PhosphoNET

           
Protein Info 
   
Short Name:  VRK3
Full Name:  Inactive serine/threonine-protein kinase VRK3
Alias:  EC 2.7.11.1; Vaccinia related kinase 3; Vaccinia-related kinase 3
Type:  Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; CK1 group; TTBK family
Mass (Da):  52881
Number AA:  474
UniProt ID:  Q8IV63
International Prot ID:  IPI00009291
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0005515  GO:0004674 PhosphoSite+ KinaseNET
Biological Process:  GO:0006468     Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S34PVEEHVGSQTFVNPH
Site 2T36EEHVGSQTFVNPHVS
Site 3S43TFVNPHVSSFQGSKR
Site 4S44FVNPHVSSFQGSKRG
Site 5S48HVSSFQGSKRGLNSS
Site 6S54GSKRGLNSSFETSPK
Site 7S55SKRGLNSSFETSPKK
Site 8T58GLNSSFETSPKKVKW
Site 9S59LNSSFETSPKKVKWS
Site 10S66SPKKVKWSSTVTSPR
Site 11S67PKKVKWSSTVTSPRL
Site 12T68KKVKWSSTVTSPRLS
Site 13T70VKWSSTVTSPRLSLF
Site 14S71KWSSTVTSPRLSLFS
Site 15S75TVTSPRLSLFSDGDS
Site 16S78SPRLSLFSDGDSSES
Site 17S82SLFSDGDSSESEDTL
Site 18S83LFSDGDSSESEDTLS
Site 19S85SDGDSSESEDTLSSS
Site 20T88DSSESEDTLSSSERS
Site 21S90SESEDTLSSSERSKG
Site 22S91ESEDTLSSSERSKGS
Site 23S92SEDTLSSSERSKGSG
Site 24S95TLSSSERSKGSGSRP
Site 25S98SSERSKGSGSRPPTP
Site 26S100ERSKGSGSRPPTPKS
Site 27T104GSGSRPPTPKSSPQK
Site 28S107SRPPTPKSSPQKTRK
Site 29S108RPPTPKSSPQKTRKS
Site 30T112PKSSPQKTRKSPQVT
Site 31S115SPQKTRKSPQVTRGS
Site 32T119TRKSPQVTRGSPQKT
Site 33S122SPQVTRGSPQKTSCS
Site 34T126TRGSPQKTSCSPQKT
Site 35S127RGSPQKTSCSPQKTR
Site 36S129SPQKTSCSPQKTRQS
Site 37T133TSCSPQKTRQSPQTL
Site 38S136SPQKTRQSPQTLKRS
Site 39T139KTRQSPQTLKRSRVT
Site 40T146TLKRSRVTTSLEALP
Site 41T147LKRSRVTTSLEALPT
Site 42S148KRSRVTTSLEALPTG
Site 43T154TSLEALPTGTVLTDK
Site 44T159LPTGTVLTDKSGRQW
Site 45S162GTVLTDKSGRQWKLK
Site 46S170GRQWKLKSFQTRDNQ
Site 47Y181RDNQGILYEAAPTST
Site 48S187LYEAAPTSTLTCDSG
Site 49T190AAPTSTLTCDSGPQK
Site 50S193TSTLTCDSGPQKQKF
Site 51T236KWKKLYSTPLLAIPT
Site 52Y254FGVHQDKYRFLVLPS
Site 53S268SLGRSLQSALDVSPK
Site 54S273LQSALDVSPKHVLSE
Site 55S279VSPKHVLSERSVLQV
Site 56S282KHVLSERSVLQVACR
Site 57Y302EFLHENEYVHGNVTA
Site 58S320FVDPEDQSQVTLAGY
Site 59Y333GYGFAFRYCPSGKHV
Site 60Y342PSGKHVAYVEGSRSP
Site 61S348AYVEGSRSPHEGDLE
Site 62S368LHKGCGPSRRSDLQS
Site 63S371GCGPSRRSDLQSLGY
Site 64S375SRRSDLQSLGYCMLK
Site 65T439LKVVMALTYEEKPPY
Site 66Y440KVVMALTYEEKPPYA
Site 67Y446TYEEKPPYAMLRNNL
Site 68Y465QDLRVSPYDPIGLPM
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


2019 Kinexus Bioinformatics Corporation