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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
WASF4
Full Name:
Putative Wiskott-Aldrich syndrome protein family member 4
Alias:
SCAR2
Type:
Cytoskeleton protein
Mass (Da):
68189
Number AA:
625
UniProt ID:
Q8IV90
International Prot ID:
IPI00002647
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
P
R
N
K
M
S
F
S
S
P
G
Q
Q
Site 2
S9
P
R
N
K
M
S
F
S
S
P
G
Q
Q
V
M
Site 3
S10
R
N
K
M
S
F
S
S
P
G
Q
Q
V
M
Y
Site 4
Y17
S
P
G
Q
Q
V
M
Y
P
P
G
Y
K
T
Q
Site 5
Y21
Q
V
M
Y
P
P
G
Y
K
T
Q
G
H
G
A
Site 6
T23
M
Y
P
P
G
Y
K
T
Q
G
H
G
A
E
P
Site 7
S31
Q
G
H
G
A
E
P
S
T
S
P
L
S
S
I
Site 8
T32
G
H
G
A
E
P
S
T
S
P
L
S
S
I
N
Site 9
S33
H
G
A
E
P
S
T
S
P
L
S
S
I
N
Y
Site 10
S36
E
P
S
T
S
P
L
S
S
I
N
Y
I
I
Q
Site 11
S37
P
S
T
S
P
L
S
S
I
N
Y
I
I
Q
S
Site 12
Y40
S
P
L
S
S
I
N
Y
I
I
Q
S
T
E
T
Site 13
T45
I
N
Y
I
I
Q
S
T
E
T
R
R
S
L
D
Site 14
S50
Q
S
T
E
T
R
R
S
L
D
K
L
L
K
G
Site 15
S63
K
G
D
I
D
I
G
S
Q
N
G
T
D
L
F
Site 16
T67
D
I
G
S
Q
N
G
T
D
L
F
G
F
G
N
Site 17
Y78
G
F
G
N
T
H
E
Y
P
D
L
Q
M
I
L
Site 18
Y109
L
I
F
P
H
R
G
Y
N
S
S
K
L
H
N
Site 19
S112
P
H
R
G
Y
N
S
S
K
L
H
N
R
G
I
Site 20
S122
H
N
R
G
I
C
L
S
L
R
S
R
S
T
V
Site 21
T128
L
S
L
R
S
R
S
T
V
P
L
V
T
R
N
Site 22
T145
P
R
H
L
C
R
Q
T
L
P
S
V
R
S
E
Site 23
S148
L
C
R
Q
T
L
P
S
V
R
S
E
L
E
C
Site 24
T157
R
S
E
L
E
C
V
T
N
I
T
L
A
N
V
Site 25
T160
L
E
C
V
T
N
I
T
L
A
N
V
I
R
Q
Site 26
S170
N
V
I
R
Q
L
G
S
L
S
K
Y
A
E
D
Site 27
S172
I
R
Q
L
G
S
L
S
K
Y
A
E
D
I
F
Site 28
Y174
Q
L
G
S
L
S
K
Y
A
E
D
I
F
G
E
Site 29
T188
E
L
F
T
Q
A
N
T
F
A
S
P
V
S
S
Site 30
S191
T
Q
A
N
T
F
A
S
P
V
S
S
L
A
E
Site 31
S195
T
F
A
S
P
V
S
S
L
A
E
R
V
D
G
Site 32
S218
D
P
K
E
E
E
V
S
L
Q
V
I
N
T
R
Site 33
S230
N
T
R
K
A
F
R
S
S
T
I
Q
D
Q
K
Site 34
S231
T
R
K
A
F
R
S
S
T
I
Q
D
Q
K
L
Site 35
T232
R
K
A
F
R
S
S
T
I
Q
D
Q
K
L
F
Site 36
S243
Q
K
L
F
D
R
N
S
L
P
V
P
V
L
E
Site 37
T254
P
V
L
E
T
Y
N
T
C
D
T
P
P
P
L
Site 38
T257
E
T
Y
N
T
C
D
T
P
P
P
L
N
N
L
Site 39
T265
P
P
P
L
N
N
L
T
P
Y
R
D
D
G
T
Site 40
Y267
P
L
N
N
L
T
P
Y
R
D
D
G
T
E
A
Site 41
T272
T
P
Y
R
D
D
G
T
E
A
L
K
F
Y
T
Site 42
Y278
G
T
E
A
L
K
F
Y
T
D
P
S
Y
F
F
Site 43
T279
T
E
A
L
K
F
Y
T
D
P
S
Y
F
F
D
Site 44
Y283
K
F
Y
T
D
P
S
Y
F
F
D
L
W
K
K
Site 45
S343
M
G
Q
E
F
V
E
S
K
E
K
L
G
P
F
Site 46
Y352
E
K
L
G
P
F
G
Y
P
P
T
L
V
Y
Q
Site 47
T355
G
P
F
G
Y
P
P
T
L
V
Y
Q
N
G
S
Site 48
Y358
G
Y
P
P
T
L
V
Y
Q
N
G
S
I
G
C
Site 49
S372
C
V
E
N
V
D
A
S
S
Y
P
P
P
S
Q
Site 50
S373
V
E
N
V
D
A
S
S
Y
P
P
P
S
Q
S
Site 51
Y374
E
N
V
D
A
S
S
Y
P
P
P
S
Q
S
D
Site 52
S378
A
S
S
Y
P
P
P
S
Q
S
D
S
A
S
S
Site 53
S380
S
Y
P
P
P
S
Q
S
D
S
A
S
S
P
S
Site 54
S382
P
P
P
S
Q
S
D
S
A
S
S
P
S
P
S
Site 55
S384
P
S
Q
S
D
S
A
S
S
P
S
P
S
F
S
Site 56
S385
S
Q
S
D
S
A
S
S
P
S
P
S
F
S
E
Site 57
S387
S
D
S
A
S
S
P
S
P
S
F
S
E
D
N
Site 58
S389
S
A
S
S
P
S
P
S
F
S
E
D
N
L
P
Site 59
S391
S
S
P
S
P
S
F
S
E
D
N
L
P
P
P
Site 60
S403
P
P
P
P
A
E
F
S
Y
P
V
D
N
Q
R
Site 61
Y404
P
P
P
A
E
F
S
Y
P
V
D
N
Q
R
G
Site 62
S412
P
V
D
N
Q
R
G
S
G
L
A
G
P
K
R
Site 63
S420
G
L
A
G
P
K
R
S
S
V
V
S
P
S
H
Site 64
S421
L
A
G
P
K
R
S
S
V
V
S
P
S
H
P
Site 65
S424
P
K
R
S
S
V
V
S
P
S
H
P
P
P
A
Site 66
S426
R
S
S
V
V
S
P
S
H
P
P
P
A
P
P
Site 67
S436
P
P
A
P
P
L
G
S
P
P
S
S
K
P
G
Site 68
S439
P
P
L
G
S
P
P
S
S
K
P
G
F
A
P
Site 69
S440
P
L
G
S
P
P
S
S
K
P
G
F
A
P
P
Site 70
S471
P
P
P
I
G
F
G
S
P
G
T
P
P
P
P
Site 71
T474
I
G
F
G
S
P
G
T
P
P
P
P
S
S
P
Site 72
S479
P
G
T
P
P
P
P
S
S
P
S
F
P
P
H
Site 73
S480
G
T
P
P
P
P
S
S
P
S
F
P
P
H
P
Site 74
S482
P
P
P
P
S
S
P
S
F
P
P
H
P
D
F
Site 75
Y503
P
P
P
P
A
A
D
Y
P
T
L
P
P
P
P
Site 76
T505
P
P
A
A
D
Y
P
T
L
P
P
P
P
L
S
Site 77
S512
T
L
P
P
P
P
L
S
Q
P
T
R
G
A
P
Site 78
T535
G
P
P
P
P
P
F
T
G
A
D
G
Q
P
A
Site 79
S548
P
A
V
P
P
P
L
S
D
T
T
K
P
K
S
Site 80
T550
V
P
P
P
L
S
D
T
T
K
P
K
S
S
L
Site 81
T551
P
P
P
L
S
D
T
T
K
P
K
S
S
L
P
Site 82
S555
S
D
T
T
K
P
K
S
S
L
P
A
I
S
D
Site 83
S556
D
T
T
K
P
K
S
S
L
P
A
I
S
D
A
Site 84
S561
K
S
S
L
P
A
I
S
D
A
H
S
D
L
L
Site 85
S569
D
A
H
S
D
L
L
S
A
I
C
Q
G
F
Q
Site 86
Y608
S
R
R
I
A
V
E
Y
S
D
S
E
D
D
S
Site 87
S609
R
R
I
A
V
E
Y
S
D
S
E
D
D
S
S
Site 88
S611
I
A
V
E
Y
S
D
S
E
D
D
S
S
E
F
Site 89
S615
Y
S
D
S
E
D
D
S
S
E
F
D
G
D
D
Site 90
S616
S
D
S
E
D
D
S
S
E
F
D
G
D
D
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation