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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CPO
Full Name:
Carboxypeptidase O
Alias:
Type:
Mass (Da):
42529
Number AA:
374
UniProt ID:
Q8IVL8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y21
L
V
P
G
G
L
G
Y
D
R
S
L
A
Q
H
Site 2
S24
G
G
L
G
Y
D
R
S
L
A
Q
H
R
Q
E
Site 3
S36
R
Q
E
I
V
D
K
S
V
S
P
W
S
L
E
Site 4
S38
E
I
V
D
K
S
V
S
P
W
S
L
E
T
Y
Site 5
S41
D
K
S
V
S
P
W
S
L
E
T
Y
S
Y
N
Site 6
Y45
S
P
W
S
L
E
T
Y
S
Y
N
I
Y
H
P
Site 7
Y47
W
S
L
E
T
Y
S
Y
N
I
Y
H
P
M
G
Site 8
Y50
E
T
Y
S
Y
N
I
Y
H
P
M
G
E
I
Y
Site 9
Y57
Y
H
P
M
G
E
I
Y
E
W
M
R
E
I
S
Site 10
Y67
M
R
E
I
S
E
K
Y
K
E
V
V
T
Q
H
Site 11
Y80
Q
H
F
L
G
V
T
Y
E
T
H
P
M
Y
Y
Site 12
Y86
T
Y
E
T
H
P
M
Y
Y
L
K
I
S
Q
P
Site 13
Y87
Y
E
T
H
P
M
Y
Y
L
K
I
S
Q
P
S
Site 14
S91
P
M
Y
Y
L
K
I
S
Q
P
S
G
N
P
K
Site 15
S133
L
Q
N
H
K
D
N
S
S
I
R
K
L
L
R
Site 16
S134
Q
N
H
K
D
N
S
S
I
R
K
L
L
R
N
Site 17
Y155
P
V
L
N
I
D
G
Y
I
Y
T
W
T
T
D
Site 18
S168
T
D
R
L
W
R
K
S
R
S
P
H
N
N
G
Site 19
S170
R
L
W
R
K
S
R
S
P
H
N
N
G
T
C
Site 20
S189
L
N
R
N
F
N
A
S
W
C
S
I
G
A
S
Site 21
S211
F
C
G
T
G
P
V
S
E
P
E
T
K
A
V
Site 22
S220
P
E
T
K
A
V
A
S
F
I
E
S
K
K
D
Site 23
Y238
C
F
L
T
M
H
S
Y
G
Q
L
I
L
T
P
Site 24
T244
S
Y
G
Q
L
I
L
T
P
Y
G
Y
T
K
N
Site 25
Y246
G
Q
L
I
L
T
P
Y
G
Y
T
K
N
K
S
Site 26
Y248
L
I
L
T
P
Y
G
Y
T
K
N
K
S
S
N
Site 27
Y278
K
A
K
Y
G
T
N
Y
R
V
G
S
S
A
D
Site 28
S282
G
T
N
Y
R
V
G
S
S
A
D
I
L
Y
A
Site 29
Y288
G
S
S
A
D
I
L
Y
A
S
S
G
S
S
R
Site 30
S290
S
A
D
I
L
Y
A
S
S
G
S
S
R
D
W
Site 31
S291
A
D
I
L
Y
A
S
S
G
S
S
R
D
W
A
Site 32
S293
I
L
Y
A
S
S
G
S
S
R
D
W
A
R
D
Site 33
S294
L
Y
A
S
S
G
S
S
R
D
W
A
R
D
I
Site 34
S306
R
D
I
G
I
P
F
S
Y
T
F
E
L
R
D
Site 35
T308
I
G
I
P
F
S
Y
T
F
E
L
R
D
S
G
Site 36
S314
Y
T
F
E
L
R
D
S
G
T
Y
G
F
V
L
Site 37
T316
F
E
L
R
D
S
G
T
Y
G
F
V
L
P
E
Site 38
Y317
E
L
R
D
S
G
T
Y
G
F
V
L
P
E
A
Site 39
Y345
L
S
V
L
D
D
V
Y
A
K
H
W
H
S
D
Site 40
S353
A
K
H
W
H
S
D
S
A
G
R
V
T
S
A
Site 41
S369
M
L
L
G
L
L
V
S
C
M
S
L
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation