
T
D
G
S
W
D
M
S
K
F
L
Site 25
S246
L
N
I
Q
C
Q
L
S
R
L
K
Y
P
P
F
Site 26
Y250
C
Q
L
S
R
L
K
Y
P
P
F
A
K
K
W
Site 27
Y264
W
I
N
I
R
K
S
Y
G
N
F
Y
K
V
P
Site 28
Y268
R
K
S
Y
G
N
F
Y
K
V
P
R
S
Q
T
Site 29
S273
N
F
Y
K
V
P
R
S
Q
T
K
L
T
I
M
Site 30
T275
Y
K
V
P
R
S
Q
T
K
L
T
I
M
L
E
Site 31
Y288
L
E
K
L
G
M
D
Y
D
G
R
P
H
C
G
Site 32
S299
P
H
C
G
L
D
D
S
K
N
I
A
R
I
A
Site 33
S333
Q
L
M
S
V
S
S
S
L
P
I
E
G
T
P
Site 34
T339
S
S
L
P
I
E
G
T
P
P
P
Q
M
P
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation