KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ANKRD18A
Full Name:
Ankyrin repeat domain-containing protein 18A
Alias:
Type:
Mass (Da):
115597
Number AA:
992
UniProt ID:
Q8IVF6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
R
K
L
F
S
F
G
R
R
L
G
Q
Site 2
S17
R
L
G
Q
A
L
L
S
S
M
D
Q
E
Y
A
Site 3
S18
L
G
Q
A
L
L
S
S
M
D
Q
E
Y
A
G
Site 4
Y23
L
S
S
M
D
Q
E
Y
A
G
P
G
Y
D
I
Site 5
Y28
Q
E
Y
A
G
P
G
Y
D
I
R
D
W
E
L
Site 6
T55
A
E
V
E
R
C
L
T
R
R
F
R
D
L
D
Site 7
T70
A
R
D
R
K
D
R
T
V
L
H
L
A
C
A
Site 8
T103
I
C
D
R
L
N
R
T
P
L
M
K
A
V
H
Site 9
Y133
N
P
N
I
E
D
I
Y
G
N
T
A
L
H
Y
Site 10
Y140
Y
G
N
T
A
L
H
Y
A
V
Y
N
K
G
T
Site 11
S148
A
V
Y
N
K
G
T
S
L
A
E
R
L
L
S
Site 12
S155
S
L
A
E
R
L
L
S
H
H
A
N
I
E
A
Site 13
S177
P
L
L
F
A
I
N
S
R
R
Q
H
M
V
E
Site 14
S227
L
Q
Q
N
I
R
I
S
S
Q
D
M
F
G
Q
Site 15
S228
Q
Q
N
I
R
I
S
S
Q
D
M
F
G
Q
T
Site 16
Y239
F
G
Q
T
A
E
D
Y
A
L
C
S
D
L
R
Site 17
S243
A
E
D
Y
A
L
C
S
D
L
R
S
I
R
Q
Site 18
S247
A
L
C
S
D
L
R
S
I
R
Q
Q
I
L
E
Site 19
S314
E
N
K
Q
P
Q
D
S
Q
S
Y
G
K
K
K
Site 20
S316
K
Q
P
Q
D
S
Q
S
Y
G
K
K
K
D
A
Site 21
Y325
G
K
K
K
D
A
M
Y
G
N
F
M
L
K
K
Site 22
Y342
A
M
L
K
E
E
L
Y
A
I
K
N
D
S
L
Site 23
S348
L
Y
A
I
K
N
D
S
L
R
K
E
K
K
Y
Site 24
Y355
S
L
R
K
E
K
K
Y
I
Q
E
I
K
S
I
Site 25
S361
K
Y
I
Q
E
I
K
S
I
T
E
I
N
A
N
Site 26
S372
I
N
A
N
F
E
K
S
V
R
L
N
E
K
M
Site 27
T381
R
L
N
E
K
M
I
T
K
T
V
A
R
Y
S
Site 28
T383
N
E
K
M
I
T
K
T
V
A
R
Y
S
Q
Q
Site 29
S388
T
K
T
V
A
R
Y
S
Q
Q
L
N
D
L
K
Site 30
S403
A
E
N
A
R
L
N
S
E
L
E
K
E
K
H
Site 31
S421
R
L
E
A
E
V
E
S
L
H
S
S
L
A
T
Site 32
S425
E
V
E
S
L
H
S
S
L
A
T
A
I
N
E
Site 33
T428
S
L
H
S
S
L
A
T
A
I
N
E
Y
N
E
Site 34
S453
L
W
R
A
D
D
V
S
R
H
E
K
M
G
S
Site 35
S460
S
R
H
E
K
M
G
S
N
I
S
Q
L
T
D
Site 36
T485
K
A
R
V
K
F
N
T
L
K
G
K
L
R
E
Site 37
T493
L
K
G
K
L
R
E
T
R
D
A
L
R
E
K
Site 38
T501
R
D
A
L
R
E
K
T
L
A
L
G
S
V
Q
Site 39
S533
P
N
G
E
A
K
E
S
Q
S
I
G
K
Q
N
Site 40
S541
Q
S
I
G
K
Q
N
S
L
E
E
R
I
R
Q
Site 41
Y602
E
L
M
K
E
Y
N
Y
L
K
E
K
L
L
Q
Site 42
T634
E
L
V
D
H
L
K
T
F
S
I
S
E
S
P
Site 43
S636
V
D
H
L
K
T
F
S
I
S
E
S
P
L
E
Site 44
S638
H
L
K
T
F
S
I
S
E
S
P
L
E
G
T
Site 45
S640
K
T
F
S
I
S
E
S
P
L
E
G
T
S
H
Site 46
Y688
E
L
I
S
L
L
N
Y
T
A
D
Q
I
R
K
Site 47
T689
L
I
S
L
L
N
Y
T
A
D
Q
I
R
K
K
Site 48
T705
R
E
L
E
E
E
A
T
G
Y
K
K
C
L
E
Site 49
Y707
L
E
E
E
A
T
G
Y
K
K
C
L
E
M
T
Site 50
T734
S
C
H
G
D
L
N
T
D
Q
L
K
M
D
I
Site 51
S762
A
E
K
E
A
V
S
S
E
C
V
N
L
A
K
Site 52
S780
V
L
H
Q
E
L
L
S
M
R
N
V
Q
E
K
Site 53
S824
G
K
L
Q
E
Y
K
S
E
L
D
E
R
A
V
Site 54
T860
E
Q
L
N
K
D
N
T
A
S
L
K
K
K
E
Site 55
S862
L
N
K
D
N
T
A
S
L
K
K
K
E
L
T
Site 56
T869
S
L
K
K
K
E
L
T
L
K
D
V
E
C
K
Site 57
T882
C
K
F
S
K
M
K
T
A
Y
E
E
V
T
T
Site 58
Y884
F
S
K
M
K
T
A
Y
E
E
V
T
T
E
L
Site 59
S907
G
A
V
K
A
N
N
S
M
S
K
K
L
M
K
Site 60
S909
V
K
A
N
N
S
M
S
K
K
L
M
K
S
D
Site 61
S915
M
S
K
K
L
M
K
S
D
K
K
I
A
V
I
Site 62
S923
D
K
K
I
A
V
I
S
T
K
L
F
T
E
K
Site 63
Y935
T
E
K
Q
R
M
K
Y
F
L
S
T
L
P
T
Site 64
S938
Q
R
M
K
Y
F
L
S
T
L
P
T
R
P
E
Site 65
T939
R
M
K
Y
F
L
S
T
L
P
T
R
P
E
P
Site 66
T942
Y
F
L
S
T
L
P
T
R
P
E
P
E
L
P
Site 67
S956
P
C
V
E
N
L
N
S
I
E
L
N
R
K
Y
Site 68
Y963
S
I
E
L
N
R
K
Y
I
P
K
T
A
I
R
Site 69
T967
N
R
K
Y
I
P
K
T
A
I
R
I
P
T
S
Site 70
T973
K
T
A
I
R
I
P
T
S
N
P
Q
T
S
N
Site 71
S974
T
A
I
R
I
P
T
S
N
P
Q
T
S
N
N
Site 72
T978
I
P
T
S
N
P
Q
T
S
N
N
C
K
N
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation