KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
LEPREL1
Full Name:
Prolyl 3-hydroxylase 2
Alias:
Leprecan-like protein 1;Myxoid liposarcoma-associated protein 4
Type:
Mass (Da):
80984
Number AA:
708
UniProt ID:
Q8IVL5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
L
W
G
G
P
P
D
S
P
R
R
E
L
E
L
Site 2
S57
S
G
A
A
A
Y
Y
S
G
D
Y
E
R
A
V
Site 3
Y60
A
A
Y
Y
S
G
D
Y
E
R
A
V
R
D
L
Site 4
S73
D
L
E
A
A
L
R
S
H
R
R
L
R
E
I
Site 5
Y120
L
L
G
R
A
R
C
Y
R
S
C
E
T
Q
R
Site 6
S122
G
R
A
R
C
Y
R
S
C
E
T
Q
R
L
G
Site 7
T125
R
C
Y
R
S
C
E
T
Q
R
L
G
G
P
A
Site 8
S133
Q
R
L
G
G
P
A
S
R
H
R
V
S
E
D
Site 9
S138
P
A
S
R
H
R
V
S
E
D
V
R
S
D
F
Site 10
S143
R
V
S
E
D
V
R
S
D
F
Q
R
R
V
P
Site 11
Y151
D
F
Q
R
R
V
P
Y
N
Y
L
Q
R
A
Y
Site 12
Y153
Q
R
R
V
P
Y
N
Y
L
Q
R
A
Y
I
K
Site 13
Y158
Y
N
Y
L
Q
R
A
Y
I
K
L
N
Q
L
E
Site 14
T194
N
I
E
N
Y
R
A
T
A
G
V
E
A
L
Q
Site 15
Y214
A
K
P
H
M
E
S
Y
N
A
G
V
K
H
Y
Site 16
Y240
F
E
Q
A
L
R
E
Y
F
V
E
D
T
E
C
Site 17
T249
V
E
D
T
E
C
R
T
L
C
E
G
P
Q
R
Site 18
Y260
G
P
Q
R
F
E
E
Y
E
Y
L
G
Y
K
A
Site 19
Y262
Q
R
F
E
E
Y
E
Y
L
G
Y
K
A
G
L
Site 20
Y265
E
E
Y
E
Y
L
G
Y
K
A
G
L
Y
E
A
Site 21
Y270
L
G
Y
K
A
G
L
Y
E
A
I
A
D
H
Y
Site 22
S299
A
T
R
P
G
R
L
S
P
I
E
N
F
L
P
Site 23
Y311
F
L
P
L
H
Y
D
Y
L
Q
F
A
Y
Y
R
Site 24
Y316
Y
D
Y
L
Q
F
A
Y
Y
R
V
G
E
Y
V
Site 25
Y317
D
Y
L
Q
F
A
Y
Y
R
V
G
E
Y
V
K
Site 26
Y322
A
Y
Y
R
V
G
E
Y
V
K
A
L
E
C
A
Site 27
Y348
D
V
L
D
N
V
D
Y
Y
E
S
L
L
D
D
Site 28
Y349
V
L
D
N
V
D
Y
Y
E
S
L
L
D
D
S
Site 29
S351
D
N
V
D
Y
Y
E
S
L
L
D
D
S
I
D
Site 30
S356
Y
E
S
L
L
D
D
S
I
D
P
A
S
I
E
Site 31
S361
D
D
S
I
D
P
A
S
I
E
A
R
E
D
L
Site 32
T369
I
E
A
R
E
D
L
T
M
F
V
K
R
H
K
Site 33
S379
V
K
R
H
K
L
E
S
E
L
I
K
S
A
A
Site 34
S392
A
A
E
G
L
G
F
S
Y
T
E
P
N
Y
W
Site 35
Y393
A
E
G
L
G
F
S
Y
T
E
P
N
Y
W
I
Site 36
Y398
F
S
Y
T
E
P
N
Y
W
I
R
Y
G
G
R
Site 37
S413
Q
D
E
N
R
V
P
S
G
V
N
V
E
G
A
Site 38
S426
G
A
E
V
H
G
F
S
M
G
K
K
L
S
P
Site 39
S432
F
S
M
G
K
K
L
S
P
K
I
D
R
D
L
Site 40
Y447
R
E
G
G
P
L
L
Y
E
N
I
T
F
V
Y
Site 41
T451
P
L
L
Y
E
N
I
T
F
V
Y
N
S
E
Q
Site 42
Y454
Y
E
N
I
T
F
V
Y
N
S
E
Q
L
N
G
Site 43
T462
N
S
E
Q
L
N
G
T
Q
R
V
L
L
D
N
Site 44
S472
V
L
L
D
N
V
L
S
E
E
Q
C
R
E
L
Site 45
Y493
I
M
L
V
G
D
G
Y
R
G
K
T
S
P
H
Site 46
T497
G
D
G
Y
R
G
K
T
S
P
H
T
P
N
E
Site 47
S498
D
G
Y
R
G
K
T
S
P
H
T
P
N
E
K
Site 48
T501
R
G
K
T
S
P
H
T
P
N
E
K
F
E
G
Site 49
S517
T
V
L
K
A
L
K
S
G
Y
E
G
R
V
P
Site 50
Y519
L
K
A
L
K
S
G
Y
E
G
R
V
P
L
K
Site 51
S527
E
G
R
V
P
L
K
S
A
R
L
F
Y
D
I
Site 52
Y532
L
K
S
A
R
L
F
Y
D
I
S
E
K
A
R
Site 53
S535
A
R
L
F
Y
D
I
S
E
K
A
R
R
I
V
Site 54
S544
K
A
R
R
I
V
E
S
Y
F
M
L
N
S
T
Site 55
T551
S
Y
F
M
L
N
S
T
L
Y
F
S
Y
T
H
Site 56
S576
Q
D
R
R
N
D
L
S
H
P
I
H
A
D
N
Site 57
Y600
C
W
K
E
P
P
A
Y
T
F
R
D
Y
S
A
Site 58
T601
W
K
E
P
P
A
Y
T
F
R
D
Y
S
A
L
Site 59
Y605
P
A
Y
T
F
R
D
Y
S
A
L
L
Y
M
N
Site 60
Y610
R
D
Y
S
A
L
L
Y
M
N
D
D
F
E
G
Site 61
T623
E
G
G
E
F
I
F
T
E
M
D
A
K
T
V
Site 62
T629
F
T
E
M
D
A
K
T
V
T
A
S
I
K
P
Site 63
T631
E
M
D
A
K
T
V
T
A
S
I
K
P
K
C
Site 64
S643
P
K
C
G
R
M
I
S
F
S
S
G
G
E
N
Site 65
S645
C
G
R
M
I
S
F
S
S
G
G
E
N
P
H
Site 66
S646
G
R
M
I
S
F
S
S
G
G
E
N
P
H
G
Site 67
Y675
W
F
T
L
D
P
L
Y
R
E
L
E
R
I
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation