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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Nav3
Full Name:
Neuron navigator 3
Alias:
KIAA0938; POMFIL1; Pore membrane and/or filament interacting like protein 1; Pore membrane and/or filament-interacting-like 1; Steerin 3; STEERIN3; Steerin-3; Unc-53 homolog 3; Unc-53 homologue 3; Unc53H3
Type:
Membrane, Nucleus, Nuclear outer membrane protein
Mass (Da):
255618
Number AA:
2385
UniProt ID:
Q8IVL0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005640
Uniprot
OncoNet
Molecular Function:
GO:0017111
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
L
R
Q
P
A
V
G
S
K
P
V
H
T
A
L
Site 2
S34
P
N
L
G
T
T
G
S
Q
H
C
S
S
R
P
Site 3
S38
T
T
G
S
Q
H
C
S
S
R
P
L
E
L
A
Site 4
T47
R
P
L
E
L
A
E
T
E
S
S
M
L
S
C
Site 5
S50
E
L
A
E
T
E
S
S
M
L
S
C
Q
L
A
Site 6
S53
E
T
E
S
S
M
L
S
C
Q
L
A
L
K
S
Site 7
S60
S
C
Q
L
A
L
K
S
T
C
E
F
G
E
K
Site 8
S80
K
A
K
E
K
E
D
S
K
I
Y
T
D
W
A
Site 9
Y83
E
K
E
D
S
K
I
Y
T
D
W
A
N
H
Y
Site 10
Y90
Y
T
D
W
A
N
H
Y
L
A
K
S
G
H
K
Site 11
S94
A
N
H
Y
L
A
K
S
G
H
K
R
L
I
K
Site 12
S134
D
I
N
G
C
P
R
S
Q
S
Q
M
I
E
N
Site 13
S136
N
G
C
P
R
S
Q
S
Q
M
I
E
N
V
D
Site 14
S180
L
G
L
F
F
S
L
S
R
Y
K
Q
Q
Q
H
Site 15
Y182
L
F
F
S
L
S
R
Y
K
Q
Q
Q
H
H
Q
Site 16
Y193
Q
H
H
Q
Q
Q
Y
Y
Q
S
L
V
E
L
Q
Site 17
S195
H
Q
Q
Q
Y
Y
Q
S
L
V
E
L
Q
Q
R
Site 18
T204
V
E
L
Q
Q
R
V
T
H
A
S
P
P
S
E
Site 19
S207
Q
Q
R
V
T
H
A
S
P
P
S
E
A
S
Q
Site 20
S210
V
T
H
A
S
P
P
S
E
A
S
Q
A
K
T
Site 21
S213
A
S
P
P
S
E
A
S
Q
A
K
T
Q
Q
D
Site 22
T217
S
E
A
S
Q
A
K
T
Q
Q
D
M
Q
S
S
Site 23
S224
T
Q
Q
D
M
Q
S
S
L
A
A
R
Y
A
T
Site 24
Y229
Q
S
S
L
A
A
R
Y
A
T
Q
S
N
H
S
Site 25
T231
S
L
A
A
R
Y
A
T
Q
S
N
H
S
G
I
Site 26
S233
A
A
R
Y
A
T
Q
S
N
H
S
G
I
A
T
Site 27
T240
S
N
H
S
G
I
A
T
S
Q
K
K
P
T
R
Site 28
S241
N
H
S
G
I
A
T
S
Q
K
K
P
T
R
L
Site 29
T246
A
T
S
Q
K
K
P
T
R
L
P
G
P
S
R
Site 30
S252
P
T
R
L
P
G
P
S
R
V
P
A
A
G
S
Site 31
S259
S
R
V
P
A
A
G
S
S
S
K
V
Q
G
A
Site 32
S261
V
P
A
A
G
S
S
S
K
V
Q
G
A
S
N
Site 33
S273
A
S
N
L
N
R
R
S
Q
S
F
N
S
I
D
Site 34
S275
N
L
N
R
R
S
Q
S
F
N
S
I
D
K
N
Site 35
S278
R
R
S
Q
S
F
N
S
I
D
K
N
K
P
P
Site 36
Y287
D
K
N
K
P
P
N
Y
A
N
G
N
E
K
D
Site 37
S296
N
G
N
E
K
D
S
S
K
G
P
Q
S
S
S
Site 38
S301
D
S
S
K
G
P
Q
S
S
S
G
V
N
G
N
Site 39
S302
S
S
K
G
P
Q
S
S
S
G
V
N
G
N
V
Site 40
S303
S
K
G
P
Q
S
S
S
G
V
N
G
N
V
Q
Site 41
S313
N
G
N
V
Q
P
P
S
T
A
G
Q
P
P
A
Site 42
T314
G
N
V
Q
P
P
S
T
A
G
Q
P
P
A
S
Site 43
S321
T
A
G
Q
P
P
A
S
A
I
P
S
P
S
A
Site 44
S325
P
P
A
S
A
I
P
S
P
S
A
S
K
P
W
Site 45
S327
A
S
A
I
P
S
P
S
A
S
K
P
W
R
S
Site 46
S329
A
I
P
S
P
S
A
S
K
P
W
R
S
K
S
Site 47
S334
S
A
S
K
P
W
R
S
K
S
M
N
V
K
H
Site 48
S336
S
K
P
W
R
S
K
S
M
N
V
K
H
S
A
Site 49
T344
M
N
V
K
H
S
A
T
S
T
M
L
T
V
K
Site 50
T346
V
K
H
S
A
T
S
T
M
L
T
V
K
Q
S
Site 51
T349
S
A
T
S
T
M
L
T
V
K
Q
S
S
T
A
Site 52
S353
T
M
L
T
V
K
Q
S
S
T
A
T
S
P
T
Site 53
S354
M
L
T
V
K
Q
S
S
T
A
T
S
P
T
P
Site 54
T355
L
T
V
K
Q
S
S
T
A
T
S
P
T
P
S
Site 55
T357
V
K
Q
S
S
T
A
T
S
P
T
P
S
S
D
Site 56
S358
K
Q
S
S
T
A
T
S
P
T
P
S
S
D
R
Site 57
T360
S
S
T
A
T
S
P
T
P
S
S
D
R
L
K
Site 58
S362
T
A
T
S
P
T
P
S
S
D
R
L
K
P
P
Site 59
S363
A
T
S
P
T
P
S
S
D
R
L
K
P
P
V
Site 60
S371
D
R
L
K
P
P
V
S
E
G
V
K
T
A
P
Site 61
T376
P
V
S
E
G
V
K
T
A
P
S
G
Q
K
S
Site 62
S379
E
G
V
K
T
A
P
S
G
Q
K
S
M
L
E
Site 63
S383
T
A
P
S
G
Q
K
S
M
L
E
K
F
K
L
Site 64
T395
F
K
L
V
N
A
R
T
A
L
R
P
P
Q
P
Site 65
S404
L
R
P
P
Q
P
P
S
S
G
P
S
D
G
G
Site 66
S405
R
P
P
Q
P
P
S
S
G
P
S
D
G
G
K
Site 67
S408
Q
P
P
S
S
G
P
S
D
G
G
K
D
D
D
Site 68
S418
G
K
D
D
D
A
F
S
E
S
G
E
M
E
G
Site 69
S428
G
E
M
E
G
F
N
S
G
L
N
S
G
G
S
Site 70
S432
G
F
N
S
G
L
N
S
G
G
S
T
N
S
S
Site 71
S435
S
G
L
N
S
G
G
S
T
N
S
S
P
K
V
Site 72
T436
G
L
N
S
G
G
S
T
N
S
S
P
K
V
S
Site 73
S438
N
S
G
G
S
T
N
S
S
P
K
V
S
P
K
Site 74
S439
S
G
G
S
T
N
S
S
P
K
V
S
P
K
L
Site 75
S443
T
N
S
S
P
K
V
S
P
K
L
A
P
P
K
Site 76
S453
L
A
P
P
K
A
G
S
K
N
L
S
N
K
K
Site 77
S457
K
A
G
S
K
N
L
S
N
K
K
S
L
L
Q
Site 78
S461
K
N
L
S
N
K
K
S
L
L
Q
P
K
E
K
Site 79
T480
R
D
K
N
K
V
C
T
E
K
P
V
K
E
E
Site 80
S500
E
M
A
P
K
K
T
S
K
I
A
S
L
I
P
Site 81
S504
K
K
T
S
K
I
A
S
L
I
P
K
G
S
K
Site 82
T512
L
I
P
K
G
S
K
T
T
A
A
K
K
E
S
Site 83
S519
T
T
A
A
K
K
E
S
L
I
P
S
S
S
G
Site 84
S523
K
K
E
S
L
I
P
S
S
S
G
I
P
K
P
Site 85
S524
K
E
S
L
I
P
S
S
S
G
I
P
K
P
G
Site 86
S525
E
S
L
I
P
S
S
S
G
I
P
K
P
G
S
Site 87
S532
S
G
I
P
K
P
G
S
K
V
P
T
V
K
Q
Site 88
T536
K
P
G
S
K
V
P
T
V
K
Q
T
I
S
P
Site 89
T540
K
V
P
T
V
K
Q
T
I
S
P
G
S
T
A
Site 90
S542
P
T
V
K
Q
T
I
S
P
G
S
T
A
S
K
Site 91
S545
K
Q
T
I
S
P
G
S
T
A
S
K
E
S
E
Site 92
T546
Q
T
I
S
P
G
S
T
A
S
K
E
S
E
K
Site 93
S548
I
S
P
G
S
T
A
S
K
E
S
E
K
F
R
Site 94
T556
K
E
S
E
K
F
R
T
T
K
G
S
P
S
Q
Site 95
T557
E
S
E
K
F
R
T
T
K
G
S
P
S
Q
S
Site 96
S560
K
F
R
T
T
K
G
S
P
S
Q
S
L
S
K
Site 97
S562
R
T
T
K
G
S
P
S
Q
S
L
S
K
P
I
Site 98
S564
T
K
G
S
P
S
Q
S
L
S
K
P
I
T
M
Site 99
S566
G
S
P
S
Q
S
L
S
K
P
I
T
M
E
K
Site 100
T570
Q
S
L
S
K
P
I
T
M
E
K
A
S
A
S
Site 101
S575
P
I
T
M
E
K
A
S
A
S
S
C
P
A
P
Site 102
S577
T
M
E
K
A
S
A
S
S
C
P
A
P
L
E
Site 103
S592
G
R
E
A
G
Q
A
S
P
S
G
S
C
T
M
Site 104
S594
E
A
G
Q
A
S
P
S
G
S
C
T
M
T
V
Site 105
S596
G
Q
A
S
P
S
G
S
C
T
M
T
V
A
Q
Site 106
T598
A
S
P
S
G
S
C
T
M
T
V
A
Q
S
S
Site 107
T600
P
S
G
S
C
T
M
T
V
A
Q
S
S
G
Q
Site 108
S605
T
M
T
V
A
Q
S
S
G
Q
S
T
G
N
G
Site 109
S608
V
A
Q
S
S
G
Q
S
T
G
N
G
A
V
Q
Site 110
T609
A
Q
S
S
G
Q
S
T
G
N
G
A
V
Q
L
Site 111
T627
Q
Q
H
S
H
P
N
T
A
T
V
A
P
F
I
Site 112
T629
H
S
H
P
N
T
A
T
V
A
P
F
I
Y
R
Site 113
Y635
A
T
V
A
P
F
I
Y
R
A
H
S
E
N
E
Site 114
S639
P
F
I
Y
R
A
H
S
E
N
E
G
T
A
L
Site 115
T644
A
H
S
E
N
E
G
T
A
L
P
S
A
D
S
Site 116
S648
N
E
G
T
A
L
P
S
A
D
S
C
T
S
P
Site 117
S651
T
A
L
P
S
A
D
S
C
T
S
P
T
K
M
Site 118
S654
P
S
A
D
S
C
T
S
P
T
K
M
D
L
S
Site 119
S661
S
P
T
K
M
D
L
S
Y
S
K
T
A
K
Q
Site 120
Y662
P
T
K
M
D
L
S
Y
S
K
T
A
K
Q
C
Site 121
S663
T
K
M
D
L
S
Y
S
K
T
A
K
Q
C
L
Site 122
T665
M
D
L
S
Y
S
K
T
A
K
Q
C
L
E
E
Site 123
T680
I
S
G
E
D
P
E
T
R
R
M
R
T
V
K
Site 124
T685
P
E
T
R
R
M
R
T
V
K
N
I
A
D
L
Site 125
S701
Q
N
L
E
E
T
M
S
S
L
R
G
T
Q
I
Site 126
S702
N
L
E
E
T
M
S
S
L
R
G
T
Q
I
S
Site 127
T706
T
M
S
S
L
R
G
T
Q
I
S
H
S
T
L
Site 128
S709
S
L
R
G
T
Q
I
S
H
S
T
L
E
T
T
Site 129
S711
R
G
T
Q
I
S
H
S
T
L
E
T
T
F
D
Site 130
T715
I
S
H
S
T
L
E
T
T
F
D
S
T
V
T
Site 131
T716
S
H
S
T
L
E
T
T
F
D
S
T
V
T
T
Site 132
T720
L
E
T
T
F
D
S
T
V
T
T
E
V
N
G
Site 133
T723
T
F
D
S
T
V
T
T
E
V
N
G
R
T
I
Site 134
T734
G
R
T
I
P
N
L
T
S
R
P
T
P
M
T
Site 135
S735
R
T
I
P
N
L
T
S
R
P
T
P
M
T
W
Site 136
T738
P
N
L
T
S
R
P
T
P
M
T
W
R
L
G
Site 137
T741
T
S
R
P
T
P
M
T
W
R
L
G
Q
A
C
Site 138
S758
L
Q
A
G
D
A
P
S
L
G
A
G
Y
P
R
Site 139
Y763
A
P
S
L
G
A
G
Y
P
R
S
G
T
S
R
Site 140
S766
L
G
A
G
Y
P
R
S
G
T
S
R
F
I
H
Site 141
T768
A
G
Y
P
R
S
G
T
S
R
F
I
H
T
D
Site 142
T774
G
T
S
R
F
I
H
T
D
P
S
R
F
M
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Q
S
C
D
Site 447
S2360
L
Q
E
A
A
N
Y
S
S
T
Q
S
C
D
S
Site 448
T2362
E
A
A
N
Y
S
S
T
Q
S
C
D
S
E
S
Site 449
S2364
A
N
Y
S
S
T
Q
S
C
D
S
E
S
T
S
Site 450
S2367
S
S
T
Q
S
C
D
S
E
S
T
S
H
H
E
Site 451
S2369
T
Q
S
C
D
S
E
S
T
S
H
H
E
D
I
Site 452
S2371
S
C
D
S
E
S
T
S
H
H
E
D
I
L
D
Site 453
S2379
H
H
E
D
I
L
D
S
S
L
E
S
T
L
_
Site 454
S2380
H
E
D
I
L
D
S
S
L
E
S
T
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation