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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CCDC50
Full Name:
Coiled-coil domain-containing protein 50
Alias:
C3orf6; CCD50; Coiled-coil domain containing 50; DFNA44; Ymer
Type:
Inhibitor protein; Signalling protein for EGF receptor
Mass (Da):
35822
Number AA:
306
UniProt ID:
Q8IVM0
International Prot ID:
IPI00383423
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007605
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
E
V
S
I
D
Q
S
K
L
P
G
V
K
E
Site 2
T28
F
A
V
L
E
D
H
T
L
A
H
S
L
Q
E
Site 3
S32
E
D
H
T
L
A
H
S
L
Q
E
Q
E
I
E
Site 4
T137
H
F
P
E
F
P
A
T
R
A
Y
A
D
S
Y
Site 5
Y140
E
F
P
A
T
R
A
Y
A
D
S
Y
Y
Y
E
Site 6
S143
A
T
R
A
Y
A
D
S
Y
Y
Y
E
D
G
G
Site 7
Y144
T
R
A
Y
A
D
S
Y
Y
Y
E
D
G
G
M
Site 8
Y145
R
A
Y
A
D
S
Y
Y
Y
E
D
G
G
M
K
Site 9
Y146
A
Y
A
D
S
Y
Y
Y
E
D
G
D
Q
P
G
Site 10
T162
V
M
K
E
A
V
S
T
P
S
R
M
A
H
R
Site 11
Y174
A
H
R
D
Q
E
W
Y
D
A
E
I
A
R
K
Site 12
T190
Q
E
E
E
L
L
A
T
Q
V
D
M
R
A
A
Site 13
Y217
M
A
E
E
K
K
A
Y
K
K
A
K
E
R
E
Site 14
S226
K
A
K
E
R
E
K
S
S
L
D
K
R
K
Q
Site 15
T241
D
P
E
W
K
P
K
T
A
K
A
A
N
S
K
Site 16
S247
K
T
A
K
A
A
N
S
K
S
K
E
S
D
E
Site 17
S249
A
K
A
A
N
S
K
S
K
E
S
D
E
P
H
Site 18
S252
A
N
S
K
S
K
E
S
D
E
P
H
H
S
K
Site 19
S258
E
S
D
E
P
H
H
S
K
N
E
R
P
A
R
Site 20
T272
R
P
P
P
P
I
M
T
D
G
E
D
A
D
Y
Site 21
Y279
T
D
G
E
D
A
D
Y
T
H
F
T
N
Q
Q
Site 22
T280
D
G
E
D
A
D
Y
T
H
F
T
N
Q
Q
S
Site 23
T283
D
A
D
Y
T
H
F
T
N
Q
Q
S
S
T
R
Site 24
S288
H
F
T
N
Q
Q
S
S
T
R
H
F
S
K
S
Site 25
S293
Q
S
S
T
R
H
F
S
K
S
E
S
S
H
K
Site 26
S295
S
T
R
H
F
S
K
S
E
S
S
H
K
G
F
Site 27
S297
R
H
F
S
K
S
E
S
S
H
K
G
F
H
Y
Site 28
Y304
S
S
H
K
G
F
H
Y
K
H
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation